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Protein

Zinc transporter ZIP1

Gene

SLC39A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells.1 Publication

Miscellaneous

Inhibited by Ni2+ ions. Fe2+ ions do not inhibit zinc uptake.

GO - Molecular functioni

  • inorganic cation transmembrane transporter activity Source: ProtInc
  • signaling receptor binding Source: Ensembl
  • zinc ion transmembrane transporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

ReactomeiR-HSA-442380 Zinc influx into cells by the SLC39 gene family

Protein family/group databases

TCDBi2.A.5.3.2 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP1
Alternative name(s):
Solute carrier family 39 member 1
Zinc-iron-regulated transporter-like
Zrt- and Irt-like protein 1
Short name:
ZIP-1
Short name:
hZIP1
Gene namesi
Name:SLC39A1
Synonyms:IRT1, ZIP1, ZIRTL
ORF Names:CGI-08, CGI-71
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143570.17
HGNCiHGNC:12876 SLC39A1
MIMi604740 gene
neXtProtiNX_Q9NY26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Topological domaini52 – 68CytoplasmicSequence analysisAdd BLAST17
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 104ExtracellularSequence analysisAdd BLAST15
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 179CytoplasmicSequence analysisAdd BLAST54
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 206ExtracellularSequence analysis6
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 237CytoplasmicSequence analysis10
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 272ExtracellularSequence analysisAdd BLAST14
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Topological domaini294 – 303CytoplasmicSequence analysis10
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27173
OpenTargetsiENSG00000143570
PharmGKBiPA37465

Polymorphism and mutation databases

DMDMi37090460

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000687631 – 324Zinc transporter ZIP1Add BLAST324

Proteomic databases

EPDiQ9NY26
MaxQBiQ9NY26
PaxDbiQ9NY26
PeptideAtlasiQ9NY26
PRIDEiQ9NY26
ProteomicsDBi83153

PTM databases

PhosphoSitePlusiQ9NY26
SwissPalmiQ9NY26

Expressioni

Tissue specificityi

Ubiquitous. Expressed in most adult and fetal tissues including the epidermis.1 Publication

Gene expression databases

BgeeiENSG00000143570 Expressed in 218 organ(s), highest expression level in prostate gland
CleanExiHS_SLC39A1
ExpressionAtlasiQ9NY26 baseline and differential
GenevisibleiQ9NY26 HS

Organism-specific databases

HPAiHPA016506

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118050, 25 interactors
IntActiQ9NY26, 7 interactors
STRINGi9606.ENSP00000309710

Structurei

3D structure databases

ProteinModelPortaliQ9NY26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni190 – 191Heavy metals bindingBy similarity2

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1558 Eukaryota
ENOG4111GP2 LUCA
GeneTreeiENSGT00530000063242
HOGENOMiHOG000236331
HOVERGENiHBG015174
InParanoidiQ9NY26
KOiK14709
OMAiVWRPEAA
OrthoDBiEOG091G0DW2
PhylomeDBiQ9NY26
TreeFamiTF317098

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NY26-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPWGEPELL VWRPEAVASE PPVPVGLEVK LGALVLLLVL TLLCSLVPIC
60 70 80 90 100
VLRRPGANHE GSASRQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL
110 120 130 140 150
AALHVTLQFP LQEFILAMGF FLVLVMEQIT LAYKEQSGPS PLEETRALLG
160 170 180 190 200
TVNGGPQHWH DGPGVPQASG APATPSALRA CVLVFSLALH SVFEGLAVGL
210 220 230 240 250
QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRAQVVA GCGILFSCMT
260 270 280 290 300
PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELASSE
310 320
QRILKVILLL AGFALLTGLL FIQI
Length:324
Mass (Da):34,250
Last modified:October 1, 2000 - v1
Checksum:i884C168AA8E8C0DF
GO
Isoform 2 (identifier: Q9NY26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: MGPWGEPELL...DEALAALHVT → MKAQ

