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Protein

Palmitoyltransferase ZDHHC7

Gene

ZDHHC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Palmitoyltransferase with broad specificity (PubMed:22031296, PubMed:28196865). Palmitoylates JAM3 (PubMed:28196865). Palmitoylates SNAP25 and DLG4/PSD95 (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity).By similarity2 Publications

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.2 Publications

GO - Molecular functioni

GO - Biological processi

  • peptidyl-L-cysteine S-palmitoylation Source: UniProtKB
  • protein palmitoylation Source: UniProtKB
  • protein targeting to membrane Source: GO_Central

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC7Curated (EC:2.3.1.2252 Publications)
Alternative name(s):
Zinc finger DHHC domain-containing protein 7Imported
Short name:
DHHC-71 Publication
Gene namesi
Name:ZDHHC7Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000153786.12
HGNCiHGNC:18459 ZDHHC7
MIMi614604 gene
neXtProtiNX_Q9NXF8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55625
OpenTargetsiENSG00000153786
PharmGKBiPA38335

Polymorphism and mutation databases

BioMutaiZDHHC7
DMDMi116242853

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128741 – 308Palmitoyltransferase ZDHHC7Add BLAST308

Post-translational modificationi

Autopalmitoylated.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiQ9NXF8
MaxQBiQ9NXF8
PeptideAtlasiQ9NXF8
PRIDEiQ9NXF8
ProteomicsDBi83089
83090 [Q9NXF8-2]

PTM databases

iPTMnetiQ9NXF8
PhosphoSitePlusiQ9NXF8

Expressioni

Gene expression databases

BgeeiENSG00000153786 Expressed in 240 organ(s), highest expression level in secondary oocyte
CleanExiHS_ZDHHC7
ExpressionAtlasiQ9NXF8 baseline and differential
GenevisibleiQ9NXF8 HS

Organism-specific databases

HPAiHPA019215
HPA059054
HPA059642

Interactioni

Protein-protein interaction databases

BioGridi120764, 11 interactors
IntActiQ9NXF8, 5 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9NXF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 180DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00880000137864
HOGENOMiHOG000234755
HOVERGENiHBG056583
InParanoidiQ9NXF8
KOiK20029
OMAiNGVLFNC
OrthoDBiEOG091G0CME
PhylomeDBiQ9NXF8
TreeFamiTF319798

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NXF8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPSGHRLRD VEHHPLLAEN DNYDSSSSSS SEADVADRVW FIRDGCGMIC
60 70 80 90 100
AVMTWLLVAY ADFVVTFVML LPSKDFWYSV VNGVIFNCLA VLALSSHLRT
110 120 130 140 150
MLTDPGAVPK GNATKEYMES LQLKPGEVIY KCPKCCCIKP ERAHHCSICK
160 170 180 190 200
RCIRKMDHHC PWVNNCVGEK NQRFFVLFTM YIALSSVHAL ILCGFQFISC
210 220 230 240 250
VRGQWTECSD FSPPITVILL IFLCLEGLLF FTFTAVMFGT QIHSICNDET
260 270 280 290 300
EIERLKSEKP TWERRLRWEG MKSVFGGPPS LLWMNPFVGF RFRRLPTRPR

KGGPEFSV
Length:308
Mass (Da):35,140
Last modified:October 17, 2006 - v2
Checksum:i0E4F2E69A62C90C3
GO
Isoform 2 (identifier: Q9NXF8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-105: P → PEKSSDCRPSACTVKTGLDPTLVGICGEGTESVQSLLL

Show »
Length:345
Mass (Da):38,917
Checksum:i70448128ABCF6626
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BNQ9H3BNQ9_HUMAN
Palmitoyltransferase
ZDHHC7
141Annotation score:
H3BMI0H3BMI0_HUMAN
Palmitoyltransferase ZDHHC7
ZDHHC7
95Annotation score:

Sequence cautioni

The sequence AAH17702 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91814 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22N → D in BAA91055 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03626144D → N in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_028360201V → I. Corresponds to variant dbSNP:rs13334011Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006942105P → PEKSSDCRPSACTVKTGLDP TLVGICGEGTESVQSLLL in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000286 mRNA Translation: BAA91055.1
AK001654 mRNA Translation: BAA91814.1 Different initiation.
CH471114 Genomic DNA Translation: EAW95464.1
CH471114 Genomic DNA Translation: EAW95465.1
BC017702 mRNA Translation: AAH17702.1 Different initiation.
BC018772 mRNA Translation: AAH18772.1
CCDSiCCDS10950.1 [Q9NXF8-1]
CCDS45538.1 [Q9NXF8-2]
RefSeqiNP_001139020.1, NM_001145548.1 [Q9NXF8-2]
NP_060210.2, NM_017740.2 [Q9NXF8-1]
UniGeneiHs.461610
Hs.723447

Genome annotation databases

EnsembliENST00000313732; ENSP00000315604; ENSG00000153786 [Q9NXF8-1]
ENST00000344861; ENSP00000341681; ENSG00000153786 [Q9NXF8-2]
ENST00000564466; ENSP00000456782; ENSG00000153786 [Q9NXF8-2]
GeneIDi55625
KEGGihsa:55625
UCSCiuc002fiq.3 human [Q9NXF8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000286 mRNA Translation: BAA91055.1
AK001654 mRNA Translation: BAA91814.1 Different initiation.
CH471114 Genomic DNA Translation: EAW95464.1
CH471114 Genomic DNA Translation: EAW95465.1
BC017702 mRNA Translation: AAH17702.1 Different initiation.
BC018772 mRNA Translation: AAH18772.1
CCDSiCCDS10950.1 [Q9NXF8-1]
CCDS45538.1 [Q9NXF8-2]
RefSeqiNP_001139020.1, NM_001145548.1 [Q9NXF8-2]
NP_060210.2, NM_017740.2 [Q9NXF8-1]
UniGeneiHs.461610
Hs.723447

3D structure databases

ProteinModelPortaliQ9NXF8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120764, 11 interactors
IntActiQ9NXF8, 5 interactors

PTM databases

iPTMnetiQ9NXF8
PhosphoSitePlusiQ9NXF8

Polymorphism and mutation databases

BioMutaiZDHHC7
DMDMi116242853

Proteomic databases

EPDiQ9NXF8
MaxQBiQ9NXF8
PeptideAtlasiQ9NXF8
PRIDEiQ9NXF8
ProteomicsDBi83089
83090 [Q9NXF8-2]

Protocols and materials databases

DNASUi55625
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313732; ENSP00000315604; ENSG00000153786 [Q9NXF8-1]
ENST00000344861; ENSP00000341681; ENSG00000153786 [Q9NXF8-2]
ENST00000564466; ENSP00000456782; ENSG00000153786 [Q9NXF8-2]
GeneIDi55625
KEGGihsa:55625
UCSCiuc002fiq.3 human [Q9NXF8-1]

Organism-specific databases

CTDi55625
DisGeNETi55625
EuPathDBiHostDB:ENSG00000153786.12
GeneCardsiZDHHC7
HGNCiHGNC:18459 ZDHHC7
HPAiHPA019215
HPA059054
HPA059642
MIMi614604 gene
neXtProtiNX_Q9NXF8
OpenTargetsiENSG00000153786
PharmGKBiPA38335
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00880000137864
HOGENOMiHOG000234755
HOVERGENiHBG056583
InParanoidiQ9NXF8
KOiK20029
OMAiNGVLFNC
OrthoDBiEOG091G0CME
PhylomeDBiQ9NXF8
TreeFamiTF319798

Miscellaneous databases

ChiTaRSiZDHHC7 human
GenomeRNAii55625
PROiPR:Q9NXF8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153786 Expressed in 240 organ(s), highest expression level in secondary oocyte
CleanExiHS_ZDHHC7
ExpressionAtlasiQ9NXF8 baseline and differential
GenevisibleiQ9NXF8 HS

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZDHC7_HUMAN
AccessioniPrimary (citable) accession number: Q9NXF8
Secondary accession number(s): D3DUM1, Q8WV42, Q9NVD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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