Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

THUMP domain-containing protein 1

Gene

THUMPD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation (PubMed:25653167).1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
THUMP domain-containing protein 1
Gene namesi
Name:THUMPD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000066654.12
HGNCiHGNC:23807 THUMPD1
MIMi616662 gene
neXtProtiNX_Q9NXG2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi55623
OpenTargetsiENSG00000066654
PharmGKBiPA134983093

Polymorphism and mutation databases

BioMutaiTHUMPD1
DMDMi61248576

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000725302 – 353THUMP domain-containing protein 1Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei79PhosphothreonineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei88PhosphoserineCombined sources1
Modified residuei119PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NXG2
MaxQBiQ9NXG2
PaxDbiQ9NXG2
PeptideAtlasiQ9NXG2
PRIDEiQ9NXG2
ProteomicsDBi83094

PTM databases

iPTMnetiQ9NXG2
PhosphoSitePlusiQ9NXG2

Expressioni

Gene expression databases

BgeeiENSG00000066654
CleanExiHS_THUMPD1
ExpressionAtlasiQ9NXG2 baseline and differential
GenevisibleiQ9NXG2 HS

Organism-specific databases

HPAiHPA027851

Interactioni

Subunit structurei

Interacts with NAT10 (PubMed:25653167).1 Publication

Protein-protein interaction databases

BioGridi120762, 25 interactors
IntActiQ9NXG2, 3 interactors
MINTiQ9NXG2
STRINGi9606.ENSP00000370741

Structurei

Secondary structure

1353
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi171 – 188Combined sources18
Beta strandi195 – 201Combined sources7
Helixi210 – 224Combined sources15
Beta strandi232 – 234Combined sources3
Beta strandi236 – 244Combined sources9
Beta strandi247 – 254Combined sources8

3D structure databases

ProteinModelPortaliQ9NXG2
SMRiQ9NXG2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NXG2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini147 – 254THUMPPROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Belongs to the THUMPD1 family.Curated

Phylogenomic databases

eggNOGiKOG3943 Eukaryota
COG1818 LUCA
GeneTreeiENSGT00390000002365
HOGENOMiHOG000139150
HOVERGENiHBG053030
InParanoidiQ9NXG2
KOiK06963
OMAiCTLNSEN
OrthoDBiEOG091G0JZV
PhylomeDBiQ9NXG2
TreeFamiTF313884

Family and domain databases

InterProiView protein in InterPro
IPR004114 THUMP_dom
PfamiView protein in Pfam
PF02926 THUMP, 1 hit
SMARTiView protein in SMART
SM00981 THUMP, 1 hit
PROSITEiView protein in PROSITE
PS51165 THUMP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NXG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPAQQTTQ PGGGKRKGKA QYVLAKRARR CDAGGPRQLE PGLQGILITC
60 70 80 90 100
NMNERKCVEE AYSLLNEYGD DMYGPEKFTD KDQQPSGSEG EDDDAEAALK
110 120 130 140 150
KEVGDIKAST EMRLRRFQSV ESGANNVVFI RTLGIEPEKL VHHILQDMYK
160 170 180 190 200
TKKKKTRVIL RMLPISGTCK AFLEDMKKYA ETFLEPWFKA PNKGTFQIVY
210 220 230 240 250
KSRNNSHVNR EEVIRELAGI VCTLNSENKV DLTNPQYTVV VEIIKAVCCL
260 270 280 290 300
SVVKDYMLFR KYNLQEVVKS PKDPSQLNSK QGNGKEAKLE SADKSDQNNT
310 320 330 340 350
AEGKNNQQVP ENTEELGQTK PTSNPQVVNE GGAKPELASQ ATEGSKSNEN

DFS
Length:353
Mass (Da):39,315
Last modified:July 5, 2004 - v2
Checksum:i7F0BBD91D204AA1B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84Q → R in BAA91050 (PubMed:14702039).Curated1
Sequence conflicti285K → E in BAA91050 (PubMed:14702039).Curated1
Sequence conflicti352F → S in BAA91050 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037645311E → D. Corresponds to variant dbSNP:rs11074471Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000281 mRNA Translation: BAA91050.1
AC004381 Genomic DNA No translation available.
BC000448 mRNA Translation: AAH00448.1
CCDSiCCDS10588.1
RefSeqiNP_001291479.1, NM_001304550.1
NP_060206.2, NM_017736.4
XP_016878922.1, XM_017023433.1
UniGeneiHs.700004

Genome annotation databases

EnsembliENST00000381337; ENSP00000370741; ENSG00000066654
ENST00000396083; ENSP00000379392; ENSG00000066654
ENST00000636554; ENSP00000490841; ENSG00000066654
GeneIDi55623
KEGGihsa:55623
UCSCiuc002dho.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTHUM1_HUMAN
AccessioniPrimary (citable) accession number: Q9NXG2
Secondary accession number(s): Q9BWC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health