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Protein

Claudin domain-containing protein 1

Gene

CLDND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein family/group databases

TCDBi8.A.16.2.9 the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin domain-containing protein 1
Alternative name(s):
Membrane protein GENX-3745
Gene namesi
Name:CLDND1
Synonyms:C3orf4
ORF Names:HSPC174, PSEC0054, UNQ2511/PRO6000
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000080822.16
HGNCiHGNC:1322 CLDND1
neXtProtiNX_Q9NY35

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56650
OpenTargetsiENSG00000080822
PharmGKBiPA25901

Polymorphism and mutation databases

BioMutaiCLDND1
DMDMi20532022

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646941 – 253Claudin domain-containing protein 1Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi72N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9NY35
PaxDbiQ9NY35
PeptideAtlasiQ9NY35
PRIDEiQ9NY35
ProteomicsDBi83161
83162 [Q9NY35-2]

PTM databases

GlyConnecti1115
iPTMnetiQ9NY35
PhosphoSitePlusiQ9NY35
SwissPalmiQ9NY35

Expressioni

Tissue specificityi

Widely distributed in the adult CNS with highest expression in the corpus callosum, caudate nucleus, cerebral cortex, medulla, putamen, spinal cord, substantia nigra and subthalamic nucleus. Weak expression was detected in the adult heart.

Gene expression databases

BgeeiENSG00000080822 Expressed in 231 organ(s), highest expression level in corpus callosum
CleanExiHS_CLDND1
ExpressionAtlasiQ9NY35 baseline and differential
GenevisibleiQ9NY35 HS

Organism-specific databases

HPAiHPA029841

Interactioni

Protein-protein interaction databases

BioGridi121164, 22 interactors
IntActiQ9NY35, 4 interactors
STRINGi9606.ENSP00000388457

Structurei

3D structure databases

ProteinModelPortaliQ9NY35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFQW Eukaryota
ENOG4110MPF LUCA
GeneTreeiENSGT00390000002596
HOVERGENiHBG050817
InParanoidiQ9NY35
PhylomeDBiQ9NY35

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
PfamiView protein in Pfam
PF13903 Claudin_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 19 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NY35-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDNRFATAFV IACVLSLIST IYMAASIGTD FWYEYRSPVQ ENSSDLNKSI
60 70 80 90 100
WDEFISDEAD EKTYNDALFR YNGTVGLWRR CITIPKNMHW YSPPERTESF
110 120 130 140 150
DVVTKCVSFT LTEQFMEKFV DPGNHNSGID LLRTYLWRCQ FLLPFVSLGL
160 170 180 190 200
MCFGALIGLC ACICRSLYPT IATGILHLLA GLCTLGSVSC YVAGIELLHQ
210 220 230 240 250
KLELPDNVSG EFGWSFCLAC VSAPLQFMAS ALFIWAAHTN RKEYTLMKAY

RVA
Length:253
Mass (Da):28,603
Last modified:October 1, 2000 - v1
Checksum:iC6459D23B28C9885
GO
Isoform 2 (identifier: Q9NY35-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-184: GLCT → DTML
     185-253: Missing.

Show »
Length:184
Mass (Da):21,052
Checksum:i21A8DF0C4229E8E4
GO
Isoform 3 (identifier: Q9NY35-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MDNRFATAFV...MHWYSPPERT → MG

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):17,464
Checksum:iAF5B09A3C83F1231
GO

Computationally mapped potential isoform sequencesi

There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YA53H0YA53_HUMAN
Claudin domain-containing protein 1
CLDND1
72Annotation score:
A0A0R4J2F2A0A0R4J2F2_HUMAN
Claudin domain-containing protein 1
CLDND1
276Annotation score:
D6R9S8D6R9S8_HUMAN
Claudin domain-containing protein 1
CLDND1
213Annotation score:
D6RB31D6RB31_HUMAN
Claudin domain-containing protein 1
CLDND1
100Annotation score:
D6RC11D6RC11_HUMAN
Claudin domain-containing protein 1
CLDND1
210Annotation score:
D6RHU6D6RHU6_HUMAN
Claudin domain-containing protein 1
CLDND1
172Annotation score:
H0Y8T9H0Y8T9_HUMAN
Claudin domain-containing protein 1
CLDND1
155Annotation score:
D6RCE6D6RCE6_HUMAN
Claudin domain-containing protein 1
CLDND1
223Annotation score:
D6RCP3D6RCP3_HUMAN
Claudin domain-containing protein 1
CLDND1
121Annotation score:
D6RIU2D6RIU2_HUMAN
Claudin domain-containing protein 1
CLDND1
138Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAF29137 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti213G → E in AAF29137 (PubMed:11042152).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0468651 – 97MDNRF…PPERT → MG in isoform 3. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_013156181 – 184GLCT → DTML in isoform 2. 1 Publication4
Alternative sequenceiVSP_013157185 – 253Missing in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ270952 mRNA Translation: CAB89684.1
AF161522 mRNA Translation: AAF29137.1 Different initiation.
AV656305 mRNA No translation available.
AY359121 mRNA Translation: AAQ89479.1
AK075367 mRNA Translation: BAG52123.1
AL080097 mRNA Translation: CAB45709.2
AC021660 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79856.1
CH471052 Genomic DNA Translation: EAW79857.1
CH471052 Genomic DNA Translation: EAW79859.1
CH471052 Genomic DNA Translation: EAW79860.1
BC001757 mRNA Translation: AAH01757.2
BC013610 mRNA Translation: AAH13610.1
BC022551 mRNA Translation: AAH22551.1
BC095441 mRNA Translation: AAH95441.1
CCDSiCCDS2930.1 [Q9NY35-1]
CCDS43116.1 [Q9NY35-3]
RefSeqiNP_001035271.1, NM_001040181.1 [Q9NY35-1]
NP_001035272.1, NM_001040182.1
NP_001035273.1, NM_001040183.1 [Q9NY35-1]
NP_001035289.1, NM_001040199.1 [Q9NY35-1]
NP_001035290.1, NM_001040200.1 [Q9NY35-3]
NP_063948.1, NM_019895.2 [Q9NY35-1]
UniGeneiHs.531371
Hs.720106

