SLC5A4

Functionⁱ

Has electrogenic activity in response to glucose, and may function as a glucose sensor (PubMed:13130073, PubMed:17110502, PubMed:20421923, PubMed:22766068). Mediates influx of sodium ions into the cell but does not transport sugars (PubMed:13130073, PubMed:22766068). Also potently activated by imino sugars such as deoxynojirimycin (DNJ) (PubMed:17110502, PubMed:20421923, PubMed:22766068).4 Publications

Activity regulationⁱ

Inhibited by phlorizin.3 Publications

GO - Molecular functionⁱ

glucose:sodium symporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

sodium ion transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ion transport, Sodium transport, Transport
Ligand	Sodium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-189200 Cellular hexose transport

Reactomeⁱ

R-HSA-189200 Cellular hexose transport

Protein family/group databases

TCDBⁱ	2.A.21.3.18 the solute:sodium symporter (sss) family

TCDBⁱ

2.A.21.3.18 the solute:sodium symporter (sss) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Solute carrier family 5 member 41 Publication
Gene namesⁱ	Name:SLC5A41 Publication Synonyms:SAAT1, SGLT31 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100191.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11039 SLC5A4
neXtProtⁱ	NX_Q9NY91

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 28	CytoplasmicSequence analysisAdd BLAST	28
Transmembraneⁱ	29 – 47	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	48 – 64	ExtracellularSequence analysisAdd BLAST	17
Transmembraneⁱ	65 – 85	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	86 – 105	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	106 – 126	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	127 – 171	ExtracellularSequence analysisAdd BLAST	45
Transmembraneⁱ	172 – 191	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	192 – 208	CytoplasmicSequence analysisAdd BLAST	17
Transmembraneⁱ	209 – 229	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	230 – 270	ExtracellularSequence analysisAdd BLAST	41
Transmembraneⁱ	271 – 291	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	292 – 314	CytoplasmicSequence analysisAdd BLAST	23
Transmembraneⁱ	315 – 334	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	335 – 423	ExtracellularSequence analysisAdd BLAST	89
Transmembraneⁱ	424 – 443	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	444 – 455	CytoplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	456 – 476	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	477 – 526	ExtracellularSequence analysisAdd BLAST	50
Transmembraneⁱ	527 – 547	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	548 – 637	CytoplasmicSequence analysisAdd BLAST	90
Transmembraneⁱ	638 – 658	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	457	E → Q: Confers sugar transport activity not found in the wild-type protein. Increased sensitivity to inhibitor phlorizin. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6527
Open Targets More...OpenTargetsⁱ	ENSG00000100191
PharmGKBⁱ	PA35904

Chemistry databases

ChEMBLⁱ	CHEMBL1770047

ChEMBLⁱ

CHEMBL1770047

Polymorphism and mutation databases

BioMutaⁱ	SLC5A4
DMDMⁱ	17433306

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000105376	1 – 659	Solute carrier family 5 member 4Add BLAST		659

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	248	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q9NY91
PeptideAtlas More...PeptideAtlasⁱ	Q9NY91
PRIDEⁱ	Q9NY91
ProteomicsDBⁱ	83196

PTM databases

iPTMnetⁱ	Q9NY91
PhosphoSitePlusⁱ	Q9NY91

Expressionⁱ

Tissue specificityⁱ

Expressed in skeletal muscle, where it may localize to the neuromuscular junction (at protein level) (PubMed:13130073). Expressed in small intestine where it may localize to cholinergic neurons of the submucosal plexus and myenteric plexus (at protein level) (PubMed:13130073). Detected in kidney (at protein level) (PubMed:22766068).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000100191 Expressed in 78 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_SLC5A4
Genevisibleⁱ	Q9NY91 HS

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q9NY91, 4 interactors
STRINGⁱ	9606.ENSP00000266086

Chemistry databases

BindingDBⁱ

Q9NY91

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NY91
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IP49 Eukaryota COG4146 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118955
HOGENOMⁱ	HOG000025422
HOVERGENⁱ	HBG052859
InParanoidⁱ	Q9NY91
KEGG Orthology (KO) More...KOⁱ	K14384
OMAⁱ	CYTPQAD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G077U
PhylomeDBⁱ	Q9NY91
TreeFamⁱ	TF352855

