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UniProtKB - Q9NX65 (ZSC32_HUMAN)

Entry version 173 (25 May 2022)
Sequence version 3 (26 Jun 2013)
Previous versions | rss
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Protein

Zinc finger and SCAN domain-containing protein 32

Gene

ZSCAN32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri521 – 543C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NX65

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NX65

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 32
Alternative name(s):
Human cervical cancer suppressor gene 5 protein
Short name:
HCCS-5
Zinc finger protein 434
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZSCAN32
Synonyms:ZNF434
ORF Names:HCCS5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20812, ZSCAN32

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NX65

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000140987

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000140987

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134902932

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NX65, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZSCAN32

Domain mapping of disease mutations (DMDM)

More...DMDMi		519668684

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475821 – 697Zinc finger and SCAN domain-containing protein 32Add BLAST697

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki152Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki163Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki400Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki685Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NX65

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NX65

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NX65

PeptideAtlas

More...PeptideAtlasi		Q9NX65

PRoteomics IDEntifications database

More...PRIDEi		Q9NX65

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5355
79059
83049 [Q9NX65-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NX65, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NX65

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NX65

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140987, Expressed in right uterine tube and 201 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NX65, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NX65, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140987, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120265, 45 interactors

Protein interaction database and analysis system

More...IntActi		Q9NX65, 33 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000380057

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NX65, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9NX65

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NX65

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 119SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini212 – 296KRABAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 33DisorderedSequence analysisAdd BLAST33
Regioni144 – 177DisorderedSequence analysisAdd BLAST34
Regioni347 – 395DisorderedSequence analysisAdd BLAST49
Regioni451 – 482DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 33Polar residuesSequence analysisAdd BLAST26
Compositional biasi146 – 174Polar residuesSequence analysisAdd BLAST29
Compositional biasi379 – 395Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri521 – 543C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159113

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_49_8_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NX65

Identification of Orthologs from Complete Genome Data

More...OMAi		HFSAHQK

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NX65

TreeFam database of animal gene trees

More...TreeFami		TF336839

Family and domain databases

Conserved Domains Database

More...CDDi		cd07936, SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036051, KRAB_dom_sf
IPR044822, Myb_DNA-bind_4
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13837, Myb_DNA-bind_4, 1 hit
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 6 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NX65-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAAVKSTEA HPSSNKDPTQ GQKSALQGNS PDSEASRQRF RQFCYQEVTG 
        60         70         80         90        100
PHEAFSKLWE LCCQWLRPKT HSKEEILELL VLEQFLTILP EEIQTWVREQ 
       110        120        130        140        150
HPENGEEAVA LVEDVQRAPG QQVLDSEKDL KVLMKEMAPL GATRESLRSQ 
       160        170        180        190        200
WKQEVQPEEP TFKGSQSSHQ RPGEQSEAWL APQAPRNLPQ NTGLHDQETG 
       210        220        230        240        250
AVVWTAGSQG PAMRDNRAVS LCQQEWMCPG PAQRALYRGA TQRKDSHVSL 
       260        270        280        290        300
ATGVPWGYEE TKTLLAILSS SQFYGKLQTC QQNSQIYRAM AEGLWEQGFL 
       310        320        330        340        350
RTPEQCRTKF KSLQLSYRKV RRGRVPEPCI FYEEMNALSG SWASAPPMAS 
       360        370        380        390        400
DAVPGQEGSD IEAGELNHQN GEPTEVEDGT VDGADRDEKD FRNPGQEVRK 
       410        420        430        440        450
LDLPVLFPNR LGFEFKNEIK KENLKWDDSE EVEINKALQR KSRGVYWHSE 
       460        470        480        490        500
LQKGLESEPT SRRQCRNSPG ESEEKTPSQE KMSHQSFCAR DKACTHILCG 
       510        520        530        540        550
KNCSQSVHSP HKPALKLEKV SQCPECGKTF SRSSYLVRHQ RIHTGEKPHK 
       560        570        580        590        600
CSECGKGFSE RSNLTAHLRT HTGERPYQCG QCGKSFNQSS SLIVHQRTHT 
       610        620        630        640        650
GEKPYQCIVC GKRFNNSSQF SAHRRIHTGE SPYKCAVCGK IFNNSSHFSA 
       660        670        680        690 
HRKTHTGEKP YRCSHCERGF TKNSALTRHQ TVHMKAVLSS QEGRDAL
Length:697
Mass (Da):78,728
Last modified:June 26, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAAD779F62506FBCB
GO
Isoform 2 (identifier: Q9NX65-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-212: Missing.

Show »
Length:485
Mass (Da):54,929
Checksum:i7746A7684DC96631
GO
Isoform 3 (identifier: Q9NX65-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-289: Missing.

Show »
Length:408
Mass (Da):46,222
Checksum:i0B8440212CC12810
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L2L7I3L2L7_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN32
427Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1S7I3L1S7_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN32
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3Y8I3L3Y8_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN32
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4W6I3L4W6_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN32
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1K0I3L1K0_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN32
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DR24B4DR24_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN32
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2V3I3L2V3_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN32
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH02859 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 426.Curated
The sequence AAH02859 differs from that shown. Reason: Frameshift.Curated
The sequence AAM73658 differs from that shown. The cDNA sequence has been translated in the reverse direction.Curated
The sequence BAA91155 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052826266A → V. Corresponds to variant dbSNP:rs17136369Ensembl.1
Natural variantiVAR_024215332Y → H. Corresponds to variant dbSNP:rs27230Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0559881 – 289Missing in isoform 3. 1 PublicationAdd BLAST289
Alternative sequenceiVSP_0465711 – 212Missing in isoform 2. 3 PublicationsAdd BLAST212

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY261676 mRNA Translation: AAP57398.1
AF390550 mRNA Translation: AAM73658.1 Sequence problems.
AY279347 mRNA Translation: AAQ62844.1
AK000424 mRNA Translation: BAA91155.1 Different initiation.
AK291213 mRNA Translation: BAF83902.1
AK301586 mRNA Translation: BAG63077.1
AC025283 Genomic DNA No translation available.
BC002859 mRNA Translation: AAH02859.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10503.1 [Q9NX65-2]
CCDS66920.1 [Q9NX65-3]
CCDS66921.1 [Q9NX65-1]

NCBI Reference Sequences

More...RefSeqi		NP_001271456.1, NM_001284527.1 [Q9NX65-1]
NP_001271457.1, NM_001284528.1 [Q9NX65-3]
NP_001271458.1, NM_001284529.1 [Q9NX65-3]
NP_001311269.1, NM_001324340.1 [Q9NX65-2]
NP_001311270.1, NM_001324341.1 [Q9NX65-2]
NP_001311271.1, NM_001324342.1 [Q9NX65-2]
NP_001311273.1, NM_001324344.1 [Q9NX65-2]
NP_001311274.1, NM_001324345.1 [Q9NX65-2]
NP_060280.2, NM_017810.3 [Q9NX65-2]
XP_011520857.1, XM_011522555.2 [Q9NX65-1]
XP_016878860.1, XM_017023371.1 [Q9NX65-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000304926.7; ENSP00000302502.3; ENSG00000140987.21 [Q9NX65-2]
ENST00000396852.9; ENSP00000380061.4; ENSG00000140987.21
ENST00000439568.2; ENSP00000391787.2; ENSG00000140987.21 [Q9NX65-3]
ENST00000618425.4; ENSP00000483210.1; ENSG00000140987.21 [Q9NX65-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54925

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54925

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000396852.9; ENSP00000380061.4; NM_001284527.2; NP_001271456.1

