Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 2, facilitated glucose transporter member 8

Gene

SLC2A8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei394MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

Protein family/group databases

TCDBi2.A.1.1.89 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 8
Alternative name(s):
Glucose transporter type 8
Short name:
GLUT-8
Glucose transporter type X1
Gene namesi
Name:SLC2A8
Synonyms:GLUT8, GLUTX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136856.17
HGNCiHGNC:13812 SLC2A8
MIMi605245 gene
neXtProtiNX_Q9NY64

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 70ExtracellularSequence analysisAdd BLAST24
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 96CytoplasmicSequence analysis5
Transmembranei97 – 117Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini118 – 127ExtracellularSequence analysis10
Transmembranei128 – 148Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini149 – 156CytoplasmicSequence analysis8
Transmembranei157 – 177Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini178 – 182ExtracellularSequence analysis5
Transmembranei183 – 203Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini204 – 256CytoplasmicSequence analysisAdd BLAST53
Transmembranei257 – 277Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini278 – 292ExtracellularSequence analysisAdd BLAST15
Transmembranei293 – 313Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini314 – 319CytoplasmicSequence analysis6
Transmembranei320 – 340Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini341 – 367ExtracellularSequence analysisAdd BLAST27
Transmembranei368 – 388Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini389 – 404CytoplasmicSequence analysisAdd BLAST16
Transmembranei405 – 425Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini426 – 438ExtracellularSequence analysisAdd BLAST13
Transmembranei439 – 459Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini460 – 477CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29988
OpenTargetsiENSG00000136856
PharmGKBiPA37813

Chemistry databases

DrugBankiDB09502 Fludeoxyglucose F-18

Polymorphism and mutation databases

DMDMi145559479

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503751 – 477Solute carrier family 2, facilitated glucose transporter member 8Add BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi349N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9NY64
PaxDbiQ9NY64
PeptideAtlasiQ9NY64
PRIDEiQ9NY64
ProteomicsDBi83182

PTM databases

iPTMnetiQ9NY64
PhosphoSitePlusiQ9NY64

Expressioni

Tissue specificityi

Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues.

Inductioni

In testis, down-regulated by estrogen.

Gene expression databases

BgeeiENSG00000136856 Expressed in 189 organ(s), highest expression level in fundus of stomach
CleanExiHS_SLC2A8
ExpressionAtlasiQ9NY64 baseline and differential
GenevisibleiQ9NY64 HS

Organism-specific databases

HPAiHPA011935

Interactioni

Subunit structurei

Interacts with AP2B1.By similarity

Protein-protein interaction databases

BioGridi119013, 12 interactors
STRINGi9606.ENSP00000362469

Structurei

3D structure databases

ProteinModelPortaliQ9NY64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni267 – 273Monosaccharide bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 13Dileucine internalization motifSequence analysis2

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0254 Eukaryota
ENOG410XNQK LUCA
GeneTreeiENSGT00920000149002
HOGENOMiHOG000202868
HOVERGENiHBG104335
InParanoidiQ9NY64
KOiK08145
OMAiAACFNYG
OrthoDBiEOG091G1600
PhylomeDBiQ9NY64
TreeFamiTF325324

