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UniProtKB - Q9NX65 (ZSC32_HUMAN)

Protein

Zinc finger and SCAN domain-containing protein 32

Gene

ZSCAN32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri521 – 543C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 32
Alternative name(s):
Human cervical cancer suppressor gene 5 protein
Short name:
HCCS-5
Zinc finger protein 434
Gene namesi
Name:ZSCAN32
Synonyms:ZNF434
ORF Names:HCCS5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000140987.19
HGNCiHGNC:20812 ZSCAN32
neXtProtiNX_Q9NX65

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140987
PharmGKBiPA134902932

Polymorphism and mutation databases

DMDMi519668684

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475821 – 697Zinc finger and SCAN domain-containing protein 32Add BLAST697

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki152Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki163Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki400Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki685Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9NX65
PaxDbiQ9NX65
PeptideAtlasiQ9NX65
PRIDEiQ9NX65
ProteomicsDBi83049

PTM databases

iPTMnetiQ9NX65
PhosphoSitePlusiQ9NX65

Expressioni

Gene expression databases

BgeeiENSG00000140987 Expressed in 188 organ(s), highest expression level in right uterine tube
CleanExiHS_ZNF434
ExpressionAtlasiQ9NX65 baseline and differential
GenevisibleiQ9NX65 HS

Organism-specific databases

HPAiHPA005758

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZNF24P170283EBI-739949,EBI-707773

Protein-protein interaction databases

BioGridi120265, 39 interactors
IntActiQ9NX65, 4 interactors
STRINGi9606.ENSP00000302502

Structurei

3D structure databases

ProteinModelPortaliQ9NX65
SMRiQ9NX65
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 119SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini212 – 296KRABAdd BLAST85

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri521 – 543C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063287
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ9NX65
KOiK09228
OMAiENLKWDD
OrthoDBiEOG091G09O3
PhylomeDBiQ9NX65
TreeFamiTF336839

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NX65-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAAVKSTEA HPSSNKDPTQ GQKSALQGNS PDSEASRQRF RQFCYQEVTG 
        60         70         80         90        100
PHEAFSKLWE LCCQWLRPKT HSKEEILELL VLEQFLTILP EEIQTWVREQ 
       110        120        130        140        150
HPENGEEAVA LVEDVQRAPG QQVLDSEKDL KVLMKEMAPL GATRESLRSQ 
       160        170        180        190        200
WKQEVQPEEP TFKGSQSSHQ RPGEQSEAWL APQAPRNLPQ NTGLHDQETG 
       210        220        230        240        250
AVVWTAGSQG PAMRDNRAVS LCQQEWMCPG PAQRALYRGA TQRKDSHVSL 
       260        270        280        290        300
ATGVPWGYEE TKTLLAILSS SQFYGKLQTC QQNSQIYRAM AEGLWEQGFL 
       310        320        330        340        350
RTPEQCRTKF KSLQLSYRKV RRGRVPEPCI FYEEMNALSG SWASAPPMAS 
       360        370        380        390        400
DAVPGQEGSD IEAGELNHQN GEPTEVEDGT VDGADRDEKD FRNPGQEVRK 
       410        420        430        440        450
LDLPVLFPNR LGFEFKNEIK KENLKWDDSE EVEINKALQR KSRGVYWHSE 
       460        470        480        490        500
LQKGLESEPT SRRQCRNSPG ESEEKTPSQE KMSHQSFCAR DKACTHILCG 
       510        520        530        540        550
KNCSQSVHSP HKPALKLEKV SQCPECGKTF SRSSYLVRHQ RIHTGEKPHK 
       560        570        580        590        600
CSECGKGFSE RSNLTAHLRT HTGERPYQCG QCGKSFNQSS SLIVHQRTHT 
       610        620        630        640        650
GEKPYQCIVC GKRFNNSSQF SAHRRIHTGE SPYKCAVCGK IFNNSSHFSA 
       660        670        680        690 
HRKTHTGEKP YRCSHCERGF TKNSALTRHQ TVHMKAVLSS QEGRDAL
Length:697
Mass (Da):78,728
Last modified:June 26, 2013 - v3
Checksum:iAAD779F62506FBCB
GO
Isoform 2 (identifier: Q9NX65-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-212: Missing.

Show »
Length:485
Mass (Da):54,929
Checksum:i7746A7684DC96631
GO
Isoform 3 (identifier: Q9NX65-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-289: Missing.

Note: No experimental confirmation available.
Show »
Length:408
Mass (Da):46,222
Checksum:i0B8440212CC12810
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3J2I3L3J2_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN32
425Annotation score:
I3L2L7I3L2L7_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN32
427Annotation score:
B4DR24B4DR24_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN32
215Annotation score:
I3L1K0I3L1K0_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN32
186Annotation score:
I3L4W6I3L4W6_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN32
229Annotation score:
I3L1S7I3L1S7_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN32
186Annotation score:
I3L3Y8I3L3Y8_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN32
217Annotation score:
I3L2V3I3L2V3_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN32
138Annotation score:

Sequence cautioni

The sequence AAH02859 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 426.Curated
The sequence AAH02859 differs from that shown. Reason: Frameshift at position 254.Curated
The sequence AAM73658 differs from that shown. The cDNA sequence has been translated in the reverse direction.Curated
The sequence BAA91155 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052826266A → V. Corresponds to variant dbSNP:rs17136369Ensembl.1
Natural variantiVAR_024215332Y → H. Corresponds to variant dbSNP:rs27230Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559881 – 289Missing in isoform 3. 1 PublicationAdd BLAST289
Alternative sequenceiVSP_0465711 – 212Missing in isoform 2. 3 PublicationsAdd BLAST212

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY261676 mRNA Translation: AAP57398.1
AF390550 mRNA Translation: AAM73658.1 Sequence problems.
AY279347 mRNA Translation: AAQ62844.1
AK000424 mRNA Translation: BAA91155.1 Different initiation.
AK291213 mRNA Translation: BAF83902.1
AK301586 mRNA Translation: BAG63077.1
AC025283 Genomic DNA No translation available.
BC002859 mRNA Translation: AAH02859.1 Sequence problems.
CCDSiCCDS10503.1 [Q9NX65-2]
CCDS66920.1 [Q9NX65-3]
CCDS66921.1 [Q9NX65-1]
RefSeqiNP_001271456.1, NM_001284527.1 [Q9NX65-1]
NP_001271457.1, NM_001284528.1 [Q9NX65-3]
NP_001271458.1, NM_001284529.1 [Q9NX65-3]
NP_001311269.1, NM_001324340.1 [Q9NX65-2]
NP_001311270.1, NM_001324341.1 [Q9NX65-2]
NP_001311271.1, NM_001324342.1 [Q9NX65-2]
NP_001311273.1, NM_001324344.1 [Q9NX65-2]
NP_001311274.1, NM_001324345.1 [Q9NX65-2]
NP_060280.2, NM_017810.3 [Q9NX65-2]
XP_011520857.1, XM_011522555.2 [Q9NX65-1]
XP_016878860.1, XM_017023371.1 [Q9NX65-1]
UniGeneiHs.592078

Genome annotation databases

EnsembliENST00000304926; ENSP00000302502; ENSG00000140987 [Q9NX65-2]
ENST00000396846; ENSP00000380057; ENSG00000140987 [Q9NX65-1]
ENST00000396852; ENSP00000380061; ENSG00000140987 [Q9NX65-1]
ENST00000439568; ENSP00000391787; ENSG00000140987 [Q9NX65-3]
ENST00000618425; ENSP00000483210; ENSG00000140987 [Q9NX65-3]
GeneIDi54925
KEGGihsa:54925
UCSCiuc002cux.5 human [Q9NX65-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY261676 mRNA Translation: AAP57398.1
AF390550 mRNA Translation: AAM73658.1 Sequence problems.
AY279347 mRNA Translation: AAQ62844.1
AK000424 mRNA Translation: BAA91155.1 Different initiation.
AK291213 mRNA Translation: BAF83902.1
AK301586 mRNA Translation: BAG63077.1
AC025283 Genomic DNA No translation available.
BC002859 mRNA Translation: AAH02859.1 Sequence problems.
CCDSiCCDS10503.1 [Q9NX65-2]
CCDS66920.1 [Q9NX65-3]
CCDS66921.1 [Q9NX65-1]
RefSeqiNP_001271456.1, NM_001284527.1 [Q9NX65-1]
NP_001271457.1, NM_001284528.1 [Q9NX65-3]
NP_001271458.1, NM_001284529.1 [Q9NX65-3]
NP_001311269.1, NM_001324340.1 [Q9NX65-2]
NP_001311270.1, NM_001324341.1 [Q9NX65-2]
NP_001311271.1, NM_001324342.1 [Q9NX65-2]
NP_001311273.1, NM_001324344.1 [Q9NX65-2]
NP_001311274.1, NM_001324345.1 [Q9NX65-2]
NP_060280.2, NM_017810.3 [Q9NX65-2]
XP_011520857.1, XM_011522555.2 [Q9NX65-1]
XP_016878860.1, XM_017023371.1 [Q9NX65-1]
UniGeneiHs.592078

3D structure databases

ProteinModelPortaliQ9NX65
SMRiQ9NX65
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120265, 39 interactors
IntActiQ9NX65, 4 interactors
STRINGi9606.ENSP00000302502

PTM databases

iPTMnetiQ9NX65
PhosphoSitePlusiQ9NX65

Polymorphism and mutation databases

DMDMi519668684

Proteomic databases

MaxQBiQ9NX65
PaxDbiQ9NX65
PeptideAtlasiQ9NX65
PRIDEiQ9NX65
ProteomicsDBi83049

Protocols and materials databases

DNASUi54925
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304926; ENSP00000302502; ENSG00000140987 [Q9NX65-2]
ENST00000396846; ENSP00000380057; ENSG00000140987 [Q9NX65-1]
ENST00000396852; ENSP00000380061; ENSG00000140987 [Q9NX65-1]
ENST00000439568; ENSP00000391787; ENSG00000140987 [Q9NX65-3]
ENST00000618425; ENSP00000483210; ENSG00000140987 [Q9NX65-3]
GeneIDi54925
KEGGihsa:54925
UCSCiuc002cux.5 human [Q9NX65-1]

Organism-specific databases

CTDi54925
EuPathDBiHostDB:ENSG00000140987.19
GeneCardsiZSCAN32
HGNCiHGNC:20812 ZSCAN32
HPAiHPA005758
neXtProtiNX_Q9NX65
OpenTargetsiENSG00000140987
PharmGKBiPA134902932
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063287
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ9NX65
KOiK09228
OMAiENLKWDD
OrthoDBiEOG091G09O3
PhylomeDBiQ9NX65
TreeFamiTF336839

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAii54925
PROiPR:Q9NX65

Gene expression databases

BgeeiENSG00000140987 Expressed in 188 organ(s), highest expression level in right uterine tube
CleanExiHS_ZNF434
ExpressionAtlasiQ9NX65 baseline and differential
GenevisibleiQ9NX65 HS

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZSC32_HUMAN
AccessioniPrimary (citable) accession number: Q9NX65
Secondary accession number(s): B4DWL5
, C9JB03, Q6WMU8, Q7Z6G2, Q8NFX8, Q9BU74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 26, 2013
Last modified: November 7, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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