Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 133 (26 Feb 2020)
Sequence version 2 (19 Mar 2014)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Rho guanine nucleotide exchange factor 38

Gene

ARHGEF38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a guanine-nucleotide releasing factor.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 38
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25968 ARHGEF38

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NXL2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54848

Open Targets

More...
OpenTargetsi
ENSG00000236699

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165663186

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NXL2 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGEF38

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74725339

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003189871 – 777Rho guanine nucleotide exchange factor 38Add BLAST777

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei34PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NXL2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NXL2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NXL2

PeptideAtlas

More...
PeptideAtlasi
Q9NXL2

PRoteomics IDEntifications database

More...
PRIDEi
Q9NXL2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
10314
83109 [Q9NXL2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NXL2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NXL2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000236699 Expressed in body of pancreas and 85 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NXL2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036510
HPA045484

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120198, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NXL2, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000416125

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NXL2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NXL2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini94 – 285DHPROSITE-ProRule annotationAdd BLAST192
Domaini327 – 536BARPROSITE-ProRule annotationAdd BLAST210
Domaini582 – 645SH3 1PROSITE-ProRule annotationAdd BLAST64
Domaini713 – 776SH3 2PROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi689 – 694Poly-Ser6

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3519 Eukaryota
ENOG410XWZ2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183088

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_107855_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NXL2

KEGG Orthology (KO)

More...
KOi
K20711

Identification of Orthologs from Complete Genome Data

More...
OMAi
NPCHDFA

Database of Orthologous Groups

More...
OrthoDBi
207472at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NXL2

TreeFam database of animal gene trees

More...
TreeFami
TF317245

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.60, 1 hit
1.20.900.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR004148 BAR_dom
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00621 RhoGEF, 1 hit
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00721 BAR, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657 SSF103657, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51021 BAR, 1 hit
PS50010 DH_2, 1 hit
PS50002 SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 2 (identifier: Q9NXL2-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPKEATGKE NMVTKKKNLA FLRSRLYMLE RRKTDTVVES SVSGDHSGTL
60 70 80 90 100
RRSQSDRTEY NQKLQEKMTP QGECSVAETL TPEEEHHMKR MMAKREKIIK
110 120 130 140 150
ELIQTEKDYL NDLELCVREV VQPLRNKKTD RLDVDSLFSN IESVHQISAK
160 170 180 190 200
LLSLLEEATT DVEPAMQVIG EVFLQIKGPL EDIYKIYCYH HDEAHSILES
210 220 230 240 250
YEKEEELKEH LSHCIQSLKK IYMQEGKPNL LDMGSLMIKP IQRVMKYPLL
260 270 280 290 300
LCELRNSTPP SHPDYRALDD AFAAVKDINV NINELKRRKD LVLKYKKNDE
310 320 330 340 350
DESLKDKLSK LNIHSISKKS KRVTNHLKIL TRGESQVKDN TFNREEKLFR
360 370 380 390 400
ALEKTVRLCV KNISLCLQHI QDAMPLALQS VMDLQEISYN KDDEMDYSET
410 420 430 440 450
LSNALNSCHD FASHLQRLIL TPLSALLSLF PGPHKLIQKR YDKLLDCNSY
460 470 480 490 500
LQRSTGEESD LAKKEYEALN AQLVEELQAF NQAARKILLN CLCSFITLLR
510 520 530 540 550
DLMLVAQQAY STLVPMPLLV SSISEIQNQV LEEIQNLNCV KENSATFIER
560 570 580 590 600
KLSFEKKKPV QILPEMPHQT DIHRSKLLST YSAEELYQAK RKCNATQEYD
610 620 630 640 650
INLLEGDLVA VIEQKDPLGS TSRWLVDTGN VKGYVYSSFL KPYNPAKMQK
660 670 680 690 700
VDAENRFCDD DFENISLFVS SRPASDSVTG TSESSIGDSS SSLSGTCGKF
710 720 730 740 750
ETNGTDVDSF QEVDEQIFYA VHAFQARSDH ELSLQEYQRV HILRFCDLSG
760 770
NKEWWLAEAQ GQKGYVPANY LGKMTYA
Length:777
Mass (Da):89,078
Last modified:March 19, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35F411FFD7704DFF
GO
Isoform 1 (identifier: Q9NXL2-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-777: Missing.

Show »
Length:219
Mass (Da):25,507
Checksum:iE997676477D9322D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03892867K → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_03892988M → V. Corresponds to variant dbSNP:rs2276970Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053830220 – 777Missing in isoform 1. 1 PublicationAdd BLAST558

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000191 mRNA Translation: BAA90998.1
AC004066 Genomic DNA No translation available.
AC105391 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX06187.1
BC105695 mRNA Translation: AAI05696.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3670.1 [Q9NXL2-1]
CCDS56338.1 [Q9NXL2-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001229658.1, NM_001242729.1 [Q9NXL2-2]
NP_060170.1, NM_017700.1 [Q9NXL2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265154; ENSP00000265154; ENSG00000236699 [Q9NXL2-1]
ENST00000420470; ENSP00000416125; ENSG00000236699 [Q9NXL2-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54848

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54848

UCSC genome browser

More...
UCSCi
uc003hxu.3 human [Q9NXL2-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000191 mRNA Translation: BAA90998.1
AC004066 Genomic DNA No translation available.
AC105391 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX06187.1
BC105695 mRNA Translation: AAI05696.1
CCDSiCCDS3670.1 [Q9NXL2-1]
CCDS56338.1 [Q9NXL2-2]
RefSeqiNP_001229658.1, NM_001242729.1 [Q9NXL2-2]
NP_060170.1, NM_017700.1 [Q9NXL2-1]

3D structure databases

SMRiQ9NXL2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120198, 4 interactors
IntActiQ9NXL2, 4 interactors
STRINGi9606.ENSP00000416125

PTM databases

iPTMnetiQ9NXL2
PhosphoSitePlusiQ9NXL2

Polymorphism and mutation databases

BioMutaiARHGEF38
DMDMi74725339

Proteomic databases

jPOSTiQ9NXL2
MassIVEiQ9NXL2
PaxDbiQ9NXL2
PeptideAtlasiQ9NXL2
PRIDEiQ9NXL2
ProteomicsDBi10314
83109 [Q9NXL2-2]

Genome annotation databases

EnsembliENST00000265154; ENSP00000265154; ENSG00000236699 [Q9NXL2-1]
ENST00000420470; ENSP00000416125; ENSG00000236699 [Q9NXL2-2]
GeneIDi54848
KEGGihsa:54848
UCSCiuc003hxu.3 human [Q9NXL2-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54848
DisGeNETi54848

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARHGEF38
HGNCiHGNC:25968 ARHGEF38
HPAiHPA036510
HPA045484
neXtProtiNX_Q9NXL2
OpenTargetsiENSG00000236699
PharmGKBiPA165663186

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3519 Eukaryota
ENOG410XWZ2 LUCA
GeneTreeiENSGT00950000183088
HOGENOMiCLU_107855_1_0_1
InParanoidiQ9NXL2
KOiK20711
OMAiNPCHDFA
OrthoDBi207472at2759
PhylomeDBiQ9NXL2
TreeFamiTF317245

Enzyme and pathway databases

ReactomeiR-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARHGEF38 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54848
PharosiQ9NXL2 Tdark

Protein Ontology

More...
PROi
PR:Q9NXL2
RNActiQ9NXL2 protein

Gene expression databases

BgeeiENSG00000236699 Expressed in body of pancreas and 85 other tissues
GenevisibleiQ9NXL2 HS

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.1270.60, 1 hit
1.20.900.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR004148 BAR_dom
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit
PS50010 DH_2, 1 hit
PS50002 SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARH38_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NXL2
Secondary accession number(s): C9JIB4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 19, 2014
Last modified: February 26, 2020
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again