UniProtKB - Q9NX65 (ZSC32_HUMAN)
Protein
Zinc finger and SCAN domain-containing protein 32
Gene
ZSCAN32
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 521 – 543 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 549 – 571 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 577 – 599 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 605 – 627 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 633 – 655 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 661 – 683 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9NX65 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and SCAN domain-containing protein 32Alternative name(s): Human cervical cancer suppressor gene 5 protein Short name: HCCS-5 Zinc finger protein 434 |
Gene namesi | Name:ZSCAN32 Synonyms:ZNF434 ORF Names:HCCS5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20812, ZSCAN32 |
neXtProti | NX_Q9NX65 |
VEuPathDBi | HostDB:ENSG00000140987.19 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000140987 |
PharmGKBi | PA134902932 |
Miscellaneous databases
Pharosi | Q9NX65, Tdark |
Genetic variation databases
BioMutai | ZSCAN32 |
DMDMi | 519668684 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047582 | 1 – 697 | Zinc finger and SCAN domain-containing protein 32Add BLAST | 697 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 152 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 163 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 400 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 685 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
MassIVEi | Q9NX65 |
MaxQBi | Q9NX65 |
PaxDbi | Q9NX65 |
PeptideAtlasi | Q9NX65 |
PRIDEi | Q9NX65 |
ProteomicsDBi | 5355 79059 83049 [Q9NX65-1] |
PTM databases
iPTMneti | Q9NX65 |
PhosphoSitePlusi | Q9NX65 |
Expressioni
Gene expression databases
Bgeei | ENSG00000140987, Expressed in right uterine tube and 200 other tissues |
ExpressionAtlasi | Q9NX65, baseline and differential |
Genevisiblei | Q9NX65, HS |
Organism-specific databases
HPAi | ENSG00000140987, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9NX65
Protein-protein interaction databases
BioGRIDi | 120265, 43 interactors |
IntActi | Q9NX65, 32 interactors |
STRINGi | 9606.ENSP00000380057 |
Miscellaneous databases
RNActi | Q9NX65, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 37 – 119 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 212 – 296 | KRABAdd BLAST | 85 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 521 – 543 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 549 – 571 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 577 – 599 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 605 – 627 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 633 – 655 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 661 – 683 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159113 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | Q9NX65 |
OMAi | TVHMKAV |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9NX65 |
TreeFami | TF336839 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NX65-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMAAVKSTEA HPSSNKDPTQ GQKSALQGNS PDSEASRQRF RQFCYQEVTG
60 70 80 90 100
PHEAFSKLWE LCCQWLRPKT HSKEEILELL VLEQFLTILP EEIQTWVREQ
110 120 130 140 150
HPENGEEAVA LVEDVQRAPG QQVLDSEKDL KVLMKEMAPL GATRESLRSQ
160 170 180 190 200
WKQEVQPEEP TFKGSQSSHQ RPGEQSEAWL APQAPRNLPQ NTGLHDQETG
210 220 230 240 250
