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Protein

Protein AATF

Gene

AATF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.4 Publications

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-193648 NRAGE signals death through JNK
SIGNORiQ9NY61

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AATF
Alternative name(s):
Apoptosis-antagonizing transcription factor
Rb-binding protein Che-1
Gene namesi
Name:AATF
Synonyms:CHE1, DED
ORF Names:HSPC277
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000275700.4
HGNCiHGNC:19235 AATF
MIMi608463 gene
neXtProtiNX_Q9NY61

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26574
OpenTargetsiENSG00000275700
PharmGKBiPA128395780

Polymorphism and mutation databases

BioMutaiAATF
DMDMi71152211

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000566162 – 560Protein AATFAdd BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei61PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei150PhosphoserineCombined sources1
Modified residuei155PhosphoserineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei316PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1

Post-translational modificationi

Hyperphosphorylated during the G1/S phase transition.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NY61
MaxQBiQ9NY61
PaxDbiQ9NY61
PeptideAtlasiQ9NY61
PRIDEiQ9NY61
ProteomicsDBi83181
TopDownProteomicsiQ9NY61

2D gel databases

SWISS-2DPAGEiQ9NY61

PTM databases

iPTMnetiQ9NY61
PhosphoSitePlusiQ9NY61

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.2 Publications

Gene expression databases

BgeeiENSG00000275700 Expressed in 112 organ(s), highest expression level in corpus callosum
CleanExiHS_AATF
ExpressionAtlasiQ9NY61 baseline and differential
GenevisibleiQ9NY61 HS

Organism-specific databases

HPAiHPA004940

Interactioni

Subunit structurei

Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117743, 75 interactors
CORUMiQ9NY61
ELMiQ9NY61
IntActiQ9NY61, 33 interactors
MINTiQ9NY61
STRINGi9606.ENSP00000225402

Structurei

3D structure databases

ProteinModelPortaliQ9NY61
SMRiQ9NY61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni273 – 315POLR2J bindingAdd BLAST43
Regioni316 – 372RB1 bindingAdd BLAST57
Regioni373 – 472RB1 and SP1 bindingAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi96 – 195Glu-richAdd BLAST100

Sequence similaritiesi

Belongs to the AATF family.Curated

Phylogenomic databases

eggNOGiKOG2773 Eukaryota
ENOG410XWGK LUCA
GeneTreeiENSGT00390000000288
HOGENOMiHOG000007555
HOVERGENiHBG080805
InParanoidiQ9NY61
KOiK14782
OMAiEVLLKWD
OrthoDBiEOG091G0F1H
PhylomeDBiQ9NY61
TreeFamiTF324341

Family and domain databases

InterProiView protein in InterPro
IPR025160 AATF
IPR039223 AATF/Bfr2
IPR012617 AATF_C
PANTHERiPTHR15565 PTHR15565, 1 hit
PfamiView protein in Pfam
PF13339 AATF-Che1, 1 hit
PF08164 TRAUB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9NY61-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGPQPLALQ LEQLLNPRPS EADPEADPEE ATAARVIDRF DEGEDGEGDF
60 70 80 90 100
LVVGSIRKLA SASLLDTDKR YCGKTTSRKA WNEDHWEQTL PGSSDEEISD
110 120 130 140 150
EEGSGDEDSE GLGLEEYDED DLGAAEEQEC GDHRESKKSR SHSAKTPGFS
160 170 180 190 200
VQSISDFEKF TKGMDDLGSS EEEEDEESGM EEGDDAEDSQ GESEEDRAGD
210 220 230 240 250
RNSEDDGVVM TFSSVKVSEE VEKGRAVKNQ IALWDQLLEG RIKLQKALLT
260 270 280 290 300
TNQLPQPDVF PLFKDKGGPE FSSALKNSHK ALKALLRSLV GLQEELLFQY
310 320 330 340 350
PDTRYLVDGT KPNAGSEEIS SEDDELVEEK KQQRRRVPAK RKLEMEDYPS
360 370 380 390 400
FMAKRFADFT VYRNRTLQKW HDKTKLASGK LGKGFGAFER SILTQIDHIL
410 420 430 440 450
MDKERLLRRT QTKRSVYRVL GKPEPAAQPV PESLPGEPEI LPQAPANAHL
460 470 480 490 500
KDLDEEIFDD DDFYHQLLRE LIERKTSSLD PNDQVAMGRQ WLAIQKLRSK
510 520 530 540 550
IHKKVDRKAS KGRKLRFHVL SKLLSFMAPI DHTTMNDDAR TELYRSLFGQ
560
LHPPDEGHGD
Length:560
Mass (Da):63,133
Last modified:October 1, 2000 - v1
Checksum:iEC493EF3B4C3A199
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWS8A0A087WWS8_HUMAN
Protein AATF
AATF
154Annotation score:
A0A087WTH8A0A087WTH8_HUMAN
Protein AATF
AATF
98Annotation score:
A0A087WW41A0A087WW41_HUMAN
Protein AATF
AATF
55Annotation score:

