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UniProtKB - Q9NY35 (CLDN1_HUMAN)

Entry version 154 (10 Feb 2021)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
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Protein

Claudin domain-containing protein 1

Gene

CLDND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NY35

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.16.2.9, the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Claudin domain-containing protein 1
Alternative name(s):
Membrane protein GENX-3745
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLDND1
Synonyms:C3orf4
ORF Names:HSPC174, PSEC0054, UNQ2511/PRO6000
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1322, CLDND1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NY35

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000080822.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		56650

Open Targets

More...OpenTargetsi		ENSG00000080822

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25901

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NY35, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CLDND1

Domain mapping of disease mutations (DMDM)

More...DMDMi		20532022

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001646941 – 253Claudin domain-containing protein 1Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi72N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NY35

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NY35

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NY35

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NY35

PeptideAtlas

More...PeptideAtlasi		Q9NY35

PRoteomics IDEntifications database

More...PRIDEi		Q9NY35

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		23686
83161 [Q9NY35-1]
83162 [Q9NY35-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1115, 2 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NY35, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NY35

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NY35

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9NY35

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely distributed in the adult CNS with highest expression in the corpus callosum, caudate nucleus, cerebral cortex, medulla, putamen, spinal cord, substantia nigra and subthalamic nucleus. Weak expression was detected in the adult heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000080822, Expressed in corpus callosum and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NY35, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NY35, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000080822, Group enriched (blood, brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121164, 26 interactors

Protein interaction database and analysis system

More...IntActi		Q9NY35, 24 interactors

Molecular INTeraction database

More...MINTi		Q9NY35

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000421226

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NY35, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRAV, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002596

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_071844_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NY35

Database of Orthologous Groups

More...OrthoDBi		1047985at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NY35

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR042356, CLDN1
IPR004031, PMP22/EMP/MP20/Claudin

The PANTHER Classification System

More...PANTHERi		PTHR14347, PTHR14347, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13903, Claudin_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 19 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NY35-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDNRFATAFV IACVLSLIST IYMAASIGTD FWYEYRSPVQ ENSSDLNKSI 
        60         70         80         90        100
WDEFISDEAD EKTYNDALFR YNGTVGLWRR CITIPKNMHW YSPPERTESF 
       110        120        130        140        150
DVVTKCVSFT LTEQFMEKFV DPGNHNSGID LLRTYLWRCQ FLLPFVSLGL 
       160        170        180        190        200
MCFGALIGLC ACICRSLYPT IATGILHLLA GLCTLGSVSC YVAGIELLHQ 
       210        220        230        240        250
KLELPDNVSG EFGWSFCLAC VSAPLQFMAS ALFIWAAHTN RKEYTLMKAY 

RVA
Length:253
Mass (Da):28,603
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6459D23B28C9885
GO
Isoform 2 (identifier: Q9NY35-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-184: GLCT → DTML
     185-253: Missing.

Show »
Length:184
Mass (Da):21,052
Checksum:i21A8DF0C4229E8E4
GO
Isoform 3 (identifier: Q9NY35-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MDNRFATAFV...MHWYSPPERT → MG

Show »
Length:158
Mass (Da):17,464
Checksum:iAF5B09A3C83F1231
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YA53H0YA53_HUMAN
Claudin domain-containing protein 1
CLDND1
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J2F2A0A0R4J2F2_HUMAN
Claudin domain-containing protein 1
CLDND1
276Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8T9H0Y8T9_HUMAN
Claudin domain-containing protein 1
CLDND1
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB31D6RB31_HUMAN
Claudin domain-containing protein 1
CLDND1
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC11D6RC11_HUMAN
Claudin domain-containing protein 1
CLDND1
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RD48D6RD48_HUMAN
Claudin domain-containing protein 1
CLDND1
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9K1D6R9K1_HUMAN
Claudin domain-containing protein 1
CLDND1
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9S8D6R9S8_HUMAN
Claudin domain-containing protein 1
CLDND1
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCE6D6RCE6_HUMAN
Claudin domain-containing protein 1
CLDND1
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RA76D6RA76_HUMAN
Claudin domain-containing protein 1
CLDND1
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF29137 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti213G → E in AAF29137 (PubMed:11042152).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0468651 – 97MDNRF…PPERT → MG in isoform 3. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_013156181 – 184GLCT → DTML in isoform 2. 1 Publication4
Alternative sequenceiVSP_013157185 – 253Missing in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ270952 mRNA Translation: CAB89684.1
AF161522 mRNA Translation: AAF29137.1 Different initiation.
AV656305 mRNA No translation available.
AY359121 mRNA Translation: AAQ89479.1
AK075367 mRNA Translation: BAG52123.1
AL080097 mRNA Translation: CAB45709.2
AC021660 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79856.1
CH471052 Genomic DNA Translation: EAW79857.1
CH471052 Genomic DNA Translation: EAW79859.1
CH471052 Genomic DNA Translation: EAW79860.1
BC001757 mRNA Translation: AAH01757.2
BC013610 mRNA Translation: AAH13610.1
BC022551 mRNA Translation: AAH22551.1
BC095441 mRNA Translation: AAH95441.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2930.1 [Q9NY35-1]
CCDS43116.1 [Q9NY35-3]

