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Protein

Glutaminyl-peptide cyclotransferase-like protein

Gene

QPCTL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the biosynthesis of pyroglutamyl peptides.2 Publications

Catalytic activityi

L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3.2 Publications

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi186Zinc; catalytic1
Active sitei225Proton acceptor1
Metal bindingi226Zinc; catalytic1
Active sitei269Proton acceptor1
Metal bindingi351Zinc; catalytic1

GO - Molecular functioni

  • glutaminyl-peptide cyclotransferase activity Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi2.3.2.5 2681

Protein family/group databases

MEROPSiM28.016

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminyl-peptide cyclotransferase-like protein (EC:2.3.2.5)
Alternative name(s):
Golgi-resident glutaminyl-peptide cyclotransferase
isoQC
Short name:
gQC
Gene namesi
Name:QPCTL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000011478.11
HGNCiHGNC:25952 QPCTL
neXtProtiNX_Q9NXS2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54814
OpenTargetsiENSG00000011478
PharmGKBiPA134922163

Chemistry databases

ChEMBLiCHEMBL3638349

Polymorphism and mutation databases

BioMutaiQPCTL
DMDMi296452875

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003020021 – 382Glutaminyl-peptide cyclotransferase-like proteinAdd BLAST382

Proteomic databases

EPDiQ9NXS2
MaxQBiQ9NXS2
PaxDbiQ9NXS2
PeptideAtlasiQ9NXS2
PRIDEiQ9NXS2
ProteomicsDBi83131

PTM databases

iPTMnetiQ9NXS2
PhosphoSitePlusiQ9NXS2

Expressioni

Gene expression databases

BgeeiENSG00000011478 Expressed in 101 organ(s), highest expression level in left coronary artery
CleanExiHS_QPCTL
ExpressionAtlasiQ9NXS2 baseline and differential
GenevisibleiQ9NXS2 HS

Organism-specific databases

HPAiHPA040797

Interactioni

Protein-protein interaction databases

BioGridi120171, 19 interactors
IntActiQ9NXS2, 23 interactors
MINTiQ9NXS2
STRINGi9606.ENSP00000012049

Chemistry databases

BindingDBiQ9NXS2

Structurei

Secondary structure

1382
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NXS2
SMRiQ9NXS2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NXS2

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3946 Eukaryota
ENOG410YIYE LUCA
GeneTreeiENSGT00390000003107
HOGENOMiHOG000189291
HOVERGENiHBG009812
InParanoidiQ9NXS2
KOiK00683
OMAiTLTAGWH
OrthoDBiEOG091G09N2
PhylomeDBiQ9NXS2
TreeFamiTF315071

Family and domain databases

CDDicd03880 M28_QC_like, 1 hit
InterProiView protein in InterPro
IPR037457 M28_QC_like
IPR007484 Peptidase_M28
PfamiView protein in Pfam
PF04389 Peptidase_M28, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q9NXS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSGGRGRPR LRLGERGLME PLLPPKRRLL PRVRLLPLLL ALAVGSAFYT
60 70 80 90 100
IWSGWHRRTE ELPLGRELRV PLIGSLPEAR LRRVVGQLDP QRLWSTYLRP
110 120 130 140 150
LLVVRTPGSP GNLQVRKFLE ATLRSLTAGW HVELDPFTAS TPLGPVDFGN
160 170 180 190 200
VVATLDPRAA RHLTLACHYD SKLFPPGSTP FVGATDSAVP CALLLELAQA
210 220 230 240 250
LDLELSRAKK QAAPVTLQLL FLDGEEALKE WGPKDSLYGS RHLAQLMESI
260 270 280 290 300
PHSPGPTRIQ AIELFMLLDL LGAPNPTFYS HFPRTVRWFH RLRSIEKRLH
310 320 330 340 350
RLNLLQSHPQ EVMYFQPGEP FGSVEDDHIP FLRRGVPVLH LISTPFPAVW
360 370 380
HTPADTEVNL HPPTVHNLCR ILAVFLAEYL GL
Length:382
Mass (Da):42,924
Last modified:May 18, 2010 - v2
Checksum:i2DCA79BED029DD4B
GO
Isoform 2 (identifier: Q9NXS2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-211: Missing.

Show »
Length:288
Mass (Da):32,912
Checksum:i9F23194B62336AD3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQG1K7EQG1_HUMAN
Glutaminyl-peptide cyclotransferase...
QPCTL
121Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti295I → T in BAD96356 (Ref. 2) Curated1
Sequence conflicti321F → S in BAA90938 (PubMed:14702039).Curated1
Sequence conflicti321F → S in BAD18747 (PubMed:14702039).Curated1
Sequence conflicti334R → G in BAD96356 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034937214P → L. Corresponds to variant dbSNP:rs28708996Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054066118 – 211Missing in isoform 2. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000091 mRNA Translation: BAA90938.1
AK172764 mRNA Translation: BAD18747.1
AK222636 mRNA Translation: BAD96356.1
AC007191 Genomic DNA No translation available.
BC011553 mRNA Translation: AAH11553.1
CCDSiCCDS12672.1 [Q9NXS2-1]
CCDS54282.1 [Q9NXS2-3]
RefSeqiNP_001156849.1, NM_001163377.1 [Q9NXS2-3]
NP_060129.2, NM_017659.3 [Q9NXS2-1]
UniGeneiHs.631556

Genome annotation databases

EnsembliENST00000012049; ENSP00000012049; ENSG00000011478 [Q9NXS2-1]
ENST00000366382; ENSP00000387944; ENSG00000011478 [Q9NXS2-3]
GeneIDi54814
KEGGihsa:54814
UCSCiuc010ekn.4 human [Q9NXS2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiQPCTL_HUMAN
AccessioniPrimary (citable) accession number: Q9NXS2
Secondary accession number(s): Q53HE4, Q96F74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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