Sequence cautioni

The sequence AAD52016 differs from that shown. Reason: Frameshift at positions 355, 365, 487, 498 and 503.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3AG → GR in AAD52016 (PubMed:10783144).Curated2
Sequence conflicti4 – 5Missing in AAD52016 (PubMed:10783144).Curated2
Sequence conflicti139S → T in AAD52016 (PubMed:10783144).Curated1
Sequence conflicti262L → V in AAD52016 (PubMed:10783144).Curated1
Sequence conflicti272S → A in AAD52016 (PubMed:10783144).Curated1
Sequence conflicti306L → V in AAD52016 (PubMed:10783144).Curated1
Sequence conflicti402D → C in AAD52016 (PubMed:10783144).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249940 mRNA Translation: CAB57451.2
AF083208 mRNA Translation: AAD52016.1 Frameshift.
AK057229 mRNA Translation: BAG51888.1
AC003103 Genomic DNA No translation available.
CH471199 Genomic DNA Translation: EAW57575.1
BC000591 mRNA Translation: AAH00591.1
AF161395 mRNA Translation: AAF28955.1
CCDSiCCDS32632.1
RefSeqiNP_036270.1, NM_012138.3
UniGeneiHs.195740

Genome annotation databases

EnsembliENST00000619387; ENSP00000477848; ENSG00000275700
ENST00000620004; ENSP00000481894; ENSG00000276072
GeneIDi26574
KEGGihsa:26574
UCSCiuc002hni.3 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249940 mRNA Translation: CAB57451.2
AF083208 mRNA Translation: AAD52016.1 Frameshift.
AK057229 mRNA Translation: BAG51888.1
AC003103 Genomic DNA No translation available.
CH471199 Genomic DNA Translation: EAW57575.1
BC000591 mRNA Translation: AAH00591.1
AF161395 mRNA Translation: AAF28955.1
CCDSiCCDS32632.1
RefSeqiNP_036270.1, NM_012138.3
UniGeneiHs.195740

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5W6AX-ray1.74E/F539-547[»]
ProteinModelPortaliQ9NY61
SMRiQ9NY61
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117743, 75 interactors
CORUMiQ9NY61
ELMiQ9NY61
IntActiQ9NY61, 33 interactors
MINTiQ9NY61
STRINGi9606.ENSP00000225402

PTM databases

iPTMnetiQ9NY61
PhosphoSitePlusiQ9NY61

Polymorphism and mutation databases

BioMutaiAATF
DMDMi71152211

2D gel databases

SWISS-2DPAGEiQ9NY61

Proteomic databases

EPDiQ9NY61
MaxQBiQ9NY61
PaxDbiQ9NY61
PeptideAtlasiQ9NY61
PRIDEiQ9NY61
ProteomicsDBi83181
TopDownProteomicsiQ9NY61

Protocols and materials databases

DNASUi26574
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000619387; ENSP00000477848; ENSG00000275700
ENST00000620004; ENSP00000481894; ENSG00000276072
GeneIDi26574
KEGGihsa:26574
UCSCiuc002hni.3 human

Organism-specific databases

CTDi26574
DisGeNETi26574
EuPathDBiHostDB:ENSG00000275700.4
GeneCardsiAATF
HGNCiHGNC:19235 AATF
HPAiHPA004940
MIMi608463 gene
neXtProtiNX_Q9NY61
OpenTargetsiENSG00000275700
PharmGKBiPA128395780
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2773 Eukaryota
ENOG410XWGK LUCA
GeneTreeiENSGT00390000000288
HOGENOMiHOG000007555
HOVERGENiHBG080805
InParanoidiQ9NY61
KOiK14782
OMAiEVLLKWD
OrthoDBiEOG091G0F1H
PhylomeDBiQ9NY61
TreeFamiTF324341

Enzyme and pathway databases

ReactomeiR-HSA-193648 NRAGE signals death through JNK
SIGNORiQ9NY61

Miscellaneous databases

ChiTaRSiAATF human
GeneWikiiApoptosis-antagonizing_transcription_factor
GenomeRNAii26574
PROiPR:Q9NY61
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000275700 Expressed in 112 organ(s), highest expression level in corpus callosum
CleanExiHS_AATF
ExpressionAtlasiQ9NY61 baseline and differential
GenevisibleiQ9NY61 HS

Family and domain databases

InterProiView protein in InterPro
IPR025160 AATF
IPR039223 AATF/Bfr2
IPR012617 AATF_C
PANTHERiPTHR15565 PTHR15565, 1 hit
PfamiView protein in Pfam
PF13339 AATF-Che1, 1 hit
PF08164 TRAUB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAATF_HUMAN
AccessioniPrimary (citable) accession number: Q9NY61
Secondary accession number(s): A6NCJ6
, B3KQ26, Q9P0A4, Q9UNX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2000
Last modified: October 10, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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