AVVWTAGSQG PAMRDNRAVS LCQQEWMCPG PAQRALYRGA TQRKDSHVSL
260 270 280 290 300
ATGVPWGYEE TKTLLAILSS SQFYGKLQTC QQNSQIYRAM AEGLWEQGFL
310 320 330 340 350
RTPEQCRTKF KSLQLSYRKV RRGRVPEPCI FYEEMNALSG SWASAPPMAS
360 370 380 390 400
DAVPGQEGSD IEAGELNHQN GEPTEVEDGT VDGADRDEKD FRNPGQEVRK
410 420 430 440 450
LDLPVLFPNR LGFEFKNEIK KENLKWDDSE EVEINKALQR KSRGVYWHSE
460 470 480 490 500
LQKGLESEPT SRRQCRNSPG ESEEKTPSQE KMSHQSFCAR DKACTHILCG
510 520 530 540 550
KNCSQSVHSP HKPALKLEKV SQCPECGKTF SRSSYLVRHQ RIHTGEKPHK
560 570 580 590 600
CSECGKGFSE RSNLTAHLRT HTGERPYQCG QCGKSFNQSS SLIVHQRTHT
610 620 630 640 650
GEKPYQCIVC GKRFNNSSQF SAHRRIHTGE SPYKCAVCGK IFNNSSHFSA
660 670 680 690
HRKTHTGEKP YRCSHCERGF TKNSALTRHQ TVHMKAVLSS QEGRDAL
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L2L7 | I3L2L7_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN32 | 427 | Annotation score: | ||
I3L4W6 | I3L4W6_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN32 | 229 | Annotation score: | ||
I3L1S7 | I3L1S7_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN32 | 186 | Annotation score: | ||
I3L3Y8 | I3L3Y8_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN32 | 217 | Annotation score: | ||
B4DR24 | B4DR24_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN32 | 215 | Annotation score: | ||
I3L1K0 | I3L1K0_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN32 | 186 | Annotation score: | ||
A0A499FJR9 | A0A499FJR9_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN32 | 397 | Annotation score: | ||
I3L2V3 | I3L2V3_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN32 | 138 | Annotation score: |
Sequence cautioni
The sequence AAH02859 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 426.Curated
The sequence AAH02859 differs from that shown. Reason: Frameshift.Curated
The sequence AAM73658 differs from that shown. The cDNA sequence has been translated in the reverse direction.Curated
The sequence BAA91155 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052826 | 266 | A → V. Corresponds to variant dbSNP:rs17136369Ensembl. | 1 | |
Natural variantiVAR_024215 | 332 | Y → H. Corresponds to variant dbSNP:rs27230Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055988 | 1 – 289 | Missing in isoform 3. 1 PublicationAdd BLAST | 289 | |
Alternative sequenceiVSP_046571 | 1 – 212 | Missing in isoform 2. 3 PublicationsAdd BLAST | 212 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY261676 mRNA Translation: AAP57398.1 AF390550 mRNA Translation: AAM73658.1 Sequence problems. AY279347 mRNA Translation: AAQ62844.1 AK000424 mRNA Translation: BAA91155.1 Different initiation. AK291213 mRNA Translation: BAF83902.1 AK301586 mRNA Translation: BAG63077.1 AC025283 Genomic DNA No translation available. BC002859 mRNA Translation: AAH02859.1 Sequence problems. |
CCDSi | CCDS10503.1 [Q9NX65-2] CCDS66920.1 [Q9NX65-3] CCDS66921.1 [Q9NX65-1] |
RefSeqi | NP_001271456.1, NM_001284527.1 [Q9NX65-1] NP_001271457.1, NM_001284528.1 [Q9NX65-3] NP_001271458.1, NM_001284529.1 [Q9NX65-3] NP_001311269.1, NM_001324340.1 [Q9NX65-2] NP_001311270.1, NM_001324341.1 [Q9NX65-2] NP_001311271.1, NM_001324342.1 [Q9NX65-2] NP_001311273.1, NM_001324344.1 [Q9NX65-2] NP_001311274.1, NM_001324345.1 [Q9NX65-2] NP_060280.2, NM_017810.3 [Q9NX65-2] XP_011520857.1, XM_011522555.2 [Q9NX65-1] XP_016878860.1, XM_017023371.1 [Q9NX65-1] |
Genome annotation databases
Ensembli | ENST00000304926; ENSP00000302502; ENSG00000140987 [Q9NX65-2] ENST00000396852; ENSP00000380061; ENSG00000140987 [Q9NX65-1] ENST00000439568; ENSP00000391787; ENSG00000140987 [Q9NX65-3] ENST00000618425; ENSP00000483210; ENSG00000140987 [Q9NX65-3] |
GeneIDi | 54925 |
KEGGi | hsa:54925 |
UCSCi | uc002cux.5, human [Q9NX65-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY261676 mRNA Translation: AAP57398.1 AF390550 mRNA Translation: AAM73658.1 Sequence problems. AY279347 mRNA Translation: AAQ62844.1 AK000424 mRNA Translation: BAA91155.1 Different initiation. AK291213 mRNA Translation: BAF83902.1 AK301586 mRNA Translation: BAG63077.1 AC025283 Genomic DNA No translation available. BC002859 mRNA Translation: AAH02859.1 Sequence problems. |
CCDSi | CCDS10503.1 [Q9NX65-2] CCDS66920.1 [Q9NX65-3] CCDS66921.1 [Q9NX65-1] |
RefSeqi | NP_001271456.1, NM_001284527.1 [Q9NX65-1] NP_001271457.1, NM_001284528.1 [Q9NX65-3] NP_001271458.1, NM_001284529.1 [Q9NX65-3] NP_001311269.1, NM_001324340.1 [Q9NX65-2] NP_001311270.1, NM_001324341.1 [Q9NX65-2] NP_001311271.1, NM_001324342.1 [Q9NX65-2] NP_001311273.1, NM_001324344.1 [Q9NX65-2] NP_001311274.1, NM_001324345.1 [Q9NX65-2] NP_060280.2, NM_017810.3 [Q9NX65-2] XP_011520857.1, XM_011522555.2 [Q9NX65-1] XP_016878860.1, XM_017023371.1 [Q9NX65-1] |
3D structure databases
SMRi | Q9NX65 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120265, 43 interactors |
IntActi | Q9NX65, 32 interactors |
STRINGi | 9606.ENSP00000380057 |
PTM databases
iPTMneti | Q9NX65 |
PhosphoSitePlusi | Q9NX65 |
Genetic variation databases
BioMutai | ZSCAN32 |
DMDMi | 519668684 |
Proteomic databases
MassIVEi | Q9NX65 |
MaxQBi | Q9NX65 |
PaxDbi | Q9NX65 |
PeptideAtlasi | Q9NX65 |
PRIDEi | Q9NX65 |
ProteomicsDBi | 5355 79059 83049 [Q9NX65-1] |
Protocols and materials databases
Antibodypediai | 1740, 107 antibodies |
DNASUi | 54925 |
Genome annotation databases
Ensembli | ENST00000304926; ENSP00000302502; ENSG00000140987 [Q9NX65-2] ENST00000396852; ENSP00000380061; ENSG00000140987 [Q9NX65-1] ENST00000439568; ENSP00000391787; ENSG00000140987 [Q9NX65-3] ENST00000618425; ENSP00000483210; ENSG00000140987 [Q9NX65-3] |
GeneIDi | 54925 |
KEGGi | hsa:54925 |
UCSCi | uc002cux.5, human [Q9NX65-1] |
Organism-specific databases
CTDi | 54925 |
GeneCardsi | ZSCAN32 |
HGNCi | HGNC:20812, ZSCAN32 |
HPAi | ENSG00000140987, Low tissue specificity |
neXtProti | NX_Q9NX65 |
OpenTargetsi | ENSG00000140987 |
PharmGKBi | PA134902932 |
VEuPathDBi | HostDB:ENSG00000140987.19 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159113 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | Q9NX65 |
OMAi | TVHMKAV |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9NX65 |
TreeFami | TF336839 |
Enzyme and pathway databases
PathwayCommonsi | Q9NX65 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 54925, 4 hits in 1016 CRISPR screens |
ChiTaRSi | ZSCAN32, human |
GenomeRNAii | 54925 |
Pharosi | Q9NX65, Tdark |
PROi | PR:Q9NX65 |
RNActi | Q9NX65, protein |
Gene expression databases
Bgeei | ENSG00000140987, Expressed in right uterine tube and 200 other tissues |
ExpressionAtlasi | Q9NX65, baseline and differential |
Genevisiblei | Q9NX65, HS |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZSC32_HUMAN | |
Accessioni | Q9NX65Primary (citable) accession number: Q9NX65 Secondary accession number(s): B4DWL5 Q9BU74 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 23, 2003 |
Last sequence update: | June 26, 2013 | |
Last modified: | April 7, 2021 | |
This is version 169 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families