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Protein

BarH-like 2 homeobox protein

Gene

BARHL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential regulator of neural basic helix-loop-helix genes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi232 – 291HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
BarH-like 2 homeobox protein
Gene namesi
Name:BARHL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143032.7
HGNCiHGNC:954 BARHL2
MIMi605212 gene
neXtProtiNX_Q9NY43

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143032
PharmGKBiPA25258

Polymorphism and mutation databases

BioMutaiBARHL2
DMDMi47117915

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488291 – 387BarH-like 2 homeobox proteinAdd BLAST387

Proteomic databases

PaxDbiQ9NY43
PeptideAtlasiQ9NY43
PRIDEiQ9NY43
ProteomicsDBi83164

PTM databases

iPTMnetiQ9NY43
PhosphoSitePlusiQ9NY43

Expressioni

Gene expression databases

BgeeiENSG00000143032
CleanExiHS_BARHL2

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RELQ048643EBI-10316571,EBI-307352

Protein-protein interaction databases

BioGridi131253, 1 interactor
IntActiQ9NY43, 2 interactors
STRINGi9606.ENSP00000359474

Structurei

3D structure databases

ProteinModelPortaliQ9NY43
SMRiQ9NY43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi92 – 127Gln/Pro-richAdd BLAST36

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000231533
HOVERGENiHBG050663
InParanoidiQ9NY43
KOiK09360
OMAiMEPPEPH
OrthoDBiEOG091G13SM
PhylomeDBiQ9NY43
TreeFamiTF316128

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NY43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMEGASGSS FGIDTILSSA SSGSPGMMNG DFRPLGEART ADFRSQATPS
60 70 80 90 100
PCSEIDTVGT APSSPISVTM EPPEPHLVAD ATQHHHHLHH SQQPPPPAAA
110 120 130 140 150
PTQSLQPLPQ QQQPLPPQQP PPPPPQQLGS AASAPRTSTS SFLIKDILGD
160 170 180 190 200
SKPLAACAPY STSVSSPHHT PKQESNAVHE SFRPKLEQED SKTKLDKRED
210 220 230 240 250
SQSDIKCHGT KEEGDREITS SRESPPVRAK KPRKARTAFS DHQLNQLERS
260 270 280 290 300
FERQKYLSVQ DRMDLAAALN LTDTQVKTWY QNRRTKWKRQ TAVGLELLAE
310 320 330 340 350
AGNYSALQRM FPSPYFYHPS LLGSMDSTTA AAAAAAMYSS MYRTPPAPHP
360 370 380
QLQRPLVPRV LIHGLGPGGQ PALNPLSSPI PGTPHPR
Length:387
Mass (Da):41,981
Last modified:May 10, 2004 - v2
Checksum:iF563EA63489D936D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY338397 mRNA Translation: AAQ01189.1
BC126439 mRNA Translation: AAI26440.1
BC126441 mRNA Translation: AAI26442.1
AJ251753 Genomic DNA Translation: CAB92440.1
CCDSiCCDS730.1
RefSeqiNP_064447.1, NM_020063.1
UniGeneiHs.451956

Genome annotation databases

EnsembliENST00000370445; ENSP00000359474; ENSG00000143032
GeneIDi343472
KEGGihsa:343472
UCSCiuc001dns.4 human

Similar proteinsi

Entry informationi

Entry nameiBARH2_HUMAN
AccessioniPrimary (citable) accession number: Q9NY43
Secondary accession number(s): A0AVP2, Q7Z4N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: May 10, 2004
Last modified: July 18, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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