UniProtKB - Q9NY27 (PP4R2_HUMAN)
Serine/threonine-protein phosphatase 4 regulatory subunit 2
PPP4R2
Functioni
GO - Molecular functioni
- protein-macromolecule adaptor activity Source: UniProtKB
- protein phosphatase regulator activity Source: UniProtKB
GO - Biological processi
- cellular protein modification process Source: ProtInc
- mRNA processing Source: UniProtKB-KW
- protein dephosphorylation Source: GO_Central
- regulation of double-strand break repair via homologous recombination Source: UniProtKB
- RNA splicing Source: UniProtKB-KW
Keywordsi
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
PathwayCommonsi | Q9NY27 |
Reactomei | R-HSA-5693607, Processing of DNA double-strand break ends |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase 4 regulatory subunit 2 |
Gene namesi | Name:PPP4R2 ORF Names:SBBI57 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18296, PPP4R2 |
MIMi | 613822, gene |
neXtProti | NX_Q9NY27 |
VEuPathDBi | HostDB:ENSG00000163605.14 |
Subcellular locationi
Nucleus
Cytoskeleton
Note: Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2.
Cytoskeleton
- centrosome Source: ProtInc
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
- protein phosphatase 4 complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 99 | F → A: No effect on RPA2-binding; decrease in PPP4C-binding. 1 Publication | 1 | |
Mutagenesisi | 103 | R → A: No effect on RPA2-binding; loss of PPP4C-binding. 1 Publication | 1 | |
Mutagenesisi | 106 | E → A: No effect on RPA2-binding, nor on PPP4C-binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 151987 |
OpenTargetsi | ENSG00000163605 |
PharmGKBi | PA38520 |
Miscellaneous databases
Pharosi | Q9NY27, Tbio |
Genetic variation databases
BioMutai | PPP4R2 |
DMDMi | 158564082 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299365 | 1 – 417 | Serine/threonine-protein phosphatase 4 regulatory subunit 2Add BLAST | 417 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 159 | PhosphoserineCombined sources | 1 | |
Modified residuei | 226 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NY27 |
jPOSTi | Q9NY27 |
MassIVEi | Q9NY27 |
MaxQBi | Q9NY27 |
PaxDbi | Q9NY27 |
PeptideAtlasi | Q9NY27 |
PRIDEi | Q9NY27 |
ProteomicsDBi | 83154 [Q9NY27-1] 83155 [Q9NY27-2] 83156 [Q9NY27-3] |
PTM databases
iPTMneti | Q9NY27 |
MetOSitei | Q9NY27 |
PhosphoSitePlusi | Q9NY27 |
SwissPalmi | Q9NY27 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000163605, Expressed in placenta and 218 other tissues |
ExpressionAtlasi | Q9NY27, baseline and differential |
Genevisiblei | Q9NY27, HS |
Organism-specific databases
HPAi | ENSG00000163605, Low tissue specificity |
Interactioni
Subunit structurei
Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.
Component of the PP4 complexes PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A and PPP4C-PPP4R2-PPP4R3B. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2.
Interacts with DDX20/GEMIN3 and GEMIN4.
Interacts with RPA2; this DNA damage-dependent interaction recruits PPP4C leading to RPA2 dephosphorylation.
3 PublicationsBinary interactionsi
Q9NY27
With | #Exp. | IntAct |
---|---|---|
PPP4C [P60510] | 13 | EBI-1048740,EBI-1046072 |
Protein-protein interaction databases
BioGRIDi | 127414, 77 interactors |
ComplexPortali | CPX-156, PPP4C-PPP4R2 protein phosphatase 4 complex CPX-1843, PPP4C-PPP4R2-PPP4R3A protein phosphatase 4 complex CPX-1844, PPP4C-PPP4R2-PPP4R3B protein phosphatase 4 complex |
CORUMi | Q9NY27 |
IntActi | Q9NY27, 40 interactors |
MINTi | Q9NY27 |
STRINGi | 9606.ENSP00000349124 |
Miscellaneous databases
RNActi | Q9NY27, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 298 – 415 | Glu-richAdd BLAST | 118 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3175, Eukaryota |
GeneTreei | ENSGT00940000160975 |
HOGENOMi | CLU_043908_1_1_1 |
InParanoidi | Q9NY27 |
OMAi | SCARQHC |
OrthoDBi | 774806at2759 |
PhylomeDBi | Q9NY27 |
TreeFami | TF105561 |
Family and domain databases
InterProi | View protein in InterPro IPR015267, PPP4R2 |
PANTHERi | PTHR16487, PTHR16487, 1 hit |
Pfami | View protein in Pfam PF09184, PPP4R2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDVERLQEAL KDFEKRGKKE VCPVLDQFLC HVAKTGETMI QWSQFKGYFI
60 70 80 90 100
FKLEKVMDDF RTSAPEPRGP PNPNVEYIPF DEMKERILKI VTGFNGIPFT
110 120 130 140 150
IQRLCELLTD PRRNYTGTDK FLRGVEKNVM VVSCVYPSSE KNNSNSLNRM
160 170 180 190 200
NGVMFPGNSP SYTERSNING PGTPRPLNRP KVSLSAPMTT NGLPESTDSK
210 220 230 240 250
EANLQQNEEK NHSDSSTSES EVSSVSPLKN KHPDEDAVEA EGHEVKRLRF
260 270 280 290 300
DKEGEVRETA SQTTSSEISS VMVGETEASS SSQDKDKDSR CTRQHCTEED
310 320 330 340 350
EEEDEEEEEE SFMTSREMIP ERKNQEKESD DALTVNEETS EENNQMEESD
360 370 380 390 400
VSQAEKDLLH SEGSENEGPV SSSSSDCRET EELVGSNSSK TGEILSESSM
410
ENDDEATEVT DEPMEQD
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9IZ04 | C9IZ04_HUMAN | Serine/threonine-protein phosphatas... | PPP4R2 | 226 | Annotation score: | ||
F8WCA1 | F8WCA1_HUMAN | Serine/threonine-protein phosphatas... | PPP4R2 | 116 | Annotation score: | ||
H7C559 | H7C559_HUMAN | Serine/threonine-protein phosphatas... | PPP4R2 | 143 | Annotation score: | ||
C9IZF4 | C9IZF4_HUMAN | HCG14948, isoform CRA_a | PPP4R2 hCG_14948 | 69 | Annotation score: | ||
F8WDK3 | F8WDK3_HUMAN | Serine/threonine-protein phosphatas... | PPP4R2 | 62 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051749 | 174 | P → L. Corresponds to variant dbSNP:rs2306983Ensembl. | 1 | |
Natural variantiVAR_034811 | 282 | S → C. Corresponds to variant dbSNP:rs34742137Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027612 | 1 – 56 | Missing in isoform 3. 1 PublicationAdd BLAST | 56 | |
Alternative sequenceiVSP_027613 | 39 – 96 | MIQWS…TGFNG → I in isoform 2. 1 PublicationAdd BLAST | 58 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ271448 mRNA Translation: CAB93534.2 Different initiation. AF327345 mRNA Translation: AAL56006.1 AK289901 mRNA Translation: BAF82590.1 CH471055 Genomic DNA Translation: EAW65530.1 BC100281 mRNA Translation: AAI00282.1 Sequence problems. BC110889 mRNA Translation: AAI10890.1 BC128136 mRNA Translation: AAI28137.1 BC128137 mRNA Translation: AAI28138.1 |
CCDSi | CCDS2917.1 [Q9NY27-1] |
RefSeqi | NP_001304954.1, NM_001318025.1 [Q9NY27-2] NP_001304955.1, NM_001318026.1 NP_001304956.1, NM_001318027.1 NP_777567.1, NM_174907.3 [Q9NY27-1] |
Genome annotation databases
