RAB20

Functionⁱ

Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	12 – 19	GTPBy similarity	8
Nucleotide bindingⁱ	55 – 59	GTPBy similarity	5
Nucleotide bindingⁱ	113 – 116	GTPBy similarity	4

GO - Molecular functionⁱ

GTPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
GTP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to interferon-gamma Source: Ensembl
intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phagosome acidification
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21255211
phagosome-lysosome fusion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21255211
Rab protein signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of endocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8873719 RAB geranylgeranylation

Reactomeⁱ

R-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein Rab-20
Gene namesⁱ	Name:RAB20
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000139832.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18260 RAB20
neXtProtⁱ	NX_Q9NX57

Keywords - Cellular componentⁱ

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55647
Open Targets More...OpenTargetsⁱ	ENSG00000139832
PharmGKBⁱ	PA34110

Polymorphism and mutation databases

BioMutaⁱ	RAB20
DMDMⁱ	20139805

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000121202	1 – 234	Ras-related protein Rab-20Add BLAST		234

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Lipidationⁱ	232	S-geranylgeranyl cysteineBy similarity		1
Lipidationⁱ	233	S-geranylgeranyl cysteineBy similarity		1

Keywords - PTMⁱ

Lipoprotein, Prenylation

Proteomic databases

EPDⁱ	Q9NX57
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NX57
PaxDbⁱ	Q9NX57
PeptideAtlas More...PeptideAtlasⁱ	Q9NX57
PRIDEⁱ	Q9NX57
ProteomicsDBⁱ	83044

PTM databases

iPTMnetⁱ	Q9NX57
PhosphoSitePlusⁱ	Q9NX57

Expressionⁱ

Tissue specificityⁱ

Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000139832 Expressed in 177 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_RAB20
Genevisibleⁱ	Q9NX57 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA052111 HPA068647

HPAⁱ

HPA052111
HPA068647

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	120781, 14 interactors
STRINGⁱ	9606.ENSP00000267328

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NX57
SMRⁱ	Q9NX57
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	33 – 41	Effector regionBy similarity		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0092 Eukaryota ENOG410YCCP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119101
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG097927
InParanoidⁱ	Q9NX57
KEGG Orthology (KO) More...KOⁱ	K07911
OMAⁱ	HRYMERR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XVL
PhylomeDBⁱ	Q9NX57
TreeFamⁱ	TF331574

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9NX57-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRKPDSKIVL LGDMNVGKTS LLQRYMERRF PDTVSTVGGA FYLKQWRSYN 
        60         70         80         90        100
ISIWDTAGRE QFHGLGSMYC RGAAAIILTY DVNHRQSLVE LEDRFLGLTD 
       110        120        130        140        150
TASKDCLFAI VGNKVDLTEE GALAGQEKEE CSPNMDAGDR VSPRAPKQVQ 
       160        170        180        190        200
LEDAVALYKK ILKYKMLDEQ DVPAAEQMCF ETSAKTGYNV DLLFETLFDL 
       210        220        230 
VVPMILQQRA ERPSHTVDIS SHKPPKRTRS GCCA

Length:234

Mass (Da):26,277

Last modified:October 1, 2000 - v1

Checksum:ⁱA0201E23BBF75DC8

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	62	F → I in BAA91171 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_017158	134	N → S. Corresponds to variant dbSNP:rs426453Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ272065 mRNA Translation: CAC81247.1 AK000436 mRNA Translation: BAA91163.1 AK000446 mRNA Translation: BAA91171.1 AL139385 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09113.1 BC026025 mRNA Translation: AAH26025.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9512.1
NCBI Reference Sequences More...RefSeqⁱ	NP_060287.1, NM_017817.2
UniGeneⁱ	Hs.743563

Genome annotation databases

Ensemblⁱ	ENST00000267328; ENSP00000267328; ENSG00000139832
GeneIDⁱ	55647
KEGGⁱ	hsa:55647
UCSC genome browser More...UCSCⁱ	uc001vqy.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NX57	Uncharacterized protein		PANPA		234	UniRef100_Q9NX57
RAB20, member RAS oncogene family		GORGO		234

Protein	Similar proteins		Species	Score	Length	Source
Q9NX57	Uncharacterized protein		PANPA		234	UniRef90_Q9NX57
RAB20, member RAS oncogene family		GORGO		234
Ras-related protein Rab-20		CALJA		234
RAB20 isoform 1		PANTR		234
RAB20 isoform 1		PONAB		234
+14

Protein	Similar proteins		Species	Score	Length	Source
Q9NX57	Ras-related protein Rab-20		MOUSE		233	UniRef50_Q9NX57
Uncharacterized protein		PANPA		234
RAB20, member RAS oncogene family		GORGO		234
Ras-related protein Rab-20		MACMU		234
Uncharacterized protein		RHIRO		234
+108

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ272065 mRNA Translation: CAC81247.1 AK000436 mRNA Translation: BAA91163.1 AK000446 mRNA Translation: BAA91171.1 AL139385 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09113.1 BC026025 mRNA Translation: AAH26025.1
CCDSⁱ	CCDS9512.1
RefSeqⁱ	NP_060287.1, NM_017817.2
UniGeneⁱ	Hs.743563

3D structure databases

ProteinModelPortalⁱ	Q9NX57
SMRⁱ	Q9NX57
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120781, 14 interactors
STRINGⁱ	9606.ENSP00000267328

PTM databases

iPTMnetⁱ	Q9NX57
PhosphoSitePlusⁱ	Q9NX57

Polymorphism and mutation databases

BioMutaⁱ	RAB20
DMDMⁱ	20139805

Proteomic databases

EPDⁱ	Q9NX57
MaxQBⁱ	Q9NX57
PaxDbⁱ	Q9NX57
PeptideAtlasⁱ	Q9NX57
PRIDEⁱ	Q9NX57
ProteomicsDBⁱ	83044

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	55647
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000267328; ENSP00000267328; ENSG00000139832
GeneIDⁱ	55647
KEGGⁱ	hsa:55647
UCSCⁱ	uc001vqy.4 human

Organism-specific databases

CTDⁱ	55647
DisGeNETⁱ	55647
EuPathDBⁱ	HostDB:ENSG00000139832.4
GeneCardsⁱ	RAB20
HGNCⁱ	HGNC:18260 RAB20
HPAⁱ	HPA052111 HPA068647
neXtProtⁱ	NX_Q9NX57
OpenTargetsⁱ	ENSG00000139832
PharmGKBⁱ	PA34110
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0092 Eukaryota ENOG410YCCP LUCA
GeneTreeⁱ	ENSGT00760000119101
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG097927
InParanoidⁱ	Q9NX57
KOⁱ	K07911
OMAⁱ	HRYMERR
OrthoDBⁱ	EOG091G0XVL
PhylomeDBⁱ	Q9NX57
TreeFamⁱ	TF331574

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8873719 RAB geranylgeranylation

Reactomeⁱ

R-HSA-8873719 RAB geranylgeranylation

Miscellaneous databases

GenomeRNAiⁱ	55647
Protein Ontology More...PROⁱ	PR:Q9NX57

Gene expression databases

Bgeeⁱ	ENSG00000139832 Expressed in 177 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_RAB20
Genevisibleⁱ	Q9NX57 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAB20_HUMAN
Accessionⁱ	Q9NX57Primary (citable) accession number: Q9NX57 Secondary accession number(s): Q5T9X5, Q9NX49
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM

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UniProtKB - Q9NX57 (RAB20_HUMAN)

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Ras-related protein Rab-20

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Other locations

Endosome

Golgi apparatus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