Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gamma-2-syntrophin

Gene

SNTG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • central nervous system development Source: ProtInc

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

SIGNORiQ9NY99

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-2-syntrophin
Short name:
G2SYN
Alternative name(s):
Syntrophin-5
Short name:
SYN5
Gene namesi
Name:SNTG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000172554.11
HGNCiHGNC:13741 SNTG2
MIMi608715 gene
neXtProtiNX_Q9NY99

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54221
OpenTargetsiENSG00000172554
PharmGKBiPA37807

Polymorphism and mutation databases

BioMutaiSNTG2
DMDMi296452909

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840151 – 539Gamma-2-syntrophinAdd BLAST539

Proteomic databases

PaxDbiQ9NY99
PeptideAtlasiQ9NY99
PRIDEiQ9NY99
ProteomicsDBi83200
83201 [Q9NY99-2]

PTM databases

iPTMnetiQ9NY99
PhosphoSitePlusiQ9NY99

Expressioni

Tissue specificityi

Widely expressed. Strong expression in brain and testis. In CNS, it is expressed in the perikaryon and proximal portion of the neuronal processes. Strong expression in the hippocampus, neuron-rich dendate granule cells, and pyramidal cell layers. Highly expressed in neurons of the cerebral cortex. Also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, and basal ganglia.1 Publication

Gene expression databases

BgeeiENSG00000172554 Expressed in 94 organ(s), highest expression level in adenohypophysis
CleanExiHS_SNTG2
ExpressionAtlasiQ9NY99 baseline and differential
GenevisibleiQ9NY99 HS

Interactioni

Subunit structurei

Interacts with the dystrophin protein DMD and related proteins DTNA and DTNB.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119929, 14 interactors
IntActiQ9NY99, 3 interactors
MINTiQ9NY99
STRINGi9606.ENSP00000311837

Structurei

3D structure databases

ProteinModelPortaliQ9NY99
SMRiQ9NY99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 156PDZPROSITE-ProRule annotationAdd BLAST84
Domaini296 – 421PHAdd BLAST126

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 9Poly-Pro4

Domaini

The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane.By similarity

Sequence similaritiesi

Belongs to the syntrophin family.Curated

Phylogenomic databases

eggNOGiKOG3549 Eukaryota
ENOG410XQXQ LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000230749
HOVERGENiHBG060412
InParanoidiQ9NY99
OMAiSFQRAIF
OrthoDBiEOG091G04YZ
PhylomeDBiQ9NY99
TreeFamiTF317932

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR015482 Syntrophin
PANTHERiPTHR10554 PTHR10554, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9NY99-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTEGPPPPA ASRGRQGCLL VPARTKTTIA LLYDEESENA YDIRLKLTKE
60 70 80 90 100
VLTIQKQDVV CVGGSHQGRN RRTVTLRRQP VGGLGLSIKG GSEHNVPVVI
110 120 130 140 150
SKIFEDQAAD QTGMLFVGDA VLQVNGIHVE NATHEEVVHL LRNAGDEVTI
160 170 180 190 200
TVEYLREAPA FLKLPLGSPG PSSDHSSGAS SPLFDSGLHL NGNSSTTAPS
210 220 230 240 250
SPSSPIAKDP RYEKRWLDTL SVPLSMARIS RYKAGTEKLR WNAFEVLALD
260 270 280 290 300
GVSSGILRFY TAQDGTDWLR AVSANIRELT LQNMKMANKC CSPSDQVVHM
310 320 330 340 350
GWVNEKLQGA DSSQTFRPKF LALKGPSFYV FSTPPVSTFD WVRAERTYHL
360 370 380 390 400
CEVLFKVHKF WLTEDCWLQA NLYLGLQDFD FEDQRPYCFS IVAGHGKSHV
410 420 430 440 450
FNVELGSELA MWEKSFQRAT FMEVQRTGSR TYMCSWQGEM LCFTVDFALG
460 470 480 490 500
FTCFESKTKN VLWRFKFSQL KGSSDDGKTR VKLLFQNLDT KQIETKELEF
510 520 530
QDLRAVLHCI HSFIAAKVAS VDPGFMDSQS LARKYMYSS
Length:539
Mass (Da):60,217
Last modified:May 18, 2010 - v2
Checksum:i0D3B1E24CC05D365
GO
Isoform 2 (identifier: Q9NY99-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-197: Missing.

Note: No experimental confirmation available.
Show »
Length:412
Mass (Da):46,842
Checksum:i79D69164BB5D8678
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2D2F2Z2D2_HUMAN
Gamma-2-syntrophin
SNTG2
129Annotation score:
A0A0G2JR78A0A0G2JR78_HUMAN
Gamma-2-syntrophin
SNTG2
231Annotation score:
A0A0G2JS85A0A0G2JS85_HUMAN
Gamma-2-syntrophin
SNTG2
80Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti495T → M in CAB92969 (PubMed:10747910).Curated1
Sequence conflicti495T → M in AAI25252 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034501168S → Y. Corresponds to variant dbSNP:rs28505970Ensembl.1
Natural variantiVAR_034502200S → L. Corresponds to variant dbSNP:rs6751090Ensembl.1
Natural variantiVAR_034503391I → V. Corresponds to variant dbSNP:rs13023962Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03917571 – 197Missing in isoform 2. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003029 mRNA Translation: CAB92969.1
AC108462 Genomic DNA No translation available.
AC114808 Genomic DNA No translation available.
AC116614 Genomic DNA No translation available.
AC140476 Genomic DNA No translation available.
AC144444 Genomic DNA No translation available.
AC144527 Genomic DNA No translation available.
AC225604 Genomic DNA No translation available.
BC125251 mRNA Translation: AAI25252.1
CCDSiCCDS46220.1 [Q9NY99-1]
RefSeqiNP_061841.2, NM_018968.3 [Q9NY99-1]
UniGeneiHs.595069

Genome annotation databases

EnsembliENST00000308624; ENSP00000311837; ENSG00000172554 [Q9NY99-1]
ENST00000407292; ENSP00000385020; ENSG00000172554 [Q9NY99-2]
GeneIDi54221
KEGGihsa:54221
UCSCiuc002qwq.4 human [Q9NY99-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSNTG2_HUMAN
AccessioniPrimary (citable) accession number: Q9NY99
Secondary accession number(s): Q05AH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again