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UniProtKB - Q9NXL6 (SIDT1_HUMAN)

Entry version 125 (02 Dec 2020)
Sequence version 2 (18 May 2010)
Previous versions | rss
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Protein

SID1 transmembrane family member 1

Gene

SIDT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NXL6

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.79.1.2, the cholesterol uptake protein (chup) or double stranded rna uptake family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SID1 transmembrane family member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIDT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000072858.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:25967, SIDT1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606816, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NXL6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 309ExtracellularSequence analysisAdd BLAST290
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 442CytoplasmicSequence analysisAdd BLAST112
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Topological domaini464 – 494ExtracellularSequence analysisAdd BLAST31
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
Topological domaini516 – 541CytoplasmicSequence analysisAdd BLAST26
Transmembranei542 – 562HelicalSequence analysisAdd BLAST21
Topological domaini563 – 572ExtracellularSequence analysis10
Transmembranei573 – 590HelicalSequence analysisAdd BLAST18
Topological domaini591 – 600CytoplasmicSequence analysis10
Transmembranei601 – 621HelicalSequence analysisAdd BLAST21
Topological domaini622 – 626ExtracellularSequence analysis5
Transmembranei627 – 647HelicalSequence analysisAdd BLAST21
Topological domaini648 – 683CytoplasmicSequence analysisAdd BLAST36
Transmembranei684 – 704HelicalSequence analysisAdd BLAST21
Topological domaini705 – 710ExtracellularSequence analysis6
Transmembranei711 – 731HelicalSequence analysisAdd BLAST21
Topological domaini732 – 741CytoplasmicSequence analysis10
Transmembranei742 – 762HelicalSequence analysisAdd BLAST21
Topological domaini763 – 791ExtracellularSequence analysisAdd BLAST29
Transmembranei792 – 812HelicalSequence analysisAdd BLAST21
Topological domaini813 – 827CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		54847

Open Targets

More...OpenTargetsi		ENSG00000072858

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134923837

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NXL6, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SIDT1

Domain mapping of disease mutations (DMDM)

More...DMDMi		296452905

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003257520 – 827SID1 transmembrane family member 1Add BLAST808

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi282N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi764N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NXL6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NXL6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NXL6

PeptideAtlas

More...PeptideAtlasi		Q9NXL6

PRoteomics IDEntifications database

More...PRIDEi		Q9NXL6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83110 [Q9NXL6-1]
83111 [Q9NXL6-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NXL6, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NXL6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NXL6

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9NXL6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000072858, Expressed in right hemisphere of cerebellum and 181 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NXL6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000072858, Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9NXL6, 2 interactors

Molecular INTeraction database

More...MINTi		Q9NXL6

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000264852

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NXL6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SID1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUXZ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000010091

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_357018_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NXL6

Identification of Orthologs from Complete Genome Data

More...OMAi		QPGQVNA

Database of Orthologous Groups

More...OrthoDBi		139174at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NXL6

TreeFam database of animal gene trees

More...TreeFami		TF313076

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025958, SID1_TM_fam

The PANTHER Classification System

More...PANTHERi		PTHR12185, PTHR12185, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13965, SID-1_RNA_chan, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NXL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGCLRLALL CALPWLLLAA SPGHPAKSPR QPPAPRRDPF DAARGADFDH 
        60         70         80         90        100
VYSGVVNLST ENIYSFNYTS QPDQVTAVRV YVNSSSENLN YPVLVVVRQQ 
       110        120        130        140        150
KEVLSWQVPL LFQGLYQRSY NYQEVSRTLC PSEATNETGP LQQLIFVDVA 
       160        170        180        190        200
SMAPLGAQYK LLVTKLKHFQ LRTNVAFHFT ASPSQPQYFL YKFPKDVDSV 
       210        220        230        240        250
IIKVVSEMAY PCSVVSVQNI MCPVYDLDHN VEFNGVYQSM TKKAAITLQK 
       260        270        280        290        300
KDFPGEQFFV VFVIKPEDYA CGGSFFIQEK ENQTWNLQRK KNLEVTIVPS 
       310        320        330        340        350
IKESVYVKSS LFSVFIFLSF YLGCLLVGFV HYLRFQRKSI DGSFGSNDGS 
       360        370        380        390        400
GNMVASHPIA ASTPEGSNYG TIDESSSSPG RQMSSSDGGP PGQSDTDSSV 
       410        420        430        440        450
EESDFDTMPD IESDKNIIRT KMFLYLSDLS RKDRRIVSKK YKIYFWNIIT 
       460        470        480        490        500
IAVFYALPVI QLVITYQTVV NVTGNQDICY YNFLCAHPLG VLSAFNNILS 
       510        520        530        540        550
NLGHVLLGFL FLLIVLRRDI LHRRALEAKD IFAVEYGIPK HFGLFYAMGI 
       560        570        580        590        600
ALMMEGVLSA CYHVCPNYSN FQFDTSFMYM IAGLCMLKLY QTRHPDINAS 
       610        620        630        640        650
AYSAYASFAV VIMVTVLGVV FGKNDVWFWV IFSAIHVLAS LALSTQIYYM 
       660        670        680        690        700
GRFKIDLGIF RRAAMVFYTD CIQQCSRPLY MDRMVLLVVG NLVNWSFALF 
       710        720        730        740        750
GLIYRPRDFA SYMLGIFICN LLLYLAFYII MKLRSSEKVL PVPLFCIVAT 
       760        770        780        790        800
AVMWAAALYF FFQNLSSWEG TPAESREKNR ECILLDFFDD HDIWHFLSAT 
       810        820 
ALFFSFLVLL TLDDDLDVVR RDQIPVF
Length:827
Mass (Da):93,839
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7C383DF74378B8C
GO
Isoform 2 (identifier: Q9NXL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     655-655: I → IDVSDT

