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UniProtKB - Q9NXF1 (TEX10_HUMAN)

Protein

Testis-expressed protein 10

Gene

TEX10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211).2 Publications

GO - Biological processi

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed protein 10
Gene namesi
Name:TEX10
ORF Names:L18, Nbla10363
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136891.13
HGNCiHGNC:25988 TEX10
neXtProtiNX_Q9NXF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136891
PharmGKBiPA134991964

Polymorphism and mutation databases

BioMutaiTEX10
DMDMi71153593

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724911 – 929Testis-expressed protein 10Add BLAST929

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NXF1
MaxQBiQ9NXF1
PaxDbiQ9NXF1
PeptideAtlasiQ9NXF1
PRIDEiQ9NXF1
ProteomicsDBi83086
83087 [Q9NXF1-2]

2D gel databases

SWISS-2DPAGEiQ9NXF1

PTM databases

iPTMnetiQ9NXF1
PhosphoSitePlusiQ9NXF1
SwissPalmiQ9NXF1

Expressioni

Gene expression databases

BgeeiENSG00000136891 Expressed in 205 organ(s), highest expression level in kidney
CleanExiHS_TEX10
ExpressionAtlasiQ9NXF1 baseline and differential
GenevisibleiQ9NXF1 HS

Interactioni

Subunit structurei

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles (PubMed:21326211).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SENP3Q9H4L42EBI-2371062,EBI-2880236

Protein-protein interaction databases

BioGridi120229, 54 interactors
CORUMiQ9NXF1
IntActiQ9NXF1, 31 interactors
MINTiQ9NXF1
STRINGi9606.ENSP00000364037

Structurei

3D structure databases

ProteinModelPortaliQ9NXF1
SMRiQ9NXF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati99 – 137HEATAdd BLAST39

Sequence similaritiesi

Belongs to the IPI1/TEX10 family.Curated

Phylogenomic databases

eggNOGiKOG2149 Eukaryota
ENOG410YR7T LUCA
GeneTreeiENSGT00390000012654
HOGENOMiHOG000133040
HOVERGENiHBG083741
InParanoidiQ9NXF1
KOiK14827
OMAiTNKSIKH
OrthoDBiEOG091G0EBA
PhylomeDBiQ9NXF1
TreeFamiTF318197

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021133 HEAT_type_2
IPR024679 Ipi1_N
IPR037947 TEX10/Ipi1
PANTHERiPTHR16056:SF2 PTHR16056:SF2, 1 hit
PfamiView protein in Pfam
PF12333 Ipi1_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NXF1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTKKRKRQHD FQKVKLKVGK KKPKLQNATP TNFKTKTIHL PEQLKEDGTL 
        60         70         80         90        100
PTNNRKLNIK DLLSQMHHYN AGVKQSALLG LKDLLSQYPF IIDAHLSNIL 
       110        120        130        140        150
SEVTAVFTDK DANVRLAAVQ LLQFLAPKIR AEQISPFFPL VSAHLSSAMT 
       160        170        180        190        200
HITEGIQEDS LKVLDILLEQ YPALITGRSS ILLKNFVELI SHQQLSKGLI 
       210        220        230        240        250
NRDRSQSWIL SVNPNRRLTS QQWRLKVLVR LSKFLQALAD GSSRLRESEG 
       260        270        280        290        300
LQEQKENPHA TSNSIFINWK EHANDQQHIQ VYENGGSQPN VSSQFRLRYL 
       310        320        330        340        350
VGGLSGVDEG LSSTENLKGF IEIIIPLLIE CWVEAVPPQL ATPVGNGIER 
       360        370        380        390        400
EPLQVMQQVL NIISLLWKLS KQQDETHKLE SWLRKNYLID FKHHFMSRFP 
       410        420        430        440        450
YVLKEITKHK RKEPNKSIKH CTVLSNNIDH LLLNLTLSDI MVSLANASTL 
       460        470        480        490        500
QKDCSWIEMI RKFVTETLED GSRLNSKQLN RLLGVSWRLM QIQPNREDTE 
       510        520        530        540        550
TLIKAVYTLY QQRGLILPVR TLLLKFFSKI YQTEELRSCR FRYRSKVLSR 
       560        570        580        590        600
WLAGLPLQLA HLGSRNPELS TQLIDIIHTA AARANKELLK SLQATALRIY 
       610        620        630        640        650
DPQEGAVVVL PADSQQRLVQ LVYFLPSLPA DLLSRLSRCC IMGRLSSSLA 
       660        670        680        690        700
AMLIGILHMR SSFSGWKYSA KDWLMSDVDY FSFLFSTLTG FSKEELTWLQ 
       710        720        730        740        750
SLRGVPHVIQ TQLSPVLLYL TDLDQFLHHW DVTEAVFHSL LVIPARSQNF 
       760        770        780        790        800
DILQSAISKH LVGLTVIPDS TAGCVFGVIC KLLDHTCVVS ETLLPFLASC 
       810        820        830        840        850
CYSLLYFLLT IEKGEAEHLR KRDKLWGVCV SILALLPRVL RLMLQSLRVN 
       860        870        880        890        900
RVGPEELPVV GQLLRLLLQH APLRTHMLTN AILVQQIIKN ITTLKSGSVQ 
       910        920 
EQWLTDLHYC FNVYITGHPQ GPSALATVY
Length:929
Mass (Da):105,674
Last modified:July 19, 2005 - v2
Checksum:i2E0F8062989415BA
GO
Isoform 2 (identifier: Q9NXF1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSRM
     822-840: Missing.

Note: No experimental confirmation available.
Show »
Length:913
Mass (Da):103,915
Checksum:iB1C70A0807B527C7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSR3A0A0A0MSR3_HUMAN
Testis-expressed protein 10
TEX10
171Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti411R → G in AAH30652 (PubMed:15489334).Curated1
Sequence conflicti430H → R in AAT06748 (PubMed:15334068).Curated1
Sequence conflicti430H → R in BAA91062 (PubMed:14702039).Curated1
Sequence conflicti526F → L in AAH30652 (PubMed:15489334).Curated1
Sequence conflicti731D → E in BAB87845 (PubMed:12880961).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0437041M → MSRM in isoform 2. 1 Publication1
Alternative sequenceiVSP_043705822 – 840Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598337 mRNA Translation: AAT06748.1
AB060968 mRNA Translation: BAB87845.1
AK000294 mRNA Translation: BAA91062.1
AK302619 mRNA Translation: BAG63864.1
AL353805 Genomic DNA No translation available.
AL445214 Genomic DNA No translation available.
BC030652 mRNA Translation: AAH30652.1
CCDSiCCDS55330.1 [Q9NXF1-2]
CCDS6748.1 [Q9NXF1-1]
RefSeqiNP_001155056.1, NM_001161584.1 [Q9NXF1-2]
NP_060216.2, NM_017746.3 [Q9NXF1-1]
UniGeneiHs.494648

Genome annotation databases

EnsembliENST00000374902; ENSP00000364037; ENSG00000136891 [Q9NXF1-1]
ENST00000535814; ENSP00000444555; ENSG00000136891 [Q9NXF1-2]
GeneIDi54881
KEGGihsa:54881
UCSCiuc004bas.4 human [Q9NXF1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598337 mRNA Translation: AAT06748.1
AB060968 mRNA Translation: BAB87845.1
AK000294 mRNA Translation: BAA91062.1
AK302619 mRNA Translation: BAG63864.1
AL353805 Genomic DNA No translation available.
AL445214 Genomic DNA No translation available.
BC030652 mRNA Translation: AAH30652.1
CCDSiCCDS55330.1 [Q9NXF1-2]
CCDS6748.1 [Q9NXF1-1]
RefSeqiNP_001155056.1, NM_001161584.1 [Q9NXF1-2]
NP_060216.2, NM_017746.3 [Q9NXF1-1]
UniGeneiHs.494648

3D structure databases

ProteinModelPortaliQ9NXF1
SMRiQ9NXF1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120229, 54 interactors
CORUMiQ9NXF1
IntActiQ9NXF1, 31 interactors
MINTiQ9NXF1
STRINGi9606.ENSP00000364037

PTM databases

iPTMnetiQ9NXF1
PhosphoSitePlusiQ9NXF1
SwissPalmiQ9NXF1

Polymorphism and mutation databases

BioMutaiTEX10
DMDMi71153593

2D gel databases

SWISS-2DPAGEiQ9NXF1

Proteomic databases

EPDiQ9NXF1
MaxQBiQ9NXF1
PaxDbiQ9NXF1
PeptideAtlasiQ9NXF1
PRIDEiQ9NXF1
ProteomicsDBi83086
83087 [Q9NXF1-2]

Protocols and materials databases

DNASUi54881
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374902; ENSP00000364037; ENSG00000136891 [Q9NXF1-1]
ENST00000535814; ENSP00000444555; ENSG00000136891 [Q9NXF1-2]
GeneIDi54881
KEGGihsa:54881
UCSCiuc004bas.4 human [Q9NXF1-1]

Organism-specific databases

CTDi54881
EuPathDBiHostDB:ENSG00000136891.13
GeneCardsiTEX10
H-InvDBiHIX0008237
HIX0169317
HGNCiHGNC:25988 TEX10
neXtProtiNX_Q9NXF1
OpenTargetsiENSG00000136891
PharmGKBiPA134991964
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2149 Eukaryota
ENOG410YR7T LUCA
GeneTreeiENSGT00390000012654
HOGENOMiHOG000133040
HOVERGENiHBG083741
InParanoidiQ9NXF1
KOiK14827
OMAiTNKSIKH
OrthoDBiEOG091G0EBA
PhylomeDBiQ9NXF1
TreeFamiTF318197

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiTEX10 human
GeneWikiiTEX10
GenomeRNAii54881
PROiPR:Q9NXF1

Gene expression databases

BgeeiENSG00000136891 Expressed in 205 organ(s), highest expression level in kidney
CleanExiHS_TEX10
ExpressionAtlasiQ9NXF1 baseline and differential
GenevisibleiQ9NXF1 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021133 HEAT_type_2
IPR024679 Ipi1_N
IPR037947 TEX10/Ipi1
PANTHERiPTHR16056:SF2 PTHR16056:SF2, 1 hit
PfamiView protein in Pfam
PF12333 Ipi1_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTEX10_HUMAN
AccessioniPrimary (citable) accession number: Q9NXF1
Secondary accession number(s): B4DYV2
, Q5T722, Q5T723, Q8NCN8, Q8TDY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 7, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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