Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 134 (13 Feb 2019)
Sequence version 2 (18 May 2010)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Glutaminyl-peptide cyclotransferase-like protein

Gene

QPCTL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the biosynthesis of pyroglutamyl peptides.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi186Zinc; catalytic1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei225Proton acceptor1
Metal bindingi226Zinc; catalytic1
Active sitei269Proton acceptor1
Metal bindingi351Zinc; catalytic1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.3.2.5 2681

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M28.016

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutaminyl-peptide cyclotransferase-like protein (EC:2.3.2.5)
Alternative name(s):
Golgi-resident glutaminyl-peptide cyclotransferase
isoQC
Short name:
gQC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:QPCTL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000011478.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25952 QPCTL

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NXS2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 55HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54814

Open Targets

More...
OpenTargetsi
ENSG00000011478

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134922163

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3638349

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
QPCTL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452875

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003020021 – 382Glutaminyl-peptide cyclotransferase-like proteinAdd BLAST382

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NXS2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NXS2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NXS2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NXS2

PeptideAtlas

More...
PeptideAtlasi
Q9NXS2

PRoteomics IDEntifications database

More...
PRIDEi
Q9NXS2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83131

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NXS2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NXS2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000011478 Expressed in 101 organ(s), highest expression level in left coronary artery

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NXS2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NXS2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040797

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120171, 23 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NXS2, 23 interactors

Molecular INTeraction database

More...
MINTi
Q9NXS2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000012049

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9NXS2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1382
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PB4X-ray1.13X53-382[»]
3PB6X-ray1.05X53-382[»]
3PB7X-ray1.40X53-382[»]
3PB8X-ray1.13X53-382[»]
3PB9X-ray1.12X53-382[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NXS2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NXS2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NXS2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3946 Eukaryota
ENOG410YIYE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003107

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000189291

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG009812

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NXS2

KEGG Orthology (KO)

More...
KOi
K00683

Identification of Orthologs from Complete Genome Data

More...
OMAi
TLTAGWH

Database of Orthologous Groups

More...
OrthoDBi
1257754at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NXS2

TreeFam database of animal gene trees

More...
TreeFami
TF315071

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03880 M28_QC_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037457 M28_QC_like
IPR007484 Peptidase_M28
IPR040234 QC/QCL

The PANTHER Classification System

More...
PANTHERi
PTHR12283 PTHR12283, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04389 Peptidase_M28, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NXS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSGGRGRPR LRLGERGLME PLLPPKRRLL PRVRLLPLLL ALAVGSAFYT
60 70 80 90 100
IWSGWHRRTE ELPLGRELRV PLIGSLPEAR LRRVVGQLDP QRLWSTYLRP
110 120 130 140 150
LLVVRTPGSP GNLQVRKFLE ATLRSLTAGW HVELDPFTAS TPLGPVDFGN
160 170 180 190 200
VVATLDPRAA RHLTLACHYD SKLFPPGSTP FVGATDSAVP CALLLELAQA
210 220 230 240 250
LDLELSRAKK QAAPVTLQLL FLDGEEALKE WGPKDSLYGS RHLAQLMESI
260 270 280 290 300
PHSPGPTRIQ AIELFMLLDL LGAPNPTFYS HFPRTVRWFH RLRSIEKRLH
310 320 330 340 350
RLNLLQSHPQ EVMYFQPGEP FGSVEDDHIP FLRRGVPVLH LISTPFPAVW
360 370 380
HTPADTEVNL HPPTVHNLCR ILAVFLAEYL GL
Length:382
Mass (Da):42,924
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2DCA79BED029DD4B
GO
Isoform 2 (identifier: Q9NXS2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-211: Missing.

Show »
Length:288
Mass (Da):32,912
Checksum:i9F23194B62336AD3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQG1K7EQG1_HUMAN
Glutaminyl-peptide cyclotransferase...
QPCTL
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti295I → T in BAD96356 (Ref. 2) Curated1
Sequence conflicti321F → S in BAA90938 (PubMed:14702039).Curated1
Sequence conflicti321F → S in BAD18747 (PubMed:14702039).Curated1
Sequence conflicti334R → G in BAD96356 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034937214P → L. Corresponds to variant dbSNP:rs28708996Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054066118 – 211Missing in isoform 2. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000091 mRNA Translation: BAA90938.1
AK172764 mRNA Translation: BAD18747.1
AK222636 mRNA Translation: BAD96356.1
AC007191 Genomic DNA No translation available.
BC011553 mRNA Translation: AAH11553.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12672.1 [Q9NXS2-1]
CCDS54282.1 [Q9NXS2-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001156849.1, NM_001163377.1 [Q9NXS2-3]
NP_060129.2, NM_017659.3 [Q9NXS2-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.631556

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000012049; ENSP00000012049; ENSG00000011478 [Q9NXS2-1]
ENST00000366382; ENSP00000387944; ENSG00000011478 [Q9NXS2-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54814

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54814

UCSC genome browser

More...
UCSCi
uc010ekn.4 human [Q9NXS2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000091 mRNA Translation: BAA90938.1
AK172764 mRNA Translation: BAD18747.1
AK222636 mRNA Translation: BAD96356.1
AC007191 Genomic DNA No translation available.
BC011553 mRNA Translation: AAH11553.1
CCDSiCCDS12672.1 [Q9NXS2-1]
CCDS54282.1 [Q9NXS2-3]
RefSeqiNP_001156849.1, NM_001163377.1 [Q9NXS2-3]
NP_060129.2, NM_017659.3 [Q9NXS2-1]
UniGeneiHs.631556

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PB4X-ray1.13X53-382[»]
3PB6X-ray1.05X53-382[»]
3PB7X-ray1.40X53-382[»]
3PB8X-ray1.13X53-382[»]
3PB9X-ray1.12X53-382[»]
ProteinModelPortaliQ9NXS2
SMRiQ9NXS2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120171, 23 interactors
IntActiQ9NXS2, 23 interactors
MINTiQ9NXS2
STRINGi9606.ENSP00000012049

Chemistry databases

BindingDBiQ9NXS2
ChEMBLiCHEMBL3638349

Protein family/group databases

MEROPSiM28.016

PTM databases

iPTMnetiQ9NXS2
PhosphoSitePlusiQ9NXS2

Polymorphism and mutation databases

BioMutaiQPCTL
DMDMi296452875

Proteomic databases

EPDiQ9NXS2
jPOSTiQ9NXS2
MaxQBiQ9NXS2
PaxDbiQ9NXS2
PeptideAtlasiQ9NXS2
PRIDEiQ9NXS2
ProteomicsDBi83131

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000012049; ENSP00000012049; ENSG00000011478 [Q9NXS2-1]
ENST00000366382; ENSP00000387944; ENSG00000011478 [Q9NXS2-3]
GeneIDi54814
KEGGihsa:54814
UCSCiuc010ekn.4 human [Q9NXS2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54814
DisGeNETi54814
EuPathDBiHostDB:ENSG00000011478.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
QPCTL

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0015239
HGNCiHGNC:25952 QPCTL
HPAiHPA040797
neXtProtiNX_Q9NXS2
OpenTargetsiENSG00000011478
PharmGKBiPA134922163

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3946 Eukaryota
ENOG410YIYE LUCA
GeneTreeiENSGT00390000003107
HOGENOMiHOG000189291
HOVERGENiHBG009812
InParanoidiQ9NXS2
KOiK00683
OMAiTLTAGWH
OrthoDBi1257754at2759
PhylomeDBiQ9NXS2
TreeFamiTF315071

Enzyme and pathway databases

BRENDAi2.3.2.5 2681

Miscellaneous databases

EvolutionaryTraceiQ9NXS2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54814

Protein Ontology

More...
PROi
PR:Q9NXS2

Gene expression databases

BgeeiENSG00000011478 Expressed in 101 organ(s), highest expression level in left coronary artery
ExpressionAtlasiQ9NXS2 baseline and differential
GenevisibleiQ9NXS2 HS

Family and domain databases

CDDicd03880 M28_QC_like, 1 hit
InterProiView protein in InterPro
IPR037457 M28_QC_like
IPR007484 Peptidase_M28
IPR040234 QC/QCL
PANTHERiPTHR12283 PTHR12283, 1 hit
PfamiView protein in Pfam
PF04389 Peptidase_M28, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQPCTL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NXS2
Secondary accession number(s): Q53HE4, Q96F74
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 18, 2010
Last modified: February 13, 2019
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again