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 2 hits
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q9NY64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPEDPEETQ PLLGPPGGSA PRGRRVFLAA FAAALGPLSF GFALGYSSPA
60 70 80 90 100
IPSLQRAAPP APRLDDAAAS WFGAVVTLGA AAGGVLGGWL VDRAGRKLSL
110 120 130 140 150
LLCSVPFVAG FAVITAAQDV WMLLGGRLLT GLACGVASLV APVYISEIAY
160 170 180 190 200
PAVRGLLGSC VQLMVVVGIL LAYLAGWVLE WRWLAVLGCV PPSLMLLLMC
210 220 230 240 250
FMPETPRFLL TQHRRQEAMA ALRFLWGSEQ GWEDPPIGAE QSFHLALLRQ
260 270 280 290 300
PGIYKPFIIG VSLMAFQQLS GVNAVMFYAE TIFEEAKFKD SSLASVVVGV
310 320 330 340 350
IQVLFTAVAA LIMDRAGRRL LLVLSGVVMV FSTSAFGAYF KLTQGGPGNS
360 370 380 390 400
SHVAISAPVS AQPVDASVGL AWLAVGSMCL FIAGFAVGWG PIPWLLMSEI
410 420 430 440 450
FPLHVKGVAT GICVLTNWLM AFLVTKEFSS LMEVLRPYGA FWLASAFCIF
460 470
SVLFTLFCVP ETKGKTLEQI TAHFEGR
Length:477
Mass (Da):50,819
Last modified:April 17, 2007 - v3
Checksum:i0B480F94AF063316
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VVV9Q5VVV9_HUMAN
Solute carrier family 2, (Facilitat...
SLC2A8 hCG_28276
411Annotation score:
A0A087WT42A0A087WT42_HUMAN
Solute carrier family 2, (Facilitat...
SLC2A8 hCG_28276
314Annotation score:
Q5VVW0Q5VVW0_HUMAN
Solute carrier family 2, facilitate...
SLC2A8
256Annotation score:
Q5VVV5Q5VVV5_HUMAN
Solute carrier family 2, facilitate...
SLC2A8
267Annotation score:
Q5VVV3Q5VVV3_HUMAN
Solute carrier family 2, facilitate...
SLC2A8
265Annotation score:
Q5VVV4Q5VVV4_HUMAN
Solute carrier family 2, facilitate...
SLC2A8
276Annotation score:
Q5VVW5Q5VVW5_HUMAN
Solute carrier family 2, facilitate...
SLC2A8
214Annotation score:
Q5VVV6Q5VVV6_HUMAN
Solute carrier family 2, facilitate...
SLC2A8
241Annotation score:
H0Y7M6H0Y7M6_HUMAN
Solute carrier family 2, facilitate...
SLC2A8
169Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti377S → N in CAB75702 (PubMed:10671487).Curated1
Sequence conflicti456 – 457LF → FS in CAB89809 (PubMed:10821868).Curated2
Sequence conflicti462T → I in CAB75702 (PubMed:10671487).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061880253I → T. Corresponds to variant dbSNP:rs34064803Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17801 mRNA Translation: CAB89809.1
AJ245937 mRNA Translation: CAB75702.1
AL445222 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87660.1
BC019043 mRNA Translation: AAH19043.1
CCDSiCCDS6870.1
RefSeqiNP_001258640.1, NM_001271711.1
NP_001258641.1, NM_001271712.1
NP_055395.2, NM_014580.4
UniGeneiHs.179522

Genome annotation databases

EnsembliENST00000373371; ENSP00000362469; ENSG00000136856
GeneIDi29988
KEGGihsa:29988
UCSCiuc004bqu.5 human

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17801 mRNA Translation: CAB89809.1
AJ245937 mRNA Translation: CAB75702.1
AL445222 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87660.1
BC019043 mRNA Translation: AAH19043.1
CCDSiCCDS6870.1
RefSeqiNP_001258640.1, NM_001271711.1
NP_001258641.1, NM_001271712.1
NP_055395.2, NM_014580.4
UniGeneiHs.179522

3D structure databases

ProteinModelPortaliQ9NY64
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119013, 12 interactors
STRINGi9606.ENSP00000362469

Chemistry databases

DrugBankiDB09502 Fludeoxyglucose F-18

Protein family/group databases

TCDBi2.A.1.1.89 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ9NY64
PhosphoSitePlusiQ9NY64

Polymorphism and mutation databases

DMDMi145559479

Proteomic databases

EPDiQ9NY64
PaxDbiQ9NY64
PeptideAtlasiQ9NY64
PRIDEiQ9NY64
ProteomicsDBi83182

Protocols and materials databases

DNASUi29988
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373371; ENSP00000362469; ENSG00000136856
GeneIDi29988
KEGGihsa:29988
UCSCiuc004bqu.5 human

Organism-specific databases

CTDi29988
DisGeNETi29988
EuPathDBiHostDB:ENSG00000136856.17
GeneCardsiSLC2A8
HGNCiHGNC:13812 SLC2A8
HPAiHPA011935
MIMi605245 gene
neXtProtiNX_Q9NY64
OpenTargetsiENSG00000136856
PharmGKBiPA37813
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0254 Eukaryota
ENOG410XNQK LUCA
GeneTreeiENSGT00920000149002
HOGENOMiHOG000202868
HOVERGENiHBG104335
InParanoidiQ9NY64
KOiK08145
OMAiAACFNYG
OrthoDBiEOG091G1600
PhylomeDBiQ9NY64
TreeFamiTF325324

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

GenomeRNAii29988
PROiPR:Q9NY64
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136856 Expressed in 189 organ(s), highest expression level in fundus of stomach
CleanExiHS_SLC2A8
ExpressionAtlasiQ9NY64 baseline and differential
GenevisibleiQ9NY64 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 2 hits
PS00217 SUGAR_TRANSPORT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGTR8_HUMAN
AccessioniPrimary (citable) accession number: Q9NY64
Secondary accession number(s): Q8WUZ9, Q9NSC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: April 17, 2007
Last modified: November 7, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again