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Protein

RING finger protein 186

Gene

RNF186

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri40 – 86RING-typePROSITE-ProRule annotationAdd BLAST47

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 186
Gene namesi
Name:RNF186
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000178828.6
HGNCiHGNC:25978 RNF186
neXtProtiNX_Q9NXI6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54546
OpenTargetsiENSG00000178828
PharmGKBiPA142671057

Polymorphism and mutation databases

BioMutaiRNF186
DMDMi74761796

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002616241 – 227RING finger protein 186Add BLAST227

Proteomic databases

PaxDbiQ9NXI6
PeptideAtlasiQ9NXI6
PRIDEiQ9NXI6
ProteomicsDBi83103

PTM databases

iPTMnetiQ9NXI6
PhosphoSitePlusiQ9NXI6

Expressioni

Gene expression databases

BgeeiENSG00000178828
CleanExiHS_RNF186
GenevisibleiQ9NXI6 HS

Organism-specific databases

HPAiHPA034547
HPA035558

Interactioni

Protein-protein interaction databases

BioGridi120033, 3 interactors
IntActiQ9NXI6, 4 interactors
STRINGi9606.ENSP00000364263

Structurei

3D structure databases

ProteinModelPortaliQ9NXI6
SMRiQ9NXI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri40 – 86RING-typePROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00510000049175
HOGENOMiHOG000231633
HOVERGENiHBG080364
InParanoidiQ9NXI6
OMAiECLVCRE
OrthoDBiEOG091G0KUF
PhylomeDBiQ9NXI6
TreeFamiTF331690

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR038878 RNF186
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR16450 PTHR16450, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NXI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACTKTLQQS QPISAGATTT TTAVAPAGGH SGSTECDLEC LVCREPYSCP
60 70 80 90 100
RLPKLLACQH AFCAICLKLL LCVQDNTWSI TCPLCRKVTA VPGGLICSLR
110 120 130 140 150
DHEAVVGQLA QPCTEVSLCP QGLVDPADLA AGHPSLVGED GQDEVSANHV
160 170 180 190 200
AARRLAAHLL LLALLIILIG PFIYPGVLRW VLTFIIALAL LMSTLFCCLP
210 220
STRGSCWPSS RTLFCREQKH SHISSIA
Length:227
Mass (Da):24,145
Last modified:October 1, 2000 - v1
Checksum:iB856398C3C73DE3A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209S → P in BAD96711 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02946023A → T. Corresponds to variant dbSNP:rs1541185Ensembl.1
Natural variantiVAR_052111208P → T. Corresponds to variant dbSNP:rs35541730Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000232 mRNA Translation: BAA91024.1
CR457228 mRNA Translation: CAG33509.1
AK222991 mRNA Translation: BAD96711.1
AL391883 Genomic DNA No translation available.
BC030960 mRNA Translation: AAH30960.1
BC051880 mRNA Translation: AAH51880.1
CCDSiCCDS199.1
RefSeqiNP_061935.1, NM_019062.1
UniGeneiHs.124835

Genome annotation databases

EnsembliENST00000375121; ENSP00000364263; ENSG00000178828
GeneIDi54546
KEGGihsa:54546
UCSCiuc001bcr.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRN186_HUMAN
AccessioniPrimary (citable) accession number: Q9NXI6
Secondary accession number(s): Q53GE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: July 18, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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