Ensembli | ENST00000356692; ENSP00000349124; ENSG00000163605 [Q9NY27-1] |
GeneIDi | 151987 |
KEGGi | hsa:151987 |
UCSCi | uc003dph.2, human [Q9NY27-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ271448 mRNA Translation: CAB93534.2 Different initiation. AF327345 mRNA Translation: AAL56006.1 AK289901 mRNA Translation: BAF82590.1 CH471055 Genomic DNA Translation: EAW65530.1 BC100281 mRNA Translation: AAI00282.1 Sequence problems. BC110889 mRNA Translation: AAI10890.1 BC128136 mRNA Translation: AAI28137.1 BC128137 mRNA Translation: AAI28138.1 |
CCDSi | CCDS2917.1 [Q9NY27-1] |
RefSeqi | NP_001304954.1, NM_001318025.1 [Q9NY27-2] NP_001304955.1, NM_001318026.1 NP_001304956.1, NM_001318027.1 NP_777567.1, NM_174907.3 [Q9NY27-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127414, 77 interactors |
ComplexPortali | CPX-156, PPP4C-PPP4R2 protein phosphatase 4 complex CPX-1843, PPP4C-PPP4R2-PPP4R3A protein phosphatase 4 complex CPX-1844, PPP4C-PPP4R2-PPP4R3B protein phosphatase 4 complex |
CORUMi | Q9NY27 |
IntActi | Q9NY27, 40 interactors |
MINTi | Q9NY27 |
STRINGi | 9606.ENSP00000349124 |
PTM databases
iPTMneti | Q9NY27 |
MetOSitei | Q9NY27 |
PhosphoSitePlusi | Q9NY27 |
SwissPalmi | Q9NY27 |
Genetic variation databases
BioMutai | PPP4R2 |
DMDMi | 158564082 |
Proteomic databases
EPDi | Q9NY27 |
jPOSTi | Q9NY27 |
MassIVEi | Q9NY27 |
MaxQBi | Q9NY27 |
PaxDbi | Q9NY27 |
PeptideAtlasi | Q9NY27 |
PRIDEi | Q9NY27 |
ProteomicsDBi | 83154 [Q9NY27-1] 83155 [Q9NY27-2] 83156 [Q9NY27-3] |
Protocols and materials databases
Antibodypediai | 35014, 158 antibodies |
Genome annotation databases
Ensembli | ENST00000356692; ENSP00000349124; ENSG00000163605 [Q9NY27-1] |
GeneIDi | 151987 |
KEGGi | hsa:151987 |
UCSCi | uc003dph.2, human [Q9NY27-1] |
Organism-specific databases
CTDi | 151987 |
DisGeNETi | 151987 |
GeneCardsi | PPP4R2 |
HGNCi | HGNC:18296, PPP4R2 |
HPAi | ENSG00000163605, Low tissue specificity |
MIMi | 613822, gene |
neXtProti | NX_Q9NY27 |
OpenTargetsi | ENSG00000163605 |
PharmGKBi | PA38520 |
VEuPathDBi | HostDB:ENSG00000163605.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3175, Eukaryota |
GeneTreei | ENSGT00940000160975 |
HOGENOMi | CLU_043908_1_1_1 |
InParanoidi | Q9NY27 |
OMAi | SCARQHC |
OrthoDBi | 774806at2759 |
PhylomeDBi | Q9NY27 |
TreeFami | TF105561 |
Enzyme and pathway databases
PathwayCommonsi | Q9NY27 |
Reactomei | R-HSA-5693607, Processing of DNA double-strand break ends |
Miscellaneous databases
BioGRID-ORCSi | 151987, 379 hits in 881 CRISPR screens |
ChiTaRSi | PPP4R2, human |
GenomeRNAii | 151987 |
Pharosi | Q9NY27, Tbio |
PROi | PR:Q9NY27 |
RNActi | Q9NY27, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163605, Expressed in placenta and 218 other tissues |
ExpressionAtlasi | Q9NY27, baseline and differential |
Genevisiblei | Q9NY27, HS |
Family and domain databases
InterProi | View protein in InterPro IPR015267, PPP4R2 |
PANTHERi | PTHR16487, PTHR16487, 1 hit |
Pfami | View protein in Pfam PF09184, PPP4R2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PP4R2_HUMAN | |
Accessioni | Q9NY27Primary (citable) accession number: Q9NY27 Secondary accession number(s): A8K1I6 Q8WXX6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | September 11, 2007 | |
Last modified: | February 10, 2021 | |
This is version 141 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM