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Protein

Rhomboid-related protein 2

Gene

RHBDL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.1 Publication EC:3.4.21.105

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei187Nucleophile1
Active sitei2501

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • serine-type endopeptidase activity Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.21.105 2681

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S54.002

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rhomboid-related protein 2 (EC:3.4.21.105)
Short name:
RRP2
Alternative name(s):
Rhomboid-like protein 2
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RHBDL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000158315.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16083 RHBDL2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608962 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NX52

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi121W → A: Reduces protease activity. 2 Publications1
Mutagenesisi122R → A: Abolishes protease activity, prevents processing and alters localization to the plasma membrane of N-terminal fragment. 2 Publications1
Mutagenesisi139N → A: Reduces protease activity. 1 Publication1
Mutagenesisi185G → A: Abolishes protease activity. 1 Publication1
Mutagenesisi187S → A or G: Abolishes protease activity. 2 Publications1
Mutagenesisi250H → A: Abolishes protease activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
54933

Open Targets

More...
OpenTargetsi
ENSG00000158315

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34383

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RHBDL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
59800189

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000408509? – 303Rhomboid-related protein 2, C-terminal fragment
ChainiPRO_00002061761 – 303Rhomboid-related protein 2Add BLAST303
ChainiPRO_00004085101 – ?Rhomboid-related protein 2, N-terminal fragment

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytic processing of the proenzyme produces a N-terminal fragment (NTF) and a C-terminal fragment (CTF). The processing is required for activation of the protease.1 Publication

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NX52

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NX52

PeptideAtlas

More...
PeptideAtlasi
Q9NX52

PRoteomics IDEntifications database

More...
PRIDEi
Q9NX52

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83039
83040 [Q9NX52-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NX52

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NX52

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000158315 Expressed in 150 organ(s), highest expression level in esophagus mucosa

CleanEx database of gene expression profiles

More...
CleanExi
HS_RHBDL2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NX52 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043807

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120273, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NX52, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000289248

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NX52

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 28Poly-Glu7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S54 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2289 Eukaryota
COG0705 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159442

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231407

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG105855

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NX52

KEGG Orthology (KO)

More...
KOi
K02857

Identification of Orthologs from Complete Genome Data

More...
OMAi
SYIAHMT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G12OK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NX52

TreeFam database of animal gene trees

More...
TreeFami
TF313540

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1540.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002610 Peptidase_S54_rhomboid
IPR022764 Peptidase_S54_rhomboid_dom
IPR017213 Peptidase_S54_rhomboid_met
IPR035952 Rhomboid-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22936 PTHR22936, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01694 Rhomboid, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037470 Rhomboid, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NX52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVHDLEME SMNLNMGREM KEELEEEEKM REDGGGKDRA KSKKVHRIVS
60 70 80 90 100
KWMLPEKSRG TYLERANCFP PPVFIISISL AELAVFIYYA VWKPQKQWIT
110 120 130 140 150
LDTGILESPF IYSPEKREEA WRFISYMLVH AGVQHILGNL CMQLVLGIPL
160 170 180 190 200
EMVHKGLRVG LVYLAGVIAG SLASSIFDPL RYLVGASGGV YALMGGYFMN
210 220 230 240 250
VLVNFQEMIP AFGIFRLLII ILIIVLDMGF ALYRRFFVPE DGSPVSFAAH
260 270 280 290 300
IAGGFAGMSI GYTVFSCFDK ALLKDPRFWI AIAAYLACVL FAVFFNIFLS

PAN
Length:303
Mass (Da):34,021
Last modified:February 1, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B6CB8291319C2D9
GO
Isoform 2 (identifier: Q9NX52-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-303: Missing.

Note: May be due to an intron retention. No experimental confirmation available.
Show »
Length:132
Mass (Da):15,442
Checksum:i38D3DBFBF34BC528
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH13103 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91168 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020328273L → M. Corresponds to variant dbSNP:rs2147914Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012692133 – 303Missing in isoform 2. 1 PublicationAdd BLAST171

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY126343 mRNA Translation: AAM95697.1
AL139260 Genomic DNA No translation available.
BC013103 mRNA Translation: AAH13103.1 Different initiation.
BC137108 mRNA Translation: AAI37109.1
BC137110 mRNA Translation: AAI37111.1
AK000442 mRNA Translation: BAA91168.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30680.1 [Q9NX52-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060291.2, NM_017821.4 [Q9NX52-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.524626

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000289248; ENSP00000289248; ENSG00000158315 [Q9NX52-1]
ENST00000372990; ENSP00000362081; ENSG00000158315 [Q9NX52-1]
ENST00000540558; ENSP00000441097; ENSG00000158315 [Q9NX52-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54933

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54933

UCSC genome browser

More...
UCSCi
uc001ccu.1 human [Q9NX52-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY126343 mRNA Translation: AAM95697.1
AL139260 Genomic DNA No translation available.
BC013103 mRNA Translation: AAH13103.1 Different initiation.
BC137108 mRNA Translation: AAI37109.1
BC137110 mRNA Translation: AAI37111.1
AK000442 mRNA Translation: BAA91168.1 Different initiation.
CCDSiCCDS30680.1 [Q9NX52-1]
RefSeqiNP_060291.2, NM_017821.4 [Q9NX52-1]
UniGeneiHs.524626

3D structure databases

ProteinModelPortaliQ9NX52
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120273, 2 interactors
IntActiQ9NX52, 2 interactors
STRINGi9606.ENSP00000289248

Protein family/group databases

MEROPSiS54.002

PTM databases

iPTMnetiQ9NX52
PhosphoSitePlusiQ9NX52

Polymorphism and mutation databases

BioMutaiRHBDL2
DMDMi59800189

Proteomic databases

MaxQBiQ9NX52
PaxDbiQ9NX52
PeptideAtlasiQ9NX52
PRIDEiQ9NX52
ProteomicsDBi83039
83040 [Q9NX52-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289248; ENSP00000289248; ENSG00000158315 [Q9NX52-1]
ENST00000372990; ENSP00000362081; ENSG00000158315 [Q9NX52-1]
ENST00000540558; ENSP00000441097; ENSG00000158315 [Q9NX52-3]
GeneIDi54933
KEGGihsa:54933
UCSCiuc001ccu.1 human [Q9NX52-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54933
DisGeNETi54933
EuPathDBiHostDB:ENSG00000158315.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RHBDL2
HGNCiHGNC:16083 RHBDL2
HPAiHPA043807
MIMi608962 gene
neXtProtiNX_Q9NX52
OpenTargetsiENSG00000158315
PharmGKBiPA34383

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2289 Eukaryota
COG0705 LUCA
GeneTreeiENSGT00940000159442
HOGENOMiHOG000231407
HOVERGENiHBG105855
InParanoidiQ9NX52
KOiK02857
OMAiSYIAHMT
OrthoDBiEOG091G12OK
PhylomeDBiQ9NX52
TreeFamiTF313540

Enzyme and pathway databases

BRENDAi3.4.21.105 2681

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RHBDL2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54933

Protein Ontology

More...
PROi
PR:Q9NX52

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000158315 Expressed in 150 organ(s), highest expression level in esophagus mucosa
CleanExiHS_RHBDL2
GenevisibleiQ9NX52 HS

Family and domain databases

Gene3Di1.20.1540.10, 1 hit
InterProiView protein in InterPro
IPR002610 Peptidase_S54_rhomboid
IPR022764 Peptidase_S54_rhomboid_dom
IPR017213 Peptidase_S54_rhomboid_met
IPR035952 Rhomboid-like_sf
PANTHERiPTHR22936 PTHR22936, 1 hit
PfamiView protein in Pfam
PF01694 Rhomboid, 1 hit
PIRSFiPIRSF037470 Rhomboid, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHBL2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NX52
Secondary accession number(s): B2RNT3
, B9EH75, Q6P175, Q8NER8, Q96E02
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: February 1, 2005
Last modified: December 5, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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