Note: No experimental confirmation available.
Show »
Length:222
Mass (Da):23,589
Checksum:i44531D0D0811E7DE
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T4K2Q5T4K2_HUMAN
Zinc transporter ZIP1
SLC39A1
206Annotation score:
Q5T4K4Q5T4K4_HUMAN
Zinc transporter ZIP1
SLC39A1
240Annotation score:
Q5T4K3Q5T4K3_HUMAN
Zinc transporter ZIP1
SLC39A1
321Annotation score:
A0A0A0MTL8A0A0A0MTL8_HUMAN
Zinc transporter ZIP1
SLC39A1
116Annotation score:

Sequence cautioni

The sequence AAD27717 differs from that shown. Reason: Frameshift at positions 16 and 40.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10 – 18LVWRPEAVA → HGVAPRGGT in AAD34066 (PubMed:10810093).Curated9
Sequence conflicti16A → S in AAH03152 (PubMed:15489334).Curated1
Sequence conflicti47 – 50VPIC → GSIG in CAB59979 (PubMed:10610721).Curated4
Sequence conflicti47 – 50VPIC → GSIG in CAB59980 (PubMed:10610721).Curated4
Sequence conflicti55P → T in CAB59979 (PubMed:10610721).Curated1
Sequence conflicti55P → T in CAB59980 (PubMed:10610721).Curated1
Sequence conflicti120F → V in AAD27717 (PubMed:10810093).Curated1
Sequence conflicti120F → V in AAD34066 (PubMed:10810093).Curated1
Sequence conflicti302R → G in BAC11502 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565221 – 106MGPWG…ALHVT → MKAQ in isoform 2. 1 PublicationAdd BLAST106

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243649 mRNA Translation: CAB59979.1
AJ243650 Genomic DNA Translation: CAB59980.1
AJ271671 mRNA Translation: CAB82784.1
AF132942 mRNA Translation: AAD27717.1 Frameshift.
AF151829 mRNA Translation: AAD34066.1
AK075257 mRNA Translation: BAC11502.1
AK074943 mRNA Translation: BAG52035.1
AK293389 mRNA Translation: BAG56898.1
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53259.1
CH471121 Genomic DNA Translation: EAW53261.1
CH471121 Genomic DNA Translation: EAW53264.1
CH471121 Genomic DNA Translation: EAW53265.1
CH471121 Genomic DNA Translation: EAW53267.1
BC002563 mRNA Translation: AAH02563.1
BC003152 mRNA Translation: AAH03152.1
BC007886 mRNA Translation: AAH07886.1
BC014303 mRNA Translation: AAH14303.1
CCDSiCCDS1055.1 [Q9NY26-1]
RefSeqiNP_001258886.1, NM_001271957.1 [Q9NY26-1]
NP_001258887.1, NM_001271958.1 [Q9NY26-1]
NP_001258888.1, NM_001271959.1 [Q9NY26-1]
NP_001258889.1, NM_001271960.1 [Q9NY26-1]
NP_001258890.1, NM_001271961.1
NP_055252.2, NM_014437.4 [Q9NY26-1]
UniGeneiHs.743291
Hs.7854

