Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Testis-expressed protein 10

Gene

TEX10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211).2 Publications

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed protein 10
Gene namesi
Name:TEX10
ORF Names:L18, Nbla10363
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136891.13
HGNCiHGNC:25988 TEX10
neXtProtiNX_Q9NXF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136891
PharmGKBiPA134991964

Polymorphism and mutation databases

BioMutaiTEX10
DMDMi71153593

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724911 – 929Testis-expressed protein 10Add BLAST929

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NXF1
MaxQBiQ9NXF1
PaxDbiQ9NXF1
PeptideAtlasiQ9NXF1
PRIDEiQ9NXF1
ProteomicsDBi83086
83087 [Q9NXF1-2]

2D gel databases

SWISS-2DPAGEiQ9NXF1

PTM databases

iPTMnetiQ9NXF1
PhosphoSitePlusiQ9NXF1
SwissPalmiQ9NXF1

Expressioni

Gene expression databases

BgeeiENSG00000136891 Expressed in 205 organ(s), highest expression level in kidney
CleanExiHS_TEX10
ExpressionAtlasiQ9NXF1 baseline and differential
GenevisibleiQ9NXF1 HS

Interactioni

Subunit structurei

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles (PubMed:21326211).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SENP3Q9H4L42EBI-2371062,EBI-2880236

Protein-protein interaction databases

BioGridi120229, 54 interactors
CORUMiQ9NXF1
IntActiQ9NXF1, 31 interactors
MINTiQ9NXF1
STRINGi9606.ENSP00000364037

Structurei

3D structure databases

ProteinModelPortaliQ9NXF1
SMRiQ9NXF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati99 – 137HEATAdd BLAST39

Sequence similaritiesi

Belongs to the IPI1/TEX10 family.Curated

Phylogenomic databases

eggNOGiKOG2149 Eukaryota
ENOG410YR7T LUCA
GeneTreeiENSGT00390000012654
HOGENOMiHOG000133040
HOVERGENiHBG083741
InParanoidiQ9NXF1
KOiK14827
OMAiTNKSIKH
OrthoDBiEOG091G0EBA
PhylomeDBiQ9NXF1
TreeFamiTF318197

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021133 HEAT_type_2
IPR024679 Ipi1_N
IPR037947 TEX10/Ipi1
PANTHERiPTHR16056:SF2 PTHR16056:SF2, 1 hit
PfamiView protein in Pfam
PF12333 Ipi1_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NXF1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTKKRKRQHD FQKVKLKVGK KKPKLQNATP TNFKTKTIHL PEQLKEDGTL
60 70 80 90 100
PTNNRKLNIK DLLSQMHHYN AGVKQSALLG LKDLLSQYPF IIDAHLSNIL
110 120 130 140 150
SEVTAVFTDK DANVRLAAVQ LLQFLAPKIR AEQISPFFPL VSAHLSSAMT
160 170 180 190 200
HITEGIQEDS LKVLDILLEQ YPALITGRSS ILLKNFVELI SHQQLSKGLI
210 220 230 240 250
NRDRSQSWIL SVNPNRRLTS QQWRLKVLVR LSKFLQALAD GSSRLRESEG
260 270 280 290 300
LQEQKENPHA TSNSIFINWK EHANDQQHIQ VYENGGSQPN VSSQFRLRYL
310 320 330 340 350
VGGLSGVDEG LSSTENLKGF IEIIIPLLIE CWVEAVPPQL ATPVGNGIER
360 370 380 390 400
EPLQVMQQVL NIISLLWKLS KQQDETHKLE SWLRKNYLID FKHHFMSRFP
410 420 430 440 450
YVLKEITKHK RKEPNKSIKH CTVLSNNIDH LLLNLTLSDI MVSLANASTL
460 470 480 490 500
QKDCSWIEMI RKFVTETLED GSRLNSKQLN RLLGVSWRLM QIQPNREDTE
510 520 530 540 550
TLIKAVYTLY QQRGLILPVR TLLLKFFSKI YQTEELRSCR FRYRSKVLSR
560 570 580 590 600
WLAGLPLQLA HLGSRNPELS TQLIDIIHTA AARANKELLK SLQATALRIY
610 620 630 640 650
DPQEGAVVVL PADSQQRLVQ LVYFLPSLPA DLLSRLSRCC IMGRLSSSLA
660 670 680 690 700
AMLIGILHMR SSFSGWKYSA KDWLMSDVDY FSFLFSTLTG FSKEELTWLQ
710 720 730 740 750
SLRGVPHVIQ TQLSPVLLYL TDLDQFLHHW DVTEAVFHSL LVIPARSQNF
760 770 780 790 800
DILQSAISKH LVGLTVIPDS TAGCVFGVIC KLLDHTCVVS ETLLPFLASC
810 820 830 840 850
CYSLLYFLLT IEKGEAEHLR KRDKLWGVCV SILALLPRVL RLMLQSLRVN
860 870 880 890 900
RVGPEELPVV GQLLRLLLQH APLRTHMLTN AILVQQIIKN ITTLKSGSVQ
910 920
EQWLTDLHYC FNVYITGHPQ GPSALATVY
Length:929
Mass (Da):105,674
Last modified:July 19, 2005 - v2
Checksum:i2E0F8062989415BA
GO
Isoform 2 (identifier: Q9NXF1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSRM
     822-840: Missing.

Note: No experimental confirmation available.
Show »
Length:913
Mass (Da):103,915
Checksum:iB1C70A0807B527C7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSR3A0A0A0MSR3_HUMAN
Testis-expressed protein 10
TEX10
171Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti411R → G in AAH30652 (PubMed:15489334).Curated1
Sequence conflicti430H → R in AAT06748 (PubMed:15334068).Curated1
Sequence conflicti430H → R in BAA91062 (PubMed:14702039).Curated1
Sequence conflicti526F → L in AAH30652 (PubMed:15489334).Curated1
Sequence conflicti731D → E in BAB87845 (PubMed:12880961).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0437041M → MSRM in isoform 2. 1 Publication1
Alternative sequenceiVSP_043705822 – 840Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598337 mRNA Translation: AAT06748.1
AB060968 mRNA Translation: BAB87845.1
AK000294 mRNA Translation: BAA91062.1
AK302619 mRNA Translation: BAG63864.1
AL353805 Genomic DNA No translation available.
AL445214 Genomic DNA No translation available.
BC030652 mRNA Translation: AAH30652.1
CCDSiCCDS55330.1 [Q9NXF1-2]
CCDS6748.1 [Q9NXF1-1]
RefSeqiNP_001155056.1, NM_001161584.1 [Q9NXF1-2]
NP_060216.2, NM_017746.3 [Q9NXF1-1]
UniGeneiHs.494648

Genome annotation databases

EnsembliENST00000374902; ENSP00000364037; ENSG00000136891 [Q9NXF1-1]
ENST00000535814; ENSP00000444555; ENSG00000136891 [Q9NXF1-2]
GeneIDi54881
KEGGihsa:54881
UCSCiuc004bas.4 human [Q9NXF1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598337 mRNA Translation: AAT06748.1
AB060968 mRNA Translation: BAB87845.1
AK000294 mRNA Translation: BAA91062.1
AK302619 mRNA Translation: BAG63864.1
AL353805 Genomic DNA No translation available.
AL445214 Genomic DNA No translation available.
BC030652 mRNA Translation: AAH30652.1
CCDSiCCDS55330.1 [Q9NXF1-2]
CCDS6748.1 [Q9NXF1-1]
RefSeqiNP_001155056.1, NM_001161584.1 [Q9NXF1-2]
NP_060216.2, NM_017746.3 [Q9NXF1-1]
UniGeneiHs.494648

3D structure databases

ProteinModelPortaliQ9NXF1
SMRiQ9NXF1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120229, 54 interactors
CORUMiQ9NXF1
IntActiQ9NXF1, 31 interactors
MINTiQ9NXF1
STRINGi9606.ENSP00000364037

PTM databases

iPTMnetiQ9NXF1
PhosphoSitePlusiQ9NXF1
SwissPalmiQ9NXF1

Polymorphism and mutation databases

BioMutaiTEX10
DMDMi71153593

2D gel databases

SWISS-2DPAGEiQ9NXF1

Proteomic databases

EPDiQ9NXF1
MaxQBiQ9NXF1
PaxDbiQ9NXF1
PeptideAtlasiQ9NXF1
PRIDEiQ9NXF1
ProteomicsDBi83086
83087 [Q9NXF1-2]

Protocols and materials databases

DNASUi54881
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374902; ENSP00000364037; ENSG00000136891 [Q9NXF1-1]
ENST00000535814; ENSP00000444555; ENSG00000136891 [Q9NXF1-2]
GeneIDi54881
KEGGihsa:54881
UCSCiuc004bas.4 human [Q9NXF1-1]

Organism-specific databases

CTDi54881
EuPathDBiHostDB:ENSG00000136891.13
GeneCardsiTEX10
H-InvDBiHIX0008237
HIX0169317
HGNCiHGNC:25988 TEX10
neXtProtiNX_Q9NXF1
OpenTargetsiENSG00000136891
PharmGKBiPA134991964
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2149 Eukaryota
ENOG410YR7T LUCA
GeneTreeiENSGT00390000012654
HOGENOMiHOG000133040
HOVERGENiHBG083741
InParanoidiQ9NXF1
KOiK14827
OMAiTNKSIKH
OrthoDBiEOG091G0EBA
PhylomeDBiQ9NXF1
TreeFamiTF318197

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiTEX10 human
GeneWikiiTEX10
GenomeRNAii54881
PROiPR:Q9NXF1

Gene expression databases

BgeeiENSG00000136891 Expressed in 205 organ(s), highest expression level in kidney
CleanExiHS_TEX10
ExpressionAtlasiQ9NXF1 baseline and differential
GenevisibleiQ9NXF1 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021133 HEAT_type_2
IPR024679 Ipi1_N
IPR037947 TEX10/Ipi1
PANTHERiPTHR16056:SF2 PTHR16056:SF2, 1 hit
PfamiView protein in Pfam
PF12333 Ipi1_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTEX10_HUMAN
AccessioniPrimary (citable) accession number: Q9NXF1
Secondary accession number(s): B4DYV2
, Q5T722, Q5T723, Q8NCN8, Q8TDY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 7, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again