We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q9NY91 (SC5A4_HUMAN)
Protein
Solute carrier family 5 member 4
Gene
SLC5A4
Organism
Homo sapiens (Human)
Status
Functioni
Has electrogenic activity in response to glucose, and may function as a glucose sensor (PubMed:13130073, PubMed:17110502, PubMed:20421923, PubMed:22766068).
Mediates influx of sodium ions into the cell but does not transport sugars (PubMed:13130073, PubMed:22766068).
Also potently activated by imino sugars such as deoxynojirimycin (DNJ) (PubMed:17110502, PubMed:20421923, PubMed:22766068).
4 PublicationsActivity regulationi
Inhibited by phlorizin.3 Publications
GO - Molecular functioni
- glucose:sodium symporter activity Source: GO_Central
GO - Biological processi
- sodium ion transport Source: GO_Central
Keywordsi
Biological process | Ion transport, Sodium transport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
PathwayCommonsi | Q9NY91 |
Reactomei | R-HSA-189200, Cellular hexose transport |
SignaLinki | Q9NY91 |
Protein family/group databases
TCDBi | 2.A.21.3.18, the solute:sodium symporter (sss) family |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 5 member 41 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11039, SLC5A4 |
MIMi | 618633, gene |
neXtProti | NX_Q9NY91 |
VEuPathDBi | HostDB:ENSG00000100191 |
Subcellular locationi
Plasma membrane
- Cell membrane 3 Publications1 Publication; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 28 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 29 – 47 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 48 – 64 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 65 – 85 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 86 – 105 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 106 – 126 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 127 – 171 | ExtracellularSequence analysisAdd BLAST | 45 | |
Transmembranei | 172 – 191 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 192 – 208 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 209 – 229 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 230 – 270 | ExtracellularSequence analysisAdd BLAST | 41 | |
Transmembranei | 271 – 291 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 292 – 314 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 315 – 334 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 335 – 423 | ExtracellularSequence analysisAdd BLAST | 89 | |
Transmembranei | 424 – 443 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 444 – 455 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 456 – 476 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 477 – 526 | ExtracellularSequence analysisAdd BLAST | 50 | |
Transmembranei | 527 – 547 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 548 – 637 | CytoplasmicSequence analysisAdd BLAST | 90 | |
Transmembranei | 638 – 658 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 457 | E → Q: Confers sugar transport activity not found in the wild-type protein. Increased sensitivity to inhibitor phlorizin. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6527 |
OpenTargetsi | ENSG00000100191 |
PharmGKBi | PA35904 |
Miscellaneous databases
Pharosi | Q9NY91, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1770047 |
DrugCentrali | Q9NY91 |
Genetic variation databases
BioMutai | SLC5A4 |
DMDMi | 17433306 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000105376 | 1 – 659 | Solute carrier family 5 member 4Add BLAST | 659 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 248 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q9NY91 |
MassIVEi | Q9NY91 |
PaxDbi | Q9NY91 |
PeptideAtlasi | Q9NY91 |
PRIDEi | Q9NY91 |
ProteomicsDBi | 83196 |
PTM databases
GlyGeni | Q9NY91, 1 site |
iPTMneti | Q9NY91 |
PhosphoSitePlusi | Q9NY91 |
Expressioni
Tissue specificityi
Expressed in skeletal muscle, where it may localize to the neuromuscular junction (at protein level) (PubMed:13130073). Expressed in small intestine where it may localize to cholinergic neurons of the submucosal plexus and myenteric plexus (at protein level) (PubMed:13130073). Detected in kidney (at protein level) (PubMed:22766068).2 Publications
Gene expression databases
Bgeei | ENSG00000100191, Expressed in intestine and 99 other tissues |
Genevisiblei | Q9NY91, HS |
Organism-specific databases
HPAi | ENSG00000100191, Tissue enriched (intestine) |
Interactioni
Binary interactionsi
Q9NY91
With | #Exp. | IntAct |
---|---|---|
GOLM1 [Q8NBJ4] | 3 | EBI-12409133,EBI-712073 |
KASH5 [Q8N6L0] | 3 | EBI-12409133,EBI-749265 |
MS4A3 [Q96HJ5] | 3 | EBI-12409133,EBI-12806656 |
TMEM237 - isoform 2 [Q96Q45-2] | 3 | EBI-12409133,EBI-10982110 |
Protein-protein interaction databases
BioGRIDi | 112418, 35 interactors |
IntActi | Q9NY91, 4 interactors |
STRINGi | 9606.ENSP00000266086 |
Chemistry databases
BindingDBi | Q9NY91 |
Miscellaneous databases
RNActi | Q9NY91, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 573 – 592 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2349, Eukaryota |
GeneTreei | ENSGT00940000160846 |
HOGENOMi | CLU_018808_9_2_1 |
InParanoidi | Q9NY91 |
OMAi | CVKHCGI |
OrthoDBi | 243316at2759 |
PhylomeDBi | Q9NY91 |
TreeFami | TF352855 |
Family and domain databases
Gene3Di | 1.20.1730.10, 1 hit |
InterProi | View protein in InterPro IPR038377, Na/Glc_symporter_sf IPR001734, Na/solute_symporter IPR018212, Na/solute_symporter_CS |
Pfami | View protein in Pfam PF00474, SSF, 1 hit |
TIGRFAMsi | TIGR00813, sss, 1 hit |
PROSITEi | View protein in PROSITE PS00456, NA_SOLUT_SYMP_1, 1 hit PS00457, NA_SOLUT_SYMP_2, 1 hit PS50283, NA_SOLUT_SYMP_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9NY91-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASTVSPSTI AETPEPPPLS DHIRNAADIS VIVIYFLVVM AVGLWAMLKT
60 70 80 90 100
NRGTIGGFFL AGRDMAWWPM GASLFASNIG SNHYVGLAGT GAASGVATVT
110 120 130 140 150
FEWTSSVMLL ILGWIFVPIY IKSGVMTMPE YLKKRFGGER LQVYLSILSL
160 170 180 190 200
FICVVLLISA DIFAGAIFIK LALGLDLYLA IFILLAMTAV YTTTGGLASV
210 220 230 240 250
IYTDTLQTII MLIGSFILMG FAFNEVGGYE SFTEKYVNAT PSVVEGDNLT
260 270 280 290 300
ISASCYTPRA DSFHIFRDAV TGDIPWPGII FGMPITALWY WCTNQVIVQR
310 320 330 340 350
CLCGKDMSHV KAACIMCAYL KLLPMFLMVM PGMISRILYT DMVACVVPSE
360 370 380 390 400
CVKHCGVDVG CTNYAYPTMV LELMPQGLRG LMLSVMLASL MSSLTSIFNS
410 420 430 440 450
ASTLFTIDLY TKMRKQASEK ELLIAGRIFV LLLTVVSIVW VPLVQVSQNG
460 470 480 490 500
QLIHYTESIS SYLGPPIAAV FVLAIFCKRV NEQGAFWGLM VGLAMGLIRM
510 520 530 540 550
ITEFAYGTGS CLAPSNCPKI ICGVHYLYFS IVLFFGSMLV TLGISLLTKP
560 570 580 590 600
IPDVHLYRLC WVLRNSTEER IDIDAEEKSQ EETDDGVEED YPEKSRGCLK
610 620 630 640 650
KAYDLFCGLQ KGPKLTKEEE EALSKKLTDT SERPSWRTIV NINAILLLAV
VVFIHGYYA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 76 | A → V in AAB61732 (Ref. 3) Curated | 1 | |
Sequence conflicti | 106 | S → P in AAB61732 (Ref. 3) Curated | 1 | |
Sequence conflicti | 243 | V → I in AAB61732 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052489 | 4 | T → M. Corresponds to variant dbSNP:rs16990065Ensembl. | 1 | |
Natural variantiVAR_021997 | 46 | A → T. Corresponds to variant dbSNP:rs2235171Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ133127 mRNA Translation: CAB81772.1 AL008723 Genomic DNA No translation available. U41897 mRNA Translation: AAB61732.1 |
CCDSi | CCDS13903.1 |
RefSeqi | NP_055042.1, NM_014227.2 |
Genome annotation databases
Ensembli | ENST00000266086.6; ENSP00000266086.3; ENSG00000100191.6 |
GeneIDi | 6527 |
KEGGi | hsa:6527 |
MANE-Selecti | ENST00000266086.6; ENSP00000266086.3; NM_014227.3; NP_055042.1 |
UCSCi | uc003ami.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ133127 mRNA Translation: CAB81772.1 AL008723 Genomic DNA No translation available. U41897 mRNA Translation: AAB61732.1 |
CCDSi | CCDS13903.1 |
RefSeqi | NP_055042.1, NM_014227.2 |
3D structure databases
AlphaFoldDBi | Q9NY91 |
SMRi | Q9NY91 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112418, 35 interactors |
IntActi | Q9NY91, 4 interactors |
STRINGi | 9606.ENSP00000266086 |
Chemistry databases
BindingDBi | Q9NY91 |
ChEMBLi | CHEMBL1770047 |
DrugCentrali | Q9NY91 |
Protein family/group databases
TCDBi | 2.A.21.3.18, the solute:sodium symporter (sss) family |
PTM databases
GlyGeni | Q9NY91, 1 site |
iPTMneti | Q9NY91 |
PhosphoSitePlusi | Q9NY91 |
Genetic variation databases
BioMutai | SLC5A4 |
DMDMi | 17433306 |
Proteomic databases
jPOSTi | Q9NY91 |
MassIVEi | Q9NY91 |
PaxDbi | Q9NY91 |
PeptideAtlasi | Q9NY91 |
PRIDEi | Q9NY91 |
ProteomicsDBi | 83196 |
Protocols and materials databases
Antibodypediai | 11228, 108 antibodies from 24 providers |
DNASUi | 6527 |
Genome annotation databases
Ensembli | ENST00000266086.6; ENSP00000266086.3; ENSG00000100191.6 |
GeneIDi | 6527 |
KEGGi | hsa:6527 |
MANE-Selecti | ENST00000266086.6; ENSP00000266086.3; NM_014227.3; NP_055042.1 |
UCSCi | uc003ami.4, human |
Organism-specific databases
CTDi | 6527 |
DisGeNETi | 6527 |
GeneCardsi | SLC5A4 |
HGNCi | HGNC:11039, SLC5A4 |
HPAi | ENSG00000100191, Tissue enriched (intestine) |
MIMi | 618633, gene |
neXtProti | NX_Q9NY91 |
OpenTargetsi | ENSG00000100191 |
PharmGKBi | PA35904 |
VEuPathDBi | HostDB:ENSG00000100191 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2349, Eukaryota |
GeneTreei | ENSGT00940000160846 |
HOGENOMi | CLU_018808_9_2_1 |
InParanoidi | Q9NY91 |
OMAi | CVKHCGI |
OrthoDBi | 243316at2759 |
PhylomeDBi | Q9NY91 |
TreeFami | TF352855 |
Enzyme and pathway databases
PathwayCommonsi | Q9NY91 |
Reactomei | R-HSA-189200, Cellular hexose transport |
SignaLinki | Q9NY91 |
Miscellaneous databases
BioGRID-ORCSi | 6527, 8 hits in 1060 CRISPR screens |
ChiTaRSi | SLC5A4, human |
GeneWikii | SLC5A4 |
GenomeRNAii | 6527 |
Pharosi | Q9NY91, Tchem |
PROi | PR:Q9NY91 |
RNActi | Q9NY91, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100191, Expressed in intestine and 99 other tissues |
Genevisiblei | Q9NY91, HS |
Family and domain databases
Gene3Di | 1.20.1730.10, 1 hit |
InterProi | View protein in InterPro IPR038377, Na/Glc_symporter_sf IPR001734, Na/solute_symporter IPR018212, Na/solute_symporter_CS |
Pfami | View protein in Pfam PF00474, SSF, 1 hit |
TIGRFAMsi | TIGR00813, sss, 1 hit |
PROSITEi | View protein in PROSITE PS00456, NA_SOLUT_SYMP_1, 1 hit PS00457, NA_SOLUT_SYMP_2, 1 hit PS50283, NA_SOLUT_SYMP_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SC5A4_HUMAN | |
Accessioni | Q9NY91Primary (citable) accession number: Q9NY91 Secondary accession number(s): O15279 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families