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Entry version 145 (12 Aug 2020)
Sequence version 2 (25 Nov 2008)
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Protein

Zinc finger protein 586

Gene

ZNF586

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri88 – 116C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST29
Zinc fingeri122 – 144C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri206 – 228C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NXT0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 586
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF586
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000083828.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25949, ZNF586

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NXT0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000083828

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134946358

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NXT0, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF586

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215273915

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002414491 – 402Zinc finger protein 586Add BLAST402

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NXT0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NXT0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NXT0

PeptideAtlas

More...
PeptideAtlasi
Q9NXT0

PRoteomics IDEntifications database

More...
PRIDEi
Q9NXT0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
33749
83134 [Q9NXT0-1]
83135 [Q9NXT0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NXT0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NXT0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000083828, Expressed in kidney and 182 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NXT0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NXT0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000083828, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
120164, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NXT0, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379458

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NXT0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NXT0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 87KRABPROSITE-ProRule annotationAdd BLAST73

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri88 – 116C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST29
Zinc fingeri122 – 144C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri206 – 228C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164743

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NXT0

Identification of Orthologs from Complete Genome Data

More...
OMAi
HICTRER

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NXT0

TreeFam database of animal gene trees

More...
TreeFami
TF339848

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NXT0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAALRAP AQSSVTFEDV AVNFSLEEWS LLNEAQRCLY RDVMLETLTL
60 70 80 90 100
ISSLGCWHGG EDEAAPSKQS TCIHIYKDQG GHSGERPYEC GEYRKLFKNK
110 120 130 140 150
SCLTEPRRDH KHRNVRTGER PYECSKYGKL FHQKPTLHIH ERFHTGQKTY
160 170 180 190 200
ECSECGKSFH QSSSLLQRQT LHTRERPYEC IECGKAFAEK SSLINHRKVH
210 220 230 240 250
SGAKRYECNE CGKSFAYTSS LIKHRRIHTG ERPYECSECG RSFAENSSLI
260 270 280 290 300
KHLRVHTGER PYECVECGKS FRRSSSLLQH QRVHTRERPY ECSECGKSFS
310 320 330 340 350
LRSNLIHHQR VHTGERHECG QCGKSFSRKS SLIIHLRVHT GERPYECSDC
360 370 380 390 400
GKSFAENSSL IKHLRVHTGE RPYECIDCGK SFRHSSSFRR HQRVHTGMRP

YK
Length:402
Mass (Da):46,413
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC2A189A0A0E696E
GO
Isoform 2 (identifier: Q9NXT0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-210: SSVTFEDVAV...SGAKRYECNE → VVGMEGKMRQ...LLKTPVLLNT
     211-402: Missing.

Show »
Length:210
Mass (Da):22,779
Checksum:iE8140FCD813EE424
GO
Isoform 3 (identifier: Q9NXT0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Show »
Length:359
Mass (Da):41,687
Checksum:i6E79F94314EDB574
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZ99M0QZ99_HUMAN
Zinc finger protein 586
ZNF586
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R166M0R166_HUMAN
Zinc finger protein 586
ZNF586
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BZW3A0A494BZW3_HUMAN
Zinc finger protein 586
ZNF586
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R336M0R336_HUMAN
Zinc finger protein 586
ZNF586
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA90930 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti306I → T in BAG63522 (PubMed:14702039).Curated1
Sequence conflicti370E → G in BAA90930 (PubMed:14702039).Curated1
Sequence conflicti393R → G in BAA90930 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0448081 – 43Missing in isoform 3. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_04342013 – 210SSVTF…YECNE → VVGMEGKMRQHLLSRARVYI YTKTREVIVEKGLMSVGNIG NYLRTSPASLNPEEITNTGM FALEKGLMSAANMGNYFTKS LHSIFMRDFILGKRPMSAVS VENHFTKALHSCSVRHFTLE KGLMSVLNVGKPLLKSPVSL TTGKFTLEQSVMNAMNVGSP LLIHLVSLNTGGFTLERGLM SAVNVGDPLLKTPVLLNT in isoform 2. 1 PublicationAdd BLAST198
Alternative sequenceiVSP_043421211 – 402Missing in isoform 2. 1 PublicationAdd BLAST192

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000077 mRNA Translation: BAA90930.1 Frameshift.
AK095993 mRNA Translation: BAG53191.1
AK302151 mRNA Translation: BAG63522.1
AC003006 Genomic DNA No translation available.
AC010645 Genomic DNA No translation available.
AC093037 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72533.1
CH471135 Genomic DNA Translation: EAW72534.1
BC124558 mRNA Translation: AAI24559.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42640.1 [Q9NXT0-1]
CCDS56107.1 [Q9NXT0-2]
CCDS56108.1 [Q9NXT0-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001070894.1, NM_001077426.2 [Q9NXT0-2]
NP_001191743.1, NM_001204814.1 [Q9NXT0-3]
NP_060122.2, NM_017652.3 [Q9NXT0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000391702; ENSP00000375583; ENSG00000083828 [Q9NXT0-3]
ENST00000396150; ENSP00000379454; ENSG00000083828 [Q9NXT0-2]
ENST00000396154; ENSP00000379458; ENSG00000083828 [Q9NXT0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54807

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54807

UCSC genome browser

More...
UCSCi
uc002qqd.4, human [Q9NXT0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000077 mRNA Translation: BAA90930.1 Frameshift.
AK095993 mRNA Translation: BAG53191.1
AK302151 mRNA Translation: BAG63522.1
AC003006 Genomic DNA No translation available.
AC010645 Genomic DNA No translation available.
AC093037 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72533.1
CH471135 Genomic DNA Translation: EAW72534.1
BC124558 mRNA Translation: AAI24559.2
CCDSiCCDS42640.1 [Q9NXT0-1]
CCDS56107.1 [Q9NXT0-2]
CCDS56108.1 [Q9NXT0-3]
RefSeqiNP_001070894.1, NM_001077426.2 [Q9NXT0-2]
NP_001191743.1, NM_001204814.1 [Q9NXT0-3]
NP_060122.2, NM_017652.3 [Q9NXT0-1]

3D structure databases

SMRiQ9NXT0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120164, 3 interactors
IntActiQ9NXT0, 4 interactors
STRINGi9606.ENSP00000379458

PTM databases

iPTMnetiQ9NXT0
PhosphoSitePlusiQ9NXT0

Polymorphism and mutation databases

BioMutaiZNF586
DMDMi215273915

Proteomic databases

MassIVEiQ9NXT0
MaxQBiQ9NXT0
PaxDbiQ9NXT0
PeptideAtlasiQ9NXT0
PRIDEiQ9NXT0
ProteomicsDBi33749
83134 [Q9NXT0-1]
83135 [Q9NXT0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
52690, 55 antibodies

Genome annotation databases

EnsembliENST00000391702; ENSP00000375583; ENSG00000083828 [Q9NXT0-3]
ENST00000396150; ENSP00000379454; ENSG00000083828 [Q9NXT0-2]
ENST00000396154; ENSP00000379458; ENSG00000083828 [Q9NXT0-1]
GeneIDi54807
KEGGihsa:54807
UCSCiuc002qqd.4, human [Q9NXT0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54807
EuPathDBiHostDB:ENSG00000083828.15

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF586
HGNCiHGNC:25949, ZNF586
HPAiENSG00000083828, Low tissue specificity
neXtProtiNX_Q9NXT0
OpenTargetsiENSG00000083828
PharmGKBiPA134946358

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000164743
HOGENOMiCLU_002678_2_1_1
InParanoidiQ9NXT0
OMAiHICTRER
OrthoDBi1318335at2759
PhylomeDBiQ9NXT0
TreeFamiTF339848

Enzyme and pathway databases

PathwayCommonsiQ9NXT0
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
54807, 6 hits in 894 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF586, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54807
PharosiQ9NXT0, Tdark

Protein Ontology

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PROi
PR:Q9NXT0
RNActiQ9NXT0, protein

Gene expression databases

BgeeiENSG00000083828, Expressed in kidney and 182 other tissues
ExpressionAtlasiQ9NXT0, baseline and differential
GenevisibleiQ9NXT0, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 10 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN586_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NXT0
Secondary accession number(s): A0JLV8
, A8MY63, B3KTS9, E7ERT1, G3XAH3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 25, 2008
Last modified: August 12, 2020
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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