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Entry version 124 (02 Jun 2021)
Sequence version 2 (01 Mar 2004)
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Protein

Ewing's tumor-associated antigen 1

Gene

ETAA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723720, PubMed:27723717).

Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723720, PubMed:27723717).

Probably only regulates a subset of ATR targets (PubMed:27723720, PubMed:27723717).

3 Publications

Caution

Initially reported to localize in the cytoplasm (PubMed:16003559). A number of studies showed that it accumulates at DNA damage sites in the nucleus (PubMed:27601467, PubMed:27723720, PubMed:27723717).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NY74

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ewing's tumor-associated antigen 1Imported
Alternative name(s):
Ewing's tumor-associated antigen 161 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ETAA1Imported
Synonyms:ETAA161 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24648, ETAA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613196, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NY74

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000143971.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi106 – 107FW → AA: Reduced ability to promote replication fork progression and integrity following DNA damage. 1 Publication2
Mutagenesisi107W → A: Reduced interaction with ATR. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
54465

Open Targets

More...
OpenTargetsi
ENSG00000143971

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162385444

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NY74, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ETAA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74734709

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002800991 – 926Ewing's tumor-associated antigen 1Add BLAST926

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki85Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei186PhosphoserineCombined sources1
Cross-linki414Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki442Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei464PhosphoserineCombined sources1
Cross-linki480Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki507Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki533Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki535Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei833PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by ATR.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NY74

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NY74

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NY74

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NY74

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NY74

PeptideAtlas

More...
PeptideAtlasi
Q9NY74

PRoteomics IDEntifications database

More...
PRIDEi
Q9NY74

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83186

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NY74

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NY74

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in the brain, liver kidney and Ewing tumor cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143971, Expressed in intestine and 199 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NY74, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NY74, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000143971, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via RBM1 motif) with RPA1 (PubMed:27601467, PubMed:27723720, PubMed:27723717).

Interacts (via RBM2 motif) with RPA2 (PubMed:27601467, PubMed:27723720, PubMed:27723717).

Interacts (via the ATR-activation domain motif) with ATR (PubMed:27723720, PubMed:27723717).

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
119971, 140 interactors

Database of interacting proteins

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DIPi
DIP-47294N

Protein interaction database and analysis system

More...
IntActi
Q9NY74, 12 interactors

Molecular INTeraction database

More...
MINTi
Q9NY74

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000272342

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NY74, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NY74

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 112DisorderedSequence analysisAdd BLAST112
Regioni640 – 663DisorderedSequence analysisAdd BLAST24
Regioni878 – 905DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili183 – 214Sequence analysisAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi105 – 111ATR-activation domain (AAD)2 Publications7
Motifi603 – 618RBM1 motif3 PublicationsAdd BLAST16
Motifi891 – 913RBM2 motif3 PublicationsAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 21Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi85 – 112Polar residuesSequence analysisAdd BLAST28
Compositional biasi879 – 905Basic and acidic residuesSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RBM1 (RPA1-binding, also named RPA70N-binding) motif mediates interaction with RPA1 (PubMed:27601467, PubMed:27723720, PubMed:27723717). The RBM2 (RPA2-binding, also named RPA32C-binding) motif mediates interaction with RPA2 (PubMed:27601467, PubMed:27723720, PubMed:27723717).3 Publications
The ATR-activation domain (AAD) motif is required to bind and activate ATR (PubMed:27723720, PubMed:27723717).2 Publications

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTMP, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009597

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015351_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
CHQLENT

Database of Orthologous Groups

More...
OrthoDBi
365628at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NY74

TreeFam database of animal gene trees

More...
TreeFami
TF333863

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029406, ETAA1

The PANTHER Classification System

More...
PANTHERi
PTHR16434, PTHR16434, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15350, ETAA1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9NY74-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRRKHDDS PSPKKTPHKT VAAEECGSVV EPGRRRLRSA RGSWPCGARE
60 70 80 90 100
GPPGPVRQRE QPPTAALCSK SNPEERYETP KRALKMDSLS SSFSSPNDPD
110 120 130 140 150
GQNDIFWDQN SPLTKQLGKG RKKQIYTTDS DEISHIVNRI APQDEKPTTN
160 170 180 190 200
SMLDMWIGET AIPCTPSVAK GKSRAKISCT KLKTQSQEEE LMKLAKQFDK
210 220 230 240 250
NMEELDVIQE QNKRNYDFTQ MISETEILSN YKDNIQMWSL HNIVPEIDNA
260 270 280 290 300
TKKPIKGNTK ISVANNQNSS QKPFDQIAEA AFNAIFDGST QKCSGQLSQE
310 320 330 340 350
LPEAFWSTSN TTFVKTNALK EEKIITNETL VIEKLSNKTP RSLSSQVDTP
360 370 380 390 400
IMTKSCVTSC TKEPETSNKY IDAFTTSDFE DDWENLLGSE PFAMQNIDMP
410 420 430 440 450
ELFPSKTAHV TDQKEICTFN SKTVKNTSRA NTSPDARLGD SKVLQDLSSK
460 470 480 490 500
TYDRELIDAE YRFSPNSNKS NKLSTGNKMK FENSSNKIVI QDEIQNCIVT
510 520 530 540 550
SNLTKIKEDI LTNSTEASER KSALNTRYSN EQKNKCILNQ SIKAPVNTDL
560 570 580 590 600
FGSANLGSKT SVSNPNQTSA SKVGSFFDDW NDPSFANEII KACHQLDNTW
610 620 630 640 650
EADDVDDDLL YQACDDIERL TQQQDIRKDS KTSESICEIN NNSEHGAKLT
660 670 680 690 700
QQQDIRKDSK TSESICEINN NSEHGAKNMF AISKQGSNLV QSKHLNPGSI
710 720 730 740 750
SVQTSLTNSS QIDKPMKMEK GEMYGNSPRF LGATNLTMYS KISNCQINNL
760 770 780 790 800
HVSYTNTDVP IQVNSSKLVL PGSSSLNVTS DHMNTEITTY KKKLSTNQPC
810 820 830 840 850
HKTVTDEAQS NLNTTVGFSK FTFTRMKNSQ ILSQFNQNCI TGSMSDTKIT
860 870 880 890 900
QGVEKKKGVN PLLEEAVGQQ SLVKLSESLK QSSKEEEEKN RKCSPEEIQR
910 920
KRQEALVRRM AKARASSVNA APTSFL
Length:926
Mass (Da):103,440
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4AD88EDD71BADED0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y7B6A0A2R8Y7B6_HUMAN
Ewing's tumor-associated antigen 1
ETAA1
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YEV8A0A2R8YEV8_HUMAN
Ewing's tumor-associated antigen 1
ETAA1
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6Y8A0A2R8Y6Y8_HUMAN
Ewing's tumor-associated antigen 1
ETAA1
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH33075 differs from that shown.Curated
The sequence AAX93100 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti439G → R in AAH33075 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03591650E → D in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_031053221M → T1 PublicationCorresponds to variant dbSNP:rs13036061Ensembl.1
Natural variantiVAR_031054389S → N1 PublicationCorresponds to variant dbSNP:rs3770657Ensembl.1
Natural variantiVAR_031055715P → L. Corresponds to variant dbSNP:rs3770656Ensembl.1
Natural variantiVAR_031056771P → S1 PublicationCorresponds to variant dbSNP:rs3770655Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ242682 mRNA Translation: CAB76378.2
AC023668 Genomic DNA Translation: AAX93100.1 Sequence problems.
BC033075 mRNA Translation: AAH33075.1 Sequence problems.
BC040001 mRNA Translation: AAH40001.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1882.1

NCBI Reference Sequences

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RefSeqi
NP_061875.2, NM_019002.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000272342; ENSP00000272342; ENSG00000143971

Database of genes from NCBI RefSeq genomes

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GeneIDi
54465

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54465

UCSC genome browser

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UCSCi
uc002sdz.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242682 mRNA Translation: CAB76378.2
AC023668 Genomic DNA Translation: AAX93100.1 Sequence problems.
BC033075 mRNA Translation: AAH33075.1 Sequence problems.
BC040001 mRNA Translation: AAH40001.1
CCDSiCCDS1882.1
RefSeqiNP_061875.2, NM_019002.3

3D structure databases

SMRiQ9NY74
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119971, 140 interactors
DIPiDIP-47294N
IntActiQ9NY74, 12 interactors
MINTiQ9NY74
STRINGi9606.ENSP00000272342

PTM databases

iPTMnetiQ9NY74
PhosphoSitePlusiQ9NY74

Genetic variation databases

BioMutaiETAA1
DMDMi74734709

Proteomic databases

EPDiQ9NY74
jPOSTiQ9NY74
MassIVEiQ9NY74
MaxQBiQ9NY74
PaxDbiQ9NY74
PeptideAtlasiQ9NY74
PRIDEiQ9NY74
ProteomicsDBi83186

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
47441, 56 antibodies

The DNASU plasmid repository

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DNASUi
54465

Genome annotation databases

EnsembliENST00000272342; ENSP00000272342; ENSG00000143971
GeneIDi54465
KEGGihsa:54465
UCSCiuc002sdz.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54465
DisGeNETi54465

GeneCards: human genes, protein and diseases

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GeneCardsi
ETAA1
HGNCiHGNC:24648, ETAA1
HPAiENSG00000143971, Low tissue specificity
MIMi613196, gene
neXtProtiNX_Q9NY74
OpenTargetsiENSG00000143971
PharmGKBiPA162385444
VEuPathDBiHostDB:ENSG00000143971.7

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QTMP, Eukaryota
GeneTreeiENSGT00390000009597
HOGENOMiCLU_015351_0_0_1
OMAiCHQLENT
OrthoDBi365628at2759
PhylomeDBiQ9NY74
TreeFamiTF333863

Enzyme and pathway databases

PathwayCommonsiQ9NY74

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
54465, 9 hits in 999 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ETAA1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54465
PharosiQ9NY74, Tbio

Protein Ontology

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PROi
PR:Q9NY74
RNActiQ9NY74, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000143971, Expressed in intestine and 199 other tissues
ExpressionAtlasiQ9NY74, baseline and differential
GenevisibleiQ9NY74, HS

Family and domain databases

InterProiView protein in InterPro
IPR029406, ETAA1
PANTHERiPTHR16434, PTHR16434, 2 hits
PfamiView protein in Pfam
PF15350, ETAA1, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiETAA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NY74
Secondary accession number(s): Q05BT7, Q53SC4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2004
Last modified: June 2, 2021
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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