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UniProtKB - Q9NXB9 (ELOV2_HUMAN)

Entry version 151 (02 Jun 2021)
Sequence version 2 (26 Feb 2008)
Previous versions | rss
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Protein

Elongation of very long chain fatty acids protein 2

Gene

ELOVL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

UniRule annotation4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: polyunsaturated fatty acid biosynthesis

This protein is involved in the pathway polyunsaturated fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation4 Publications
View all proteins of this organism that are known to be involved in the pathway polyunsaturated fatty acid biosynthesis and in Lipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:ENSG00000096256-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NXB9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2046105, Linoleic acid (LA) metabolism
R-HSA-2046106, alpha-linolenic acid (ALA) metabolism
R-HSA-75876, Synthesis of very long-chain fatty acyl-CoAs

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00658

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000245

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Elongation of very long chain fatty acids protein 2UniRule annotationCurated (EC:2.3.1.199UniRule annotation4 Publications)
Alternative name(s):
3-keto acyl-CoA synthase ELOVL2UniRule annotation
ELOVL fatty acid elongase 2UniRule annotation
Short name:
ELOVL FA elongase 2UniRule annotation
Very long chain 3-ketoacyl-CoA synthase 2UniRule annotation
Very long chain 3-oxoacyl-CoA synthase 2UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ELOVL2UniRule annotation
Synonyms:ELG31 Publication, SSC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14416, ELOVL2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611814, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NXB9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000197977.3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 49HelicalUniRule annotationAdd BLAST21
Transmembranei67 – 87HelicalUniRule annotationAdd BLAST21
Transmembranei115 – 135HelicalUniRule annotationAdd BLAST21
Transmembranei153 – 173HelicalUniRule annotationAdd BLAST21
Transmembranei175 – 195HelicalUniRule annotationAdd BLAST21
Transmembranei208 – 225HelicalUniRule annotationAdd BLAST18
Transmembranei230 – 250HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		54898

Open Targets

More...OpenTargetsi		ENSG00000197977

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27761

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NXB9, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5911

Drug and drug target database

More...DrugBanki		DB00132, alpha-Linolenic acid

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ELOVL2

Domain mapping of disease mutations (DMDM)

More...DMDMi		187472388

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002075381 – 296Elongation of very long chain fatty acids protein 2Add BLAST296

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NXB9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NXB9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NXB9

PeptideAtlas

More...PeptideAtlasi		Q9NXB9

PRoteomics IDEntifications database

More...PRIDEi		Q9NXB9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83070

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NXB9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NXB9

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9NXB9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197977, Expressed in ventricular zone and 172 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NXB9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NXB9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197977, Tissue enhanced (brain, liver, parathyroid gland, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120244, 15 interactors

Protein interaction database and analysis system

More...IntActi		Q9NXB9, 12 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000346693

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9NXB9

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NXB9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi293 – 296Di-lysine motifUniRule annotation4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal di-lysine motif may confer endoplasmic reticulum localization.UniRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ELO family. ELOVL2 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3071, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234600

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_048483_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NXB9

Identification of Orthologs from Complete Genome Data

More...OMAi		ATWEGGY

Database of Orthologous Groups

More...OrthoDBi		1094172at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NXB9

TreeFam database of animal gene trees

More...TreeFami		TF323454

Family and domain databases

HAMAP database of protein families

More...HAMAPi		MF_03202, VLCF_elongase_2, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030457, ELO_CS
IPR002076, ELO_fam
IPR033680, ELOVL2

The PANTHER Classification System

More...PANTHERi		PTHR11157, PTHR11157, 1 hit
PTHR11157:SF16, PTHR11157:SF16, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01151, ELO, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01188, ELO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NXB9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHLKAFDDE INAFLDNMFG PRDSRVRGWF MLDSYLPTFF LTVMYLLSIW 
        60         70         80         90        100
LGNKYMKNRP ALSLRGILTL YNLGITLLSA YMLAELILST WEGGYNLQCQ 
       110        120        130        140        150
DLTSAGEADI RVAKVLWWYY FSKSVEFLDT IFFVLRKKTS QITFLHVYHH 
       160        170        180        190        200
ASMFNIWWCV LNWIPCGQSF FGPTLNSFIH ILMYSYYGLS VFPSMHKYLW 
       210        220        230        240        250
WKKYLTQAQL VQFVLTITHT MSAVVKPCGF PFGCLIFQSS YMLTLVILFL 
       260        270        280        290 
NFYVQTYRKK PMKKDMQEPP AGKEVKNGFS KAYFTAANGV MNKKAQ
Length:296
Mass (Da):34,585
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFB09952FBE90957
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti31M → T in BAA91096 (PubMed:14702039).Curated1
Sequence conflicti179I → V in BAA91096 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039039216T → A1 PublicationCorresponds to variant dbSNP:rs17855038Ensembl.1
Natural variantiVAR_039040225V → M. Corresponds to variant dbSNP:rs6919726Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK000341 mRNA Translation: BAA91096.1
AL121955 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55291.1
BC050278 mRNA Translation: AAH50278.2
BC060809 mRNA Translation: AAH60809.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4518.1

NCBI Reference Sequences

More...RefSeqi		NP_060240.3, NM_017770.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000354666; ENSP00000346693; ENSG00000197977

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54898

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54898

UCSC genome browser

More...UCSCi		uc003mzp.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000341 mRNA Translation: BAA91096.1
AL121955 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55291.1
BC050278 mRNA Translation: AAH50278.2
BC060809 mRNA Translation: AAH60809.1
CCDSiCCDS4518.1
RefSeqiNP_060240.3, NM_017770.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120244, 15 interactors
IntActiQ9NXB9, 12 interactors
STRINGi9606.ENSP00000346693

Chemistry databases

BindingDBiQ9NXB9
ChEMBLiCHEMBL5911
DrugBankiDB00132, alpha-Linolenic acid
SwissLipidsiSLP:000000245

PTM databases

iPTMnetiQ9NXB9
PhosphoSitePlusiQ9NXB9
SwissPalmiQ9NXB9

Genetic variation databases

BioMutaiELOVL2
DMDMi187472388

Proteomic databases

MassIVEiQ9NXB9
MaxQBiQ9NXB9
PaxDbiQ9NXB9
PeptideAtlasiQ9NXB9
PRIDEiQ9NXB9
ProteomicsDBi83070

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		44274, 166 antibodies

The DNASU plasmid repository

More...DNASUi		54898

Genome annotation databases

EnsembliENST00000354666; ENSP00000346693; ENSG00000197977
GeneIDi54898
KEGGihsa:54898
UCSCiuc003mzp.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54898
DisGeNETi54898

GeneCards: human genes, protein and diseases

More...GeneCardsi		ELOVL2
HGNCiHGNC:14416, ELOVL2
HPAiENSG00000197977, Tissue enhanced (brain, liver, parathyroid gland, placenta)
MIMi611814, gene
neXtProtiNX_Q9NXB9
OpenTargetsiENSG00000197977
PharmGKBiPA27761
VEuPathDBiHostDB:ENSG00000197977.3

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3071, Eukaryota
GeneTreeiENSGT01030000234600
HOGENOMiCLU_048483_0_1_1
InParanoidiQ9NXB9
OMAiATWEGGY
OrthoDBi1094172at2759
PhylomeDBiQ9NXB9
TreeFamiTF323454

Enzyme and pathway databases

UniPathwayiUPA00658
BioCyciMetaCyc:ENSG00000096256-MONOMER
PathwayCommonsiQ9NXB9
ReactomeiR-HSA-2046105, Linoleic acid (LA) metabolism
R-HSA-2046106, alpha-linolenic acid (ALA) metabolism
R-HSA-75876, Synthesis of very long-chain fatty acyl-CoAs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54898, 3 hits in 987 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ELOVL2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54898
PharosiQ9NXB9, Tbio

Protein Ontology

More...PROi		PR:Q9NXB9
RNActiQ9NXB9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197977, Expressed in ventricular zone and 172 other tissues
ExpressionAtlasiQ9NXB9, baseline and differential
GenevisibleiQ9NXB9, HS

Family and domain databases

HAMAPiMF_03202, VLCF_elongase_2, 1 hit
InterProiView protein in InterPro
IPR030457, ELO_CS
IPR002076, ELO_fam
IPR033680, ELOVL2
PANTHERiPTHR11157, PTHR11157, 1 hit
PTHR11157:SF16, PTHR11157:SF16, 1 hit
PfamiView protein in Pfam
PF01151, ELO, 1 hit
PROSITEiView protein in PROSITE
PS01188, ELO, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELOV2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NXB9
Secondary accession number(s): Q6P9E1, Q86W94
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: February 26, 2008
Last modified: June 2, 2021
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
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