Family and domain databases

Gene3Dⁱ	1.20.1730.10, 1 hit
InterProⁱ	View protein in InterPro IPR038377 Na/Glc_symporter_sf IPR001734 Na/solute_symporter IPR018212 Na/solute_symporter_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00474 SSF, 1 hit
TIGRFAMsⁱ	TIGR00813 sss, 1 hit
PROSITEⁱ	View protein in PROSITE PS00456 NA_SOLUT_SYMP_1, 1 hit PS00457 NA_SOLUT_SYMP_2, 1 hit PS50283 NA_SOLUT_SYMP_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9NY91-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASTVSPSTI AETPEPPPLS DHIRNAADIS VIVIYFLVVM AVGLWAMLKT 
        60         70         80         90        100
NRGTIGGFFL AGRDMAWWPM GASLFASNIG SNHYVGLAGT GAASGVATVT 
       110        120        130        140        150
FEWTSSVMLL ILGWIFVPIY IKSGVMTMPE YLKKRFGGER LQVYLSILSL 
       160        170        180        190        200
FICVVLLISA DIFAGAIFIK LALGLDLYLA IFILLAMTAV YTTTGGLASV 
       210        220        230        240        250
IYTDTLQTII MLIGSFILMG FAFNEVGGYE SFTEKYVNAT PSVVEGDNLT 
       260        270        280        290        300
ISASCYTPRA DSFHIFRDAV TGDIPWPGII FGMPITALWY WCTNQVIVQR 
       310        320        330        340        350
CLCGKDMSHV KAACIMCAYL KLLPMFLMVM PGMISRILYT DMVACVVPSE 
       360        370        380        390        400
CVKHCGVDVG CTNYAYPTMV LELMPQGLRG LMLSVMLASL MSSLTSIFNS 
       410        420        430        440        450
ASTLFTIDLY TKMRKQASEK ELLIAGRIFV LLLTVVSIVW VPLVQVSQNG 
       460        470        480        490        500
QLIHYTESIS SYLGPPIAAV FVLAIFCKRV NEQGAFWGLM VGLAMGLIRM 
       510        520        530        540        550
ITEFAYGTGS CLAPSNCPKI ICGVHYLYFS IVLFFGSMLV TLGISLLTKP 
       560        570        580        590        600
IPDVHLYRLC WVLRNSTEER IDIDAEEKSQ EETDDGVEED YPEKSRGCLK 
       610        620        630        640        650
KAYDLFCGLQ KGPKLTKEEE EALSKKLTDT SERPSWRTIV NINAILLLAV 

VVFIHGYYA

Length:659

Mass (Da):72,456

Last modified:October 1, 2000 - v1

Checksum:ⁱF8A34AED648B523A

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	76	A → V in AAB61732 (Ref. 3) Curated	1
Sequence conflictⁱ	106	S → P in AAB61732 (Ref. 3) Curated	1
Sequence conflictⁱ	243	V → I in AAB61732 (Ref. 3) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052489	4	T → M. Corresponds to variant dbSNP:rs16990065Ensembl.		1
Natural variantⁱVAR_021997	46	A → T. Corresponds to variant dbSNP:rs2235171Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ133127 mRNA Translation: CAB81772.1 AL008723 Genomic DNA No translation available. U41897 mRNA Translation: AAB61732.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13903.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055042.1, NM_014227.2
UniGeneⁱ	Hs.130101

Genome annotation databases

Ensemblⁱ	ENST00000266086; ENSP00000266086; ENSG00000100191
GeneIDⁱ	6527
KEGGⁱ	hsa:6527
UCSC genome browser More...UCSCⁱ	uc003ami.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NY91	Solute carrier family 5 member 4		PANTR		659	UniRef90_Q9NY91
Uncharacterized protein		PANPA		659
Uncharacterized protein		NOMLE		659
SLC5A4 isoform 1		PONAB		659
Uncharacterized protein		MACFA		659
+11

