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Entry version 129 (31 Jul 2019)
Sequence version 3 (25 Nov 2008)
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Protein

Myotubularin-related protein 10

Gene

MTMR10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 403 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity.Curated

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myotubularin-related protein 10
Alternative name(s):
Inactive phosphatidylinositol 3-phosphatase 10Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTMR10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25999 MTMR10

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NXD2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54893

Open Targets

More...
OpenTargetsi
ENSG00000166912

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394676

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MTMR10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274131

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002843601 – 777Myotubularin-related protein 10Add BLAST777

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei607PhosphoserineCombined sources1
Modified residuei751PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NXD2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NXD2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NXD2

PeptideAtlas

More...
PeptideAtlasi
Q9NXD2

PRoteomics IDEntifications database

More...
PRIDEi
Q9NXD2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83076 [Q9NXD2-1]
83077 [Q9NXD2-2]
83078 [Q9NXD2-3]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
Q9NXD2

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NXD2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NXD2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166912 Expressed in 206 organ(s), highest expression level in placenta

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NXD2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NXD2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006081

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120240, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NXD2, 6 interactors

Molecular INTeraction database

More...
MINTi
Q9NXD2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000402537

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini221 – 661Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST441

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi198 – 213Poly-GlyAdd BLAST16

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1089 Eukaryota
ENOG410XPTU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156900

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113684

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NXD2

KEGG Orthology (KO)

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KOi
K18085

Identification of Orthologs from Complete Genome Data

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OMAi
VNEGYMI

Database of Orthologous Groups

More...
OrthoDBi
620702at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NXD2

TreeFam database of animal gene trees

More...
TreeFami
TF315197

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13346 PH-GRAM_MTMR10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030573 MTMR10
IPR036004 MTMR10_PH-GRAM
IPR022587 MTMR12-like_C
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR029021 Prot-tyrosine_phosphatase-like

The PANTHER Classification System

More...
PANTHERi
PTHR10807 PTHR10807, 1 hit
PTHR10807:SF39 PTHR10807:SF39, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12578 3-PAP, 1 hit
PF06602 Myotub-related, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NXD2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSLKPPKPT FRSYLLPPPQ TDDKINSEPK IKKLEPVLLP GEIVVNEVNF
60 70 80 90 100
VRKCIATDTS QYDLWGKLIC SNFKISFITD DPMPLQKFHY RNLLLGEHDV
110 120 130 140 150
PLTCIEQIVT VNDHKRKQKV LGPNQKLKFN PTELIIYCKD FRIVRFRFDE
160 170 180 190 200
SGPESAKKVC LAIAHYSQPT DLQLLFAFEY VGKKYHNSAN KINGIPSGDG
210 220 230 240 250
GGGGGGGNGA GGGSSQKTPL FETYSDWDRE IKRTGASGWR VCSINEGYMI
260 270 280 290 300
STCLPEYIVV PSSLADQDLK IFSHSFVGRR MPLWCWSHSN GSALVRMALI
310 320 330 340 350
KDVLQQRKID QRICNAITKS HPQRSDVYKS DLDKTLPNIQ EVQAAFVKLK
360 370 380 390 400
QLCVNEPFEE TEEKWLSSLE NTRWLEYVRA FLKHSAELVY MLESKHLSVV
410 420 430 440 450
LQEEEGRDLS CCVASLVQVM LDPYFRTITG FQSLIQKEWV MAGYQFLDRC
460 470 480 490 500
NHLKRSEKES PLFLLFLDAT WQLLEQYPAA FEFSETYLAV LYDSTRISLF
510 520 530 540 550
GTFLFNSPHQ RVKQSTEFAI SKNIQLGDEK GLKFPSVWDW SLQFTAKDRT
560 570 580 590 600
LFHNPFYIGK STPCIQNGSV KSFKRTKKSY SSTLRGMPSA LKNGIISDQE
610 620 630 640 650
LLPRRNSLIL KPKPDPAQQT DSQNSDTEQY FREWFSKPAN LHGVILPRVS
660 670 680 690 700
GTHIKLWKLC YFRWVPEAQI SLGGSITAFH KLSLLADEVD VLSRMLRQQR
710 720 730 740 750
SGPLEACYGE LGQSRMYFNA SGPHHTDTSG TPEFLSSSFP FSPVGNLCRR
760 770
SILGTPLSKF LSGAKIWLST ETLANED
Length:777
Mass (Da):88,273
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2160728E16E0A98
GO
Isoform 2 (identifier: Q9NXD2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
     517-533: EFAISKNIQLGDEKGLK → VSRIKSCTKQDYFPSRV
     534-777: Missing.

Show »
Length:451
Mass (Da):51,620
Checksum:iDFA1407A1F7302F0
GO
Isoform 3 (identifier: Q9NXD2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-218: VCLAIAHYSQ...GAGGGSSQKT → QTKLMEFPQE...GEFVLLTRVT
     219-777: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:218
Mass (Da):25,184
Checksum:i31C6F2EEFAB20EEA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQR5H3BQR5_HUMAN
Myotubularin related protein 10 iso...
MTMR10
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUZ0H3BUZ0_HUMAN
Myotubularin-related protein 10
MTMR10
303Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUS9H3BUS9_HUMAN
Myotubularin-related protein 10
MTMR10
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQP4H3BQP4_HUMAN
Myotubularin-related protein 10
MTMR10
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti342V → I in AL832603 (PubMed:17974005).Curated1
Sequence conflicti710E → G in AL832603 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047539648R → H. Corresponds to variant dbSNP:rs6493352Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0357741 – 82Missing in isoform 2. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_024465159 – 218VCLAI…SSQKT → QTKLMEFPQEMEEEEEEEVM ELVVAAARKLHSLKLTRIGT EKSRGQVLPGGEFVLLTRVT in isoform 3. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_024466219 – 777Missing in isoform 3. 1 PublicationAdd BLAST559
Alternative sequenceiVSP_024467517 – 533EFAIS…EKGLK → VSRIKSCTKQDYFPSRV in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_024468534 – 777Missing in isoform 2. 1 PublicationAdd BLAST244

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK000320 mRNA Translation: BAA91083.1
AL832603 mRNA No translation available.
AC090829 Genomic DNA No translation available.
BC063296 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45204.1 [Q9NXD2-1]

NCBI Reference Sequences

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RefSeqi
NP_060232.2, NM_017762.2 [Q9NXD2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000435680; ENSP00000402537; ENSG00000166912 [Q9NXD2-1]
ENST00000563714; ENSP00000457390; ENSG00000166912 [Q9NXD2-2]
ENST00000568604; ENSP00000457903; ENSG00000166912 [Q9NXD2-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54893

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54893

UCSC genome browser

More...
UCSCi
uc001zfj.3 human [Q9NXD2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000320 mRNA Translation: BAA91083.1
AL832603 mRNA No translation available.
AC090829 Genomic DNA No translation available.
BC063296 mRNA No translation available.
CCDSiCCDS45204.1 [Q9NXD2-1]
RefSeqiNP_060232.2, NM_017762.2 [Q9NXD2-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120240, 19 interactors
IntActiQ9NXD2, 6 interactors
MINTiQ9NXD2
STRINGi9606.ENSP00000402537

PTM databases

DEPODiQ9NXD2
iPTMnetiQ9NXD2
PhosphoSitePlusiQ9NXD2

Polymorphism and mutation databases

BioMutaiMTMR10
DMDMi215274131

Proteomic databases

EPDiQ9NXD2
jPOSTiQ9NXD2
PaxDbiQ9NXD2
PeptideAtlasiQ9NXD2
PRIDEiQ9NXD2
ProteomicsDBi83076 [Q9NXD2-1]
83077 [Q9NXD2-2]
83078 [Q9NXD2-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54893
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000435680; ENSP00000402537; ENSG00000166912 [Q9NXD2-1]
ENST00000563714; ENSP00000457390; ENSG00000166912 [Q9NXD2-2]
ENST00000568604; ENSP00000457903; ENSG00000166912 [Q9NXD2-3]
GeneIDi54893
KEGGihsa:54893
UCSCiuc001zfj.3 human [Q9NXD2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54893
DisGeNETi54893

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MTMR10
HGNCiHGNC:25999 MTMR10
HPAiHPA006081
neXtProtiNX_Q9NXD2
OpenTargetsiENSG00000166912
PharmGKBiPA128394676

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1089 Eukaryota
ENOG410XPTU LUCA
GeneTreeiENSGT00940000156900
HOGENOMiHOG000113684
InParanoidiQ9NXD2
KOiK18085
OMAiVNEGYMI
OrthoDBi620702at2759
PhylomeDBiQ9NXD2
TreeFamiTF315197

Enzyme and pathway databases

ReactomeiR-HSA-1660516 Synthesis of PIPs at the early endosome membrane

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MTMR10 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54893

Protein Ontology

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PROi
PR:Q9NXD2

Gene expression databases

BgeeiENSG00000166912 Expressed in 206 organ(s), highest expression level in placenta
ExpressionAtlasiQ9NXD2 baseline and differential
GenevisibleiQ9NXD2 HS

Family and domain databases

CDDicd13346 PH-GRAM_MTMR10, 1 hit
InterProiView protein in InterPro
IPR030573 MTMR10
IPR036004 MTMR10_PH-GRAM
IPR022587 MTMR12-like_C
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR029021 Prot-tyrosine_phosphatase-like
PANTHERiPTHR10807 PTHR10807, 1 hit
PTHR10807:SF39 PTHR10807:SF39, 1 hit
PfamiView protein in Pfam
PF12578 3-PAP, 1 hit
PF06602 Myotub-related, 2 hits
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTMRA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NXD2
Secondary accession number(s): Q6P4Q6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 25, 2008
Last modified: July 31, 2019
This is version 129 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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