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Entry version 128 (08 May 2019)
Sequence version 2 (05 Jul 2005)
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Protein

Non-structural maintenance of chromosomes element 4 homolog A

Gene

NSMCE4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • DNA recombination Source: UniProtKB-KW
  • DNA repair Source: GO_Central
  • positive regulation of response to DNA damage stimulus Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA recombination, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-structural maintenance of chromosomes element 4 homolog A
Short name:
NS4EA
Short name:
Non-SMC element 4 homolog A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NSMCE4A
Synonyms:C10orf86
ORF Names:PP4762
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25935 NSMCE4A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612987 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NXX6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000107672

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162398205

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NSMCE4A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68565328

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002141011 – 385Non-structural maintenance of chromosomes element 4 homolog AAdd BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei345PhosphothreonineCombined sources1
Modified residuei377PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NXX6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NXX6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NXX6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NXX6

PeptideAtlas

More...
PeptideAtlasi
Q9NXX6

PRoteomics IDEntifications database

More...
PRIDEi
Q9NXX6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83143
83144 [Q9NXX6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NXX6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NXX6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000107672 Expressed in 224 organ(s), highest expression level in oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NXX6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037459
HPA038412
HPA044872

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer (PubMed:18086888). Interacts with NSMCE3 (PubMed:27427983).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NSMCE3Q96MG72EBI-2557393,EBI-2557356

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120147, 38 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NXX6

Protein interaction database and analysis system

More...
IntActi
Q9NXX6, 14 interactors

Molecular INTeraction database

More...
MINTi
Q9NXX6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358019

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NSE4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2866 Eukaryota
COG5125 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011476

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000088652

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NXX6

KEGG Orthology (KO)

More...
KOi
K22825

Identification of Orthologs from Complete Genome Data

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OMAi
ESEGIDQ

Database of Orthologous Groups

More...
OrthoDBi
935469at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NXX6

TreeFam database of animal gene trees

More...
TreeFami
TF313999

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027786 Nse4/EID
IPR014854 Nse4_C
IPR029225 Nse4_Nse3-bd

The PANTHER Classification System

More...
PANTHERi
PTHR16140 PTHR16140, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15412 Nse4-Nse3_bdg, 1 hit
PF08743 Nse4_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NXX6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGDSSGRGP EGRGRGRDPH RDRTRSRSRS RSPLSPRSRR GSARERREAP
60 70 80 90 100
ERPSLEDTEP SDSGDEMMDP ASLEAEADQG LCRQIRHQYR ALINSVQQNR
110 120 130 140 150
EDILNAGDKL TEVLEEANTL FNEVSRAREA VLDAHFLVLA SDLGKEKAKQ
160 170 180 190 200
LRSDLSSFDM LRYVETLLTH MGVNPLEAEE LIRDEDSPDF EFIVYDSWKI
210 220 230 240 250
TGRTAENTFN KTHTFHFLLG SIYGECPVPK PRVDRPRKVP VIQEERAMPA
260 270 280 290 300
QLRRMEESHQ EATEKEVERI LGLLQTYFRE DPDTPMSFFD FVVDPHSFPR
310 320 330 340 350
TVENIFHVSF IIRDGFARIR LDQDRLPVIE PVSINEENEG FEHNTQVRNQ
360 370 380
GIIALSYRDW EEIVKTFEIS EPVITPSQRQ QKPSA
Length:385
Mass (Da):44,301
Last modified:July 5, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8BB8C54C8A6D0A1E
GO
Isoform 2 (identifier: Q9NXX6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     282-316: PDTPMSFFDFVVDPHSFPRTVENIFHVSFIIRDGF → RDSLTLSPRLECSGTISTHCNLHLLDSSNSPASAS
     317-385: Missing.

