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Entry version 127 (17 Jun 2020)
Sequence version 3 (18 May 2010)
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Protein

Transmembrane protein 260

Gene

TMEM260

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 260
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM260
Synonyms:C14orf101
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000070269.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20185 TMEM260

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617449 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NX78

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Structural heart defects and renal anomalies syndrome (SHDRA)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive syndrome characterized by central nervous system, cardiac, renal, and digit abnormalities. Clinical features include ventricular and atrial septal defects, truncus arteriosus, tetralogy of Fallot, partial anomalous pulmonary venous return, renal cysts, renal failure, and generalized edema. Some patients show partial agenesis of corpus callosum.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_078766465 – 707Missing in SHDRA; reduced expression of isoform 1 due to nonsense-mediated decay in patient-derived cells. 1 PublicationAdd BLAST243

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
54916

MalaCards human disease database

More...
MalaCardsi
TMEM260
MIMi617478 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000070269

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134894829

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NX78 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM260

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439393

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000899051 – 707Transmembrane protein 260Add BLAST707

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NX78

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NX78

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NX78

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NX78

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NX78

PeptideAtlas

More...
PeptideAtlasi
Q9NX78

PRoteomics IDEntifications database

More...
PRIDEi
Q9NX78

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58786
83054 [Q9NX78-1]
83055 [Q9NX78-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NX78

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NX78

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 3 are expressed in brain, heart, kidney, liver, lung, pancreas and placenta but are not detected in skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000070269 Expressed in caput epididymis and 211 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NX78 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NX78 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000070269 Tissue enhanced (enhanced)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120258, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NX78, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261556

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NX78 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM260 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IHX8 Eukaryota
ENOG410XQTX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013544

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_019631_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NX78

Identification of Orthologs from Complete Genome Data

More...
OMAi
KAPNDPQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NX78

TreeFam database of animal gene trees

More...
TreeFami
TF329604

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR021280 DUF2723

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11028 DUF2723, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NX78-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSPHGDGRGQ AQGRAVRVGL RRSGGIRGGV AVFAAVAAVF TFTLPPSVPG
60 70 80 90 100
GDSGELITAA HELGVAHPPG YPLFTLVAKL AITLFPFGSI AYRVNLLCGL
110 120 130 140 150
FGAVAASLLF FTVFRLSGSS AGGILAAGVF SFSRLTWQWS IAAEVFSLNN
160 170 180 190 200
LFVGLLMALT VHFEEAATAK ERSKVAKIGA FCCGLSLCNQ HTIILYVLCI
210 220 230 240 250
IPWILFQLLK KKELSLGSLL KLSLYFSAGL LPYVHLPISS YLNHARWTWG
260 270 280 290 300
DQTTLQGFLT HFLREEYGTF SLAKSEIGSS MSEILLSQVT NMRTELSFNI
310 320 330 340 350
QALAVCANIC LATKDRQNPS LVWLFTGMFC IYSLFFAWRA NLDISKPLFM
360 370 380 390 400
GVVERFWMQS NAVVAVLAGI GLAAVVSETN RVLNSNGLQC LEWLSATLFV
410 420 430 440 450
VYQIYSNYSV CDQRTNYVID KFAKNLLTSM PHDAIILLRG DLPGNSLRYM
460 470 480 490 500
HYCEGLRPDI SLVDQEMMTY EWYLPKMAKH LPGVNFPGNR WNPVEGILPS
510 520 530 540 550
GMVTFNLYHF LEVNKQKETF VCIGIHEGDP TWKKNYSLWP WGSCDKLVPL
560 570 580 590 600
EIVFNPEEWI KLTKSIYNWT EEYGRFDPSS WESVANEEMW QARMKTPFFI
610 620 630 640 650
FNLAETAHMP SKVKAQLYAQ AYDLYKEIVY LQKEHPVNWH KNYAIACERM
660 670 680 690 700
LRLQARDADP EVLLSETIRH FRLYSQKAPN DPQQADILGA LKHLRKELQS

LRNRKNV
Length:707
Mass (Da):79,536
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3EAB7ED42B77489
GO
Isoform 2 (identifier: Q9NX78-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-707: Missing.

Show »
Length:286
Mass (Da):30,702
Checksum:iC8F4DC3BB7A8F640
GO
Isoform 3 (identifier: Q9NX78-3) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     409-409: S → R
     410-707: Missing.

Show »
Length:409
Mass (Da):44,539
Checksum:i36196D2B3B315264
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H7D0F5H7D0_HUMAN
Transmembrane protein 260
TMEM260
324Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4A2G3V4A2_HUMAN
Transmembrane protein 260
TMEM260
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V320G3V320_HUMAN
Transmembrane protein 260
TMEM260
253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4Y3G3V4Y3_HUMAN
Transmembrane protein 260
TMEM260
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJX9H0YJX9_HUMAN
Transmembrane protein 260
TMEM260
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJK2H0YJK2_HUMAN
Transmembrane protein 260
TMEM260
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YK00H0YK00_HUMAN
Transmembrane protein 260
TMEM260
20Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91139 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BC045556 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3P → H in BC045556 (PubMed:15489334).Curated1
Sequence conflicti57I → T in BAF85788 (PubMed:14702039).Curated1
Sequence conflicti335F → V in BAA91139 (PubMed:14702039).Curated1
Sequence conflicti680N → S in BAF85788 (PubMed:14702039).Curated1
Sequence conflicti680N → S in BAG51667 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057823245A → S1 PublicationCorresponds to variant dbSNP:rs17776256Ensembl.1
Natural variantiVAR_078766465 – 707Missing in SHDRA; reduced expression of isoform 1 due to nonsense-mediated decay in patient-derived cells. 1 PublicationAdd BLAST243
Natural variantiVAR_057824565S → N. Corresponds to variant dbSNP:rs1041316Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008621287 – 707Missing in isoform 2. 1 PublicationAdd BLAST421
Alternative sequenceiVSP_058993409S → R in isoform 3. 1 Publication1
Alternative sequenceiVSP_058994410 – 707Missing in isoform 3. 1 PublicationAdd BLAST298

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000399 mRNA Translation: BAA91139.1 Different initiation.
AK293099 mRNA Translation: BAF85788.1
AK056291 mRNA Translation: BAG51667.1
AL161757 Genomic DNA No translation available.
AL355103 Genomic DNA No translation available.
AL359234 Genomic DNA No translation available.
KF455900 Genomic DNA No translation available.
BC045556 mRNA No translation available.
BC121163 mRNA Translation: AAI21164.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9727.2 [Q9NX78-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060269.3, NM_017799.3 [Q9NX78-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261556; ENSP00000261556; ENSG00000070269 [Q9NX78-1]
ENST00000538838; ENSP00000441934; ENSG00000070269 [Q9NX78-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54916

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54916

UCSC genome browser

More...
UCSCi
uc001xcm.4 human [Q9NX78-1]
uc059bva.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000399 mRNA Translation: BAA91139.1 Different initiation.
AK293099 mRNA Translation: BAF85788.1
AK056291 mRNA Translation: BAG51667.1
AL161757 Genomic DNA No translation available.
AL355103 Genomic DNA No translation available.
AL359234 Genomic DNA No translation available.
KF455900 Genomic DNA No translation available.
BC045556 mRNA No translation available.
BC121163 mRNA Translation: AAI21164.1
CCDSiCCDS9727.2 [Q9NX78-1]
RefSeqiNP_060269.3, NM_017799.3 [Q9NX78-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120258, 9 interactors
IntActiQ9NX78, 6 interactors
STRINGi9606.ENSP00000261556

PTM databases

iPTMnetiQ9NX78
PhosphoSitePlusiQ9NX78

Polymorphism and mutation databases

BioMutaiTMEM260
DMDMi296439393

Proteomic databases

EPDiQ9NX78
jPOSTiQ9NX78
MassIVEiQ9NX78
MaxQBiQ9NX78
PaxDbiQ9NX78
PeptideAtlasiQ9NX78
PRIDEiQ9NX78
ProteomicsDBi58786
83054 [Q9NX78-1]
83055 [Q9NX78-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
185 45 antibodies

Genome annotation databases

EnsembliENST00000261556; ENSP00000261556; ENSG00000070269 [Q9NX78-1]
ENST00000538838; ENSP00000441934; ENSG00000070269 [Q9NX78-3]
GeneIDi54916
KEGGihsa:54916
UCSCiuc001xcm.4 human [Q9NX78-1]
uc059bva.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54916
DisGeNETi54916
EuPathDBiHostDB:ENSG00000070269.13

GeneCards: human genes, protein and diseases

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GeneCardsi
TMEM260
HGNCiHGNC:20185 TMEM260
HPAiENSG00000070269 Tissue enhanced (enhanced)
MalaCardsiTMEM260
MIMi617449 gene
617478 phenotype
neXtProtiNX_Q9NX78
OpenTargetsiENSG00000070269
PharmGKBiPA134894829

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IHX8 Eukaryota
ENOG410XQTX LUCA
GeneTreeiENSGT00390000013544
HOGENOMiCLU_019631_1_0_1
InParanoidiQ9NX78
OMAiKAPNDPQ
PhylomeDBiQ9NX78
TreeFamiTF329604

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
54916 1 hit in 791 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TMEM260 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54916
PharosiQ9NX78 Tdark

Protein Ontology

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PROi
PR:Q9NX78
RNActiQ9NX78 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000070269 Expressed in caput epididymis and 211 other tissues
ExpressionAtlasiQ9NX78 baseline and differential
GenevisibleiQ9NX78 HS

Family and domain databases

InterProiView protein in InterPro
IPR021280 DUF2723
PfamiView protein in Pfam
PF11028 DUF2723, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM260_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NX78
Secondary accession number(s): A8KAN4
, B3KPF5, Q0VAA1, Q86XE1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: May 18, 2010
Last modified: June 17, 2020
This is version 127 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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