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Protein

DnaJ homolog subfamily C member 28

Gene

DNAJC28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a role in protein folding or as a chaperone.

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 28
Gene namesi
Name:DNAJC28
Synonyms:C21orf55, C21orf78
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000177692.11
HGNCiHGNC:1297 DNAJC28
neXtProtiNX_Q9NX36

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi54943
OpenTargetsiENSG00000177692
PharmGKBiPA162383922

Polymorphism and mutation databases

DMDMi23396536

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000711391 – 388DnaJ homolog subfamily C member 28Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei347PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NX36
MaxQBiQ9NX36
PaxDbiQ9NX36
PeptideAtlasiQ9NX36
PRIDEiQ9NX36
ProteomicsDBi83029

PTM databases

iPTMnetiQ9NX36
PhosphoSitePlusiQ9NX36

Expressioni

Tissue specificityi

Expressed in the fetal and adult brain, testis, uterus, spleen and liver.

Developmental stagei

Not expressed in 8 and 10 weeks old fetuses.

Gene expression databases

BgeeiENSG00000177692 Expressed in 132 organ(s), highest expression level in testis
CleanExiHS_DNAJC28
GenevisibleiQ9NX36 HS

Organism-specific databases

HPAiHPA018003
HPA030076

Interactioni

Protein-protein interaction databases

BioGridi120283, 6 interactors
IntActiQ9NX36, 2 interactors
MINTiQ9NX36
STRINGi9606.ENSP00000320303

Structurei

3D structure databases

ProteinModelPortaliQ9NX36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 115JPROSITE-ProRule annotationAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili261 – 349Sequence analysisAdd BLAST89

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi118 – 121Poly-Glu4

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0568 Eukaryota
ENOG410ZU5V LUCA
GeneTreeiENSGT00390000008217
HOGENOMiHOG000010237
HOVERGENiHBG051232
InParanoidiQ9NX36
KOiK19373
OMAiGYQPEWI
OrthoDBiEOG091G0LRM
PhylomeDBiQ9NX36
TreeFamiTF323730

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR018961 DnaJ_homolog_subfam-C_membr-28
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF09350 DUF1992, 1 hit
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NX36-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTMYVMMAQ ILRSHLIKAT VIPNRVKMLP YFGIIRNRMM STHKSKKKIR
60 70 80 90 100
EYYRLLNVEE GCSADEVRES FHKLAKQYHP DSGSNTADSA TFIRIEKAYR
110 120 130 140 150
KVLSHVIEQT NASQSKGEEE EDVEKFKYKT PQHRHYLSFE GIGFGTPTQR
160 170 180 190 200
EKHYRQFRAD RAAEQVMEYQ KQKLQSQYFP DSVIVKNIRQ SKQQKITQAI
210 220 230 240 250
ERLVEDLIQE SMAKGDFDNL SGKGKPLKKF SDCSYIDPMT HNLNRILIDN
260 270 280 290 300
GYQPEWILKQ KEISDTIEQL REAILVSRKK LGNPMTPTEK KQWNHVCEQF
310 320 330 340 350
QENIRKLNKR INDFNLIVPI LTRQKVHFDA QKEIVRAQKI YETLIKTKEV
360 370 380
TDRNPNNLDQ GEGEKTPEIK KGFLNWMNLW KFIKIRSF
Length:388
Mass (Da):45,806
Last modified:September 19, 2002 - v2
Checksum:iCB19D9FD060031D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti316 – 388LIVPI…KIRSF → CSHPDQAKSPF in BAA91185 (PubMed:14702039).CuratedAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462153 mRNA Translation: AAL59618.2
AK000468 mRNA Translation: BAA91185.1
CH471079 Genomic DNA Translation: EAX09830.1
CH471079 Genomic DNA Translation: EAX09831.1
CCDSiCCDS13626.1
RefSeqiNP_001035282.1, NM_001040192.2
NP_001307675.1, NM_001320746.2
NP_060303.2, NM_017833.4
UniGeneiHs.458308

Genome annotation databases

EnsembliENST00000314399; ENSP00000320303; ENSG00000177692
ENST00000381947; ENSP00000371373; ENSG00000177692
ENST00000402202; ENSP00000385777; ENSG00000177692
ENST00000571432; ENSP00000461665; ENSG00000262911
ENST00000572540; ENSP00000461737; ENSG00000262911
ENST00000573306; ENSP00000461084; ENSG00000262911
ENST00000615701; ENSP00000483670; ENSG00000262911
ENST00000617313; ENSP00000479716; ENSG00000177692
GeneIDi54943
KEGGihsa:54943
UCSCiuc002yrv.5 human

Similar proteinsi

Entry informationi

Entry nameiDJC28_HUMAN
AccessioniPrimary (citable) accession number: Q9NX36
Secondary accession number(s): D3DSF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: September 12, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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