UCSC genome browser

More...UCSCi		uc002cux.5, human [Q9NX65-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY261676 mRNA Translation: AAP57398.1
AF390550 mRNA Translation: AAM73658.1 Sequence problems.
AY279347 mRNA Translation: AAQ62844.1
AK000424 mRNA Translation: BAA91155.1 Different initiation.
AK291213 mRNA Translation: BAF83902.1
AK301586 mRNA Translation: BAG63077.1
AC025283 Genomic DNA No translation available.
BC002859 mRNA Translation: AAH02859.1 Sequence problems.
CCDSiCCDS10503.1 [Q9NX65-2]
CCDS66920.1 [Q9NX65-3]
CCDS66921.1 [Q9NX65-1]
RefSeqiNP_001271456.1, NM_001284527.1 [Q9NX65-1]
NP_001271457.1, NM_001284528.1 [Q9NX65-3]
NP_001271458.1, NM_001284529.1 [Q9NX65-3]
NP_001311269.1, NM_001324340.1 [Q9NX65-2]
NP_001311270.1, NM_001324341.1 [Q9NX65-2]
NP_001311271.1, NM_001324342.1 [Q9NX65-2]
NP_001311273.1, NM_001324344.1 [Q9NX65-2]
NP_001311274.1, NM_001324345.1 [Q9NX65-2]
NP_060280.2, NM_017810.3 [Q9NX65-2]
XP_011520857.1, XM_011522555.2 [Q9NX65-1]
XP_016878860.1, XM_017023371.1 [Q9NX65-1]

3D structure databases

AlphaFoldDBiQ9NX65
SMRiQ9NX65
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120265, 45 interactors
IntActiQ9NX65, 33 interactors
STRINGi9606.ENSP00000380057

PTM databases

GlyGeniQ9NX65, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9NX65
PhosphoSitePlusiQ9NX65

Genetic variation databases

BioMutaiZSCAN32
DMDMi519668684

Proteomic databases

MassIVEiQ9NX65
MaxQBiQ9NX65
PaxDbiQ9NX65
PeptideAtlasiQ9NX65
PRIDEiQ9NX65
ProteomicsDBi5355
79059
83049 [Q9NX65-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1740, 110 antibodies from 19 providers

The DNASU plasmid repository

More...DNASUi		54925

Genome annotation databases

EnsembliENST00000304926.7; ENSP00000302502.3; ENSG00000140987.21 [Q9NX65-2]
ENST00000396852.9; ENSP00000380061.4; ENSG00000140987.21
ENST00000439568.2; ENSP00000391787.2; ENSG00000140987.21 [Q9NX65-3]
ENST00000618425.4; ENSP00000483210.1; ENSG00000140987.21 [Q9NX65-3]
GeneIDi54925
KEGGihsa:54925
MANE-SelectiENST00000396852.9; ENSP00000380061.4; NM_001284527.2; NP_001271456.1
UCSCiuc002cux.5, human [Q9NX65-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54925

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZSCAN32
HGNCiHGNC:20812, ZSCAN32
HPAiENSG00000140987, Low tissue specificity
neXtProtiNX_Q9NX65
OpenTargetsiENSG00000140987
PharmGKBiPA134902932
VEuPathDBiHostDB:ENSG00000140987

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000159113
HOGENOMiCLU_002678_49_8_1
InParanoidiQ9NX65
OMAiHFSAHQK
OrthoDBi1318335at2759
PhylomeDBiQ9NX65
TreeFamiTF336839

Enzyme and pathway databases

PathwayCommonsiQ9NX65
ReactomeiR-HSA-212436, Generic Transcription Pathway
SignaLinkiQ9NX65

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54925, 11 hits in 1100 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZSCAN32, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54925
PharosiQ9NX65, Tdark

Protein Ontology

More...PROi		PR:Q9NX65
RNActiQ9NX65, protein

Gene expression databases

BgeeiENSG00000140987, Expressed in right uterine tube and 201 other tissues
ExpressionAtlasiQ9NX65, baseline and differential
GenevisibleiQ9NX65, HS

Family and domain databases

CDDicd07936, SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR036051, KRAB_dom_sf
IPR044822, Myb_DNA-bind_4
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF13837, Myb_DNA-bind_4, 1 hit
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 6 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 6 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZSC32_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NX65
Secondary accession number(s): B4DWL5
, C9JB03, Q6WMU8, Q7Z6G2, Q8NFX8, Q9BU74
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 26, 2013
Last modified: May 25, 2022
This is version 173 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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