Note: No experimental confirmation available.
Show »
Length:316
Mass (Da):35,859
Checksum:i7045FBC70BA77996
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti145K → I in BAA90881 (PubMed:14702039).Curated1
Sequence conflicti361Missing in AAH62427 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05765772S → T. Corresponds to variant dbSNP:rs1065683Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014601282 – 316PDTPM…IRDGF → RDSLTLSPRLECSGTISTHC NLHLLDSSNSPASAS in isoform 2. 2 PublicationsAdd BLAST35
Alternative sequenceiVSP_014602317 – 385Missing in isoform 2. 2 PublicationsAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000010 mRNA Translation: BAA90881.1
AK222487 mRNA Translation: BAD96207.1
AL731566 Genomic DNA No translation available.
BC005212 mRNA Translation: AAH05212.1
BC062427 mRNA Translation: AAH62427.1
AF258584 mRNA Translation: AAG23787.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7624.1 [Q9NXX6-1]

NCBI Reference Sequences

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RefSeqi
NP_001161337.1, NM_001167865.1
NP_060085.2, NM_017615.2 [Q9NXX6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369017; ENSP00000358013; ENSG00000107672 [Q9NXX6-2]
ENST00000369023; ENSP00000358019; ENSG00000107672 [Q9NXX6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54780

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54780

UCSC genome browser

More...
UCSCi
uc001lfs.4 human [Q9NXX6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000010 mRNA Translation: BAA90881.1
AK222487 mRNA Translation: BAD96207.1
AL731566 Genomic DNA No translation available.
BC005212 mRNA Translation: AAH05212.1
BC062427 mRNA Translation: AAH62427.1
AF258584 mRNA Translation: AAG23787.1
CCDSiCCDS7624.1 [Q9NXX6-1]
RefSeqiNP_001161337.1, NM_001167865.1
NP_060085.2, NM_017615.2 [Q9NXX6-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120147, 38 interactors
CORUMiQ9NXX6
IntActiQ9NXX6, 14 interactors
MINTiQ9NXX6
STRINGi9606.ENSP00000358019

PTM databases

iPTMnetiQ9NXX6
PhosphoSitePlusiQ9NXX6

Polymorphism and mutation databases

BioMutaiNSMCE4A
DMDMi68565328

Proteomic databases

EPDiQ9NXX6
jPOSTiQ9NXX6
MaxQBiQ9NXX6
PaxDbiQ9NXX6
PeptideAtlasiQ9NXX6
PRIDEiQ9NXX6
ProteomicsDBi83143
83144 [Q9NXX6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369017; ENSP00000358013; ENSG00000107672 [Q9NXX6-2]
ENST00000369023; ENSP00000358019; ENSG00000107672 [Q9NXX6-1]
GeneIDi54780
KEGGihsa:54780
UCSCiuc001lfs.4 human [Q9NXX6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54780

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NSMCE4A
HGNCiHGNC:25935 NSMCE4A
HPAiHPA037459
HPA038412
HPA044872
MIMi612987 gene
neXtProtiNX_Q9NXX6
OpenTargetsiENSG00000107672
PharmGKBiPA162398205

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2866 Eukaryota
COG5125 LUCA
GeneTreeiENSGT00390000011476
HOGENOMiHOG000088652
InParanoidiQ9NXX6
KOiK22825
OMAiESEGIDQ
OrthoDBi935469at2759
PhylomeDBiQ9NXX6
TreeFamiTF313999

Enzyme and pathway databases

ReactomeiR-HSA-3108214 SUMOylation of DNA damage response and repair proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NSMCE4A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NSMCE4A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54780

Protein Ontology

More...
PROi
PR:Q9NXX6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000107672 Expressed in 224 organ(s), highest expression level in oocyte
GenevisibleiQ9NXX6 HS

Family and domain databases

InterProiView protein in InterPro
IPR027786 Nse4/EID
IPR014854 Nse4_C
IPR029225 Nse4_Nse3-bd
PANTHERiPTHR16140 PTHR16140, 1 hit
PfamiView protein in Pfam
PF15412 Nse4-Nse3_bdg, 1 hit
PF08743 Nse4_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNSE4A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NXX6
Secondary accession number(s): Q5SQQ5
, Q6P673, Q8WY66, Q9BS90
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: May 8, 2019
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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