Show »
Length:832
Mass (Da):94,356
Checksum:iB0709610421A9D01
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti572Q → R in BAA90994 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0617933G → S. Corresponds to variant dbSNP:rs9879313Ensembl.1
Natural variantiVAR_05718478V → M. Corresponds to variant dbSNP:rs2271496Ensembl.1
Natural variantiVAR_057185363T → I. Corresponds to variant dbSNP:rs33990195Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039174655I → IDVSDT in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK000181 mRNA Translation: BAA90994.1
AC055740 Genomic DNA No translation available.
AC112128 Genomic DNA No translation available.
BC117222 mRNA Translation: AAI17223.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2974.1 [Q9NXL6-1]
CCDS77790.1 [Q9NXL6-2]

NCBI Reference Sequences

More...RefSeqi		NP_001295279.1, NM_001308350.1 [Q9NXL6-2]
NP_060169.2, NM_017699.2 [Q9NXL6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264852; ENSP00000264852; ENSG00000072858 [Q9NXL6-1]
ENST00000393830; ENSP00000377416; ENSG00000072858 [Q9NXL6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54847

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54847

UCSC genome browser

More...UCSCi		uc003eak.4, human [Q9NXL6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000181 mRNA Translation: BAA90994.1
AC055740 Genomic DNA No translation available.
AC112128 Genomic DNA No translation available.
BC117222 mRNA Translation: AAI17223.1
CCDSiCCDS2974.1 [Q9NXL6-1]
CCDS77790.1 [Q9NXL6-2]
RefSeqiNP_001295279.1, NM_001308350.1 [Q9NXL6-2]
NP_060169.2, NM_017699.2 [Q9NXL6-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9NXL6, 2 interactors
MINTiQ9NXL6
STRINGi9606.ENSP00000264852

Protein family/group databases

TCDBi1.A.79.1.2, the cholesterol uptake protein (chup) or double stranded rna uptake family

PTM databases

GlyGeniQ9NXL6, 8 sites
iPTMnetiQ9NXL6
PhosphoSitePlusiQ9NXL6
SwissPalmiQ9NXL6

Polymorphism and mutation databases

BioMutaiSIDT1
DMDMi296452905

Proteomic databases

jPOSTiQ9NXL6
MassIVEiQ9NXL6
PaxDbiQ9NXL6
PeptideAtlasiQ9NXL6
PRIDEiQ9NXL6
ProteomicsDBi83110 [Q9NXL6-1]
83111 [Q9NXL6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32584, 151 antibodies

Genome annotation databases

EnsembliENST00000264852; ENSP00000264852; ENSG00000072858 [Q9NXL6-1]
ENST00000393830; ENSP00000377416; ENSG00000072858 [Q9NXL6-2]
GeneIDi54847
KEGGihsa:54847
UCSCiuc003eak.4, human [Q9NXL6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54847
DisGeNETi54847
EuPathDBiHostDB:ENSG00000072858.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		SIDT1
HGNCiHGNC:25967, SIDT1
HPAiENSG00000072858, Tissue enhanced (blood)
MIMi606816, gene
neXtProtiNX_Q9NXL6
OpenTargetsiENSG00000072858
PharmGKBiPA134923837

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QUXZ, Eukaryota
GeneTreeiENSGT00390000010091
HOGENOMiCLU_357018_0_0_1
InParanoidiQ9NXL6
OMAiQPGQVNA
OrthoDBi139174at2759
PhylomeDBiQ9NXL6
TreeFamiTF313076

Enzyme and pathway databases

PathwayCommonsiQ9NXL6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54847, 2 hits in 840 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SIDT1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54847
PharosiQ9NXL6, Tbio

Protein Ontology

More...PROi		PR:Q9NXL6
RNActiQ9NXL6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000072858, Expressed in right hemisphere of cerebellum and 181 other tissues
GenevisibleiQ9NXL6, HS

Family and domain databases

InterProiView protein in InterPro
IPR025958, SID1_TM_fam
PANTHERiPTHR12185, PTHR12185, 1 hit
PfamiView protein in Pfam
PF13965, SID-1_RNA_chan, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIDT1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NXL6
Secondary accession number(s): Q17RR4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 18, 2010
Last modified: December 2, 2020
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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