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Entry version 152 (08 May 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Zinc transporter ZIP1

Gene

SLC39A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells.1 Publication

Miscellaneous

Inhibited by Ni2+ ions. Fe2+ ions do not inhibit zinc uptake.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-442380 Zinc influx into cells by the SLC39 gene family

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.5.3.2 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc transporter ZIP1
Alternative name(s):
Solute carrier family 39 member 1
Zinc-iron-regulated transporter-like
Zrt- and Irt-like protein 1
Short name:
ZIP-1
Short name:
hZIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC39A1
Synonyms:IRT1, ZIP1, ZIRTL
ORF Names:CGI-08, CGI-71
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12876 SLC39A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604740 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NY26

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Topological domaini52 – 68CytoplasmicSequence analysisAdd BLAST17
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 104ExtracellularSequence analysisAdd BLAST15
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 179CytoplasmicSequence analysisAdd BLAST54
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 206ExtracellularSequence analysis6
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 237CytoplasmicSequence analysis10
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 272ExtracellularSequence analysisAdd BLAST14
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Topological domaini294 – 303CytoplasmicSequence analysis10
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
27173

Open Targets

More...
OpenTargetsi
ENSG00000143570

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37465

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC39A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
37090460

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000687631 – 324Zinc transporter ZIP1Add BLAST324

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NY26

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NY26

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NY26

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NY26

PeptideAtlas

More...
PeptideAtlasi
Q9NY26

PRoteomics IDEntifications database

More...
PRIDEi
Q9NY26

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83153

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NY26

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NY26

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expressed in most adult and fetal tissues including the epidermis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143570 Expressed in 218 organ(s), highest expression level in prostate gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NY26 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NY26 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA016506

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118050, 25 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NY26, 9 interactors

Molecular INTeraction database

More...
MINTi
Q9NY26

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357612

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni190 – 191Heavy metals bindingBy similarity2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1558 Eukaryota
ENOG4111GP2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157062

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236331

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NY26

KEGG Orthology (KO)

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KOi
K14709

Identification of Orthologs from Complete Genome Data

More...
OMAi
FGLLAKW

Database of Orthologous Groups

More...
OrthoDBi
981397at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NY26

TreeFam database of animal gene trees

More...
TreeFami
TF317098

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003689 ZIP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02535 Zip, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NY26-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPWGEPELL VWRPEAVASE PPVPVGLEVK LGALVLLLVL TLLCSLVPIC
60 70 80 90 100
VLRRPGANHE GSASRQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL
110 120 130 140 150
AALHVTLQFP LQEFILAMGF FLVLVMEQIT LAYKEQSGPS PLEETRALLG
160 170 180 190 200
TVNGGPQHWH DGPGVPQASG APATPSALRA CVLVFSLALH SVFEGLAVGL
210 220 230 240 250
QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRAQVVA GCGILFSCMT
260 270 280 290 300
PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELASSE
310 320
QRILKVILLL AGFALLTGLL FIQI
Length:324
Mass (Da):34,250
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i884C168AA8E8C0DF
GO
Isoform 2 (identifier: Q9NY26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: MGPWGEPELL...DEALAALHVT → MKAQ

Note: No experimental confirmation available.
Show »
Length:222
Mass (Da):23,589
Checksum:i44531D0D0811E7DE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T4K2Q5T4K2_HUMAN
Zinc transporter ZIP1
SLC39A1
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T4K4Q5T4K4_HUMAN
Zinc transporter ZIP1
SLC39A1
240Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T4K3Q5T4K3_HUMAN
Zinc transporter ZIP1
SLC39A1
321Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTL8A0A0A0MTL8_HUMAN
Zinc transporter ZIP1
SLC39A1
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD27717 differs from that shown. Reason: Frameshift at positions 16 and 40.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10 – 18LVWRPEAVA → HGVAPRGGT in AAD34066 (PubMed:10810093).Curated9
Sequence conflicti16A → S in AAH03152 (PubMed:15489334).Curated1
Sequence conflicti47 – 50VPIC → GSIG in CAB59979 (PubMed:10610721).Curated4
Sequence conflicti47 – 50VPIC → GSIG in CAB59980 (PubMed:10610721).Curated4
Sequence conflicti55P → T in CAB59979 (PubMed:10610721).Curated1
Sequence conflicti55P → T in CAB59980 (PubMed:10610721).Curated1
Sequence conflicti120F → V in AAD27717 (PubMed:10810093).Curated1
Sequence conflicti120F → V in AAD34066 (PubMed:10810093).Curated1
Sequence conflicti302R → G in BAC11502 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0565221 – 106MGPWG…ALHVT → MKAQ in isoform 2. 1 PublicationAdd BLAST106

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ243649 mRNA Translation: CAB59979.1
AJ243650 Genomic DNA Translation: CAB59980.1
AJ271671 mRNA Translation: CAB82784.1
AF132942 mRNA Translation: AAD27717.1 Frameshift.
AF151829 mRNA Translation: AAD34066.1
AK075257 mRNA Translation: BAC11502.1
AK074943 mRNA Translation: BAG52035.1
AK293389 mRNA Translation: BAG56898.1
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53259.1
CH471121 Genomic DNA Translation: EAW53261.1
CH471121 Genomic DNA Translation: EAW53264.1
CH471121 Genomic DNA Translation: EAW53265.1
CH471121 Genomic DNA Translation: EAW53267.1
BC002563 mRNA Translation: AAH02563.1
BC003152 mRNA Translation: AAH03152.1
BC007886 mRNA Translation: AAH07886.1
BC014303 mRNA Translation: AAH14303.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1055.1 [Q9NY26-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001258886.1, NM_001271957.1 [Q9NY26-1]
NP_001258887.1, NM_001271958.1 [Q9NY26-1]
NP_001258888.1, NM_001271959.1 [Q9NY26-1]
NP_001258889.1, NM_001271960.1 [Q9NY26-1]
NP_001258890.1, NM_001271961.1
NP_055252.2, NM_014437.4 [Q9NY26-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000310483; ENSP00000309710; ENSG00000143570 [Q9NY26-1]
ENST00000356205; ENSP00000348535; ENSG00000143570 [Q9NY26-1]
ENST00000368621; ENSP00000357610; ENSG00000143570 [Q9NY26-1]
ENST00000368623; ENSP00000357612; ENSG00000143570 [Q9NY26-1]
ENST00000617697; ENSP00000479421; ENSG00000143570 [Q9NY26-1]
ENST00000621013; ENSP00000484182; ENSG00000143570 [Q9NY26-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27173

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27173

UCSC genome browser

More...
UCSCi
uc001fdi.5 human [Q9NY26-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243649 mRNA Translation: CAB59979.1
AJ243650 Genomic DNA Translation: CAB59980.1
AJ271671 mRNA Translation: CAB82784.1
AF132942 mRNA Translation: AAD27717.1 Frameshift.
AF151829 mRNA Translation: AAD34066.1
AK075257 mRNA Translation: BAC11502.1
AK074943 mRNA Translation: BAG52035.1
AK293389 mRNA Translation: BAG56898.1
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53259.1
CH471121 Genomic DNA Translation: EAW53261.1
CH471121 Genomic DNA Translation: EAW53264.1
CH471121 Genomic DNA Translation: EAW53265.1
CH471121 Genomic DNA Translation: EAW53267.1
BC002563 mRNA Translation: AAH02563.1
BC003152 mRNA Translation: AAH03152.1
BC007886 mRNA Translation: AAH07886.1
BC014303 mRNA Translation: AAH14303.1
CCDSiCCDS1055.1 [Q9NY26-1]
RefSeqiNP_001258886.1, NM_001271957.1 [Q9NY26-1]
NP_001258887.1, NM_001271958.1 [Q9NY26-1]
NP_001258888.1, NM_001271959.1 [Q9NY26-1]
NP_001258889.1, NM_001271960.1 [Q9NY26-1]
NP_001258890.1, NM_001271961.1
NP_055252.2, NM_014437.4 [Q9NY26-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi118050, 25 interactors
IntActiQ9NY26, 9 interactors
MINTiQ9NY26
STRINGi9606.ENSP00000357612

Protein family/group databases

TCDBi2.A.5.3.2 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

PTM databases

PhosphoSitePlusiQ9NY26
SwissPalmiQ9NY26

Polymorphism and mutation databases

BioMutaiSLC39A1
DMDMi37090460

Proteomic databases

EPDiQ9NY26
jPOSTiQ9NY26
MaxQBiQ9NY26
PaxDbiQ9NY26
PeptideAtlasiQ9NY26
PRIDEiQ9NY26
ProteomicsDBi83153

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
27173
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310483; ENSP00000309710; ENSG00000143570 [Q9NY26-1]
ENST00000356205; ENSP00000348535; ENSG00000143570 [Q9NY26-1]
ENST00000368621; ENSP00000357610; ENSG00000143570 [Q9NY26-1]
ENST00000368623; ENSP00000357612; ENSG00000143570 [Q9NY26-1]
ENST00000617697; ENSP00000479421; ENSG00000143570 [Q9NY26-1]
ENST00000621013; ENSP00000484182; ENSG00000143570 [Q9NY26-1]
GeneIDi27173
KEGGihsa:27173
UCSCiuc001fdi.5 human [Q9NY26-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
27173
DisGeNETi27173

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC39A1
HGNCiHGNC:12876 SLC39A1
HPAiHPA016506
MIMi604740 gene
neXtProtiNX_Q9NY26
OpenTargetsiENSG00000143570
PharmGKBiPA37465

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1558 Eukaryota
ENOG4111GP2 LUCA
GeneTreeiENSGT00940000157062
HOGENOMiHOG000236331
InParanoidiQ9NY26
KOiK14709
OMAiFGLLAKW
OrthoDBi981397at2759
PhylomeDBiQ9NY26
TreeFamiTF317098

Enzyme and pathway databases

ReactomeiR-HSA-442380 Zinc influx into cells by the SLC39 gene family

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC39A1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC39A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
27173

Protein Ontology

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PROi
PR:Q9NY26

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143570 Expressed in 218 organ(s), highest expression level in prostate gland
ExpressionAtlasiQ9NY26 baseline and differential
GenevisibleiQ9NY26 HS

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS39A1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NY26
Secondary accession number(s): B4DDY7
, Q5T4K1, Q8N2H7, Q9BTV0, Q9UBI7, Q9Y2Z7, Q9Y380
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2000
Last modified: May 8, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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