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UniProtKB - Q9NXR5 (ANR10_HUMAN)
Protein
Ankyrin repeat domain-containing protein 10
Gene
ANKRD10
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Ankyrin repeat domain-containing protein 10 |
Gene namesi | Name:ANKRD10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20265, ANKRD10 |
neXtProti | NX_Q9NXR5 |
VEuPathDBi | HostDB:ENSG00000088448 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 55608 |
OpenTargetsi | ENSG00000088448 |
PharmGKBi | PA134911073 |
Miscellaneous databases
Pharosi | Q9NXR5, Tdark |
Genetic variation databases
BioMutai | ANKRD10 |
DMDMi | 212287924 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066905 | 1 – 420 | Ankyrin repeat domain-containing protein 10Add BLAST | 420 |
Proteomic databases
EPDi | Q9NXR5 |
jPOSTi | Q9NXR5 |
MassIVEi | Q9NXR5 |
MaxQBi | Q9NXR5 |
PaxDbi | Q9NXR5 |
PeptideAtlasi | Q9NXR5 |
PRIDEi | Q9NXR5 |
ProteomicsDBi | 83122 [Q9NXR5-1] 83123 [Q9NXR5-2] |
PTM databases
iPTMneti | Q9NXR5 |
PhosphoSitePlusi | Q9NXR5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000088448, Expressed in intestine and 239 other tissues |
ExpressionAtlasi | Q9NXR5, baseline and differential |
Genevisiblei | Q9NXR5, HS |
Organism-specific databases
HPAi | ENSG00000088448, Low tissue specificity |
Interactioni
Binary interactionsi
Q9NXR5
With | #Exp. | IntAct |
---|---|---|
APPBP2 [Q92624] | 3 | EBI-10316475,EBI-743771 |
Isoform 2 [Q9NXR5-2]
Protein-protein interaction databases
BioGRIDi | 120748, 21 interactors |
IntActi | Q9NXR5, 20 interactors |
STRINGi | 9606.ENSP00000267339 |
Miscellaneous databases
RNActi | Q9NXR5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 21 – 50 | ANK 1Add BLAST | 30 | |
Repeati | 57 – 86 | ANK 2Add BLAST | 30 | |
Repeati | 91 – 120 | ANK 3Add BLAST | 30 | |
Repeati | 124 – 153 | ANK 4Add BLAST | 30 |
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000156564 |
HOGENOMi | CLU_052448_0_0_1 |
InParanoidi | Q9NXR5 |
OMAi | CHLNRFY |
PhylomeDBi | Q9NXR5 |
TreeFami | TF330752 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NXR5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAAGAGAGV EAGFSSEELL SLRFPLHRAC RDGDLATLCS LLQQTPHAHL
60 70 80 90 100
ASEDSFYGWT PVHWAAHFGK LECLVQLVRA GATLNVSTTR YAQTPAHIAA
110 120 130 140 150
FGGHPQCLVW LIQAGANINK PDCEGETPIH KAARSGSLEC ISALVANGAH
160 170 180 190 200
VDLRNASGLT AADIAQTQGF QECAQFLLNL QNCHLNHFYN NGILNGGHQN
210 220 230 240 250
VFPNHISVGT NRKRCLEDSE DFGVKKARTE AQSLDSAVPL TNGDTEDDAD
260 270 280 290 300
KMHVDREFAV VTDMKNSSSV SNTLTNGCVI NGHLDFPSTT PLSGMESRNG
310 320 330 340 350
QCLTGTNGIS SGLAPGQPFP SSQGSLCISG TEEPEKTLRA NPELCGSLHL
360 370 380 390 400
NGSPSSCIAS RPSWVEDIGD NLYYGHYHGF GDTAESIPEL NSVVEHSKSV
410 420
KVQERYDSAV LGTMHLHHGS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8IUW1 | Q8IUW1_HUMAN | ANKRD10 protein | ANKRD10 | 161 | Annotation score: | ||
S4R3R2 | S4R3R2_HUMAN | Ankyrin repeat domain-containing pr... | ANKRD10 | 121 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 176 | F → S in BAA90945 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020095 | 320 | P → L. Corresponds to variant dbSNP:rs3742185Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034637 | 152 – 220 | DLRNA…LEDSE → EFISQSSVHSCLPGELQHGV TFDPSVLIQCLKPEKCQWPD SSRHCTNPGFPRVCPVSLEP PELSSEPFL in isoform 2. 1 PublicationAdd BLAST | 69 | |
Alternative sequenceiVSP_034638 | 221 – 420 | Missing in isoform 2. 1 PublicationAdd BLAST | 200 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000100 mRNA Translation: BAA90945.1 AL157875 Genomic DNA No translation available. AL442128 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09134.1 CH471085 Genomic DNA Translation: EAX09135.1 BC001727 mRNA Translation: AAH01727.1 |
CCDSi | CCDS66580.1 [Q9NXR5-2] CCDS9520.1 [Q9NXR5-1] |
RefSeqi | NP_001273650.1, NM_001286721.1 [Q9NXR5-2] NP_060134.2, NM_017664.3 [Q9NXR5-1] |
Genome annotation databases
Ensembli | ENST00000267339; ENSP00000267339; ENSG00000088448 ENST00000310847; ENSP00000312534; ENSG00000088448 [Q9NXR5-2] |
GeneIDi | 55608 |
KEGGi | hsa:55608 |
MANE-Selecti | ENST00000267339.6; ENSP00000267339.2; NM_017664.4; NP_060134.2 |
UCSCi | uc001vrn.5, human [Q9NXR5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000100 mRNA Translation: BAA90945.1 AL157875 Genomic DNA No translation available. AL442128 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09134.1 CH471085 Genomic DNA Translation: EAX09135.1 BC001727 mRNA Translation: AAH01727.1 |
CCDSi | CCDS66580.1 [Q9NXR5-2] CCDS9520.1 [Q9NXR5-1] |
RefSeqi | NP_001273650.1, NM_001286721.1 [Q9NXR5-2] NP_060134.2, NM_017664.3 [Q9NXR5-1] |
3D structure databases
SMRi | Q9NXR5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120748, 21 interactors |
IntActi | Q9NXR5, 20 interactors |
STRINGi | 9606.ENSP00000267339 |
PTM databases
iPTMneti | Q9NXR5 |
PhosphoSitePlusi | Q9NXR5 |
Genetic variation databases
BioMutai | ANKRD10 |
DMDMi | 212287924 |
Proteomic databases
EPDi | Q9NXR5 |
jPOSTi | Q9NXR5 |
MassIVEi | Q9NXR5 |
MaxQBi | Q9NXR5 |
PaxDbi | Q9NXR5 |
PeptideAtlasi | Q9NXR5 |
PRIDEi | Q9NXR5 |
ProteomicsDBi | 83122 [Q9NXR5-1] 83123 [Q9NXR5-2] |
Protocols and materials databases
Antibodypediai | 67648, 55 antibodies from 14 providers |
DNASUi | 55608 |
Genome annotation databases
Ensembli | ENST00000267339; ENSP00000267339; ENSG00000088448 ENST00000310847; ENSP00000312534; ENSG00000088448 [Q9NXR5-2] |
GeneIDi | 55608 |
KEGGi | hsa:55608 |
MANE-Selecti | ENST00000267339.6; ENSP00000267339.2; NM_017664.4; NP_060134.2 |
UCSCi | uc001vrn.5, human [Q9NXR5-1] |
Organism-specific databases
CTDi | 55608 |
DisGeNETi | 55608 |
GeneCardsi | ANKRD10 |
HGNCi | HGNC:20265, ANKRD10 |
HPAi | ENSG00000088448, Low tissue specificity |
neXtProti | NX_Q9NXR5 |
OpenTargetsi | ENSG00000088448 |
PharmGKBi | PA134911073 |
VEuPathDBi | HostDB:ENSG00000088448 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000156564 |
HOGENOMi | CLU_052448_0_0_1 |
InParanoidi | Q9NXR5 |
OMAi | CHLNRFY |
PhylomeDBi | Q9NXR5 |
TreeFami | TF330752 |
Enzyme and pathway databases
PathwayCommonsi | Q9NXR5 |
SignaLinki | Q9NXR5 |
Miscellaneous databases
BioGRID-ORCSi | 55608, 9 hits in 1047 CRISPR screens |
ChiTaRSi | ANKRD10, human |
GenomeRNAii | 55608 |
Pharosi | Q9NXR5, Tdark |
PROi | PR:Q9NXR5 |
RNActi | Q9NXR5, protein |
Gene expression databases
Bgeei | ENSG00000088448, Expressed in intestine and 239 other tissues |
ExpressionAtlasi | Q9NXR5, baseline and differential |
Genevisiblei | Q9NXR5, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ANR10_HUMAN | |
Accessioni | Q9NXR5Primary (citable) accession number: Q9NXR5 Secondary accession number(s): Q5VW12, Q9BV12 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 22, 2003 |
Last sequence update: | July 22, 2008 | |
Last modified: | February 23, 2022 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports