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Protein

ADP-ribosylation factor-like protein 15

Gene

ARL15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 46GTPBy similarity8
Nucleotide bindingi82 – 86GTPBy similarity5
Nucleotide bindingi142 – 145GTPBy similarity4

GO - Molecular functioni

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 15
Alternative name(s):
ADP-ribosylation factor-related protein 2
Short name:
ARF-related protein 2
Gene namesi
Name:ARL15
Synonyms:ARFRP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000185305.10
HGNCiHGNC:25945 ARL15
neXtProtiNX_Q9NXU5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi54622
OpenTargetsiENSG00000185305
PharmGKBiPA134960964

Polymorphism and mutation databases

BioMutaiARL15
DMDMi74734700

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002823871 – 204ADP-ribosylation factor-like protein 15Add BLAST204

Proteomic databases

EPDiQ9NXU5
MaxQBiQ9NXU5
PaxDbiQ9NXU5
PeptideAtlasiQ9NXU5
PRIDEiQ9NXU5
ProteomicsDBi83136

PTM databases

iPTMnetiQ9NXU5
PhosphoSitePlusiQ9NXU5
SwissPalmiQ9NXU5

Expressioni

Gene expression databases

BgeeiENSG00000185305 Expressed in 205 organ(s), highest expression level in endothelial cell
CleanExiHS_ARL15
ExpressionAtlasiQ9NXU5 baseline and differential
GenevisibleiQ9NXU5 HS

Organism-specific databases

HPAiHPA044604
HPA063820

Interactioni

Protein-protein interaction databases

BioGridi120080, 36 interactors
IntActiQ9NXU5, 16 interactors
STRINGi9606.ENSP00000433427

Structurei

3D structure databases

ProteinModelPortaliQ9NXU5
SMRiQ9NXU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0071 Eukaryota
ENOG410XP1U LUCA
GeneTreeiENSGT00780000121855
HOVERGENiHBG106645
InParanoidiQ9NXU5
KOiK17201
OMAiLASHQDK
PhylomeDBiQ9NXU5
TreeFamiTF329693

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9NXU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDLRITEAF LYMDYLCFRA LCCKGPPPAR PEYDLVCIGL TGSGKTSLLS
60 70 80 90 100
KLCSESPDNV VSTTGFSIKA VPFQNAILNV KELGGADNIR KYWSRYYQGS
110 120 130 140 150
QGVIFVLDSA SSEDDLEAAR NELHSALQHP QLCTLPFLIL ANHQDKPAAR
160 170 180 190 200
SVQEIKKYFE LEPLARGKRW ILQPCSLDDM DALKDSFSQL INLLEEKDHE

AVRM
Length:204
Mass (Da):22,876
Last modified:October 1, 2000 - v1
Checksum:i22CE5654057B734C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUW9A0A087WUW9_HUMAN
ADP-ribosylation factor-like protei...
ARL15
204Annotation score:
A0A0B4J222A0A0B4J222_HUMAN
ADP-ribosylation factor-like protei...
ARL15
158Annotation score:
R4GN67R4GN67_HUMAN
ADP-ribosylation factor-like protei...
ARL15
25Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204M → I in CAG33506 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000058 mRNA Translation: BAA90915.1
CR457225 mRNA Translation: CAG33506.1
BC026093 mRNA Translation: AAH26093.1
CCDSiCCDS54850.1
RefSeqiNP_061960.1, NM_019087.2
UniGeneiHs.659125

Genome annotation databases

EnsembliENST00000504924; ENSP00000433427; ENSG00000185305
GeneIDi54622
KEGGihsa:54622
UCSCiuc003jpg.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000058 mRNA Translation: BAA90915.1
CR457225 mRNA Translation: CAG33506.1
BC026093 mRNA Translation: AAH26093.1
CCDSiCCDS54850.1
RefSeqiNP_061960.1, NM_019087.2
UniGeneiHs.659125

3D structure databases

ProteinModelPortaliQ9NXU5
SMRiQ9NXU5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120080, 36 interactors
IntActiQ9NXU5, 16 interactors
STRINGi9606.ENSP00000433427

PTM databases

iPTMnetiQ9NXU5
PhosphoSitePlusiQ9NXU5
SwissPalmiQ9NXU5

Polymorphism and mutation databases

BioMutaiARL15
DMDMi74734700

Proteomic databases

EPDiQ9NXU5
MaxQBiQ9NXU5
PaxDbiQ9NXU5
PeptideAtlasiQ9NXU5
PRIDEiQ9NXU5
ProteomicsDBi83136

Protocols and materials databases

DNASUi54622
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000504924; ENSP00000433427; ENSG00000185305
GeneIDi54622
KEGGihsa:54622
UCSCiuc003jpg.1 human

Organism-specific databases

CTDi54622
DisGeNETi54622
EuPathDBiHostDB:ENSG00000185305.10
GeneCardsiARL15
HGNCiHGNC:25945 ARL15
HPAiHPA044604
HPA063820
neXtProtiNX_Q9NXU5
OpenTargetsiENSG00000185305
PharmGKBiPA134960964
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0071 Eukaryota
ENOG410XP1U LUCA
GeneTreeiENSGT00780000121855
HOVERGENiHBG106645
InParanoidiQ9NXU5
KOiK17201
OMAiLASHQDK
PhylomeDBiQ9NXU5
TreeFamiTF329693

Miscellaneous databases

ChiTaRSiARL15 human
GenomeRNAii54622
PROiPR:Q9NXU5

Gene expression databases

BgeeiENSG00000185305 Expressed in 205 organ(s), highest expression level in endothelial cell
CleanExiHS_ARL15
ExpressionAtlasiQ9NXU5 baseline and differential
GenevisibleiQ9NXU5 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARL15_HUMAN
AccessioniPrimary (citable) accession number: Q9NXU5
Secondary accession number(s): Q6IAD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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