UniProtKB - Q9NXF1 (TEX10_HUMAN)
Testis-expressed protein 10
TEX10
Functioni
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859).
Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211).
2 PublicationsEnzyme and pathway databases
PathwayCommonsi | Q9NXF1 |
Reactomei | R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
SignaLinki | Q9NXF1 |
SIGNORi | Q9NXF1 |
Names & Taxonomyi
Protein namesi | Recommended name: Testis-expressed protein 10 |
Gene namesi | Name:TEX10 ORF Names:L18, Nbla10363 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25988, TEX10 |
neXtProti | NX_Q9NXF1 |
VEuPathDBi | HostDB:ENSG00000136891 |
Subcellular locationi
Nucleus
- nucleoplasm By similarity
- nucleolus 2 Publications
Cytoplasm and Cytosol
- Cytoplasm By similarity
Note: Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions.By similarity
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- MLL1 complex Source: UniProtKB
- nucleolus Source: UniProtKB-SubCell
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 54881 |
OpenTargetsi | ENSG00000136891 |
PharmGKBi | PA134991964 |
Miscellaneous databases
Pharosi | Q9NXF1, Tdark |
Genetic variation databases
BioMutai | TEX10 |
DMDMi | 71153593 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072491 | 1 – 929 | Testis-expressed protein 10Add BLAST | 929 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 29 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NXF1 |
jPOSTi | Q9NXF1 |
MassIVEi | Q9NXF1 |
MaxQBi | Q9NXF1 |
PaxDbi | Q9NXF1 |
PeptideAtlasi | Q9NXF1 |
PRIDEi | Q9NXF1 |
ProteomicsDBi | 83086 [Q9NXF1-1] 83087 [Q9NXF1-2] |
2D gel databases
SWISS-2DPAGEi | Q9NXF1 |
PTM databases
GlyGeni | Q9NXF1, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9NXF1 |
PhosphoSitePlusi | Q9NXF1 |
SwissPalmi | Q9NXF1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000136891, Expressed in ventricular zone and 218 other tissues |
ExpressionAtlasi | Q9NXF1, baseline and differential |
Genevisiblei | Q9NXF1, HS |
Organism-specific databases
HPAi | ENSG00000136891, Low tissue specificity |
Interactioni
Subunit structurei
Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.
Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148.
Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles (PubMed:21326211).
3 PublicationsBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 120229, 132 interactors |
CORUMi | Q9NXF1 |
IntActi | Q9NXF1, 52 interactors |
MINTi | Q9NXF1 |
STRINGi | 9606.ENSP00000364037 |
Miscellaneous databases
RNActi | Q9NXF1, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 99 – 137 | HEATAdd BLAST | 39 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2149, Eukaryota |
GeneTreei | ENSGT00950000182992 |
HOGENOMi | CLU_014208_0_0_1 |
InParanoidi | Q9NXF1 |
OMAi | EADGDWL |
PhylomeDBi | Q9NXF1 |
TreeFami | TF318197 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR021133, HEAT_type_2 IPR024679, Ipi1_N IPR037947, TEX10/Ipi1 |
PANTHERi | PTHR16056:SF2, PTHR16056:SF2, 1 hit |
Pfami | View protein in Pfam PF12333, Ipi1_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50077, HEAT_REPEAT, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTKKRKRQHD FQKVKLKVGK KKPKLQNATP TNFKTKTIHL PEQLKEDGTL
60 70 80 90 100
PTNNRKLNIK DLLSQMHHYN AGVKQSALLG LKDLLSQYPF IIDAHLSNIL
110 120 130 140 150
SEVTAVFTDK DANVRLAAVQ LLQFLAPKIR AEQISPFFPL VSAHLSSAMT
160 170 180 190 200
HITEGIQEDS LKVLDILLEQ YPALITGRSS ILLKNFVELI SHQQLSKGLI
210 220 230 240 250
NRDRSQSWIL SVNPNRRLTS QQWRLKVLVR LSKFLQALAD GSSRLRESEG
260 270 280 290 300
LQEQKENPHA TSNSIFINWK EHANDQQHIQ VYENGGSQPN VSSQFRLRYL
310 320 330 340 350
VGGLSGVDEG LSSTENLKGF IEIIIPLLIE CWVEAVPPQL ATPVGNGIER
360 370 380 390 400
EPLQVMQQVL NIISLLWKLS KQQDETHKLE SWLRKNYLID FKHHFMSRFP
410 420 430 440 450
YVLKEITKHK RKEPNKSIKH CTVLSNNIDH LLLNLTLSDI MVSLANASTL
460 470 480 490 500
QKDCSWIEMI RKFVTETLED GSRLNSKQLN RLLGVSWRLM QIQPNREDTE
510 520 530 540 550
TLIKAVYTLY QQRGLILPVR TLLLKFFSKI YQTEELRSCR FRYRSKVLSR
560 570 580 590 600
WLAGLPLQLA HLGSRNPELS TQLIDIIHTA AARANKELLK SLQATALRIY
610 620 630 640 650
DPQEGAVVVL PADSQQRLVQ LVYFLPSLPA DLLSRLSRCC IMGRLSSSLA
660 670 680 690 700
AMLIGILHMR SSFSGWKYSA KDWLMSDVDY FSFLFSTLTG FSKEELTWLQ
710 720 730 740 750
SLRGVPHVIQ TQLSPVLLYL TDLDQFLHHW DVTEAVFHSL LVIPARSQNF
760 770 780 790 800
DILQSAISKH LVGLTVIPDS TAGCVFGVIC KLLDHTCVVS ETLLPFLASC
810 820 830 840 850
CYSLLYFLLT IEKGEAEHLR KRDKLWGVCV SILALLPRVL RLMLQSLRVN
860 870 880 890 900
RVGPEELPVV GQLLRLLLQH APLRTHMLTN AILVQQIIKN ITTLKSGSVQ
910 920
EQWLTDLHYC FNVYITGHPQ GPSALATVY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MSR3 | A0A0A0MSR3_HUMAN | Testis-expressed protein 10 | TEX10 | 171 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 411 | R → G in AAH30652 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 430 | H → R in AAT06748 (PubMed:15334068).Curated | 1 | |
Sequence conflicti | 430 | H → R in BAA91062 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 526 | F → L in AAH30652 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 731 | D → E in BAB87845 (PubMed:12880961).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043704 | 1 | M → MSRM in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_043705 | 822 – 840 | Missing in isoform 2. 1 PublicationAdd BLAST | 19 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY598337 mRNA Translation: AAT06748.1 AB060968 mRNA Translation: BAB87845.1 AK000294 mRNA Translation: BAA91062.1 AK302619 mRNA Translation: BAG63864.1 AL353805 Genomic DNA No translation available. AL445214 Genomic DNA No translation available. BC030652 mRNA Translation: AAH30652.1 |
CCDSi | CCDS55330.1 [Q9NXF1-2] CCDS6748.1 [Q9NXF1-1] |
RefSeqi | NP_001155056.1, NM_001161584.1 [Q9NXF1-2] NP_060216.2, NM_017746.3 [Q9NXF1-1] |
Genome annotation databases
Ensembli | ENST00000374902; ENSP00000364037; ENSG00000136891 ENST00000535814; ENSP00000444555; ENSG00000136891 [Q9NXF1-2] |
GeneIDi | 54881 |
KEGGi | hsa:54881 |
MANE-Selecti | ENST00000374902.9; ENSP00000364037.4; NM_017746.4; NP_060216.2 |
UCSCi | uc004bas.4, human [Q9NXF1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY598337 mRNA Translation: AAT06748.1 AB060968 mRNA Translation: BAB87845.1 AK000294 mRNA Translation: BAA91062.1 AK302619 mRNA Translation: BAG63864.1 AL353805 Genomic DNA No translation available. AL445214 Genomic DNA No translation available. BC030652 mRNA Translation: AAH30652.1 |
CCDSi | CCDS55330.1 [Q9NXF1-2] CCDS6748.1 [Q9NXF1-1] |
RefSeqi | NP_001155056.1, NM_001161584.1 [Q9NXF1-2] NP_060216.2, NM_017746.3 [Q9NXF1-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120229, 132 interactors |
CORUMi | Q9NXF1 |
IntActi | Q9NXF1, 52 interactors |
MINTi | Q9NXF1 |
STRINGi | 9606.ENSP00000364037 |
PTM databases
GlyGeni | Q9NXF1, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9NXF1 |
PhosphoSitePlusi | Q9NXF1 |
SwissPalmi | Q9NXF1 |
Genetic variation databases
BioMutai | TEX10 |
DMDMi | 71153593 |
2D gel databases
SWISS-2DPAGEi | Q9NXF1 |
Proteomic databases
EPDi | Q9NXF1 |
jPOSTi | Q9NXF1 |
MassIVEi | Q9NXF1 |
MaxQBi | Q9NXF1 |
PaxDbi | Q9NXF1 |
PeptideAtlasi | Q9NXF1 |
PRIDEi | Q9NXF1 |
ProteomicsDBi | 83086 [Q9NXF1-1] 83087 [Q9NXF1-2] |
Protocols and materials databases
Antibodypediai | 43979, 29 antibodies from 13 providers |
DNASUi | 54881 |
Genome annotation databases
Ensembli | ENST00000374902; ENSP00000364037; ENSG00000136891 ENST00000535814; ENSP00000444555; ENSG00000136891 [Q9NXF1-2] |
GeneIDi | 54881 |
KEGGi | hsa:54881 |
MANE-Selecti | ENST00000374902.9; ENSP00000364037.4; NM_017746.4; NP_060216.2 |
UCSCi | uc004bas.4, human [Q9NXF1-1] |
Organism-specific databases
CTDi | 54881 |
DisGeNETi | 54881 |
GeneCardsi | TEX10 |
HGNCi | HGNC:25988, TEX10 |
HPAi | ENSG00000136891, Low tissue specificity |
neXtProti | NX_Q9NXF1 |
OpenTargetsi | ENSG00000136891 |
PharmGKBi | PA134991964 |
VEuPathDBi | HostDB:ENSG00000136891 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2149, Eukaryota |
GeneTreei | ENSGT00950000182992 |
HOGENOMi | CLU_014208_0_0_1 |
InParanoidi | Q9NXF1 |
OMAi | EADGDWL |
PhylomeDBi | Q9NXF1 |
TreeFami | TF318197 |
Enzyme and pathway databases
PathwayCommonsi | Q9NXF1 |
Reactomei | R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
SignaLinki | Q9NXF1 |
SIGNORi | Q9NXF1 |
Miscellaneous databases
BioGRID-ORCSi | 54881, 602 hits in 1060 CRISPR screens |
ChiTaRSi | TEX10, human |
GeneWikii | TEX10 |
GenomeRNAii | 54881 |
Pharosi | Q9NXF1, Tdark |
PROi | PR:Q9NXF1 |
RNActi | Q9NXF1, protein |
Gene expression databases
Bgeei | ENSG00000136891, Expressed in ventricular zone and 218 other tissues |
ExpressionAtlasi | Q9NXF1, baseline and differential |
Genevisiblei | Q9NXF1, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR021133, HEAT_type_2 IPR024679, Ipi1_N IPR037947, TEX10/Ipi1 |
PANTHERi | PTHR16056:SF2, PTHR16056:SF2, 1 hit |
Pfami | View protein in Pfam PF12333, Ipi1_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50077, HEAT_REPEAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TEX10_HUMAN | |
Accessioni | Q9NXF1Primary (citable) accession number: Q9NXF1 Secondary accession number(s): B4DYV2 Q8TDY0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | July 19, 2005 | |
Last modified: | February 23, 2022 | |
This is version 176 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families