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Protein

Ras-related protein Rab-20

Gene

RAB20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19GTPBy similarity8
Nucleotide bindingi55 – 59GTPBy similarity5
Nucleotide bindingi113 – 116GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-20
Gene namesi
Name:RAB20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000139832.4
HGNCiHGNC:18260 RAB20
neXtProtiNX_Q9NX57

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55647
OpenTargetsiENSG00000139832
PharmGKBiPA34110

Polymorphism and mutation databases

BioMutaiRAB20
DMDMi20139805

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212021 – 234Ras-related protein Rab-20Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi232S-geranylgeranyl cysteineBy similarity1
Lipidationi233S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiQ9NX57
MaxQBiQ9NX57
PaxDbiQ9NX57
PeptideAtlasiQ9NX57
PRIDEiQ9NX57
ProteomicsDBi83044

PTM databases

iPTMnetiQ9NX57
PhosphoSitePlusiQ9NX57

Expressioni

Tissue specificityi

Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000139832 Expressed in 177 organ(s), highest expression level in secondary oocyte
CleanExiHS_RAB20
GenevisibleiQ9NX57 HS

Organism-specific databases

HPAiHPA052111
HPA068647

Interactioni

Protein-protein interaction databases

BioGridi120781, 14 interactors
STRINGi9606.ENSP00000267328

Structurei

3D structure databases

ProteinModelPortaliQ9NX57
SMRiQ9NX57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 41Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00760000119101
HOGENOMiHOG000233968
HOVERGENiHBG097927
InParanoidiQ9NX57
KOiK07911
OMAiHRYMERR
OrthoDBiEOG091G0XVL
PhylomeDBiQ9NX57
TreeFamiTF331574

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NX57-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKPDSKIVL LGDMNVGKTS LLQRYMERRF PDTVSTVGGA FYLKQWRSYN
60 70 80 90 100
ISIWDTAGRE QFHGLGSMYC RGAAAIILTY DVNHRQSLVE LEDRFLGLTD
110 120 130 140 150
TASKDCLFAI VGNKVDLTEE GALAGQEKEE CSPNMDAGDR VSPRAPKQVQ
160 170 180 190 200
LEDAVALYKK ILKYKMLDEQ DVPAAEQMCF ETSAKTGYNV DLLFETLFDL
210 220 230
VVPMILQQRA ERPSHTVDIS SHKPPKRTRS GCCA
Length:234
Mass (Da):26,277
Last modified:October 1, 2000 - v1
Checksum:iA0201E23BBF75DC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62F → I in BAA91171 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017158134N → S. Corresponds to variant dbSNP:rs426453Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272065 mRNA Translation: CAC81247.1
AK000436 mRNA Translation: BAA91163.1
AK000446 mRNA Translation: BAA91171.1
AL139385 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09113.1
BC026025 mRNA Translation: AAH26025.1
CCDSiCCDS9512.1
RefSeqiNP_060287.1, NM_017817.2
UniGeneiHs.743563

Genome annotation databases

EnsembliENST00000267328; ENSP00000267328; ENSG00000139832
GeneIDi55647
KEGGihsa:55647
UCSCiuc001vqy.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272065 mRNA Translation: CAC81247.1
AK000436 mRNA Translation: BAA91163.1
AK000446 mRNA Translation: BAA91171.1
AL139385 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09113.1
BC026025 mRNA Translation: AAH26025.1
CCDSiCCDS9512.1
RefSeqiNP_060287.1, NM_017817.2
UniGeneiHs.743563

3D structure databases

ProteinModelPortaliQ9NX57
SMRiQ9NX57
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120781, 14 interactors
STRINGi9606.ENSP00000267328

PTM databases

iPTMnetiQ9NX57
PhosphoSitePlusiQ9NX57

Polymorphism and mutation databases

BioMutaiRAB20
DMDMi20139805

Proteomic databases

EPDiQ9NX57
MaxQBiQ9NX57
PaxDbiQ9NX57
PeptideAtlasiQ9NX57
PRIDEiQ9NX57
ProteomicsDBi83044

Protocols and materials databases

DNASUi55647
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267328; ENSP00000267328; ENSG00000139832
GeneIDi55647
KEGGihsa:55647
UCSCiuc001vqy.4 human

Organism-specific databases

CTDi55647
DisGeNETi55647
EuPathDBiHostDB:ENSG00000139832.4
GeneCardsiRAB20
HGNCiHGNC:18260 RAB20
HPAiHPA052111
HPA068647
neXtProtiNX_Q9NX57
OpenTargetsiENSG00000139832
PharmGKBiPA34110
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00760000119101
HOGENOMiHOG000233968
HOVERGENiHBG097927
InParanoidiQ9NX57
KOiK07911
OMAiHRYMERR
OrthoDBiEOG091G0XVL
PhylomeDBiQ9NX57
TreeFamiTF331574

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation

Miscellaneous databases

GenomeRNAii55647
PROiPR:Q9NX57

Gene expression databases

BgeeiENSG00000139832 Expressed in 177 organ(s), highest expression level in secondary oocyte
CleanExiHS_RAB20
GenevisibleiQ9NX57 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB20_HUMAN
AccessioniPrimary (citable) accession number: Q9NX57
Secondary accession number(s): Q5T9X5, Q9NX49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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