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Entry version 151 (29 Sep 2021)
Sequence version 4 (16 May 2012)
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Protein

DNA helicase MCM9

Gene

MCM9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855).

Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093).

Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855).

Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262).

In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262).

The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855).

Probably by regulating HR, plays a key role during gametogenesis (By similarity).

By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi352 – 359ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NXL9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA helicase MCM9 (EC:3.6.4.121 Publication)
Short name:
hMCM9
Alternative name(s):
Mini-chromosome maintenance deficient domain-containing protein 1
Minichromosome maintenance 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MCM9
Synonyms:C6orf61, MCMDC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21484, MCM9

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610098, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9NXL9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000111877

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ovarian dysgenesis 4 (ODG4)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. ODG4 is an autosomal recessive condition.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi358K → A: Loss of helicase activity and DNA mismatch repair function but does not affect the interaction with MCM8, MSH2 or chromatin; when associated with A-482. 1 Publication1
Mutagenesisi482R → A: Loss of helicase activity and DNA mismatch repair function but does not affect the interaction with MCM8, MSH2 or chromatin; when associated with A-358. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
254394

MalaCards human disease database

More...
MalaCardsi
MCM9
MIMi616185, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000111877

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
444048, 46,XX ovarian dysgenesis-short stature syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162395071

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NXL9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MCM9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
387912921

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000895131 – 1143DNA helicase MCM9Add BLAST1143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei762PhosphoserineCombined sources1
Modified residuei802PhosphoserineCombined sources1
Modified residuei1109PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NXL9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NXL9

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NXL9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NXL9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NXL9

PeptideAtlas

More...
PeptideAtlasi
Q9NXL9

PRoteomics IDEntifications database

More...
PRIDEi
Q9NXL9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83112 [Q9NXL9-1]
83113 [Q9NXL9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NXL9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NXL9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

The expression of isoform L and isoform M is cell cycle regulated: induced in S-phase, decreases through G2/M, and becomes constant through G1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111877, Expressed in sural nerve and 188 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NXL9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NXL9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000111877, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the MCM8-MCM9 complex, which forms a hexamer composed of MCM8 and MCM9 (PubMed:23401855, PubMed:26300262, PubMed:26215093).

Interacts with the DNA mismatch repair (MMR) complex composed at least of MSH2, MSH3, MSH6, PMS1 and MLH1 (PubMed:26300262).

Interacts with MLH1; the interaction recruits MLH1 to chromatin (PubMed:26300262).

Interacts with MSH2; the interaction recruits MCM9 to chromatin (PubMed:26300262).

Interacts with MSH6 (PubMed:26300262).

Interacts with the MRN complex composed of MRE11, RAD50 and NBN/NBS1; the interaction recruits the MRN complex to DNA damage sites (PubMed:26215093).

Interacts with RAD51; the interaction recruits RAD51 to DNA damage sites (PubMed:23401855).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
129033, 41 interactors

Protein interaction database and analysis system

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IntActi
Q9NXL9, 12 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000314505

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NXL9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NXL9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini300 – 505MCMSequence analysisAdd BLAST206

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni656 – 738DisorderedSequence analysisAdd BLAST83
Regioni755 – 815DisorderedSequence analysisAdd BLAST61
Regioni868 – 916DisorderedSequence analysisAdd BLAST49
Regioni942 – 1011DisorderedSequence analysisAdd BLAST70
Regioni1063 – 1105DisorderedSequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi656 – 670Polar residuesSequence analysisAdd BLAST15
Compositional biasi678 – 705Polar residuesSequence analysisAdd BLAST28
Compositional biasi722 – 738Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi755 – 786Polar residuesSequence analysisAdd BLAST32
Compositional biasi868 – 884Polar residuesSequence analysisAdd BLAST17
Compositional biasi886 – 901Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi974 – 993Polar residuesSequence analysisAdd BLAST20
Compositional biasi994 – 1011Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1085 – 1099Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MCM family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0477, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT01040000240446

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_000995_7_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NXL9

Identification of Orthologs from Complete Genome Data

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OMAi
RKSFQLH

Database of Orthologous Groups

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OrthoDBi
266497at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NXL9

TreeFam database of animal gene trees

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TreeFami
TF329421

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR031327, MCM
IPR001208, MCM_dom
IPR041562, MCM_lid
IPR033762, MCM_OB
IPR012340, NA-bd_OB-fold
IPR027417, P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR11630, PTHR11630, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00493, MCM, 1 hit
PF17855, MCM_lid, 1 hit
PF17207, MCM_OB, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01657, MCMFAMILY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00382, AAA, 1 hit
SM00350, MCM, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50249, SSF50249, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50051, MCM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform L (identifier: Q9NXL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSDQVTLVG QVFESYVSEY HKNDILLILK ERDEDAHYPV VVNAMTLFET
60 70 80 90 100
NMEIGEYFNM FPSEVLTIFD SALRRSALTI LQSLSQPEAV SMKQNLHARI
110 120 130 140 150
SGLPVCPELV REHIPKTKDV GHFLSVTGTV IRTSLVKVLE FERDYMCNKC
160 170 180 190 200
KHVFVIKADF EQYYTFCRPS SCPSLESCDS SKFTCLSGLS SSPTRCRDYQ
210 220 230 240 250
EIKIQEQVQR LSVGSIPRSM KVILEDDLVD SCKSGDDLTI YGIVMQRWKP
260 270 280 290 300
FQQDVRCEVE IVLKANYIQV NNEQSSGIIM DEEVQKEFED FWEYYKSDPF
310 320 330 340 350
AGRNVILASL CPQVFGMYLV KLAVAMVLAG GIQRTDATGT RVRGESHLLL
360 370 380 390 400
VGDPGTGKSQ FLKYAAKITP RSVLTTGIGS TSAGLTVTAV KDSGEWNLEA
410 420 430 440 450
GALVLADAGL CCIDEFNSLK EHDRTSIHEA MEQQTISVAK AGLVCKLNTR
460 470 480 490 500
TTILAATNPK GQYDPQESVS VNIALGSPLL SRFDLILVLL DTKNEDWDRI
510 520 530 540 550
ISSFILENKG YPSKSEKLWS MEKMKTYFCL IRNLQPTLSD VGNQVLLRYY
560 570 580 590 600
QMQRQSDCRN AARTTIRLLE SLIRLAEAHA RLMFRDTVTL EDAITVVSVM
610 620 630 640 650
ESSMQGGALL GGVNALHTSF PENPGEQYQR QCELILEKLE LQSLLSEELR
660 670 680 690 700
RLERLQNQSV HQSQPRVLEV ETTPGSLRNG PGEESNFRTS SQQEINYSTH
710 720 730 740 750
IFSPGGSPEG SPVLDPPPHL EPNRSTSRKH SAQHKNNRDD SLDWFDFMAT
760 770 780 790 800
HQSEPKNTVV VSPHPKTSGE NMASKISNST SQGKEKSEPG QRSKVDIGLL
810 820 830 840 850
PSPGETGVPW RADNVESNKK KRLALDSEAA VSADKPDSVL THHVPRNLQK
860 870 880 890 900
LCKERAQKLC RNSTRVPAQC TVPSHPQSTP VHSPDRMLDS PKRKRPKSLA
910 920 930 940 950
QVEEPAIENV KPPGSPVAKL AKFTFKQKSK LIHSFEDHSH VSPGATKIAV
960 970 980 990 1000
HSPKISQRRT RRDAALPVKR PGKLTSTPGN QISSQPQGET KEVSQQPPEK
1010 1020 1030 1040 1050
HGPREKVMCA PEKRIIQPEL ELGNETGCAH LTCEGDKKEE VSGSNKSGKV
1060 1070 1080 1090 1100
HACTLARLAN FCFTPPSESK SKSPPPERKN RGERGPSSPP TTTAPMRVSK
1110 1120 1130 1140
RKSFQLRGST EKLIVSKESL FTLPELGDEA FDCDWDEEMR KKS
Note: Most abundant isoform.
Length:1,143
Mass (Da):127,313
Last modified:May 16, 2012 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C35C8B3476A470F
GO
Isoform M (identifier: Q9NXL9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     606-648: GGALLGGVNA...LELQSLLSEE → VTESECAPIP...QNFITAGNQL
     649-1143: Missing.

Show »
Length:648
Mass (Da):72,737
Checksum:i344DC7E1E4BB7C40
GO
Isoform S (identifier: Q9NXL9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     383-391: AGLTVTAVK → AGIVCDNFK
     392-1143: Missing.

Show »
Length:391
Mass (Da):43,983
Checksum:i1AB5A6CFBCF4E40C
GO
Isoform 4 (identifier: Q9NXL9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-381: Missing.
     382-383: SA → MS

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Length:762
Mass (Da):84,442
Checksum:i2C3190DA9ACCA977
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y6M9H0Y6M9_HUMAN
DNA helicase MCM9
MCM9
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHY8D6RHY8_HUMAN
DNA helicase MCM9
MCM9
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RE85D6RE85_HUMAN
DNA helicase MCM9
MCM9
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA90991 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG61142 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti433Q → R in BAG61142 (PubMed:14702039).Curated1
Sequence conflicti558C → S in BAG61142 (PubMed:14702039).Curated1
Sequence conflicti1063F → V in BAA90991 (PubMed:14702039).Curated1
Sequence conflicti1136D → G in BAA90991 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0441801 – 381Missing in isoform 4. 1 PublicationAdd BLAST381
Alternative sequenceiVSP_044181382 – 383SA → MS in isoform 4. 1 Publication2
Alternative sequenceiVSP_028013383 – 391AGLTVTAVK → AGIVCDNFK in isoform S. 1 Publication9
Alternative sequenceiVSP_028014392 – 1143Missing in isoform S. 1 PublicationAdd BLAST752
Alternative sequenceiVSP_047462606 – 648GGALL…LLSEE → VTESECAPIPTTGIGGRDYS RILEKWSRGRIKLQNFITAG NQL in isoform M. CuratedAdd BLAST43
Alternative sequenceiVSP_047463649 – 1143Missing in isoform M. CuratedAdd BLAST495

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK299076 mRNA Translation: BAG61142.1 Sequence problems.
AK000177 mRNA Translation: BAA90991.1 Different initiation.
AL132874 Genomic DNA No translation available.
AL359634 Genomic DNA No translation available.
BC031658 mRNA Translation: AAH31658.1
BN000882 mRNA Translation: CAJ70648.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5121.1 [Q9NXL9-3]
CCDS56447.1 [Q9NXL9-1]

NCBI Reference Sequences

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RefSeqi
NP_060166.2, NM_017696.2 [Q9NXL9-1]
NP_694987.1, NM_153255.4 [Q9NXL9-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000316068; ENSP00000312870; ENSG00000111877 [Q9NXL9-3]
ENST00000316316; ENSP00000314505; ENSG00000111877 [Q9NXL9-1]
ENST00000619706; ENSP00000480469; ENSG00000111877 [Q9NXL9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
254394

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:254394

UCSC genome browser

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UCSCi
uc003pyh.4, human [Q9NXL9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299076 mRNA Translation: BAG61142.1 Sequence problems.
AK000177 mRNA Translation: BAA90991.1 Different initiation.
AL132874 Genomic DNA No translation available.
AL359634 Genomic DNA No translation available.
BC031658 mRNA Translation: AAH31658.1
BN000882 mRNA Translation: CAJ70648.1
CCDSiCCDS5121.1 [Q9NXL9-3]
CCDS56447.1 [Q9NXL9-1]
RefSeqiNP_060166.2, NM_017696.2 [Q9NXL9-1]
NP_694987.1, NM_153255.4 [Q9NXL9-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7DPDX-ray2.55A/B1-277[»]
SMRiQ9NXL9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi129033, 41 interactors
IntActiQ9NXL9, 12 interactors
STRINGi9606.ENSP00000314505

PTM databases

iPTMnetiQ9NXL9
PhosphoSitePlusiQ9NXL9

Genetic variation databases

BioMutaiMCM9
DMDMi387912921

Proteomic databases

EPDiQ9NXL9
jPOSTiQ9NXL9
MassIVEiQ9NXL9
MaxQBiQ9NXL9
PaxDbiQ9NXL9
PeptideAtlasiQ9NXL9
PRIDEiQ9NXL9
ProteomicsDBi83112 [Q9NXL9-1]
83113 [Q9NXL9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
34788, 93 antibodies

The DNASU plasmid repository

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DNASUi
254394

Genome annotation databases

EnsembliENST00000316068; ENSP00000312870; ENSG00000111877 [Q9NXL9-3]
ENST00000316316; ENSP00000314505; ENSG00000111877 [Q9NXL9-1]
ENST00000619706; ENSP00000480469; ENSG00000111877 [Q9NXL9-1]
GeneIDi254394
KEGGihsa:254394
UCSCiuc003pyh.4, human [Q9NXL9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
254394
DisGeNETi254394

GeneCards: human genes, protein and diseases

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GeneCardsi
MCM9
HGNCiHGNC:21484, MCM9
HPAiENSG00000111877, Low tissue specificity
MalaCardsiMCM9
MIMi610098, gene
616185, phenotype
neXtProtiNX_Q9NXL9
OpenTargetsiENSG00000111877
Orphaneti444048, 46,XX ovarian dysgenesis-short stature syndrome
PharmGKBiPA162395071
VEuPathDBiHostDB:ENSG00000111877

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0477, Eukaryota
GeneTreeiENSGT01040000240446
HOGENOMiCLU_000995_7_2_1
InParanoidiQ9NXL9
OMAiRKSFQLH
OrthoDBi266497at2759
PhylomeDBiQ9NXL9
TreeFamiTF329421

Enzyme and pathway databases

PathwayCommonsiQ9NXL9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
254394, 25 hits in 1020 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MCM9, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
254394
PharosiQ9NXL9, Tbio

Protein Ontology

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PROi
PR:Q9NXL9
RNActiQ9NXL9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111877, Expressed in sural nerve and 188 other tissues
ExpressionAtlasiQ9NXL9, baseline and differential
GenevisibleiQ9NXL9, HS

Family and domain databases

Gene3Di3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR031327, MCM
IPR001208, MCM_dom
IPR041562, MCM_lid
IPR033762, MCM_OB
IPR012340, NA-bd_OB-fold
IPR027417, P-loop_NTPase
PANTHERiPTHR11630, PTHR11630, 1 hit
PfamiView protein in Pfam
PF00493, MCM, 1 hit
PF17855, MCM_lid, 1 hit
PF17207, MCM_OB, 1 hit
PRINTSiPR01657, MCMFAMILY
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SM00350, MCM, 1 hit
SUPFAMiSSF50249, SSF50249, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50051, MCM_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCM9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NXL9
Secondary accession number(s): B4DR30
, B9DI77, Q2KHJ0, Q8N5S5, Q9HCV5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 16, 2012
Last modified: September 29, 2021
This is version 151 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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