SIDT1

Functionⁱ

In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded.By similarity

GO - Molecular functionⁱ

RNA binding Source: UniProtKB-KW
RNA transmembrane transporter activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

dsRNA transport Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding

Molecular function

RNA-binding

Protein family/group databases

TCDBⁱ	1.A.79.1.2 the cholesterol uptake protein (chup) or double stranded rna uptake family

TCDBⁱ

1.A.79.1.2 the cholesterol uptake protein (chup) or double stranded rna uptake family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SID1 transmembrane family member 1
Gene namesⁱ	Name:SIDT1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000072858.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25967 SIDT1
MIMⁱ	606816 gene
neXtProtⁱ	NX_Q9NXL6

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 309	ExtracellularSequence analysisAdd BLAST	290
Transmembraneⁱ	310 – 330	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	331 – 442	CytoplasmicSequence analysisAdd BLAST	112
Transmembraneⁱ	443 – 463	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	464 – 494	ExtracellularSequence analysisAdd BLAST	31
Transmembraneⁱ	495 – 515	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	516 – 541	CytoplasmicSequence analysisAdd BLAST	26
Transmembraneⁱ	542 – 562	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	563 – 572	ExtracellularSequence analysis	10
Transmembraneⁱ	573 – 590	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	591 – 600	CytoplasmicSequence analysis	10
Transmembraneⁱ	601 – 621	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	622 – 626	ExtracellularSequence analysis	5
Transmembraneⁱ	627 – 647	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	648 – 683	CytoplasmicSequence analysisAdd BLAST	36
Transmembraneⁱ	684 – 704	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	705 – 710	ExtracellularSequence analysis	6
Transmembraneⁱ	711 – 731	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	732 – 741	CytoplasmicSequence analysis	10
Transmembraneⁱ	742 – 762	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	763 – 791	ExtracellularSequence analysisAdd BLAST	29
Transmembraneⁱ	792 – 812	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	813 – 827	CytoplasmicSequence analysisAdd BLAST	15

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	54847
Open Targets More...OpenTargetsⁱ	ENSG00000072858
PharmGKBⁱ	PA134923837

Polymorphism and mutation databases

BioMutaⁱ	SIDT1
DMDMⁱ	296452905

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000032575	20 – 827	SID1 transmembrane family member 1Add BLAST		808

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	57	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	67	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	83	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	136	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	282	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	471	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	567	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	764	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q9NXL6
PeptideAtlas More...PeptideAtlasⁱ	Q9NXL6
PRIDEⁱ	Q9NXL6
ProteomicsDBⁱ	83110 83111 [Q9NXL6-2]

PTM databases

iPTMnetⁱ	Q9NXL6
PhosphoSitePlusⁱ	Q9NXL6
SwissPalmⁱ	Q9NXL6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000072858 Expressed in 166 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_SIDT1
Genevisibleⁱ	Q9NXL6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA035862

HPAⁱ

HPA035862

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q9NXL6, 1 interactor

IntActⁱ

Q9NXL6, 1 interactor

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NXL6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SID1 family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IF6Z Eukaryota ENOG410XPBN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010091
HOGENOMⁱ	HOG000020635
HOVERGENⁱ	HBG079188
InParanoidⁱ	Q9NXL6
OMAⁱ	FFIQEKE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01Q2
PhylomeDBⁱ	Q9NXL6
TreeFamⁱ	TF313076

Family and domain databases

InterProⁱ	View protein in InterPro IPR025958 SID1_TM_fam
PANTHERⁱ	PTHR12185 PTHR12185, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13965 SID-1_RNA_chan, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9NXL6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGCLRLALL CALPWLLLAA SPGHPAKSPR QPPAPRRDPF DAARGADFDH 
        60         70         80         90        100
VYSGVVNLST ENIYSFNYTS QPDQVTAVRV YVNSSSENLN YPVLVVVRQQ 
       110        120        130        140        150
KEVLSWQVPL LFQGLYQRSY NYQEVSRTLC PSEATNETGP LQQLIFVDVA 
       160        170        180        190        200
SMAPLGAQYK LLVTKLKHFQ LRTNVAFHFT ASPSQPQYFL YKFPKDVDSV 
       210        220        230        240        250
IIKVVSEMAY PCSVVSVQNI MCPVYDLDHN VEFNGVYQSM TKKAAITLQK 
       260        270        280        290        300
KDFPGEQFFV VFVIKPEDYA CGGSFFIQEK ENQTWNLQRK KNLEVTIVPS 
       310        320        330        340        350
IKESVYVKSS LFSVFIFLSF YLGCLLVGFV HYLRFQRKSI DGSFGSNDGS 
       360        370        380        390        400
GNMVASHPIA ASTPEGSNYG TIDESSSSPG RQMSSSDGGP PGQSDTDSSV 
       410        420        430        440        450
EESDFDTMPD IESDKNIIRT KMFLYLSDLS RKDRRIVSKK YKIYFWNIIT 
       460        470        480        490        500
IAVFYALPVI QLVITYQTVV NVTGNQDICY YNFLCAHPLG VLSAFNNILS 
       510        520        530        540        550
NLGHVLLGFL FLLIVLRRDI LHRRALEAKD IFAVEYGIPK HFGLFYAMGI 
       560        570        580        590        600
ALMMEGVLSA CYHVCPNYSN FQFDTSFMYM IAGLCMLKLY QTRHPDINAS 
       610        620        630        640        650
AYSAYASFAV VIMVTVLGVV FGKNDVWFWV IFSAIHVLAS LALSTQIYYM 
       660        670        680        690        700
GRFKIDLGIF RRAAMVFYTD CIQQCSRPLY MDRMVLLVVG NLVNWSFALF 
       710        720        730        740        750
GLIYRPRDFA SYMLGIFICN LLLYLAFYII MKLRSSEKVL PVPLFCIVAT 
       760        770        780        790        800
AVMWAAALYF FFQNLSSWEG TPAESREKNR ECILLDFFDD HDIWHFLSAT 
       810        820 
ALFFSFLVLL TLDDDLDVVR RDQIPVF

Length:827

Mass (Da):93,839

Last modified:May 18, 2010 - v2

Checksum:ⁱE7C383DF74378B8C

GO

Isoform 2 (identifier: Q9NXL6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
655-655: I → IDVSDT

« Hide

        10         20         30         40         50
MRGCLRLALL CALPWLLLAA SPGHPAKSPR QPPAPRRDPF DAARGADFDH 
        60         70         80         90        100
VYSGVVNLST ENIYSFNYTS QPDQVTAVRV YVNSSSENLN YPVLVVVRQQ 
       110        120        130        140        150
KEVLSWQVPL LFQGLYQRSY NYQEVSRTLC PSEATNETGP LQQLIFVDVA 
       160        170        180        190        200
SMAPLGAQYK LLVTKLKHFQ LRTNVAFHFT ASPSQPQYFL YKFPKDVDSV 
       210        220        230        240        250
IIKVVSEMAY PCSVVSVQNI MCPVYDLDHN VEFNGVYQSM TKKAAITLQK 
       260        270        280        290        300
KDFPGEQFFV VFVIKPEDYA CGGSFFIQEK ENQTWNLQRK KNLEVTIVPS 
       310        320        330        340        350
IKESVYVKSS LFSVFIFLSF YLGCLLVGFV HYLRFQRKSI DGSFGSNDGS 
       360        370        380        390        400
GNMVASHPIA ASTPEGSNYG TIDESSSSPG RQMSSSDGGP PGQSDTDSSV 
       410        420        430        440        450
EESDFDTMPD IESDKNIIRT KMFLYLSDLS RKDRRIVSKK YKIYFWNIIT 
       460        470        480        490        500
IAVFYALPVI QLVITYQTVV NVTGNQDICY YNFLCAHPLG VLSAFNNILS 
       510        520        530        540        550
NLGHVLLGFL FLLIVLRRDI LHRRALEAKD IFAVEYGIPK HFGLFYAMGI 
       560        570        580        590        600
ALMMEGVLSA CYHVCPNYSN FQFDTSFMYM IAGLCMLKLY QTRHPDINAS 
       610        620        630        640        650
AYSAYASFAV VIMVTVLGVV FGKNDVWFWV IFSAIHVLAS LALSTQIYYM 
       660        670        680        690        700
GRFKIDVSDT DLGIFRRAAM VFYTDCIQQC SRPLYMDRMV LLVVGNLVNW 
       710        720        730        740        750
SFALFGLIYR PRDFASYMLG IFICNLLLYL AFYIIMKLRS SEKVLPVPLF 
       760        770        780        790        800
CIVATAVMWA AALYFFFQNL SSWEGTPAES REKNRECILL DFFDDHDIWH 
       810        820        830 
FLSATALFFS FLVLLTLDDD LDVVRRDQIP VF

Note: No experimental confirmation available.

Show »

Length:832

Mass (Da):94,356

Checksum:ⁱB0709610421A9D01

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	572	Q → R in BAA90994 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_061793	3	G → S. Corresponds to variant dbSNP:rs9879313Ensembl.	1
Natural variantⁱVAR_057184	78	V → M. Corresponds to variant dbSNP:rs2271496Ensembl.	1
Natural variantⁱVAR_057185	363	T → I. Corresponds to variant dbSNP:rs33990195Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_039174	655	I → IDVSDT in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000181 mRNA Translation: BAA90994.1 AC055740 Genomic DNA No translation available. AC112128 Genomic DNA No translation available. BC117222 mRNA Translation: AAI17223.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2974.1 [Q9NXL6-1] CCDS77790.1 [Q9NXL6-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001295279.1, NM_001308350.1 [Q9NXL6-2] NP_060169.2, NM_017699.2 [Q9NXL6-1]
UniGeneⁱ	Hs.591291

Genome annotation databases

Ensemblⁱ	ENST00000264852; ENSP00000264852; ENSG00000072858 [Q9NXL6-1] ENST00000393830; ENSP00000377416; ENSG00000072858 [Q9NXL6-2]
GeneIDⁱ	54847
KEGGⁱ	hsa:54847
UCSC genome browser More...UCSCⁱ	uc003eak.4 human [Q9NXL6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NXL6	SID1 transmembrane family member 1		MOUSE		827	UniRef90_Q6AXF6
SID1 transmembrane family member 1		ICTTR		836
SID1 transmembrane family member 1		MACMU		832
SID1 transmembrane family member 1		MACFA		832
SID1 transmembrane family member 1		MACNE		832
+103

Protein	Similar proteins		Species	Score	Length	Source
Q9NXL6	SID1 transmembrane family member 1		MOUSE		827	UniRef50_Q6AXF6
SID1 transmembrane family member 1		ICTTR		836
SID1 transmembrane family member 1		HETGA		832
SID1 transmembrane family member 1		GORGO		832
SID1 transmembrane family member 1		CHLSB		832
+105

Entry informationⁱ

Entry nameⁱ	SIDT1_HUMAN
Accessionⁱ	Q9NXL6Primary (citable) accession number: Q9NXL6 Secondary accession number(s): Q17RR4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
	Last sequence update:	May 18, 2010
	Last modified:	September 12, 2018
	This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NXL6 (SIDT1_HUMAN)

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SID1 transmembrane family member 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