Genome annotation databases

EnsembliENST00000341181; ENSP00000340247; ENSG00000080822 [Q9NY35-1]
ENST00000394180; ENSP00000377734; ENSG00000080822 [Q9NY35-1]
ENST00000394185; ENSP00000377739; ENSG00000080822 [Q9NY35-1]
ENST00000503004; ENSP00000421226; ENSG00000080822 [Q9NY35-1]
ENST00000510545; ENSP00000423590; ENSG00000080822 [Q9NY35-1]
ENST00000511081; ENSP00000424669; ENSG00000080822 [Q9NY35-3]
ENST00000513287; ENSP00000426869; ENSG00000080822 [Q9NY35-1]
GeneIDi56650
KEGGihsa:56650
UCSCiuc003dsp.4 human [Q9NY35-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ270952 mRNA Translation: CAB89684.1
AF161522 mRNA Translation: AAF29137.1 Different initiation.
AV656305 mRNA No translation available.
AY359121 mRNA Translation: AAQ89479.1
AK075367 mRNA Translation: BAG52123.1
AL080097 mRNA Translation: CAB45709.2
AC021660 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79856.1
CH471052 Genomic DNA Translation: EAW79857.1
CH471052 Genomic DNA Translation: EAW79859.1
CH471052 Genomic DNA Translation: EAW79860.1
BC001757 mRNA Translation: AAH01757.2
BC013610 mRNA Translation: AAH13610.1
BC022551 mRNA Translation: AAH22551.1
BC095441 mRNA Translation: AAH95441.1
CCDSiCCDS2930.1 [Q9NY35-1]
CCDS43116.1 [Q9NY35-3]
RefSeqiNP_001035271.1, NM_001040181.1 [Q9NY35-1]
NP_001035272.1, NM_001040182.1
NP_001035273.1, NM_001040183.1 [Q9NY35-1]
NP_001035289.1, NM_001040199.1 [Q9NY35-1]
NP_001035290.1, NM_001040200.1 [Q9NY35-3]
NP_063948.1, NM_019895.2 [Q9NY35-1]
UniGeneiHs.531371
Hs.720106

3D structure databases

ProteinModelPortaliQ9NY35
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121164, 22 interactors
IntActiQ9NY35, 4 interactors
STRINGi9606.ENSP00000388457

Protein family/group databases

TCDBi8.A.16.2.9 the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family

PTM databases

GlyConnecti1115
iPTMnetiQ9NY35
PhosphoSitePlusiQ9NY35
SwissPalmiQ9NY35

Polymorphism and mutation databases

BioMutaiCLDND1
DMDMi20532022

Proteomic databases

MaxQBiQ9NY35
PaxDbiQ9NY35
PeptideAtlasiQ9NY35
PRIDEiQ9NY35
ProteomicsDBi83161
83162 [Q9NY35-2]

Protocols and materials databases

DNASUi56650
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341181; ENSP00000340247; ENSG00000080822 [Q9NY35-1]
ENST00000394180; ENSP00000377734; ENSG00000080822 [Q9NY35-1]
ENST00000394185; ENSP00000377739; ENSG00000080822 [Q9NY35-1]
ENST00000503004; ENSP00000421226; ENSG00000080822 [Q9NY35-1]
ENST00000510545; ENSP00000423590; ENSG00000080822 [Q9NY35-1]
ENST00000511081; ENSP00000424669; ENSG00000080822 [Q9NY35-3]
ENST00000513287; ENSP00000426869; ENSG00000080822 [Q9NY35-1]
GeneIDi56650
KEGGihsa:56650
UCSCiuc003dsp.4 human [Q9NY35-1]

Organism-specific databases

CTDi56650
DisGeNETi56650
EuPathDBiHostDB:ENSG00000080822.16
GeneCardsiCLDND1
HGNCiHGNC:1322 CLDND1
HPAiHPA029841
neXtProtiNX_Q9NY35
OpenTargetsiENSG00000080822
PharmGKBiPA25901
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFQW Eukaryota
ENOG4110MPF LUCA
GeneTreeiENSGT00390000002596
HOVERGENiHBG050817
InParanoidiQ9NY35
PhylomeDBiQ9NY35

Miscellaneous databases

ChiTaRSiCLDND1 human
GeneWikiiCLDND1
GenomeRNAii56650
PROiPR:Q9NY35

Gene expression databases

BgeeiENSG00000080822 Expressed in 231 organ(s), highest expression level in corpus callosum
CleanExiHS_CLDND1
ExpressionAtlasiQ9NY35 baseline and differential
GenevisibleiQ9NY35 HS

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
PfamiView protein in Pfam
PF13903 Claudin_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLDN1_HUMAN
AccessioniPrimary (citable) accession number: Q9NY35
Secondary accession number(s): B3KQR1
, D3DN36, F2Z2D9, Q502Y8, Q6UVX2, Q9BUZ9, Q9NZZ5, Q9Y4S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2000
Last modified: October 10, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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