NCBI Reference Sequences

More...RefSeqi		NP_001035271.1, NM_001040181.1 [Q9NY35-1]
NP_001035272.1, NM_001040182.1
NP_001035273.1, NM_001040183.1 [Q9NY35-1]
NP_001035289.1, NM_001040199.1 [Q9NY35-1]
NP_001035290.1, NM_001040200.1 [Q9NY35-3]
NP_063948.1, NM_019895.2 [Q9NY35-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000341181; ENSP00000340247; ENSG00000080822 [Q9NY35-1]
ENST00000394180; ENSP00000377734; ENSG00000080822 [Q9NY35-1]
ENST00000394185; ENSP00000377739; ENSG00000080822 [Q9NY35-1]
ENST00000503004; ENSP00000421226; ENSG00000080822 [Q9NY35-1]
ENST00000510545; ENSP00000423590; ENSG00000080822 [Q9NY35-1]
ENST00000511081; ENSP00000424669; ENSG00000080822 [Q9NY35-3]
ENST00000513287; ENSP00000426869; ENSG00000080822 [Q9NY35-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56650

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56650

UCSC genome browser

More...UCSCi		uc003dsp.4, human [Q9NY35-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ270952 mRNA Translation: CAB89684.1
AF161522 mRNA Translation: AAF29137.1 Different initiation.
AV656305 mRNA No translation available.
AY359121 mRNA Translation: AAQ89479.1
AK075367 mRNA Translation: BAG52123.1
AL080097 mRNA Translation: CAB45709.2
AC021660 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79856.1
CH471052 Genomic DNA Translation: EAW79857.1
CH471052 Genomic DNA Translation: EAW79859.1
CH471052 Genomic DNA Translation: EAW79860.1
BC001757 mRNA Translation: AAH01757.2
BC013610 mRNA Translation: AAH13610.1
BC022551 mRNA Translation: AAH22551.1
BC095441 mRNA Translation: AAH95441.1
CCDSiCCDS2930.1 [Q9NY35-1]
CCDS43116.1 [Q9NY35-3]
RefSeqiNP_001035271.1, NM_001040181.1 [Q9NY35-1]
NP_001035272.1, NM_001040182.1
NP_001035273.1, NM_001040183.1 [Q9NY35-1]
NP_001035289.1, NM_001040199.1 [Q9NY35-1]
NP_001035290.1, NM_001040200.1 [Q9NY35-3]
NP_063948.1, NM_019895.2 [Q9NY35-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121164, 26 interactors
IntActiQ9NY35, 24 interactors
MINTiQ9NY35
STRINGi9606.ENSP00000421226

Protein family/group databases

TCDBi8.A.16.2.9, the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family

PTM databases

GlyConnecti1115, 2 N-Linked glycans (2 sites)
GlyGeniQ9NY35, 2 sites
iPTMnetiQ9NY35
PhosphoSitePlusiQ9NY35
SwissPalmiQ9NY35

Genetic variation databases

BioMutaiCLDND1
DMDMi20532022

Proteomic databases

jPOSTiQ9NY35
MassIVEiQ9NY35
MaxQBiQ9NY35
PaxDbiQ9NY35
PeptideAtlasiQ9NY35
PRIDEiQ9NY35
ProteomicsDBi23686
83161 [Q9NY35-1]
83162 [Q9NY35-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32146, 145 antibodies

The DNASU plasmid repository

More...DNASUi		56650

Genome annotation databases

EnsembliENST00000341181; ENSP00000340247; ENSG00000080822 [Q9NY35-1]
ENST00000394180; ENSP00000377734; ENSG00000080822 [Q9NY35-1]
ENST00000394185; ENSP00000377739; ENSG00000080822 [Q9NY35-1]
ENST00000503004; ENSP00000421226; ENSG00000080822 [Q9NY35-1]
ENST00000510545; ENSP00000423590; ENSG00000080822 [Q9NY35-1]
ENST00000511081; ENSP00000424669; ENSG00000080822 [Q9NY35-3]
ENST00000513287; ENSP00000426869; ENSG00000080822 [Q9NY35-1]
GeneIDi56650
KEGGihsa:56650
UCSCiuc003dsp.4, human [Q9NY35-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56650
DisGeNETi56650

GeneCards: human genes, protein and diseases

More...GeneCardsi		CLDND1
HGNCiHGNC:1322, CLDND1
HPAiENSG00000080822, Group enriched (blood, brain)
neXtProtiNX_Q9NY35
OpenTargetsiENSG00000080822
PharmGKBiPA25901
VEuPathDBiHostDB:ENSG00000080822.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRAV, Eukaryota
GeneTreeiENSGT00390000002596
HOGENOMiCLU_071844_0_0_1
InParanoidiQ9NY35
OrthoDBi1047985at2759
PhylomeDBiQ9NY35

Enzyme and pathway databases

PathwayCommonsiQ9NY35

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56650, 60 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CLDND1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CLDND1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56650
PharosiQ9NY35, Tbio

Protein Ontology

More...PROi		PR:Q9NY35
RNActiQ9NY35, protein

Gene expression databases

BgeeiENSG00000080822, Expressed in corpus callosum and 243 other tissues
ExpressionAtlasiQ9NY35, baseline and differential
GenevisibleiQ9NY35, HS

Family and domain databases

InterProiView protein in InterPro
IPR042356, CLDN1
IPR004031, PMP22/EMP/MP20/Claudin
PANTHERiPTHR14347, PTHR14347, 1 hit
PfamiView protein in Pfam
PF13903, Claudin_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLDN1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NY35
Secondary accession number(s): B3KQR1
, D3DN36, F2Z2D9, Q502Y8, Q6UVX2, Q9BUZ9, Q9NZZ5, Q9Y4S9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2000
Last modified: February 10, 2021
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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