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UniProtKB - Q9NY91 (SC5A4_HUMAN)

Entry version 161 (25 May 2022)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
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Protein

Solute carrier family 5 member 4

Gene

SLC5A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has electrogenic activity in response to glucose, and may function as a glucose sensor (PubMed:13130073, PubMed:17110502, PubMed:20421923, PubMed:22766068).

Mediates influx of sodium ions into the cell but does not transport sugars (PubMed:13130073, PubMed:22766068).

Also potently activated by imino sugars such as deoxynojirimycin (DNJ) (PubMed:17110502, PubMed:20421923, PubMed:22766068).

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by phlorizin.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NY91

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-189200, Cellular hexose transport

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NY91

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.21.3.18, the solute:sodium symporter (sss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 5 member 41 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC5A41 Publication
Synonyms:SAAT1, SGLT31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11039, SLC5A4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618633, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NY91

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100191

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 47HelicalSequence analysisAdd BLAST19
Topological domaini48 – 64ExtracellularSequence analysisAdd BLAST17
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 105CytoplasmicSequence analysisAdd BLAST20
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 171ExtracellularSequence analysisAdd BLAST45
Transmembranei172 – 191HelicalSequence analysisAdd BLAST20
Topological domaini192 – 208CytoplasmicSequence analysisAdd BLAST17
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 270ExtracellularSequence analysisAdd BLAST41
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 314CytoplasmicSequence analysisAdd BLAST23
Transmembranei315 – 334HelicalSequence analysisAdd BLAST20
Topological domaini335 – 423ExtracellularSequence analysisAdd BLAST89
Transmembranei424 – 443HelicalSequence analysisAdd BLAST20
Topological domaini444 – 455CytoplasmicSequence analysisAdd BLAST12
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Topological domaini477 – 526ExtracellularSequence analysisAdd BLAST50
Transmembranei527 – 547HelicalSequence analysisAdd BLAST21
Topological domaini548 – 637CytoplasmicSequence analysisAdd BLAST90
Transmembranei638 – 658HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi457E → Q: Confers sugar transport activity not found in the wild-type protein. Increased sensitivity to inhibitor phlorizin. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		6527

Open Targets

More...OpenTargetsi		ENSG00000100191

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35904

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NY91, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1770047

DrugCentral

More...DrugCentrali		Q9NY91

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC5A4

Domain mapping of disease mutations (DMDM)

More...DMDMi		17433306

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001053761 – 659Solute carrier family 5 member 4Add BLAST659

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NY91

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NY91

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NY91

PeptideAtlas

More...PeptideAtlasi		Q9NY91

PRoteomics IDEntifications database

More...PRIDEi		Q9NY91

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83196

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NY91, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NY91

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NY91

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal muscle, where it may localize to the neuromuscular junction (at protein level) (PubMed:13130073). Expressed in small intestine where it may localize to cholinergic neurons of the submucosal plexus and myenteric plexus (at protein level) (PubMed:13130073). Detected in kidney (at protein level) (PubMed:22766068).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100191, Expressed in intestine and 99 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NY91, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100191, Tissue enriched (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112418, 35 interactors

Protein interaction database and analysis system

More...IntActi		Q9NY91, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000266086

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9NY91

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NY91, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9NY91

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NY91

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni573 – 592DisorderedSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2349, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160846

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018808_9_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NY91

Identification of Orthologs from Complete Genome Data

More...OMAi		CVKHCGI

Database of Orthologous Groups

More...OrthoDBi		243316at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NY91

TreeFam database of animal gene trees

More...TreeFami		TF352855

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1730.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038377, Na/Glc_symporter_sf
IPR001734, Na/solute_symporter
IPR018212, Na/solute_symporter_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00474, SSF, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00813, sss, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00456, NA_SOLUT_SYMP_1, 1 hit
PS00457, NA_SOLUT_SYMP_2, 1 hit
PS50283, NA_SOLUT_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NY91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTVSPSTI AETPEPPPLS DHIRNAADIS VIVIYFLVVM AVGLWAMLKT 
        60         70         80         90        100
NRGTIGGFFL AGRDMAWWPM GASLFASNIG SNHYVGLAGT GAASGVATVT 
       110        120        130        140        150
FEWTSSVMLL ILGWIFVPIY IKSGVMTMPE YLKKRFGGER LQVYLSILSL 
       160        170        180        190        200
FICVVLLISA DIFAGAIFIK LALGLDLYLA IFILLAMTAV YTTTGGLASV 
       210        220        230        240        250
IYTDTLQTII MLIGSFILMG FAFNEVGGYE SFTEKYVNAT PSVVEGDNLT 
       260        270        280        290        300
ISASCYTPRA DSFHIFRDAV TGDIPWPGII FGMPITALWY WCTNQVIVQR 
       310        320        330        340        350
CLCGKDMSHV KAACIMCAYL KLLPMFLMVM PGMISRILYT DMVACVVPSE 
       360        370        380        390        400
CVKHCGVDVG CTNYAYPTMV LELMPQGLRG LMLSVMLASL MSSLTSIFNS 
       410        420        430        440        450
ASTLFTIDLY TKMRKQASEK ELLIAGRIFV LLLTVVSIVW VPLVQVSQNG 
       460        470        480        490        500
QLIHYTESIS SYLGPPIAAV FVLAIFCKRV NEQGAFWGLM VGLAMGLIRM 
       510        520        530        540        550
ITEFAYGTGS CLAPSNCPKI ICGVHYLYFS IVLFFGSMLV TLGISLLTKP 
       560        570        580        590        600
IPDVHLYRLC WVLRNSTEER IDIDAEEKSQ EETDDGVEED YPEKSRGCLK 
       610        620        630        640        650
KAYDLFCGLQ KGPKLTKEEE EALSKKLTDT SERPSWRTIV NINAILLLAV 

