UniProtKB - Q9NXR7 (BABA2_HUMAN)
BRISC and BRCA1-A complex member 2
BABAM2
Functioni
GO - Molecular functioni
- peroxisome targeting sequence binding Source: UniProtKB
- polyubiquitin modification-dependent protein binding Source: UniProtKB
- tumor necrosis factor receptor binding Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cellular response to DNA damage stimulus Source: UniProtKB
- chromatin organization Source: UniProtKB-KW
- double-strand break repair Source: UniProtKB
- double-strand break repair via nonhomologous end joining Source: Reactome
- negative regulation of apoptotic process Source: UniProtKB
- positive regulation of DNA repair Source: UniProtKB
- protein deubiquitination Source: Reactome
- protein K63-linked deubiquitination Source: UniProtKB
- response to ionizing radiation Source: UniProtKB
- signal transduction Source: ProtInc
- signal transduction involved in G2 DNA damage checkpoint Source: UniProtKB
Keywordsi
Molecular function | Chromatin regulator |
Biological process | Apoptosis, Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9NXR7 |
Reactomei | R-HSA-5689901, Metalloprotease DUBs R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693571, Nonhomologous End-Joining (NHEJ) R-HSA-5693607, Processing of DNA double-strand break ends R-HSA-69473, G2/M DNA damage checkpoint |
Names & Taxonomyi
Protein namesi | Recommended name: BRISC and BRCA1-A complex member 2ImportedAlternative name(s): BRCA1-A complex subunit BRE BRCA1/BRCA2-containing complex subunit 451 Publication Brain and reproductive organ-expressed protein1 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000158019.20 |
HGNCi | HGNC:1106, BABAM2 |
MIMi | 610497, gene |
neXtProti | NX_Q9NXR7 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- BRCA1-A complex Source: UniProtKB
- BRISC complex Source: UniProtKB
- nuclear ubiquitin ligase complex Source: UniProtKB
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9577 |
OpenTargetsi | ENSG00000158019 |
PharmGKBi | PA25419 |
Miscellaneous databases
Pharosi | Q9NXR7, Tbio |
Polymorphism and mutation databases
BioMutai | BABAM2 |
DMDMi | 229462810 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000224189 | 1 – 383 | BRISC and BRCA1-A complex member 2Add BLAST | 383 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 2 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9NXR7 |
jPOSTi | Q9NXR7 |
MassIVEi | Q9NXR7 |
PaxDbi | Q9NXR7 |
PeptideAtlasi | Q9NXR7 |
PRIDEi | Q9NXR7 |
ProteomicsDBi | 83124 [Q9NXR7-2] 83125 [Q9NXR7-1] 83126 [Q9NXR7-3] 83127 [Q9NXR7-4] |
PTM databases
iPTMneti | Q9NXR7 |
PhosphoSitePlusi | Q9NXR7 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000158019, Expressed in right adrenal gland and 234 other tissues |
ExpressionAtlasi | Q9NXR7, baseline and differential |
Genevisiblei | Q9NXR7, HS |
Organism-specific databases
HPAi | ENSG00000158019, Tissue enriched (adrenal) |
Interactioni
Subunit structurei
Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1 (PubMed:21282113, PubMed:24075985).
Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1, BRCC3/BRCC36 and BABAM1/NBA1. Binds polyubiquitin.
Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1 (PubMed:19214193, PubMed:21282113, PubMed:24075985, PubMed:25283148).
Identified in a complex with SHMT2 and the other subunits of the BRISC complex (PubMed:24075985).
Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BRCC3/BRCC36 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. May interact with FAS and TNFRSF1A (PubMed:15465831).