Protein	Similar proteins		Species	Score	Length	Source
Q9NY91	Solute carrier family 5 member 4		PIG		660	UniRef50_Q9NY91
Solute carrier family 5 member 4A		MOUSE		656
Solute carrier family 5 member 4		PANTR		659
Uncharacterized protein		PANPA		659
SLC5A4 isoform 1		PONAB		659
+318

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ133127 mRNA Translation: CAB81772.1 AL008723 Genomic DNA No translation available. U41897 mRNA Translation: AAB61732.1
CCDSⁱ	CCDS13903.1
RefSeqⁱ	NP_055042.1, NM_014227.2
UniGeneⁱ	Hs.130101

3D structure databases

ProteinModelPortalⁱ	Q9NY91
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q9NY91, 4 interactors
STRINGⁱ	9606.ENSP00000266086

Chemistry databases

BindingDBⁱ	Q9NY91
ChEMBLⁱ	CHEMBL1770047

Protein family/group databases

TCDBⁱ	2.A.21.3.18 the solute:sodium symporter (sss) family

TCDBⁱ

2.A.21.3.18 the solute:sodium symporter (sss) family

PTM databases

iPTMnetⁱ	Q9NY91
PhosphoSitePlusⁱ	Q9NY91

Polymorphism and mutation databases

BioMutaⁱ	SLC5A4
DMDMⁱ	17433306

Proteomic databases

PaxDbⁱ	Q9NY91
PeptideAtlasⁱ	Q9NY91
PRIDEⁱ	Q9NY91
ProteomicsDBⁱ	83196

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6527
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000266086; ENSP00000266086; ENSG00000100191
GeneIDⁱ	6527
KEGGⁱ	hsa:6527
UCSCⁱ	uc003ami.4 human

Organism-specific databases

CTDⁱ	6527
DisGeNETⁱ	6527
EuPathDBⁱ	HostDB:ENSG00000100191.5
GeneCardsⁱ	SLC5A4
HGNCⁱ	HGNC:11039 SLC5A4
neXtProtⁱ	NX_Q9NY91
OpenTargetsⁱ	ENSG00000100191
PharmGKBⁱ	PA35904
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IP49 Eukaryota COG4146 LUCA
GeneTreeⁱ	ENSGT00760000118955
HOGENOMⁱ	HOG000025422
HOVERGENⁱ	HBG052859
InParanoidⁱ	Q9NY91
KOⁱ	K14384
OMAⁱ	CYTPQAD
OrthoDBⁱ	EOG091G077U
PhylomeDBⁱ	Q9NY91
TreeFamⁱ	TF352855

Enzyme and pathway databases

Reactomeⁱ	R-HSA-189200 Cellular hexose transport

Reactomeⁱ

R-HSA-189200 Cellular hexose transport

Miscellaneous databases

ChiTaRSⁱ	SLC5A4 human
GeneWikiⁱ	SLC5A4
GenomeRNAiⁱ	6527
Protein Ontology More...PROⁱ	PR:Q9NY91

Gene expression databases

Bgeeⁱ	ENSG00000100191 Expressed in 78 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_SLC5A4
Genevisibleⁱ	Q9NY91 HS

Family and domain databases

Gene3Dⁱ	1.20.1730.10, 1 hit
InterProⁱ	View protein in InterPro IPR038377 Na/Glc_symporter_sf IPR001734 Na/solute_symporter IPR018212 Na/solute_symporter_CS
Pfamⁱ	View protein in Pfam PF00474 SSF, 1 hit
TIGRFAMsⁱ	TIGR00813 sss, 1 hit
PROSITEⁱ	View protein in PROSITE PS00456 NA_SOLUT_SYMP_1, 1 hit PS00457 NA_SOLUT_SYMP_2, 1 hit PS50283 NA_SOLUT_SYMP_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SC5A4_HUMAN
Accessionⁱ	Q9NY91Primary (citable) accession number: Q9NY91 Secondary accession number(s): O15279
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM

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UniRef

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Supporting data

UniProtKB - Q9NY91 (SC5A4_HUMAN)

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Solute carrier family 5 member 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