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Entry version 146 (13 Feb 2019)
Sequence version 2 (08 Apr 2008)
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Protein

GATOR complex protein MIOS

Gene

MIOS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NXC5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GATOR complex protein MIOSCurated
Alternative name(s):
Missing oocyte meiosis regulator homologImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MIOSImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164654.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21905 MIOS

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615359 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NXC5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54468

Open Targets

More...
OpenTargetsi
ENSG00000164654

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164722300

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MIOS

Domain mapping of disease mutations (DMDM)

More...
DMDMi
182662411

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003294041 – 875GATOR complex protein MIOSAdd BLAST875

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei759PhosphoserineCombined sources1
Modified residuei766PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NXC5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NXC5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NXC5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NXC5

PeptideAtlas

More...
PeptideAtlasi
Q9NXC5

PRoteomics IDEntifications database

More...
PRIDEi
Q9NXC5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83074
83075 [Q9NXC5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NXC5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NXC5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164654 Expressed in 228 organ(s), highest expression level in gastrocnemius

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NXC5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NXC5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042928
HPA052223

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers. The GATOR2 complex interacts with CASTOR2 and CASTOR1; the interaction is negatively regulated by arginine (PubMed:26972053). The GATOR2 complex interacts with the sestrins SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids (PubMed:25263562, PubMed:25457612, PubMed:26586190).5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119974, 45 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NXC5

Database of interacting proteins

More...
DIPi
DIP-53801N

Protein interaction database and analysis system

More...
IntActi
Q9NXC5, 18 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000339881

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NXC5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati58 – 100WD 1Add BLAST43
Repeati111 – 155WD 2Add BLAST45
Repeati182 – 221WD 3Add BLAST40
Repeati223 – 261WD 4Add BLAST39
Repeati265 – 306WD 5Add BLAST42
Repeati395 – 437WD 6Add BLAST43

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat mio family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1008 Eukaryota
ENOG410YY2R LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015038

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000047176

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108136

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NXC5

KEGG Orthology (KO)

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KOi
K20407

Identification of Orthologs from Complete Genome Data

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OMAi
CAEEEND

Database of Orthologous Groups

More...
OrthoDBi
890767at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NXC5

TreeFam database of animal gene trees

More...
TreeFami
TF324074

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037593 MIOS/Sea4
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
IPR031488 Zn_ribbon_mio

The PANTHER Classification System

More...
PANTHERi
PTHR16453 PTHR16453, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17034 zinc_ribbon_16, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NXC5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGTKPDILW APHHVDRFVV CDSELSLYHV ESTVNSELKA GSLRLSEDSA
60 70 80 90 100
ATLLSINSDT PYMKCVAWYL NYDPECLLAV GQANGRVVLT SLGQDHNSKF
110 120 130 140 150
KDLIGKEFVP KHARQCNTLA WNPLDSNWLA AGLDKHRADF SVLIWDICSK
160 170 180 190 200
YTPDIVPMEK VKLSAGETET TLLVTKPLYE LGQNDACLSL CWLPRDQKLL
210 220 230 240 250
LAGMHRNLAI FDLRNTSQKM FVNTKAVQGV TVDPYFHDRV ASFYEGQVAI
260 270 280 290 300
WDLRKFEKPV LTLTEQPKPL TKVAWCPTRT GLLATLTRDS NIIRLYDMQH
310 320 330 340 350
TPTPIGDETE PTIIERSVQP CDNYIASFAW HPTSQNRMIV VTPNRTMSDF
360 370 380 390 400
TVFERISLAW SPITSLMWAC GRHLYECTEE ENDNSLEKDI ATKMRLRALS
410 420 430 440 450
RYGLDTEQVW RNHILAGNED PQLKSLWYTL HFMKQYTEDM DQKSPGNKGS
460 470 480 490 500
LVYAGIKSIV KSSLGMVESS RHNWSGLDKQ SDIQNLNEER ILALQLCGWI
510 520 530 540 550
KKGTDVDVGP FLNSLVQEGE WERAAAVALF NLDIRRAIQI LNEGASSEKG
560 570 580 590 600
DLNLNVVAMA LSGYTDEKNS LWREMCSTLR LQLNNPYLCV MFAFLTSETG
610 620 630 640 650
SYDGVLYENK VAVRDRVAFA CKFLSDTQLN RYIEKLTNEM KEAGNLEGIL
660 670 680 690 700
LTGLTKDGVD LMESYVDRTG DVQTASYCML QGSPLDVLKD ERVQYWIENY
710 720 730 740 750
RNLLDAWRFW HKRAEFDIHR SKLDPSSKPL AQVFVSCNFC GKSISYSCSA
760 770 780 790 800
VPHQGRGFSQ YGVSGSPTKS KVTSCPGCRK PLPRCALCLI NMGTPVSSCP
810 820 830 840 850
GGTKSDEKVD LSKDKKLAQF NNWFTWCHNC RHGGHAGHML SWFRDHAECP
860 870
VSACTCKCMQ LDTTGNLVPA ETVQP
Length:875
Mass (Da):98,584
Last modified:April 8, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i481D3AA0C9A3A1CB
GO
Isoform 2 (identifier: Q9NXC5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     551-567: DLNLNVVAMALSGYTDE → RRSESQCGSNGFIGLYG
     568-875: Missing.

Show »
Length:567
Mass (Da):64,016
Checksum:i033FD6DDF52B8B90
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JTV2C9JTV2_HUMAN
GATOR complex protein MIOS
MIOS
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JAQ1C9JAQ1_HUMAN
GATOR complex protein MIOS
MIOS
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUE6C9JUE6_HUMAN
GATOR complex protein MIOS
MIOS
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032979551 – 567DLNLN…GYTDE → RRSESQCGSNGFIGLYG in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_032980568 – 875Missing in isoform 2. 1 PublicationAdd BLAST308

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000330 mRNA Translation: BAA91090.1
AC004982 Genomic DNA Translation: AAC31788.1 Sequence problems.
CH471073 Genomic DNA Translation: EAW93598.1
CH471073 Genomic DNA Translation: EAW93601.1
BC005883 mRNA Translation: AAH05883.2
BC140833 mRNA Translation: AAI40834.1
BC140834 mRNA Translation: AAI40835.1
AL136892 mRNA Translation: CAB66826.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43554.1 [Q9NXC5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_061878.3, NM_019005.3 [Q9NXC5-1]
XP_005249837.1, XM_005249780.3 [Q9NXC5-1]
XP_005249838.1, XM_005249781.3 [Q9NXC5-1]
XP_005249839.1, XM_005249782.3 [Q9NXC5-1]
XP_016867850.1, XM_017012361.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.520215

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340080; ENSP00000339881; ENSG00000164654 [Q9NXC5-1]
ENST00000405785; ENSP00000384088; ENSG00000164654 [Q9NXC5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54468

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54468

UCSC genome browser

More...
UCSCi
uc003srf.4 human [Q9NXC5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000330 mRNA Translation: BAA91090.1
AC004982 Genomic DNA Translation: AAC31788.1 Sequence problems.
CH471073 Genomic DNA Translation: EAW93598.1
CH471073 Genomic DNA Translation: EAW93601.1
BC005883 mRNA Translation: AAH05883.2
BC140833 mRNA Translation: AAI40834.1
BC140834 mRNA Translation: AAI40835.1
AL136892 mRNA Translation: CAB66826.2
CCDSiCCDS43554.1 [Q9NXC5-1]
RefSeqiNP_061878.3, NM_019005.3 [Q9NXC5-1]
XP_005249837.1, XM_005249780.3 [Q9NXC5-1]
XP_005249838.1, XM_005249781.3 [Q9NXC5-1]
XP_005249839.1, XM_005249782.3 [Q9NXC5-1]
XP_016867850.1, XM_017012361.1
UniGeneiHs.520215

3D structure databases

ProteinModelPortaliQ9NXC5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119974, 45 interactors
CORUMiQ9NXC5
DIPiDIP-53801N
IntActiQ9NXC5, 18 interactors
STRINGi9606.ENSP00000339881

PTM databases

iPTMnetiQ9NXC5
PhosphoSitePlusiQ9NXC5

Polymorphism and mutation databases

BioMutaiMIOS
DMDMi182662411

Proteomic databases

EPDiQ9NXC5
jPOSTiQ9NXC5
MaxQBiQ9NXC5
PaxDbiQ9NXC5
PeptideAtlasiQ9NXC5
PRIDEiQ9NXC5
ProteomicsDBi83074
83075 [Q9NXC5-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340080; ENSP00000339881; ENSG00000164654 [Q9NXC5-1]
ENST00000405785; ENSP00000384088; ENSG00000164654 [Q9NXC5-1]
GeneIDi54468
KEGGihsa:54468
UCSCiuc003srf.4 human [Q9NXC5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54468
DisGeNETi54468
EuPathDBiHostDB:ENSG00000164654.15

GeneCards: human genes, protein and diseases

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GeneCardsi
MIOS

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0006477
HGNCiHGNC:21905 MIOS
HPAiHPA042928
HPA052223
MIMi615359 gene
neXtProtiNX_Q9NXC5
OpenTargetsiENSG00000164654
PharmGKBiPA164722300

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1008 Eukaryota
ENOG410YY2R LUCA
GeneTreeiENSGT00390000015038
HOGENOMiHOG000047176
HOVERGENiHBG108136
InParanoidiQ9NXC5
KOiK20407
OMAiCAEEEND
OrthoDBi890767at2759
PhylomeDBiQ9NXC5
TreeFamiTF324074

Enzyme and pathway databases

SIGNORiQ9NXC5

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54468

Protein Ontology

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PROi
PR:Q9NXC5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000164654 Expressed in 228 organ(s), highest expression level in gastrocnemius
ExpressionAtlasiQ9NXC5 baseline and differential
GenevisibleiQ9NXC5 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR037593 MIOS/Sea4
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
IPR031488 Zn_ribbon_mio
PANTHERiPTHR16453 PTHR16453, 2 hits
PfamiView protein in Pfam
PF17034 zinc_ribbon_16, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMIO_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NXC5
Secondary accession number(s): B2RTV6
, O75216, Q7L551, Q9H092
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: February 13, 2019
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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