UniProtKB - Q9NY35 (CLDN1_HUMAN)
Protein
Claudin domain-containing protein 1
Gene
CLDND1
Organism
Homo sapiens (Human)
Status
Functioni
Enzyme and pathway databases
PathwayCommonsi | Q9NY35 |
Protein family/group databases
TCDBi | 8.A.16.2.9, the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family |
Names & Taxonomyi
Protein namesi | Recommended name: Claudin domain-containing protein 1Alternative name(s): Membrane protein GENX-3745 |
Gene namesi | Name:CLDND1 Synonyms:C3orf4 ORF Names:HSPC174, PSEC0054, UNQ2511/PRO6000 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1322, CLDND1 |
neXtProti | NX_Q9NY35 |
VEuPathDBi | HostDB:ENSG00000080822.16 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- cell surface Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 5 – 25 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 141 – 161 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 175 – 195 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 216 – 236 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 56650 |
OpenTargetsi | ENSG00000080822 |
PharmGKBi | PA25901 |
Miscellaneous databases
Pharosi | Q9NY35, Tbio |
Genetic variation databases
BioMutai | CLDND1 |
DMDMi | 20532022 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000164694 | 1 – 253 | Claudin domain-containing protein 1Add BLAST | 253 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 42 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 72 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q9NY35 |
MassIVEi | Q9NY35 |
MaxQBi | Q9NY35 |
PaxDbi | Q9NY35 |
PeptideAtlasi | Q9NY35 |
PRIDEi | Q9NY35 |
ProteomicsDBi | 23686 83161 [Q9NY35-1] 83162 [Q9NY35-2] |
PTM databases
GlyConnecti | 1115, 2 N-Linked glycans (2 sites) |
GlyGeni | Q9NY35, 2 sites |
iPTMneti | Q9NY35 |
PhosphoSitePlusi | Q9NY35 |
SwissPalmi | Q9NY35 |
Expressioni
Tissue specificityi
Widely distributed in the adult CNS with highest expression in the corpus callosum, caudate nucleus, cerebral cortex, medulla, putamen, spinal cord, substantia nigra and subthalamic nucleus. Weak expression was detected in the adult heart.
Gene expression databases
Bgeei | ENSG00000080822, Expressed in corpus callosum and 243 other tissues |
ExpressionAtlasi | Q9NY35, baseline and differential |
Genevisiblei | Q9NY35, HS |
Organism-specific databases
HPAi | ENSG00000080822, Group enriched (blood, brain) |
Interactioni
Binary interactionsi
Hide detailsQ9NY35
With | #Exp. | IntAct |
---|---|---|
CXCR1 [P25024] | 3 | EBI-4319704,EBI-3905522 |
GPR61 [Q9BZJ8] | 3 | EBI-4319704,EBI-12808020 |
ZDHHC4 [Q9NPG8] | 3 | EBI-4319704,EBI-20009624 |
Protein-protein interaction databases
BioGRIDi | 121164, 26 interactors |
IntActi | Q9NY35, 24 interactors |
MINTi | Q9NY35 |
STRINGi | 9606.ENSP00000421226 |
Miscellaneous databases
RNActi | Q9NY35, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the PMP-22/EMP/MP20 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QRAV, Eukaryota |
GeneTreei | ENSGT00390000002596 |
HOGENOMi | CLU_071844_0_0_1 |
InParanoidi | Q9NY35 |
OrthoDBi | 1047985at2759 |
PhylomeDBi | Q9NY35 |
Family and domain databases
InterProi | View protein in InterPro IPR042356, CLDN1 IPR004031, PMP22/EMP/MP20/Claudin |
PANTHERi | PTHR14347, PTHR14347, 1 hit |
Pfami | View protein in Pfam PF13903, Claudin_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 19 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NY35-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDNRFATAFV IACVLSLIST IYMAASIGTD FWYEYRSPVQ ENSSDLNKSI
60 70 80 90 100
WDEFISDEAD EKTYNDALFR YNGTVGLWRR CITIPKNMHW YSPPERTESF
110 120 130 140 150
DVVTKCVSFT LTEQFMEKFV DPGNHNSGID LLRTYLWRCQ FLLPFVSLGL
160 170 180 190 200
MCFGALIGLC ACICRSLYPT IATGILHLLA GLCTLGSVSC YVAGIELLHQ
210 220 230 240 250
KLELPDNVSG EFGWSFCLAC VSAPLQFMAS ALFIWAAHTN RKEYTLMKAY
RVA
Computationally mapped potential isoform sequencesi
There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YA53 | H0YA53_HUMAN | Claudin domain-containing protein 1 | CLDND1 | 72 | Annotation score: | ||
A0A0R4J2F2 | A0A0R4J2F2_HUMAN | Claudin domain-containing protein 1 | CLDND1 | 276 | Annotation score: | ||
H0Y8T9 | H0Y8T9_HUMAN | Claudin domain-containing protein 1 | CLDND1 | 155 | Annotation score: | ||
D6RB31 | D6RB31_HUMAN | Claudin domain-containing protein 1 | CLDND1 | 100 | Annotation score: | ||
D6RC11 | D6RC11_HUMAN | Claudin domain-containing protein 1 | CLDND1 | 210 | Annotation score: | ||
D6RD48 | D6RD48_HUMAN | Claudin domain-containing protein 1 | CLDND1 | 89 | Annotation score: | ||
D6R9K1 | D6R9K1_HUMAN | Claudin domain-containing protein 1 | CLDND1 | 87 | Annotation score: | ||
D6R9S8 | D6R9S8_HUMAN | Claudin domain-containing protein 1 | CLDND1 | 213 | Annotation score: | ||
D6RCE6 | D6RCE6_HUMAN | Claudin domain-containing protein 1 | CLDND1 | 223 | Annotation score: | ||
D6RA76 | D6RA76_HUMAN | Claudin domain-containing protein 1 | CLDND1 | 180 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
The sequence AAF29137 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 213 | G → E in AAF29137 (PubMed:11042152).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046865 | 1 – 97 | MDNRF…PPERT → MG in isoform 3. 1 PublicationAdd BLAST | 97 | |
Alternative sequenceiVSP_013156 | 181 – 184 | GLCT → DTML in isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_013157 | 185 – 253 | Missing in isoform 2. 1 PublicationAdd BLAST | 69 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ270952 mRNA Translation: CAB89684.1 AF161522 mRNA Translation: AAF29137.1 Different initiation. AV656305 mRNA No translation available. AY359121 mRNA Translation: AAQ89479.1 AK075367 mRNA Translation: BAG52123.1 AL080097 mRNA Translation: CAB45709.2 AC021660 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79856.1 CH471052 Genomic DNA Translation: EAW79857.1 CH471052 Genomic DNA Translation: EAW79859.1 CH471052 Genomic DNA Translation: EAW79860.1 BC001757 mRNA Translation: AAH01757.2 BC013610 mRNA Translation: AAH13610.1 BC022551 mRNA Translation: AAH22551.1 BC095441 mRNA Translation: AAH95441.1 |
CCDSi | CCDS2930.1 [Q9NY35-1] CCDS43116.1 [Q9NY35-3] |
RefSeqi | NP_001035271.1, NM_001040181.1 [Q9NY35-1] NP_001035272.1, NM_001040182.1 NP_001035273.1, NM_001040183.1 [Q9NY35-1] NP_001035289.1, NM_001040199.1 [Q9NY35-1] NP_001035290.1, NM_001040200.1 [Q9NY35-3] NP_063948.1, NM_019895.2 [Q9NY35-1] |
Genome annotation databases
Ensembli | ENST00000341181; ENSP00000340247; ENSG00000080822 [Q9NY35-1] ENST00000394180; ENSP00000377734; ENSG00000080822 [Q9NY35-1] ENST00000394185; ENSP00000377739; ENSG00000080822 [Q9NY35-1] ENST00000503004; ENSP00000421226; ENSG00000080822 [Q9NY35-1] ENST00000510545; ENSP00000423590; ENSG00000080822 [Q9NY35-1] ENST00000511081; ENSP00000424669; ENSG00000080822 [Q9NY35-3] ENST00000513287; ENSP00000426869; ENSG00000080822 [Q9NY35-1] |
GeneIDi | 56650 |
KEGGi | hsa:56650 |
UCSCi | uc003dsp.4, human [Q9NY35-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ270952 mRNA Translation: CAB89684.1 AF161522 mRNA Translation: AAF29137.1 Different initiation. AV656305 mRNA No translation available. AY359121 mRNA Translation: AAQ89479.1 AK075367 mRNA Translation: BAG52123.1 AL080097 mRNA Translation: CAB45709.2 AC021660 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79856.1 CH471052 Genomic DNA Translation: EAW79857.1 CH471052 Genomic DNA Translation: EAW79859.1 CH471052 Genomic DNA Translation: EAW79860.1 BC001757 mRNA Translation: AAH01757.2 BC013610 mRNA Translation: AAH13610.1 BC022551 mRNA Translation: AAH22551.1 BC095441 mRNA Translation: AAH95441.1 |
CCDSi | CCDS2930.1 [Q9NY35-1] CCDS43116.1 [Q9NY35-3] |
RefSeqi | NP_001035271.1, NM_001040181.1 [Q9NY35-1] NP_001035272.1, NM_001040182.1 NP_001035273.1, NM_001040183.1 [Q9NY35-1] NP_001035289.1, NM_001040199.1 [Q9NY35-1] NP_001035290.1, NM_001040200.1 [Q9NY35-3] NP_063948.1, NM_019895.2 [Q9NY35-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121164, 26 interactors |
IntActi | Q9NY35, 24 interactors |
MINTi | Q9NY35 |
STRINGi | 9606.ENSP00000421226 |
Protein family/group databases
TCDBi | 8.A.16.2.9, the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family |
PTM databases
GlyConnecti | 1115, 2 N-Linked glycans (2 sites) |
GlyGeni | Q9NY35, 2 sites |
iPTMneti | Q9NY35 |
PhosphoSitePlusi | Q9NY35 |
SwissPalmi | Q9NY35 |
Genetic variation databases
BioMutai | CLDND1 |
DMDMi | 20532022 |
Proteomic databases
jPOSTi | Q9NY35 |
MassIVEi | Q9NY35 |
MaxQBi | Q9NY35 |
PaxDbi | Q9NY35 |
PeptideAtlasi | Q9NY35 |
PRIDEi | Q9NY35 |
ProteomicsDBi | 23686 83161 [Q9NY35-1] 83162 [Q9NY35-2] |
Protocols and materials databases
Antibodypediai | 32146, 145 antibodies |
DNASUi | 56650 |
Genome annotation databases
Organism-specific databases
CTDi | 56650 |
DisGeNETi | 56650 |
GeneCardsi | CLDND1 |
HGNCi | HGNC:1322, CLDND1 |
HPAi | ENSG00000080822, Group enriched (blood, brain) |
neXtProti | NX_Q9NY35 |
OpenTargetsi | ENSG00000080822 |
PharmGKBi | PA25901 |
VEuPathDBi | HostDB:ENSG00000080822.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRAV, Eukaryota |
GeneTreei | ENSGT00390000002596 |
HOGENOMi | CLU_071844_0_0_1 |
InParanoidi | Q9NY35 |
OrthoDBi | 1047985at2759 |
PhylomeDBi | Q9NY35 |
Enzyme and pathway databases
PathwayCommonsi | Q9NY35 |
Miscellaneous databases
BioGRID-ORCSi | 56650, 60 hits in 871 CRISPR screens |
ChiTaRSi | CLDND1, human |
GeneWikii | CLDND1 |
GenomeRNAii | 56650 |
Pharosi | Q9NY35, Tbio |
PROi | PR:Q9NY35 |
RNActi | Q9NY35, protein |
Gene expression databases
Bgeei | ENSG00000080822, Expressed in corpus callosum and 243 other tissues |
ExpressionAtlasi | Q9NY35, baseline and differential |
Genevisiblei | Q9NY35, HS |
Family and domain databases
InterProi | View protein in InterPro IPR042356, CLDN1 IPR004031, PMP22/EMP/MP20/Claudin |
PANTHERi | PTHR14347, PTHR14347, 1 hit |
Pfami | View protein in Pfam PF13903, Claudin_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLDN1_HUMAN | |
Accessioni | Q9NY35Primary (citable) accession number: Q9NY35 Secondary accession number(s): B3KQR1 Q9Y4S9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families