UniProtKB - Q9NXL6 (SIDT1_HUMAN)
Protein
SID1 transmembrane family member 1
Gene
SIDT1
Organism
Homo sapiens (Human)
Status
Functioni
In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded.By similarity
GO - Molecular functioni
- cholesterol binding Source: UniProtKB
- double-stranded RNA binding Source: GO_Central
- RNA transmembrane transporter activity Source: GO_Central
GO - Biological processi
- RNA transport Source: GO_Central
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9NXL6 |
Protein family/group databases
TCDBi | 1.A.79.1.2, the cholesterol uptake protein (chup) or double stranded rna uptake family |
Names & Taxonomyi
Protein namesi | Recommended name: SID1 transmembrane family member 1 |
Gene namesi | Name:SIDT1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000072858.10 |
HGNCi | HGNC:25967, SIDT1 |
MIMi | 606816, gene |
neXtProti | NX_Q9NXL6 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Lysosome
- lysosome Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 309 | ExtracellularSequence analysisAdd BLAST | 290 | |
Transmembranei | 310 – 330 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 331 – 442 | CytoplasmicSequence analysisAdd BLAST | 112 | |
Transmembranei | 443 – 463 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 464 – 494 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 495 – 515 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 516 – 541 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 542 – 562 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 563 – 572 | ExtracellularSequence analysis | 10 | |
Transmembranei | 573 – 590 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 591 – 600 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 601 – 621 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 622 – 626 | ExtracellularSequence analysis | 5 | |
Transmembranei | 627 – 647 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 648 – 683 | CytoplasmicSequence analysisAdd BLAST | 36 | |
Transmembranei | 684 – 704 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 705 – 710 | ExtracellularSequence analysis | 6 | |
Transmembranei | 711 – 731 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 732 – 741 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 742 – 762 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 763 – 791 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 792 – 812 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 813 – 827 | CytoplasmicSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 54847 |
OpenTargetsi | ENSG00000072858 |
PharmGKBi | PA134923837 |
Miscellaneous databases
Pharosi | Q9NXL6, Tbio |
Polymorphism and mutation databases
BioMutai | SIDT1 |
DMDMi | 296452905 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000032575 | 20 – 827 | SID1 transmembrane family member 1Add BLAST | 808 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 57 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 67 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 83 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 136 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 282 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 471 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 567 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 764 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q9NXL6 |
MassIVEi | Q9NXL6 |
PaxDbi | Q9NXL6 |
PeptideAtlasi | Q9NXL6 |
PRIDEi | Q9NXL6 |
ProteomicsDBi | 83110 [Q9NXL6-1] 83111 [Q9NXL6-2] |
PTM databases
GlyGeni | Q9NXL6, 8 sites |
iPTMneti | Q9NXL6 |
PhosphoSitePlusi | Q9NXL6 |
SwissPalmi | Q9NXL6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000072858, Expressed in right hemisphere of cerebellum and 181 other tissues |
Genevisiblei | Q9NXL6, HS |
Organism-specific databases
HPAi | ENSG00000072858, Tissue enhanced (blood) |
Interactioni
Protein-protein interaction databases
IntActi | Q9NXL6, 2 interactors |
MINTi | Q9NXL6 |
STRINGi | 9606.ENSP00000264852 |
Miscellaneous databases
RNActi | Q9NXL6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the SID1 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QUXZ, Eukaryota |
GeneTreei | ENSGT00390000010091 |
HOGENOMi | CLU_357018_0_0_1 |
InParanoidi | Q9NXL6 |
OMAi | QPGQVNA |
OrthoDBi | 139174at2759 |
PhylomeDBi | Q9NXL6 |
TreeFami | TF313076 |
Family and domain databases
InterProi | View protein in InterPro IPR025958, SID1_TM_fam |
PANTHERi | PTHR12185, PTHR12185, 1 hit |
Pfami | View protein in Pfam PF13965, SID-1_RNA_chan, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9NXL6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRGCLRLALL CALPWLLLAA SPGHPAKSPR QPPAPRRDPF DAARGADFDH
60 70 80 90 100
VYSGVVNLST ENIYSFNYTS QPDQVTAVRV YVNSSSENLN YPVLVVVRQQ
110 120 130 140 150
KEVLSWQVPL LFQGLYQRSY NYQEVSRTLC PSEATNETGP LQQLIFVDVA
160 170 180 190 200
SMAPLGAQYK LLVTKLKHFQ LRTNVAFHFT ASPSQPQYFL YKFPKDVDSV
210 220 230 240 250
IIKVVSEMAY PCSVVSVQNI MCPVYDLDHN VEFNGVYQSM TKKAAITLQK
260 270 280 290 300
KDFPGEQFFV VFVIKPEDYA CGGSFFIQEK ENQTWNLQRK KNLEVTIVPS
310 320 330 340 350
IKESVYVKSS LFSVFIFLSF YLGCLLVGFV HYLRFQRKSI DGSFGSNDGS
360 370 380 390 400
GNMVASHPIA ASTPEGSNYG TIDESSSSPG RQMSSSDGGP PGQSDTDSSV
410 420 430 440 450
EESDFDTMPD IESDKNIIRT KMFLYLSDLS RKDRRIVSKK YKIYFWNIIT
460 470 480 490 500
IAVFYALPVI QLVITYQTVV NVTGNQDICY YNFLCAHPLG VLSAFNNILS
510 520 530 540 550
NLGHVLLGFL FLLIVLRRDI LHRRALEAKD IFAVEYGIPK HFGLFYAMGI
560 570 580 590 600
ALMMEGVLSA CYHVCPNYSN FQFDTSFMYM IAGLCMLKLY QTRHPDINAS
610 620 630 640 650
AYSAYASFAV VIMVTVLGVV FGKNDVWFWV IFSAIHVLAS LALSTQIYYM
660 670 680 690 700
GRFKIDLGIF RRAAMVFYTD CIQQCSRPLY MDRMVLLVVG NLVNWSFALF
710 720 730 740 750
GLIYRPRDFA SYMLGIFICN LLLYLAFYII MKLRSSEKVL PVPLFCIVAT
760 770 780 790 800
AVMWAAALYF FFQNLSSWEG TPAESREKNR ECILLDFFDD HDIWHFLSAT
810 820
ALFFSFLVLL TLDDDLDVVR RDQIPVF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 572 | Q → R in BAA90994 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061793 | 3 | G → S. Corresponds to variant dbSNP:rs9879313Ensembl. | 1 | |
Natural variantiVAR_057184 | 78 | V → M. Corresponds to variant dbSNP:rs2271496Ensembl. | 1 | |
Natural variantiVAR_057185 | 363 | T → I. Corresponds to variant dbSNP:rs33990195Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039174 | 655 | I → IDVSDT in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000181 mRNA Translation: BAA90994.1 AC055740 Genomic DNA No translation available. AC112128 Genomic DNA No translation available. BC117222 mRNA Translation: AAI17223.1 |
CCDSi | CCDS2974.1 [Q9NXL6-1] CCDS77790.1 [Q9NXL6-2] |
RefSeqi | NP_001295279.1, NM_001308350.1 [Q9NXL6-2] NP_060169.2, NM_017699.2 [Q9NXL6-1] |
Genome annotation databases
Ensembli | ENST00000264852; ENSP00000264852; ENSG00000072858 [Q9NXL6-1] ENST00000393830; ENSP00000377416; ENSG00000072858 [Q9NXL6-2] |
GeneIDi | 54847 |
KEGGi | hsa:54847 |
UCSCi | uc003eak.4, human [Q9NXL6-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000181 mRNA Translation: BAA90994.1 AC055740 Genomic DNA No translation available. AC112128 Genomic DNA No translation available. BC117222 mRNA Translation: AAI17223.1 |
CCDSi | CCDS2974.1 [Q9NXL6-1] CCDS77790.1 [Q9NXL6-2] |
RefSeqi | NP_001295279.1, NM_001308350.1 [Q9NXL6-2] NP_060169.2, NM_017699.2 [Q9NXL6-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q9NXL6, 2 interactors |
MINTi | Q9NXL6 |
STRINGi | 9606.ENSP00000264852 |
Protein family/group databases
TCDBi | 1.A.79.1.2, the cholesterol uptake protein (chup) or double stranded rna uptake family |
PTM databases
GlyGeni | Q9NXL6, 8 sites |
iPTMneti | Q9NXL6 |
PhosphoSitePlusi | Q9NXL6 |
SwissPalmi | Q9NXL6 |
Polymorphism and mutation databases
BioMutai | SIDT1 |
DMDMi | 296452905 |
Proteomic databases
jPOSTi | Q9NXL6 |
MassIVEi | Q9NXL6 |
PaxDbi | Q9NXL6 |
PeptideAtlasi | Q9NXL6 |
PRIDEi | Q9NXL6 |
ProteomicsDBi | 83110 [Q9NXL6-1] 83111 [Q9NXL6-2] |
Protocols and materials databases
Antibodypediai | 32584, 151 antibodies |
Genome annotation databases
Ensembli | ENST00000264852; ENSP00000264852; ENSG00000072858 [Q9NXL6-1] ENST00000393830; ENSP00000377416; ENSG00000072858 [Q9NXL6-2] |
GeneIDi | 54847 |
KEGGi | hsa:54847 |
UCSCi | uc003eak.4, human [Q9NXL6-1] |
Organism-specific databases
CTDi | 54847 |
DisGeNETi | 54847 |
EuPathDBi | HostDB:ENSG00000072858.10 |
GeneCardsi | SIDT1 |
HGNCi | HGNC:25967, SIDT1 |
HPAi | ENSG00000072858, Tissue enhanced (blood) |
MIMi | 606816, gene |
neXtProti | NX_Q9NXL6 |
OpenTargetsi | ENSG00000072858 |
PharmGKBi | PA134923837 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUXZ, Eukaryota |
GeneTreei | ENSGT00390000010091 |
HOGENOMi | CLU_357018_0_0_1 |
InParanoidi | Q9NXL6 |
OMAi | QPGQVNA |
OrthoDBi | 139174at2759 |
PhylomeDBi | Q9NXL6 |
TreeFami | TF313076 |
Enzyme and pathway databases
PathwayCommonsi | Q9NXL6 |
Miscellaneous databases
BioGRID-ORCSi | 54847, 2 hits in 840 CRISPR screens |
ChiTaRSi | SIDT1, human |
GenomeRNAii | 54847 |
Pharosi | Q9NXL6, Tbio |
PROi | PR:Q9NXL6 |
RNActi | Q9NXL6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000072858, Expressed in right hemisphere of cerebellum and 181 other tissues |
Genevisiblei | Q9NXL6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR025958, SID1_TM_fam |
PANTHERi | PTHR12185, PTHR12185, 1 hit |
Pfami | View protein in Pfam PF13965, SID-1_RNA_chan, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SIDT1_HUMAN | |
Accessioni | Q9NXL6Primary (citable) accession number: Q9NXL6 Secondary accession number(s): Q17RR4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2005 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations