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Entry version 121 (05 Jun 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Protein Abitram

Gene

ABITRAM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons.By similarity

Miscellaneous

Depletion of ABITRAM by siRNA or neutralizing antibodies results in cell death within a few hours.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein AbitramCurated
Alternative name(s):
Actin-binding transcription modulatorImported
Protein SimiateCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABITRAMImported
Synonyms:C9orf6, FAM206AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:1364 ABITRAM

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NX38

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54942

Open Targets

More...
OpenTargetsi
ENSG00000119328

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25981

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM206A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74753037

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002919281 – 181Protein AbitramAdd BLAST181

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NX38

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NX38

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NX38

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NX38

PeptideAtlas

More...
PeptideAtlasi
Q9NX38

PRoteomics IDEntifications database

More...
PRIDEi
Q9NX38

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83030

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NX38

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NX38

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119328 Expressed in 223 organ(s), highest expression level in bronchial epithelial cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NX38 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NX38 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035917
HPA035918

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with F-actin (By similarity). Interacts with G-actin (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120282, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NX38, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363753

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABITRAM family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3266 Eukaryota
ENOG4111FVG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00450000040303

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000235011

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NX38

Identification of Orthologs from Complete Genome Data

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OMAi
ENILHEP

Database of Orthologous Groups

More...
OrthoDBi
1277002at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NX38

TreeFam database of animal gene trees

More...
TreeFami
TF313930

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039169 Abitram
IPR033753 GCV_H/Fam206
IPR011053 Single_hybrid_motif

The PANTHER Classification System

More...
PANTHERi
PTHR13651 PTHR13651, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01597 GCV_H, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51230 SSF51230, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9NX38-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATEPEAAEP VVPSLVDRYF TRWYKPDVKG KFCEDHCILQ HSNRICVITL
60 70 80 90 100
AESHPVLQSG KTIKSISYQI STNCSRLQNK VSGKFKRGAQ FLTELAPLCK
110 120 130 140 150
IYCSDGEEYT VSSCVRGRLM EVNENILHKP SILQEKPSTE GYIAVVLPKF
160 170 180
EESKSITEGL LTQKQYEEVM VKRINATTAT S
Length:181
Mass (Da):20,378
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2336750B1E59EB32
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R8U7X6R8U7_HUMAN
Protein Abitram
ABITRAM
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6REY2X6REY2_HUMAN
Protein Abitram
ABITRAM
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF153417 mRNA Translation: AAG43367.1
AK000464 mRNA Translation: BAA91183.1
AL354797 Genomic DNA No translation available.
BC015795 mRNA Translation: AAH15795.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6774.1

NCBI Reference Sequences

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RefSeqi
NP_060302.1, NM_017832.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000322940; ENSP00000363753; ENSG00000119328

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54942

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54942

UCSC genome browser

More...
UCSCi
uc004bdn.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153417 mRNA Translation: AAG43367.1
AK000464 mRNA Translation: BAA91183.1
AL354797 Genomic DNA No translation available.
BC015795 mRNA Translation: AAH15795.1
CCDSiCCDS6774.1
RefSeqiNP_060302.1, NM_017832.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120282, 8 interactors
IntActiQ9NX38, 5 interactors
STRINGi9606.ENSP00000363753

PTM databases

iPTMnetiQ9NX38
PhosphoSitePlusiQ9NX38

Polymorphism and mutation databases

BioMutaiFAM206A
DMDMi74753037

Proteomic databases

EPDiQ9NX38
jPOSTiQ9NX38
MaxQBiQ9NX38
PaxDbiQ9NX38
PeptideAtlasiQ9NX38
PRIDEiQ9NX38
ProteomicsDBi83030

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54942
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322940; ENSP00000363753; ENSG00000119328
GeneIDi54942
KEGGihsa:54942
UCSCiuc004bdn.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54942
DisGeNETi54942

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM206A

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0019438
HGNCiHGNC:1364 ABITRAM
HPAiHPA035917
HPA035918
neXtProtiNX_Q9NX38
OpenTargetsiENSG00000119328
PharmGKBiPA25981

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3266 Eukaryota
ENOG4111FVG LUCA
GeneTreeiENSGT00450000040303
HOGENOMiHOG000235011
InParanoidiQ9NX38
OMAiENILHEP
OrthoDBi1277002at2759
PhylomeDBiQ9NX38
TreeFamiTF313930

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54942

Protein Ontology

More...
PROi
PR:Q9NX38

Gene expression databases

BgeeiENSG00000119328 Expressed in 223 organ(s), highest expression level in bronchial epithelial cell
ExpressionAtlasiQ9NX38 baseline and differential
GenevisibleiQ9NX38 HS

Family and domain databases

InterProiView protein in InterPro
IPR039169 Abitram
IPR033753 GCV_H/Fam206
IPR011053 Single_hybrid_motif
PANTHERiPTHR13651 PTHR13651, 1 hit
PfamiView protein in Pfam
PF01597 GCV_H, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABITM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NX38
Secondary accession number(s): Q5JTR0, Q5JTR1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2000
Last modified: June 5, 2019
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
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