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UniProtKB - Q9NX45 (SOLH2_HUMAN)
Protein
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
Gene
SOHLH2
Organism
Homo sapiens (Human)
Status
Functioni
Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I (By similarity).
By similarityGO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- cell differentiation Source: UniProtKB
- oocyte differentiation Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- spermatogenesis Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Oogenesis, Spermatogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9NX45 |
SignaLinki | Q9NX45 |
SIGNORi | Q9NX45 |
Names & Taxonomyi
Protein namesi | Recommended name: Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 |
Gene namesi | Name:SOHLH2 Synonyms:TEB1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26026, SOHLH2 |
MIMi | 616066, gene |
neXtProti | NX_Q9NX45 |
VEuPathDBi | HostDB:ENSG00000120669 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 100526761 54937 |
OpenTargetsi | ENSG00000120669 ENSG00000250709 |
Orphaneti | 619, NON RARE IN EUROPE: Primary ovarian failure |
PharmGKBi | PA144596273 |
Miscellaneous databases
Pharosi | Q9NX45, Tbio |
Genetic variation databases
BioMutai | SOHLH2 |
DMDMi | 166200297 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315700 | 1 – 425 | Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2Add BLAST | 425 |
Proteomic databases
jPOSTi | Q9NX45 |
MaxQBi | Q9NX45 |
PaxDbi | Q9NX45 |
PeptideAtlasi | Q9NX45 |
PRIDEi | Q9NX45 |
ProteomicsDBi | 83036 [Q9NX45-3] |
PTM databases
GlyGeni | Q9NX45, 1 site, 1 N-linked glycan (1 site) |
iPTMneti | Q9NX45 |
PhosphoSitePlusi | Q9NX45 |
Expressioni
Gene expression databases
Bgeei | ENSG00000120669, Expressed in secondary oocyte and 119 other tissues |
Genevisiblei | Q9NX45, HS |
Organism-specific databases
HPAi | ENSG00000120669, Tissue enriched (testis) |
Interactioni
Subunit structurei
Forms both hetero- and homodimers with SOHLH1.
By similarityGO - Molecular functioni
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 120277, 1 interactor |
IntActi | Q9NX45, 2 interactors |
STRINGi | 9606.ENSP00000369210 |
Miscellaneous databases
RNActi | Q9NX45, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 201 – 252 | bHLHPROSITE-ProRule annotationAdd BLAST | 52 |
Phylogenomic databases
eggNOGi | ENOG502S71C, Eukaryota |
GeneTreei | ENSGT00390000016050 |
HOGENOMi | CLU_056118_0_0_1 |
InParanoidi | Q9NX45 |
OMAi | RLWLEDW |
OrthoDBi | 643083at2759 |
PhylomeDBi | Q9NX45 |
TreeFami | TF336841 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032669, SOHLH2 |
PANTHERi | PTHR16223:SF16, PTHR16223:SF16, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9NX45-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASSIICQEH CQISGQAKID ILLVGDVTVG YLADTVQKLF ANIAEVTITI
60 70 80 90 100
SDTKEAAALL DDCIFNMVLL KVPSSLSAEE LEAIKLIRFG KKKNTHSLFV
110 120 130 140 150
FIIPENFKGC ISGHGMDIAL TEPLTMEKMS NVVKYWTTCP SNTVKTENAT
160 170 180 190 200
GPEELGLPLQ RSYSEHLGYF PTDLFACSES LRNGNGLELN ASLSEFEKNK
210 220 230 240 250
KISLLHSSKE KLRRERIKYC CEQLRTLLPY VKGRKNDAAS VLEATVDYVK
260 270 280 290 300
YIREKISPAV MAQITEALQS NMRFCKKQQT PIELSLPGTV MAQRENSVMS
310 320 330 340 350
TYSPERGLQF LTNTCWNGCS TPDAESSLDE AVRVPSSSAS ENAIGDPYKT
360 370 380 390 400
HISSAALSLN SLHTVRYYSK VTPSYDATAV TNQNISIHLP SAMPPVSKLL
410 420
PRHCTSGLGQ TCTTHPNCLQ QFWAY
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 211 | K → N in BAA91175 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 211 | K → N in AAW78547 (Ref. 5) Curated | 1 | |
Sequence conflicti | 312 | T → A in BAA91175 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 312 | T → A in AAW78547 (Ref. 5) Curated | 1 | |
Sequence conflicti | 403 | H → Y in BAA91175 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 403 | H → Y in AAW78547 (Ref. 5) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038283 | 14 | S → L. Corresponds to variant dbSNP:rs12873478Ensembl. | 1 | |
Natural variantiVAR_038284 | 339 | A → T. Corresponds to variant dbSNP:rs2296968Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042423 | 1 – 16 | MASSI…QISGQ → METLQESLNTLLKQLEEEKK TLESQVKYYALKLEQESKAY QKINNERRTYLAEMSQGSGL HQVSKRQQVDQLPRMQENLV KTLLLKEELDPLK in isoform 3. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_030652 | 215 – 225 | ERIKYCCEQLR → LYRKHSSFCFW in isoform 2. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_030653 | 226 – 425 | Missing in isoform 2. 1 PublicationAdd BLAST | 200 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000456 mRNA Translation: BAA91175.1 AK301863 mRNA Translation: BAG63302.1 AL139377 Genomic DNA No translation available. AL160392 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08554.1 CH471075 Genomic DNA Translation: EAX08555.1 BC025383 mRNA Translation: AAH25383.1 AY884305 mRNA Translation: AAW78547.1 |
CCDSi | CCDS61309.1 [Q9NX45-2] CCDS9355.1 [Q9NX45-1] |
RefSeqi | NP_001185839.1, NM_001198910.1 [Q9NX45-3] NP_001269076.1, NM_001282147.1 [Q9NX45-2] NP_060296.2, NM_017826.2 [Q9NX45-1] |
Genome annotation databases
Ensembli | ENST00000317764; ENSP00000326838; ENSG00000120669 [Q9NX45-2] ENST00000379881; ENSP00000369210; ENSG00000120669 |
GeneIDi | 100526761 54937 |
KEGGi | hsa:100526761 hsa:54937 |
MANE-Selecti | ENST00000379881.8; ENSP00000369210.3; NM_017826.3; NP_060296.2 |
UCSCi | uc001uvj.3, human [Q9NX45-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000456 mRNA Translation: BAA91175.1 AK301863 mRNA Translation: BAG63302.1 AL139377 Genomic DNA No translation available. AL160392 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08554.1 CH471075 Genomic DNA Translation: EAX08555.1 BC025383 mRNA Translation: AAH25383.1 AY884305 mRNA Translation: AAW78547.1 |
CCDSi | CCDS61309.1 [Q9NX45-2] CCDS9355.1 [Q9NX45-1] |
RefSeqi | NP_001185839.1, NM_001198910.1 [Q9NX45-3] NP_001269076.1, NM_001282147.1 [Q9NX45-2] NP_060296.2, NM_017826.2 [Q9NX45-1] |
3D structure databases
SMRi | Q9NX45 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120277, 1 interactor |
IntActi | Q9NX45, 2 interactors |
STRINGi | 9606.ENSP00000369210 |
PTM databases
GlyGeni | Q9NX45, 1 site, 1 N-linked glycan (1 site) |
iPTMneti | Q9NX45 |
PhosphoSitePlusi | Q9NX45 |
Genetic variation databases
BioMutai | SOHLH2 |
DMDMi | 166200297 |
Proteomic databases
jPOSTi | Q9NX45 |
MaxQBi | Q9NX45 |
PaxDbi | Q9NX45 |
PeptideAtlasi | Q9NX45 |
PRIDEi | Q9NX45 |
ProteomicsDBi | 83036 [Q9NX45-3] |
Protocols and materials databases
Antibodypediai | 34997, 154 antibodies from 17 providers |
DNASUi | 54937 |
Genome annotation databases
Ensembli | ENST00000317764; ENSP00000326838; ENSG00000120669 [Q9NX45-2] ENST00000379881; ENSP00000369210; ENSG00000120669 |
GeneIDi | 100526761 54937 |
KEGGi | hsa:100526761 hsa:54937 |
MANE-Selecti | ENST00000379881.8; ENSP00000369210.3; NM_017826.3; NP_060296.2 |
UCSCi | uc001uvj.3, human [Q9NX45-1] |
Organism-specific databases
CTDi | 100526761 54937 |
DisGeNETi | 100526761 54937 |
GeneCardsi | SOHLH2 |
HGNCi | HGNC:26026, SOHLH2 |
HPAi | ENSG00000120669, Tissue enriched (testis) |
MIMi | 616066, gene |
neXtProti | NX_Q9NX45 |
OpenTargetsi | ENSG00000120669 ENSG00000250709 |
Orphaneti | 619, NON RARE IN EUROPE: Primary ovarian failure |
PharmGKBi | PA144596273 |
VEuPathDBi | HostDB:ENSG00000120669 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S71C, Eukaryota |
GeneTreei | ENSGT00390000016050 |
HOGENOMi | CLU_056118_0_0_1 |
InParanoidi | Q9NX45 |
OMAi | RLWLEDW |
OrthoDBi | 643083at2759 |
PhylomeDBi | Q9NX45 |
TreeFami | TF336841 |
Enzyme and pathway databases
PathwayCommonsi | Q9NX45 |
SignaLinki | Q9NX45 |
SIGNORi | Q9NX45 |
Miscellaneous databases
BioGRID-ORCSi | 100526761, 6 hits in 920 CRISPR screens 54937, 36 hits in 712 CRISPR screens |
Pharosi | Q9NX45, Tbio |
PROi | PR:Q9NX45 |
RNActi | Q9NX45, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000120669, Expressed in secondary oocyte and 119 other tissues |
Genevisiblei | Q9NX45, HS |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032669, SOHLH2 |
PANTHERi | PTHR16223:SF16, PTHR16223:SF16, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SOLH2_HUMAN | |
Accessioni | Q9NX45Primary (citable) accession number: Q9NX45 Secondary accession number(s): B4DX90 Q96QX4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | January 15, 2008 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot