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Protein

Ankyrin repeat domain-containing protein 10

Gene

ANKRD10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 10
Gene namesi
Name:ANKRD10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000088448.14
HGNCiHGNC:20265 ANKRD10
neXtProtiNX_Q9NXR5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000088448
PharmGKBiPA134911073

Polymorphism and mutation databases

BioMutaiANKRD10
DMDMi212287924

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669051 – 420Ankyrin repeat domain-containing protein 10Add BLAST420

Proteomic databases

EPDiQ9NXR5
MaxQBiQ9NXR5
PaxDbiQ9NXR5
PeptideAtlasiQ9NXR5
PRIDEiQ9NXR5
ProteomicsDBi83122
83123 [Q9NXR5-2]

PTM databases

iPTMnetiQ9NXR5
PhosphoSitePlusiQ9NXR5

Expressioni

Gene expression databases

BgeeiENSG00000088448 Expressed in 229 organ(s), highest expression level in intestine
CleanExiHS_ANKRD10
ExpressionAtlasiQ9NXR5 baseline and differential
GenevisibleiQ9NXR5 HS

Organism-specific databases

HPAiCAB034211
HPA038878
HPA038879

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-10316475,EBI-743771

Protein-protein interaction databases

BioGridi120748, 5 interactors
IntActiQ9NXR5, 16 interactors
STRINGi9606.ENSP00000267339

Structurei

3D structure databases

ProteinModelPortaliQ9NXR5
SMRiQ9NXR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 50ANK 1Add BLAST30
Repeati57 – 86ANK 2Add BLAST30
Repeati91 – 120ANK 3Add BLAST30
Repeati124 – 153ANK 4Add BLAST30

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00530000063667
HOGENOMiHOG000294117
HOVERGENiHBG050508
InParanoidiQ9NXR5
OMAiNLHYGHY
OrthoDBiEOG091G0DE3
PhylomeDBiQ9NXR5
TreeFamiTF330752

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NXR5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAAGAGAGV EAGFSSEELL SLRFPLHRAC RDGDLATLCS LLQQTPHAHL
60 70 80 90 100
ASEDSFYGWT PVHWAAHFGK LECLVQLVRA GATLNVSTTR YAQTPAHIAA
110 120 130 140 150
FGGHPQCLVW LIQAGANINK PDCEGETPIH KAARSGSLEC ISALVANGAH
160 170 180 190 200
VDLRNASGLT AADIAQTQGF QECAQFLLNL QNCHLNHFYN NGILNGGHQN
210 220 230 240 250
VFPNHISVGT NRKRCLEDSE DFGVKKARTE AQSLDSAVPL TNGDTEDDAD
260 270 280 290 300
KMHVDREFAV VTDMKNSSSV SNTLTNGCVI NGHLDFPSTT PLSGMESRNG
310 320 330 340 350
QCLTGTNGIS SGLAPGQPFP SSQGSLCISG TEEPEKTLRA NPELCGSLHL
360 370 380 390 400
NGSPSSCIAS RPSWVEDIGD NLYYGHYHGF GDTAESIPEL NSVVEHSKSV
410 420
KVQERYDSAV LGTMHLHHGS
Length:420
Mass (Da):44,768
Last modified:July 22, 2008 - v2
Checksum:i3656BE31D8B9CB23
GO
Isoform 2 (identifier: Q9NXR5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-220: DLRNASGLTA...NRKRCLEDSE → EFISQSSVHS...PPELSSEPFL
     221-420: Missing.

Show »
Length:220
Mass (Da):23,529
Checksum:iC800FCAA3B6F64BE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8IUW1Q8IUW1_HUMAN
ANKRD10 protein
ANKRD10
161Annotation score:
S4R3R2S4R3R2_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD10
121Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176F → S in BAA90945 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020095320P → L. Corresponds to variant dbSNP:rs3742185Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034637152 – 220DLRNA…LEDSE → EFISQSSVHSCLPGELQHGV TFDPSVLIQCLKPEKCQWPD SSRHCTNPGFPRVCPVSLEP PELSSEPFL in isoform 2. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_034638221 – 420Missing in isoform 2. 1 PublicationAdd BLAST200

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000100 mRNA Translation: BAA90945.1
AL157875 Genomic DNA No translation available.
AL442128 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09134.1
CH471085 Genomic DNA Translation: EAX09135.1
BC001727 mRNA Translation: AAH01727.1
CCDSiCCDS66580.1 [Q9NXR5-2]
CCDS9520.1 [Q9NXR5-1]
RefSeqiNP_001273650.1, NM_001286721.1 [Q9NXR5-2]
NP_060134.2, NM_017664.3 [Q9NXR5-1]
UniGeneiHs.525163

Genome annotation databases

EnsembliENST00000267339; ENSP00000267339; ENSG00000088448 [Q9NXR5-1]
ENST00000310847; ENSP00000312534; ENSG00000088448 [Q9NXR5-2]
GeneIDi55608
KEGGihsa:55608
UCSCiuc001vrn.5 human [Q9NXR5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000100 mRNA Translation: BAA90945.1
AL157875 Genomic DNA No translation available.
AL442128 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09134.1
CH471085 Genomic DNA Translation: EAX09135.1
BC001727 mRNA Translation: AAH01727.1
CCDSiCCDS66580.1 [Q9NXR5-2]
CCDS9520.1 [Q9NXR5-1]
RefSeqiNP_001273650.1, NM_001286721.1 [Q9NXR5-2]
NP_060134.2, NM_017664.3 [Q9NXR5-1]
UniGeneiHs.525163

3D structure databases

ProteinModelPortaliQ9NXR5
SMRiQ9NXR5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120748, 5 interactors
IntActiQ9NXR5, 16 interactors
STRINGi9606.ENSP00000267339

PTM databases

iPTMnetiQ9NXR5
PhosphoSitePlusiQ9NXR5

Polymorphism and mutation databases

BioMutaiANKRD10
DMDMi212287924

Proteomic databases

EPDiQ9NXR5
MaxQBiQ9NXR5
PaxDbiQ9NXR5
PeptideAtlasiQ9NXR5
PRIDEiQ9NXR5
ProteomicsDBi83122
83123 [Q9NXR5-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267339; ENSP00000267339; ENSG00000088448 [Q9NXR5-1]
ENST00000310847; ENSP00000312534; ENSG00000088448 [Q9NXR5-2]
GeneIDi55608
KEGGihsa:55608
UCSCiuc001vrn.5 human [Q9NXR5-1]

Organism-specific databases

CTDi55608
EuPathDBiHostDB:ENSG00000088448.14
GeneCardsiANKRD10
HGNCiHGNC:20265 ANKRD10
HPAiCAB034211
HPA038878
HPA038879
neXtProtiNX_Q9NXR5
OpenTargetsiENSG00000088448
PharmGKBiPA134911073
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00530000063667
HOGENOMiHOG000294117
HOVERGENiHBG050508
InParanoidiQ9NXR5
OMAiNLHYGHY
OrthoDBiEOG091G0DE3
PhylomeDBiQ9NXR5
TreeFamiTF330752

Miscellaneous databases

ChiTaRSiANKRD10 human
GenomeRNAii55608
PROiPR:Q9NXR5

Gene expression databases

BgeeiENSG00000088448 Expressed in 229 organ(s), highest expression level in intestine
CleanExiHS_ANKRD10
ExpressionAtlasiQ9NXR5 baseline and differential
GenevisibleiQ9NXR5 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiANR10_HUMAN
AccessioniPrimary (citable) accession number: Q9NXR5
Secondary accession number(s): Q5VW12, Q9BV12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: July 22, 2008
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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