1 Publication8 PublicationsBinary interactionsi
Q9NXR7
With | #Exp. | IntAct |
---|---|---|
BABAM1 [Q9NWV8] | 6 | EBI-949389,EBI-745725 |
GO - Molecular functioni
- polyubiquitin modification-dependent protein binding Source: UniProtKB
- tumor necrosis factor receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114946, 69 interactors |
ComplexPortali | CPX-4425, BRCA1-A complex CPX-955, BRCC ubiquitin ligase complex |
CORUMi | Q9NXR7 |
IntActi | Q9NXR7, 31 interactors |
STRINGi | 9606.ENSP00000343412 |
Chemistry databases
BindingDBi | Q9NXR7 |
Miscellaneous databases
RNActi | Q9NXR7, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 30 – 147 | UEV-like 1Add BLAST | 118 | |
Regioni | 275 – 364 | UEV-like 2Add BLAST | 90 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QUU0, Eukaryota |
GeneTreei | ENSGT00390000004208 |
HOGENOMi | CLU_057019_0_0_1 |
InParanoidi | Q9NXR7 |
OMAi | LVQWDAG |
PhylomeDBi | Q9NXR7 |
TreeFami | TF328507 |
Family and domain databases
InterProi | View protein in InterPro IPR010358, BRE |
PANTHERi | PTHR15189, PTHR15189, 1 hit |
Pfami | View protein in Pfam PF06113, BRE, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSPEVALNRI SPMLSPFISS VVRNGKVGLD ATNCLRITDL KSGCTSLTPG
60 70 80 90 100
PNCDRFKLHI PYAGETLKWD IIFNAQYPEL PPDFIFGEDA EFLPDPSALQ
110 120 130 140 150
NLASWNPSNP ECLLLVVKEL VQQYHQFQCS RLRESSRLMF EYQTLLEEPQ
160 170 180 190 200
YGENMEIYAG KKNNWTGEFS ARFLLKLPVD FSNIPTYLLK DVNEDPGEDV
210 220 230 240 250
ALLSVSFEDT EATQVYPKLY LSPRIEHALG GSSALHIPAF PGGGCLIDYV
260 270 280 290 300
PQVCHLLTNK VQYVIQGYHK RREYIAAFLS HFGTGVVEYD AEGFTKLTLL
310 320 330 340 350
LMWKDFCFLV HIDLPLFFPR DQPTLTFQSV YHFTNSGQLY SQAQKNYPYS
360 370 380
PRWDGNEMAK RAKAYFKTFV PQFQEAAFAN GKL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J2G0 | C9J2G0_HUMAN | BRCA1-A complex subunit BRE | BABAM2 | 153 | Annotation score: | ||
F8W733 | F8W733_HUMAN | BRCA1-A complex subunit BRE | BABAM2 | 284 | Annotation score: | ||
A0A075B7D2 | A0A075B7D2_HUMAN | BRCA1-A complex subunit BRE | BABAM2 | 166 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 192 | V → L in BAF83775 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_051957 | 363 – 383 | KAYFK…ANGKL → NSRRQHLPMESSRKHQS in isoform 3. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_051956 | 364 – 383 | AYFKT…ANGKL → GCQGSRDACSPWEQVLAFAV AKTGCKLLQPQRNWPSSRGP PWRASEGERTAQ in isoform 1. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_037261 | 364 – 383 | AYFKT…ANGKL → RESNRDGEESSSA in isoform 4. 1 PublicationAdd BLAST | 20 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000342045; ENSP00000339371; ENSG00000158019 [Q9NXR7-2] ENST00000344773; ENSP00000343412; ENSG00000158019 [Q9NXR7-1] ENST00000361704; ENSP00000354699; ENSG00000158019 [Q9NXR7-4] ENST00000379624; ENSP00000368945; ENSG00000158019 [Q9NXR7-2] ENST00000379632; ENSP00000368953; ENSG00000158019 [Q9NXR7-4] |
GeneIDi | 9577 |
KEGGi | hsa:9577 |
UCSCi | uc002rlq.4, human [Q9NXR7-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6H3C | electron microscopy | 3.90 | C/H | 1-383 | [»] | |
6R8F | electron microscopy | 3.80 | E/G | 1-133 | [»] | |
SMRi | Q9NXR7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114946, 69 interactors |
ComplexPortali | CPX-4425, BRCA1-A complex CPX-955, BRCC ubiquitin ligase complex |
CORUMi | Q9NXR7 |
IntActi | Q9NXR7, 31 interactors |
STRINGi | 9606.ENSP00000343412 |
Chemistry databases
BindingDBi | Q9NXR7 |
PTM databases
iPTMneti | Q9NXR7 |
PhosphoSitePlusi | Q9NXR7 |
Polymorphism and mutation databases
BioMutai | BABAM2 |
DMDMi | 229462810 |
Proteomic databases
EPDi | Q9NXR7 |
jPOSTi | Q9NXR7 |
MassIVEi | Q9NXR7 |
PaxDbi | Q9NXR7 |
PeptideAtlasi | Q9NXR7 |
PRIDEi | Q9NXR7 |
ProteomicsDBi | 83124 [Q9NXR7-2] 83125 [Q9NXR7-1] 83126 [Q9NXR7-3] 83127 [Q9NXR7-4] |
Protocols and materials databases
Antibodypediai | 13903, 238 antibodies |
DNASUi | 9577 |
Genome annotation databases
Ensembli | ENST00000342045; ENSP00000339371; ENSG00000158019 [Q9NXR7-2] ENST00000344773; ENSP00000343412; ENSG00000158019 [Q9NXR7-1] ENST00000361704; ENSP00000354699; ENSG00000158019 [Q9NXR7-4] ENST00000379624; ENSP00000368945; ENSG00000158019 [Q9NXR7-2] ENST00000379632; ENSP00000368953; ENSG00000158019 [Q9NXR7-4] |
GeneIDi | 9577 |
KEGGi | hsa:9577 |
UCSCi | uc002rlq.4, human [Q9NXR7-2] |
Organism-specific databases
CTDi | 9577 |
DisGeNETi | 9577 |
EuPathDBi | HostDB:ENSG00000158019.20 |
GeneCardsi | BABAM2 |
HGNCi | HGNC:1106, BABAM2 |
HPAi | ENSG00000158019, Tissue enriched (adrenal) |
MIMi | 610497, gene |
neXtProti | NX_Q9NXR7 |
OpenTargetsi | ENSG00000158019 |
PharmGKBi | PA25419 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUU0, Eukaryota |
GeneTreei | ENSGT00390000004208 |
HOGENOMi | CLU_057019_0_0_1 |
InParanoidi | Q9NXR7 |
OMAi | LVQWDAG |
PhylomeDBi | Q9NXR7 |
TreeFami | TF328507 |
Enzyme and pathway databases
PathwayCommonsi | Q9NXR7 |
Reactomei | R-HSA-5689901, Metalloprotease DUBs R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693571, Nonhomologous End-Joining (NHEJ) R-HSA-5693607, Processing of DNA double-strand break ends R-HSA-69473, G2/M DNA damage checkpoint |
Miscellaneous databases
BioGRID-ORCSi | 9577, 4 hits in 848 CRISPR screens |
ChiTaRSi | BRE, human |
GeneWikii | BRE_(gene) |
GenomeRNAii | 9577 |
Pharosi | Q9NXR7, Tbio |
PROi | PR:Q9NXR7 |
RNActi | Q9NXR7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000158019, Expressed in right adrenal gland and 234 other tissues |
ExpressionAtlasi | Q9NXR7, baseline and differential |
Genevisiblei | Q9NXR7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR010358, BRE |
PANTHERi | PTHR15189, PTHR15189, 1 hit |
Pfami | View protein in Pfam PF06113, BRE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BABA2_HUMAN | |
Accessioni | Q9NXR7Primary (citable) accession number: Q9NXR7 Secondary accession number(s): A8K4X1 Q96P06 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2006 |
Last sequence update: | May 5, 2009 | |
Last modified: | December 2, 2020 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM