Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9NXS2 (QPCTL_HUMAN)

Entry version 148 (07 Apr 2021)
Sequence version 2 (18 May 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Glutaminyl-peptide cyclotransferase-like protein

Gene

QPCTL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the biosynthesis of pyroglutamyl peptides.2 Publications

Caution

It is unclear whether this protein requires a metal cofactor for catalysis. It was originally proposed to be a Zn2+-dependent metalloenzyme based on structural similarities to bacterial aminopeptidases and the observation that it can bind Zn2+ ions, typically in a 1:1 stoichiometry (PubMed:21288892). However, a recent study suggests a Zn2+-independent catalytic mechanism (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi186ZincBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei225Proton acceptorBy similarity1
Metal bindingi226ZincBy similarity1
Active sitei269Proton acceptorBy similarity1
Metal bindingi351ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.2.5, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NXS2

Protein family/group databases

MEROPS protease database

More...MEROPSi		M28.016

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutaminyl-peptide cyclotransferase-like protein (EC:2.3.2.5)
Alternative name(s):
Golgi-resident glutaminyl-peptide cyclotransferase
isoQC
Short name:
gQC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:QPCTL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25952, QPCTL

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NXS2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000011478.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 55HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		54814

Open Targets

More...OpenTargetsi		ENSG00000011478

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134922163

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NXS2, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3638349

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		QPCTL

Domain mapping of disease mutations (DMDM)

More...DMDMi		296452875

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003020021 – 382Glutaminyl-peptide cyclotransferase-like proteinAdd BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi167 ↔ 191By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NXS2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NXS2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NXS2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NXS2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NXS2

PeptideAtlas

More...PeptideAtlasi		Q9NXS2

PRoteomics IDEntifications database

More...PRIDEi		Q9NXS2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83131 [Q9NXS2-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NXS2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NXS2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000011478, Expressed in left coronary artery and 121 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NXS2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NXS2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000011478, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120171, 60 interactors

Protein interaction database and analysis system

More...IntActi		Q9NXS2, 35 interactors

Molecular INTeraction database

More...MINTi		Q9NXS2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000012049

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9NXS2

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NXS2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1382
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NXS2

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9NXS2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glutaminyl-peptide cyclotransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3946, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003107

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_045003_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NXS2

Identification of Orthologs from Complete Genome Data

More...OMAi		DTEENMH

Database of Orthologous Groups

More...OrthoDBi		1257754at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NXS2

TreeFam database of animal gene trees

More...TreeFami		TF315071

Family and domain databases

Conserved Domains Database

More...CDDi		cd03880, M28_QC_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037457, M28_QC
IPR007484, Peptidase_M28
IPR040234, QC/QCL

The PANTHER Classification System

More...PANTHERi		PTHR12283, PTHR12283, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04389, Peptidase_M28, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NXS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSGGRGRPR LRLGERGLME PLLPPKRRLL PRVRLLPLLL ALAVGSAFYT 
        60         70         80         90        100
IWSGWHRRTE ELPLGRELRV PLIGSLPEAR LRRVVGQLDP QRLWSTYLRP 
       110        120        130        140        150
LLVVRTPGSP GNLQVRKFLE ATLRSLTAGW HVELDPFTAS TPLGPVDFGN 
       160        170        180        190        200
VVATLDPRAA RHLTLACHYD SKLFPPGSTP FVGATDSAVP CALLLELAQA 
       210        220        230        240        250
LDLELSRAKK QAAPVTLQLL FLDGEEALKE WGPKDSLYGS RHLAQLMESI 
       260        270        280        290        300
PHSPGPTRIQ AIELFMLLDL LGAPNPTFYS HFPRTVRWFH RLRSIEKRLH 
       310        320        330        340        350
RLNLLQSHPQ EVMYFQPGEP FGSVEDDHIP FLRRGVPVLH LISTPFPAVW 
       360        370        380 
HTPADTEVNL HPPTVHNLCR ILAVFLAEYL GL
Length:382
Mass (Da):42,924
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2DCA79BED029DD4B
GO
Isoform 2 (identifier: Q9NXS2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-211: Missing.

Show »
Length:288
Mass (Da):32,912
Checksum:i9F23194B62336AD3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQG1K7EQG1_HUMAN
Glutaminyl-peptide cyclotransferase
QPCTL
121Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V353A0A7I2V353_HUMAN
Glutaminyl-peptide cyclotransferase...
QPCTL
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V5X1A0A7I2V5X1_HUMAN
Glutaminyl-peptide cyclotransferase...
QPCTL
268Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti295I → T in BAD96356 (Ref. 2) Curated1
Sequence conflicti321F → S in BAA90938 (PubMed:14702039).Curated1
Sequence conflicti321F → S in BAD18747 (PubMed:14702039).Curated1
Sequence conflicti334R → G in BAD96356 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034937214P → L. Corresponds to variant dbSNP:rs28708996Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054066118 – 211Missing in isoform 2. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK000091 mRNA Translation: BAA90938.1
AK172764 mRNA Translation: BAD18747.1
AK222636 mRNA Translation: BAD96356.1
AC007191 Genomic DNA No translation available.
BC011553 mRNA Translation: AAH11553.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12672.1 [Q9NXS2-1]
CCDS54282.1 [Q9NXS2-3]

NCBI Reference Sequences

More...RefSeqi		NP_001156849.1, NM_001163377.1 [Q9NXS2-3]
NP_060129.2, NM_017659.3 [Q9NXS2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000012049; ENSP00000012049; ENSG00000011478 [Q9NXS2-1]
ENST00000366382; ENSP00000387944; ENSG00000011478 [Q9NXS2-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54814

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54814

UCSC genome browser

More...UCSCi		uc010ekn.4, human [Q9NXS2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000091 mRNA Translation: BAA90938.1
AK172764 mRNA Translation: BAD18747.1
AK222636 mRNA Translation: BAD96356.1
AC007191 Genomic DNA No translation available.
BC011553 mRNA Translation: AAH11553.1
CCDSiCCDS12672.1 [Q9NXS2-1]
CCDS54282.1 [Q9NXS2-3]
RefSeqiNP_001156849.1, NM_001163377.1 [Q9NXS2-3]
NP_060129.2, NM_017659.3 [Q9NXS2-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PB4X-ray1.13X53-382[»]
3PB6X-ray1.05X53-382[»]
3PB7X-ray1.40X53-382[»]
3PB8X-ray1.13X53-382[»]
3PB9X-ray1.12X53-382[»]
SMRiQ9NXS2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120171, 60 interactors
IntActiQ9NXS2, 35 interactors
MINTiQ9NXS2
STRINGi9606.ENSP00000012049

Chemistry databases

BindingDBiQ9NXS2
ChEMBLiCHEMBL3638349

Protein family/group databases

MEROPSiM28.016

PTM databases

iPTMnetiQ9NXS2
PhosphoSitePlusiQ9NXS2

Genetic variation databases

BioMutaiQPCTL
DMDMi296452875

Proteomic databases

EPDiQ9NXS2
jPOSTiQ9NXS2
MassIVEiQ9NXS2
MaxQBiQ9NXS2
PaxDbiQ9NXS2
PeptideAtlasiQ9NXS2
PRIDEiQ9NXS2
ProteomicsDBi83131 [Q9NXS2-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31379, 113 antibodies

Genome annotation databases

EnsembliENST00000012049; ENSP00000012049; ENSG00000011478 [Q9NXS2-1]
ENST00000366382; ENSP00000387944; ENSG00000011478 [Q9NXS2-3]
GeneIDi54814
KEGGihsa:54814
UCSCiuc010ekn.4, human [Q9NXS2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54814
DisGeNETi54814

GeneCards: human genes, protein and diseases

More...GeneCardsi		QPCTL
HGNCiHGNC:25952, QPCTL
HPAiENSG00000011478, Low tissue specificity
neXtProtiNX_Q9NXS2
OpenTargetsiENSG00000011478
PharmGKBiPA134922163
VEuPathDBiHostDB:ENSG00000011478.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3946, Eukaryota
GeneTreeiENSGT00390000003107
HOGENOMiCLU_045003_3_0_1
InParanoidiQ9NXS2
OMAiDTEENMH
OrthoDBi1257754at2759
PhylomeDBiQ9NXS2
TreeFamiTF315071

Enzyme and pathway databases

BRENDAi2.3.2.5, 2681
PathwayCommonsiQ9NXS2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54814, 9 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		QPCTL, human
EvolutionaryTraceiQ9NXS2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54814
PharosiQ9NXS2, Tchem

Protein Ontology

More...PROi		PR:Q9NXS2
RNActiQ9NXS2, protein

Gene expression databases

BgeeiENSG00000011478, Expressed in left coronary artery and 121 other tissues
ExpressionAtlasiQ9NXS2, baseline and differential
GenevisibleiQ9NXS2, HS

Family and domain databases

CDDicd03880, M28_QC_like, 1 hit
InterProiView protein in InterPro
IPR037457, M28_QC
IPR007484, Peptidase_M28
IPR040234, QC/QCL
PANTHERiPTHR12283, PTHR12283, 1 hit
PfamiView protein in Pfam
PF04389, Peptidase_M28, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQPCTL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NXS2
Secondary accession number(s): Q53HE4, Q96F74
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 18, 2010
Last modified: April 7, 2021
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again