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UniProtKB - Q9NXL6 (SIDT1_HUMAN)

Protein

SID1 transmembrane family member 1

Gene

SIDT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded.By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionRNA-binding

Protein family/group databases

TCDBi1.A.79.1.2 the cholesterol uptake protein (chup) or double stranded rna uptake family

Names & Taxonomyi

Protein namesi
Recommended name:
SID1 transmembrane family member 1
Gene namesi
Name:SIDT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000072858.10
HGNCiHGNC:25967 SIDT1
MIMi606816 gene
neXtProtiNX_Q9NXL6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 309ExtracellularSequence analysisAdd BLAST290
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 442CytoplasmicSequence analysisAdd BLAST112
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Topological domaini464 – 494ExtracellularSequence analysisAdd BLAST31
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
Topological domaini516 – 541CytoplasmicSequence analysisAdd BLAST26
Transmembranei542 – 562HelicalSequence analysisAdd BLAST21
Topological domaini563 – 572ExtracellularSequence analysis10
Transmembranei573 – 590HelicalSequence analysisAdd BLAST18
Topological domaini591 – 600CytoplasmicSequence analysis10
Transmembranei601 – 621HelicalSequence analysisAdd BLAST21
Topological domaini622 – 626ExtracellularSequence analysis5
Transmembranei627 – 647HelicalSequence analysisAdd BLAST21
Topological domaini648 – 683CytoplasmicSequence analysisAdd BLAST36
Transmembranei684 – 704HelicalSequence analysisAdd BLAST21
Topological domaini705 – 710ExtracellularSequence analysis6
Transmembranei711 – 731HelicalSequence analysisAdd BLAST21
Topological domaini732 – 741CytoplasmicSequence analysis10
Transmembranei742 – 762HelicalSequence analysisAdd BLAST21
Topological domaini763 – 791ExtracellularSequence analysisAdd BLAST29
Transmembranei792 – 812HelicalSequence analysisAdd BLAST21
Topological domaini813 – 827CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54847
OpenTargetsiENSG00000072858
PharmGKBiPA134923837

Polymorphism and mutation databases

BioMutaiSIDT1
DMDMi296452905

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003257520 – 827SID1 transmembrane family member 1Add BLAST808

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi282N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi764N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NXL6
PeptideAtlasiQ9NXL6
PRIDEiQ9NXL6
ProteomicsDBi83110
83111 [Q9NXL6-2]

PTM databases

iPTMnetiQ9NXL6
PhosphoSitePlusiQ9NXL6
SwissPalmiQ9NXL6

Expressioni

Gene expression databases

BgeeiENSG00000072858 Expressed in 166 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_SIDT1
GenevisibleiQ9NXL6 HS

Organism-specific databases

HPAiHPA035862

Interactioni

Protein-protein interaction databases

IntActiQ9NXL6, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ9NXL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SID1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF6Z Eukaryota
ENOG410XPBN LUCA
GeneTreeiENSGT00390000010091
HOGENOMiHOG000020635
HOVERGENiHBG079188
InParanoidiQ9NXL6
OMAiDIVCPVY
OrthoDBiEOG091G01Q2
PhylomeDBiQ9NXL6
TreeFamiTF313076

Family and domain databases

InterProiView protein in InterPro
IPR025958 SID1_TM_fam
PANTHERiPTHR12185 PTHR12185, 1 hit
PfamiView protein in Pfam
PF13965 SID-1_RNA_chan, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NXL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGCLRLALL CALPWLLLAA SPGHPAKSPR QPPAPRRDPF DAARGADFDH 
        60         70         80         90        100
VYSGVVNLST ENIYSFNYTS QPDQVTAVRV YVNSSSENLN YPVLVVVRQQ 
       110        120        130        140        150
KEVLSWQVPL LFQGLYQRSY NYQEVSRTLC PSEATNETGP LQQLIFVDVA 
       160        170        180        190        200
SMAPLGAQYK LLVTKLKHFQ LRTNVAFHFT ASPSQPQYFL YKFPKDVDSV 
       210        220        230        240        250
IIKVVSEMAY PCSVVSVQNI MCPVYDLDHN VEFNGVYQSM TKKAAITLQK 
       260        270        280        290        300
KDFPGEQFFV VFVIKPEDYA CGGSFFIQEK ENQTWNLQRK KNLEVTIVPS 
       310        320        330        340        350
IKESVYVKSS LFSVFIFLSF YLGCLLVGFV HYLRFQRKSI DGSFGSNDGS 
       360        370        380        390        400
GNMVASHPIA ASTPEGSNYG TIDESSSSPG RQMSSSDGGP PGQSDTDSSV 
       410        420        430        440        450
EESDFDTMPD IESDKNIIRT KMFLYLSDLS RKDRRIVSKK YKIYFWNIIT 
       460        470        480        490        500
IAVFYALPVI QLVITYQTVV NVTGNQDICY YNFLCAHPLG VLSAFNNILS 
       510        520        530        540        550
NLGHVLLGFL FLLIVLRRDI LHRRALEAKD IFAVEYGIPK HFGLFYAMGI 
       560        570        580        590        600
ALMMEGVLSA CYHVCPNYSN FQFDTSFMYM IAGLCMLKLY QTRHPDINAS 
       610        620        630        640        650
AYSAYASFAV VIMVTVLGVV FGKNDVWFWV IFSAIHVLAS LALSTQIYYM 
       660        670        680        690        700
GRFKIDLGIF RRAAMVFYTD CIQQCSRPLY MDRMVLLVVG NLVNWSFALF 
       710        720        730        740        750
GLIYRPRDFA SYMLGIFICN LLLYLAFYII MKLRSSEKVL PVPLFCIVAT 
       760        770        780        790        800
AVMWAAALYF FFQNLSSWEG TPAESREKNR ECILLDFFDD HDIWHFLSAT 
       810        820 
ALFFSFLVLL TLDDDLDVVR RDQIPVF
Length:827
Mass (Da):93,839
Last modified:May 18, 2010 - v2
Checksum:iE7C383DF74378B8C
GO
Isoform 2 (identifier: Q9NXL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     655-655: I → IDVSDT

Note: No experimental confirmation available.
Show »
Length:832
Mass (Da):94,356
Checksum:iB0709610421A9D01
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti572Q → R in BAA90994 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0617933G → S. Corresponds to variant dbSNP:rs9879313Ensembl.1
Natural variantiVAR_05718478V → M. Corresponds to variant dbSNP:rs2271496Ensembl.1
Natural variantiVAR_057185363T → I. Corresponds to variant dbSNP:rs33990195Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039174655I → IDVSDT in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000181 mRNA Translation: BAA90994.1
AC055740 Genomic DNA No translation available.
AC112128 Genomic DNA No translation available.
BC117222 mRNA Translation: AAI17223.1
CCDSiCCDS2974.1 [Q9NXL6-1]
CCDS77790.1 [Q9NXL6-2]
RefSeqiNP_001295279.1, NM_001308350.1 [Q9NXL6-2]
NP_060169.2, NM_017699.2 [Q9NXL6-1]
UniGeneiHs.591291

Genome annotation databases

EnsembliENST00000264852; ENSP00000264852; ENSG00000072858 [Q9NXL6-1]
ENST00000393830; ENSP00000377416; ENSG00000072858 [Q9NXL6-2]
GeneIDi54847
KEGGihsa:54847
UCSCiuc003eak.4 human [Q9NXL6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000181 mRNA Translation: BAA90994.1
AC055740 Genomic DNA No translation available.
AC112128 Genomic DNA No translation available.
BC117222 mRNA Translation: AAI17223.1
CCDSiCCDS2974.1 [Q9NXL6-1]
CCDS77790.1 [Q9NXL6-2]
RefSeqiNP_001295279.1, NM_001308350.1 [Q9NXL6-2]
NP_060169.2, NM_017699.2 [Q9NXL6-1]
UniGeneiHs.591291

3D structure databases

ProteinModelPortaliQ9NXL6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NXL6, 1 interactor

Protein family/group databases

TCDBi1.A.79.1.2 the cholesterol uptake protein (chup) or double stranded rna uptake family

PTM databases

iPTMnetiQ9NXL6
PhosphoSitePlusiQ9NXL6
SwissPalmiQ9NXL6

Polymorphism and mutation databases

BioMutaiSIDT1
DMDMi296452905

Proteomic databases

PaxDbiQ9NXL6
PeptideAtlasiQ9NXL6
PRIDEiQ9NXL6
ProteomicsDBi83110
83111 [Q9NXL6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264852; ENSP00000264852; ENSG00000072858 [Q9NXL6-1]
ENST00000393830; ENSP00000377416; ENSG00000072858 [Q9NXL6-2]
GeneIDi54847
KEGGihsa:54847
UCSCiuc003eak.4 human [Q9NXL6-1]

Organism-specific databases

CTDi54847
DisGeNETi54847
EuPathDBiHostDB:ENSG00000072858.10
GeneCardsiSIDT1
HGNCiHGNC:25967 SIDT1
HPAiHPA035862
MIMi606816 gene
neXtProtiNX_Q9NXL6
OpenTargetsiENSG00000072858
PharmGKBiPA134923837
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF6Z Eukaryota
ENOG410XPBN LUCA
GeneTreeiENSGT00390000010091
HOGENOMiHOG000020635
HOVERGENiHBG079188
InParanoidiQ9NXL6
OMAiDIVCPVY
OrthoDBiEOG091G01Q2
PhylomeDBiQ9NXL6
TreeFamiTF313076

Miscellaneous databases

ChiTaRSiSIDT1 human
GenomeRNAii54847
PROiPR:Q9NXL6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000072858 Expressed in 166 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_SIDT1
GenevisibleiQ9NXL6 HS

Family and domain databases

InterProiView protein in InterPro
IPR025958 SID1_TM_fam
PANTHERiPTHR12185 PTHR12185, 1 hit
PfamiView protein in Pfam
PF13965 SID-1_RNA_chan, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSIDT1_HUMAN
AccessioniPrimary (citable) accession number: Q9NXL6
Secondary accession number(s): Q17RR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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