VVFIHGYYA
Length:659
Mass (Da):72,456
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8A34AED648B523A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti76A → V in AAB61732 (Ref. 3) Curated1
Sequence conflicti106S → P in AAB61732 (Ref. 3) Curated1
Sequence conflicti243V → I in AAB61732 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0524894T → M. Corresponds to variant dbSNP:rs16990065Ensembl.1
Natural variantiVAR_02199746A → T. Corresponds to variant dbSNP:rs2235171Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ133127 mRNA Translation: CAB81772.1
AL008723 Genomic DNA No translation available.
U41897 mRNA Translation: AAB61732.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13903.1

NCBI Reference Sequences

More...RefSeqi		NP_055042.1, NM_014227.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000266086.6; ENSP00000266086.3; ENSG00000100191.6

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6527

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6527

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000266086.6; ENSP00000266086.3; NM_014227.3; NP_055042.1

UCSC genome browser

More...UCSCi		uc003ami.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133127 mRNA Translation: CAB81772.1
AL008723 Genomic DNA No translation available.
U41897 mRNA Translation: AAB61732.1
CCDSiCCDS13903.1
RefSeqiNP_055042.1, NM_014227.2

3D structure databases

AlphaFoldDBiQ9NY91
SMRiQ9NY91
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112418, 35 interactors
IntActiQ9NY91, 4 interactors
STRINGi9606.ENSP00000266086

Chemistry databases

BindingDBiQ9NY91
ChEMBLiCHEMBL1770047
DrugCentraliQ9NY91

Protein family/group databases

TCDBi2.A.21.3.18, the solute:sodium symporter (sss) family

PTM databases

GlyGeniQ9NY91, 1 site
iPTMnetiQ9NY91
PhosphoSitePlusiQ9NY91

Genetic variation databases

BioMutaiSLC5A4
DMDMi17433306

Proteomic databases

jPOSTiQ9NY91
MassIVEiQ9NY91
PaxDbiQ9NY91
PeptideAtlasiQ9NY91
PRIDEiQ9NY91
ProteomicsDBi83196

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11228, 108 antibodies from 24 providers

The DNASU plasmid repository

More...DNASUi		6527

Genome annotation databases

EnsembliENST00000266086.6; ENSP00000266086.3; ENSG00000100191.6
GeneIDi6527
KEGGihsa:6527
MANE-SelectiENST00000266086.6; ENSP00000266086.3; NM_014227.3; NP_055042.1
UCSCiuc003ami.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6527
DisGeNETi6527

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC5A4
HGNCiHGNC:11039, SLC5A4
HPAiENSG00000100191, Tissue enriched (intestine)
MIMi618633, gene
neXtProtiNX_Q9NY91
OpenTargetsiENSG00000100191
PharmGKBiPA35904
VEuPathDBiHostDB:ENSG00000100191

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2349, Eukaryota
GeneTreeiENSGT00940000160846
HOGENOMiCLU_018808_9_2_1
InParanoidiQ9NY91
OMAiCVKHCGI
OrthoDBi243316at2759
PhylomeDBiQ9NY91
TreeFamiTF352855

Enzyme and pathway databases

PathwayCommonsiQ9NY91
ReactomeiR-HSA-189200, Cellular hexose transport
SignaLinkiQ9NY91

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6527, 8 hits in 1060 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC5A4, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SLC5A4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6527
PharosiQ9NY91, Tchem

Protein Ontology

More...PROi		PR:Q9NY91
RNActiQ9NY91, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100191, Expressed in intestine and 99 other tissues
GenevisibleiQ9NY91, HS

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377, Na/Glc_symporter_sf
IPR001734, Na/solute_symporter
IPR018212, Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474, SSF, 1 hit
TIGRFAMsiTIGR00813, sss, 1 hit
PROSITEiView protein in PROSITE
PS00456, NA_SOLUT_SYMP_1, 1 hit
PS00457, NA_SOLUT_SYMP_2, 1 hit
PS50283, NA_SOLUT_SYMP_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC5A4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NY91
Secondary accession number(s): O15279
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: May 25, 2022
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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