Genome annotation databases

EnsembliENST00000310483; ENSP00000309710; ENSG00000143570 [Q9NY26-1]
ENST00000356205; ENSP00000348535; ENSG00000143570 [Q9NY26-1]
ENST00000368621; ENSP00000357610; ENSG00000143570 [Q9NY26-1]
ENST00000368623; ENSP00000357612; ENSG00000143570 [Q9NY26-1]
ENST00000617697; ENSP00000479421; ENSG00000143570 [Q9NY26-1]
ENST00000621013; ENSP00000484182; ENSG00000143570 [Q9NY26-1]
GeneIDi27173
KEGGihsa:27173
UCSCiuc001fdi.5 human [Q9NY26-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243649 mRNA Translation: CAB59979.1
AJ243650 Genomic DNA Translation: CAB59980.1
AJ271671 mRNA Translation: CAB82784.1
AF132942 mRNA Translation: AAD27717.1 Frameshift.
AF151829 mRNA Translation: AAD34066.1
AK075257 mRNA Translation: BAC11502.1
AK074943 mRNA Translation: BAG52035.1
AK293389 mRNA Translation: BAG56898.1
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53259.1
CH471121 Genomic DNA Translation: EAW53261.1
CH471121 Genomic DNA Translation: EAW53264.1
CH471121 Genomic DNA Translation: EAW53265.1
CH471121 Genomic DNA Translation: EAW53267.1
BC002563 mRNA Translation: AAH02563.1
BC003152 mRNA Translation: AAH03152.1
BC007886 mRNA Translation: AAH07886.1
BC014303 mRNA Translation: AAH14303.1
CCDSiCCDS1055.1 [Q9NY26-1]
RefSeqiNP_001258886.1, NM_001271957.1 [Q9NY26-1]
NP_001258887.1, NM_001271958.1 [Q9NY26-1]
NP_001258888.1, NM_001271959.1 [Q9NY26-1]
NP_001258889.1, NM_001271960.1 [Q9NY26-1]
NP_001258890.1, NM_001271961.1
NP_055252.2, NM_014437.4 [Q9NY26-1]
UniGeneiHs.743291
Hs.7854

3D structure databases

ProteinModelPortaliQ9NY26
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118050, 25 interactors
IntActiQ9NY26, 7 interactors
STRINGi9606.ENSP00000309710

Protein family/group databases

TCDBi2.A.5.3.2 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

PTM databases

PhosphoSitePlusiQ9NY26
SwissPalmiQ9NY26

Polymorphism and mutation databases

DMDMi37090460

Proteomic databases

EPDiQ9NY26
MaxQBiQ9NY26
PaxDbiQ9NY26
PeptideAtlasiQ9NY26
PRIDEiQ9NY26
ProteomicsDBi83153

Protocols and materials databases

DNASUi27173
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310483; ENSP00000309710; ENSG00000143570 [Q9NY26-1]
ENST00000356205; ENSP00000348535; ENSG00000143570 [Q9NY26-1]
ENST00000368621; ENSP00000357610; ENSG00000143570 [Q9NY26-1]
ENST00000368623; ENSP00000357612; ENSG00000143570 [Q9NY26-1]
ENST00000617697; ENSP00000479421; ENSG00000143570 [Q9NY26-1]
ENST00000621013; ENSP00000484182; ENSG00000143570 [Q9NY26-1]
GeneIDi27173
KEGGihsa:27173
UCSCiuc001fdi.5 human [Q9NY26-1]

Organism-specific databases

CTDi27173
DisGeNETi27173
EuPathDBiHostDB:ENSG00000143570.17
GeneCardsiSLC39A1
HGNCiHGNC:12876 SLC39A1
HPAiHPA016506
MIMi604740 gene
neXtProtiNX_Q9NY26
OpenTargetsiENSG00000143570
PharmGKBiPA37465
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1558 Eukaryota
ENOG4111GP2 LUCA
GeneTreeiENSGT00530000063242
HOGENOMiHOG000236331
HOVERGENiHBG015174
InParanoidiQ9NY26
KOiK14709
OMAiVWRPEAA
OrthoDBiEOG091G0DW2
PhylomeDBiQ9NY26
TreeFamiTF317098

Enzyme and pathway databases

ReactomeiR-HSA-442380 Zinc influx into cells by the SLC39 gene family

Miscellaneous databases

ChiTaRSiSLC39A1 human
GeneWikiiSLC39A1
GenomeRNAii27173
PROiPR:Q9NY26
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143570 Expressed in 218 organ(s), highest expression level in prostate gland
CleanExiHS_SLC39A1
ExpressionAtlasiQ9NY26 baseline and differential
GenevisibleiQ9NY26 HS

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS39A1_HUMAN
AccessioniPrimary (citable) accession number: Q9NY26
Secondary accession number(s): B4DDY7
, Q5T4K1, Q8N2H7, Q9BTV0, Q9UBI7, Q9Y2Z7, Q9Y380
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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