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UniProtKB - Q9NX57 (RAB20_HUMAN)
Protein
Ras-related protein Rab-20
Gene
RAB20
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 12 – 19 | GTPBy similarity | 8 | |
Nucleotide bindingi | 55 – 59 | GTPBy similarity | 5 | |
Nucleotide bindingi | 113 – 116 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: UniProtKB-KW
GO - Biological processi
- cellular response to interferon-gamma Source: Ensembl
- intracellular protein transport Source: GO_Central
- phagosome acidification Source: UniProtKB
- phagosome-lysosome fusion Source: UniProtKB
Keywordsi
Biological process | Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9NX57 |
Reactomei | R-HSA-8873719, RAB geranylgeranylation |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-20 |
Gene namesi | Name:RAB20 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18260, RAB20 |
neXtProti | NX_Q9NX57 |
VEuPathDBi | HostDB:ENSG00000139832 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus 1 Publication
Other locations
- phagosome 1 Publication
- phagosome membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Note: Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules (By similarity). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).By similarity1 Publication
Golgi apparatus
- Golgi apparatus Source: HPA
Other locations
- endomembrane system Source: GO_Central
- intracellular membrane-bounded organelle Source: HPA
- phagocytic vesicle Source: UniProtKB
- phagocytic vesicle membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasmic vesicle, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 55647 |
OpenTargetsi | ENSG00000139832 |
PharmGKBi | PA34110 |
Miscellaneous databases
Pharosi | Q9NX57, Tbio |
Genetic variation databases
BioMutai | RAB20 |
DMDMi | 20139805 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121202 | 1 – 234 | Ras-related protein Rab-20Add BLAST | 234 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 232 | S-geranylgeranyl cysteineBy similarity | 1 | |
Lipidationi | 233 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, PrenylationProteomic databases
EPDi | Q9NX57 |
jPOSTi | Q9NX57 |
MassIVEi | Q9NX57 |
MaxQBi | Q9NX57 |
PaxDbi | Q9NX57 |
PeptideAtlasi | Q9NX57 |
PRIDEi | Q9NX57 |
ProteomicsDBi | 83044 |
PTM databases
iPTMneti | Q9NX57 |
PhosphoSitePlusi | Q9NX57 |
Expressioni
Tissue specificityi
Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000139832, Expressed in secondary oocyte and 193 other tissues |
Genevisiblei | Q9NX57, HS |
Organism-specific databases
HPAi | ENSG00000139832, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120781, 18 interactors |
STRINGi | 9606.ENSP00000267328 |
Miscellaneous databases
RNActi | Q9NX57, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 125 – 144 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 212 – 234 | DisorderedSequence analysisAdd BLAST | 23 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 33 – 41 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0092, Eukaryota |
GeneTreei | ENSGT00940000161024 |
HOGENOMi | CLU_041217_12_0_1 |
InParanoidi | Q9NX57 |
OMAi | HDCIYAL |
OrthoDBi | 1340129at2759 |
PhylomeDBi | Q9NX57 |
TreeFami | TF331574 |
Family and domain databases
CDDi | cd04126, Rab20, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR041836, Rab20 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9NX57-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRKPDSKIVL LGDMNVGKTS LLQRYMERRF PDTVSTVGGA FYLKQWRSYN
60 70 80 90 100
ISIWDTAGRE QFHGLGSMYC RGAAAIILTY DVNHRQSLVE LEDRFLGLTD
110 120 130 140 150
TASKDCLFAI VGNKVDLTEE GALAGQEKEE CSPNMDAGDR VSPRAPKQVQ
160 170 180 190 200
LEDAVALYKK ILKYKMLDEQ DVPAAEQMCF ETSAKTGYNV DLLFETLFDL
210 220 230
VVPMILQQRA ERPSHTVDIS SHKPPKRTRS GCCA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 62 | F → I in BAA91171 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_017158 | 134 | N → S. Corresponds to variant dbSNP:rs426453Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ272065 mRNA Translation: CAC81247.1 AK000436 mRNA Translation: BAA91163.1 AK000446 mRNA Translation: BAA91171.1 AL139385 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09113.1 BC026025 mRNA Translation: AAH26025.1 |
CCDSi | CCDS9512.1 |
RefSeqi | NP_060287.1, NM_017817.2 |
Genome annotation databases
Ensembli | ENST00000267328.5; ENSP00000267328.3; ENSG00000139832.5 |
GeneIDi | 55647 |
KEGGi | hsa:55647 |
MANE-Selecti | ENST00000267328.5; ENSP00000267328.3; NM_017817.3; NP_060287.1 |
UCSCi | uc001vqy.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ272065 mRNA Translation: CAC81247.1 AK000436 mRNA Translation: BAA91163.1 AK000446 mRNA Translation: BAA91171.1 AL139385 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09113.1 BC026025 mRNA Translation: AAH26025.1 |
CCDSi | CCDS9512.1 |
RefSeqi | NP_060287.1, NM_017817.2 |
3D structure databases
AlphaFoldDBi | Q9NX57 |
SMRi | Q9NX57 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120781, 18 interactors |
STRINGi | 9606.ENSP00000267328 |
PTM databases
iPTMneti | Q9NX57 |
PhosphoSitePlusi | Q9NX57 |
Genetic variation databases
BioMutai | RAB20 |
DMDMi | 20139805 |
Proteomic databases
EPDi | Q9NX57 |
jPOSTi | Q9NX57 |
MassIVEi | Q9NX57 |
MaxQBi | Q9NX57 |
PaxDbi | Q9NX57 |
PeptideAtlasi | Q9NX57 |
PRIDEi | Q9NX57 |
ProteomicsDBi | 83044 |
Protocols and materials databases
Antibodypediai | 25565, 287 antibodies from 28 providers |
DNASUi | 55647 |
Genome annotation databases
Ensembli | ENST00000267328.5; ENSP00000267328.3; ENSG00000139832.5 |
GeneIDi | 55647 |
KEGGi | hsa:55647 |
MANE-Selecti | ENST00000267328.5; ENSP00000267328.3; NM_017817.3; NP_060287.1 |
UCSCi | uc001vqy.4, human |
Organism-specific databases
CTDi | 55647 |
DisGeNETi | 55647 |
GeneCardsi | RAB20 |
HGNCi | HGNC:18260, RAB20 |
HPAi | ENSG00000139832, Low tissue specificity |
neXtProti | NX_Q9NX57 |
OpenTargetsi | ENSG00000139832 |
PharmGKBi | PA34110 |
VEuPathDBi | HostDB:ENSG00000139832 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0092, Eukaryota |
GeneTreei | ENSGT00940000161024 |
HOGENOMi | CLU_041217_12_0_1 |
InParanoidi | Q9NX57 |
OMAi | HDCIYAL |
OrthoDBi | 1340129at2759 |
PhylomeDBi | Q9NX57 |
TreeFami | TF331574 |
Enzyme and pathway databases
PathwayCommonsi | Q9NX57 |
Reactomei | R-HSA-8873719, RAB geranylgeranylation |
Miscellaneous databases
BioGRID-ORCSi | 55647, 13 hits in 1078 CRISPR screens |
GenomeRNAii | 55647 |
Pharosi | Q9NX57, Tbio |
PROi | PR:Q9NX57 |
RNActi | Q9NX57, protein |
Gene expression databases
Bgeei | ENSG00000139832, Expressed in secondary oocyte and 193 other tissues |
Genevisiblei | Q9NX57, HS |
Family and domain databases
CDDi | cd04126, Rab20, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR041836, Rab20 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RAB20_HUMAN | |
Accessioni | Q9NX57Primary (citable) accession number: Q9NX57 Secondary accession number(s): Q5T9X5, Q9NX49 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 31, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families