UniProtKB - Q9NXR5 (ANR10_HUMAN)

BLAST

>sp|Q9NXR5|ANR10_HUMAN Ankyrin repeat domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ANKRD10 PE=1 SV=2
MSAAGAGAGVEAGFSSEELLSLRFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWT
PVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINK
PDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNL
QNCHLNHFYNNGILNGGHQNVFPNHISVGTNRKRCLEDSEDFGVKKARTEAQSLDSAVPL
TNGDTEDDADKMHVDREFAVVTDMKNSSSVSNTLTNGCVINGHLDFPSTTPLSGMESRNG
QCLTGTNGISSGLAPGQPFPSSQGSLCISGTEEPEKTLRANPELCGSLHLNGSPSSCIAS
RPSWVEDIGDNLYYGHYHGFGDTAESIPELNSVVEHSKSVKVQERYDSAVLGTMHLHHGS

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History
Entry version 133 (07 Nov 2018)
Sequence version 2 (22 Jul 2008)
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Protein

Ankyrin repeat domain-containing protein 10

Gene

ANKRD10

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ankyrin repeat domain-containing protein 10
Gene namesⁱ	Name:ANKRD10
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000088448.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20265 ANKRD10
neXtProtⁱ	NX_Q9NXR5

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000088448
PharmGKBⁱ	PA134911073

Polymorphism and mutation databases

BioMutaⁱ	ANKRD10
DMDMⁱ	212287924

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000066905	1 – 420	Ankyrin repeat domain-containing protein 10Add BLAST		420

Proteomic databases

EPDⁱ	Q9NXR5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NXR5
PaxDbⁱ	Q9NXR5
PeptideAtlas More...PeptideAtlasⁱ	Q9NXR5
PRIDEⁱ	Q9NXR5
ProteomicsDBⁱ	83122 83123 [Q9NXR5-2]

PTM databases

iPTMnetⁱ	Q9NXR5
PhosphoSitePlusⁱ	Q9NXR5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000088448 Expressed in 229 organ(s), highest expression level in intestine
CleanExⁱ	HS_ANKRD10
ExpressionAtlasⁱ	Q9NXR5 baseline and differential
Genevisibleⁱ	Q9NXR5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB034211 HPA038878 HPA038879

HPAⁱ

CAB034211
HPA038878
HPA038879

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
APPBP2	Q92624	3	EBI-10316475,EBI-743771

With

Entry

#Exp.

IntAct

Notes

APPBP2

Q92624

EBI-10316475,EBI-743771

Protein-protein interaction databases

BioGridⁱ	120748, 5 interactors
IntActⁱ	Q9NXR5, 16 interactors
STRINGⁱ	9606.ENSP00000267339

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NXR5
SMRⁱ	Q9NXR5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	21 – 50	ANK 1Add BLAST	30
Repeatⁱ	57 – 86	ANK 2Add BLAST	30
Repeatⁱ	91 – 120	ANK 3Add BLAST	30
Repeatⁱ	124 – 153	ANK 4Add BLAST	30

Keywords - Domainⁱ

ANK repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0504 Eukaryota COG0666 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063667
HOGENOMⁱ	HOG000294117
HOVERGENⁱ	HBG050508
InParanoidⁱ	Q9NXR5
OMAⁱ	NLHYGHY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DE3
PhylomeDBⁱ	Q9NXR5
TreeFamⁱ	TF330752

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 2 hits
SMARTⁱ	View protein in SMART SM00248 ANK, 4 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 3 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NXR5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAAGAGAGV EAGFSSEELL SLRFPLHRAC RDGDLATLCS LLQQTPHAHL 
        60         70         80         90        100
ASEDSFYGWT PVHWAAHFGK LECLVQLVRA GATLNVSTTR YAQTPAHIAA 
       110        120        130        140        150
FGGHPQCLVW LIQAGANINK PDCEGETPIH KAARSGSLEC ISALVANGAH 
       160        170        180        190        200
VDLRNASGLT AADIAQTQGF QECAQFLLNL QNCHLNHFYN NGILNGGHQN 
       210        220        230        240        250
VFPNHISVGT NRKRCLEDSE DFGVKKARTE AQSLDSAVPL TNGDTEDDAD 
       260        270        280        290        300
KMHVDREFAV VTDMKNSSSV SNTLTNGCVI NGHLDFPSTT PLSGMESRNG 
       310        320        330        340        350
QCLTGTNGIS SGLAPGQPFP SSQGSLCISG TEEPEKTLRA NPELCGSLHL 
       360        370        380        390        400
NGSPSSCIAS RPSWVEDIGD NLYYGHYHGF GDTAESIPEL NSVVEHSKSV 
       410        420
KVQERYDSAV LGTMHLHHGS

Length:420

Mass (Da):44,768

Last modified:July 22, 2008 - v2

Checksum:ⁱ3656BE31D8B9CB23

Isoform 2 (identifier: Q9NXR5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
152-220: DLRNASGLTA...NRKRCLEDSE → EFISQSSVHS...PPELSSEPFL
221-420: Missing.

« Hide

        10         20         30         40         50
MSAAGAGAGV EAGFSSEELL SLRFPLHRAC RDGDLATLCS LLQQTPHAHL 
        60         70         80         90        100
ASEDSFYGWT PVHWAAHFGK LECLVQLVRA GATLNVSTTR YAQTPAHIAA 
       110        120        130        140        150
FGGHPQCLVW LIQAGANINK PDCEGETPIH KAARSGSLEC ISALVANGAH 
       160        170        180        190        200
VEFISQSSVH SCLPGELQHG VTFDPSVLIQ CLKPEKCQWP DSSRHCTNPG 
       210        220
FPRVCPVSLE PPELSSEPFL

Show »

Length:220

Mass (Da):23,529

Checksum:ⁱC800FCAA3B6F64BE

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q8IUW1	Q8IUW1_HUMAN	ANKRD10 protein ANKRD10 protein (Ankyrin repeat domain-containing protein 10)	ANKRD10	161	Annotation score:
S4R3R2	S4R3R2_HUMAN	Ankyrin repeat domain-containing pr... Ankyrin repeat domain-containing protein 10	ANKRD10	121	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	176	F → S in BAA90945 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_020095	320	P → L. Corresponds to variant dbSNP:rs3742185Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_034637	152 – 220	DLRNA…LEDSE → EFISQSSVHSCLPGELQHGV TFDPSVLIQCLKPEKCQWPD SSRHCTNPGFPRVCPVSLEP PELSSEPFL in isoform 2. 1 PublicationAdd BLAST		69
Alternative sequenceⁱVSP_034638	221 – 420	Missing in isoform 2. 1 PublicationAdd BLAST		200

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000100 mRNA Translation: BAA90945.1 AL157875 Genomic DNA No translation available. AL442128 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09134.1 CH471085 Genomic DNA Translation: EAX09135.1 BC001727 mRNA Translation: AAH01727.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS66580.1 [Q9NXR5-2] CCDS9520.1 [Q9NXR5-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001273650.1, NM_001286721.1 [Q9NXR5-2] NP_060134.2, NM_017664.3 [Q9NXR5-1]
UniGeneⁱ	Hs.525163

Genome annotation databases

Ensemblⁱ	ENST00000267339; ENSP00000267339; ENSG00000088448 [Q9NXR5-1] ENST00000310847; ENSP00000312534; ENSG00000088448 [Q9NXR5-2]
GeneIDⁱ	55608
KEGGⁱ	hsa:55608
UCSC genome browser More...UCSCⁱ	uc001vrn.5 human [Q9NXR5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q9NXR5	Ankyrin repeat domain 10, isoform CRA_a		HUMAN		420	UniRef100_Q9NXR5
Q9NXR5-2	ANKRD10 isoform 3		PANTR		220	UniRef100_A0A2I3SXI1

Protein	Similar proteins		Species	Score	Length	Source
Q9NXR5	Ankyrin repeat domain 10, isoform CRA_a		HUMAN		420	UniRef90_Q9NXR5
Uncharacterized protein		AOTNA		436
Uncharacterized protein		COLAP		421
Uncharacterized protein		RHIBE		420
Ankyrin repeat domain 10		MACMU		420
+17
Q9NXR5-2	ANKRD10 isoform 3		PANTR		220	UniRef90_A0A2I3SXI1
ankyrin repeat domain-containing protein 10 isoform X4		DELLE		223
ankyrin repeat domain-containing protein 10 isoform X2		PHYCD		223
ankyrin repeat domain-containing protein 10 isoform X2		LIPVE		223
ankyrin repeat domain-containing protein 10 isoform X2		TURTR		223
+8

Protein	Similar proteins		Species	Score	Length	Source
Q9NXR5	Ankyrin repeat domain-containing protein 10		CHICK		414	UniRef50_Q9NXR5
Ankyrin repeat domain 10, isoform CRA_a		HUMAN		420
Uncharacterized protein		AOTNA		436
Uncharacterized protein		COLAP		421
Uncharacterized protein		CHLSB		420
+175
Q9NXR5-2	Uncharacterized protein		MACMU		220	UniRef50_F6YSG0
Uncharacterized protein		CERAT		220
Uncharacterized protein		PAPAN		220
Uncharacterized protein		MACFA		220
Uncharacterized protein		MACNE		220
+26

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000100 mRNA Translation: BAA90945.1 AL157875 Genomic DNA No translation available. AL442128 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09134.1 CH471085 Genomic DNA Translation: EAX09135.1 BC001727 mRNA Translation: AAH01727.1
CCDSⁱ	CCDS66580.1 [Q9NXR5-2] CCDS9520.1 [Q9NXR5-1]
RefSeqⁱ	NP_001273650.1, NM_001286721.1 [Q9NXR5-2] NP_060134.2, NM_017664.3 [Q9NXR5-1]
UniGeneⁱ	Hs.525163

3D structure databases

ProteinModelPortalⁱ	Q9NXR5
SMRⁱ	Q9NXR5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120748, 5 interactors
IntActⁱ	Q9NXR5, 16 interactors
STRINGⁱ	9606.ENSP00000267339

PTM databases

iPTMnetⁱ	Q9NXR5
PhosphoSitePlusⁱ	Q9NXR5

Polymorphism and mutation databases

BioMutaⁱ	ANKRD10
DMDMⁱ	212287924

Proteomic databases

EPDⁱ	Q9NXR5
MaxQBⁱ	Q9NXR5
PaxDbⁱ	Q9NXR5
PeptideAtlasⁱ	Q9NXR5
PRIDEⁱ	Q9NXR5
ProteomicsDBⁱ	83122 83123 [Q9NXR5-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000267339; ENSP00000267339; ENSG00000088448 [Q9NXR5-1] ENST00000310847; ENSP00000312534; ENSG00000088448 [Q9NXR5-2]
GeneIDⁱ	55608
KEGGⁱ	hsa:55608
UCSCⁱ	uc001vrn.5 human [Q9NXR5-1]

Organism-specific databases

CTDⁱ	55608
EuPathDBⁱ	HostDB:ENSG00000088448.14
GeneCardsⁱ	ANKRD10
HGNCⁱ	HGNC:20265 ANKRD10
HPAⁱ	CAB034211 HPA038878 HPA038879
neXtProtⁱ	NX_Q9NXR5
OpenTargetsⁱ	ENSG00000088448
PharmGKBⁱ	PA134911073
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0504 Eukaryota COG0666 LUCA
GeneTreeⁱ	ENSGT00530000063667
HOGENOMⁱ	HOG000294117
HOVERGENⁱ	HBG050508
InParanoidⁱ	Q9NXR5
OMAⁱ	NLHYGHY
OrthoDBⁱ	EOG091G0DE3
PhylomeDBⁱ	Q9NXR5
TreeFamⁱ	TF330752

Miscellaneous databases

ChiTaRSⁱ	ANKRD10 human
GenomeRNAiⁱ	55608
Protein Ontology More...PROⁱ	PR:Q9NXR5

Gene expression databases

Bgeeⁱ	ENSG00000088448 Expressed in 229 organ(s), highest expression level in intestine
CleanExⁱ	HS_ANKRD10
ExpressionAtlasⁱ	Q9NXR5 baseline and differential
Genevisibleⁱ	Q9NXR5 HS

Family and domain databases

CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf
Pfamⁱ	View protein in Pfam PF12796 Ank_2, 2 hits
SMARTⁱ	View protein in SMART SM00248 ANK, 4 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ANR10_HUMAN
Accessionⁱ	Q9NXR5Primary (citable) accession number: Q9NXR5 Secondary accession number(s): Q5VW12, Q9BV12
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 22, 2003
	Last sequence update:	July 22, 2008
	Last modified:	November 7, 2018
	This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM

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UniProtKB - Q9NXR5 (ANR10_HUMAN)

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Ankyrin repeat domain-containing protein 10

ANKRD10

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