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UniProtKB - Q9NX36 (DJC28_HUMAN)
Protein
DnaJ homolog subfamily C member 28
Gene
DNAJC28
Organism
Homo sapiens (Human)
Status
Functioni
May have a role in protein folding or as a chaperone.
GO - Biological processi
- Golgi organization Source: GO_Central
- Golgi vesicle prefusion complex stabilization Source: GO_Central
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central
Keywordsi
Molecular function | Chaperone |
Enzyme and pathway databases
PathwayCommonsi | Q9NX36 |
SignaLinki | Q9NX36 |
Names & Taxonomyi
Protein namesi | Recommended name: DnaJ homolog subfamily C member 28 |
Gene namesi | Name:DNAJC28 Synonyms:C21orf55, C21orf78 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1297, DNAJC28 |
neXtProti | NX_Q9NX36 |
VEuPathDBi | HostDB:ENSG00000177692 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000177692 |
PharmGKBi | PA162383922 |
Miscellaneous databases
Pharosi | Q9NX36, Tbio |
Genetic variation databases
BioMutai | DNAJC28 |
DMDMi | 23396536 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071139 | 1 – 388 | DnaJ homolog subfamily C member 28Add BLAST | 388 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 347 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NX36 |
MassIVEi | Q9NX36 |
MaxQBi | Q9NX36 |
PaxDbi | Q9NX36 |
PeptideAtlasi | Q9NX36 |
PRIDEi | Q9NX36 |
ProteomicsDBi | 83029 |
PTM databases
iPTMneti | Q9NX36 |
PhosphoSitePlusi | Q9NX36 |
Expressioni
Tissue specificityi
Expressed in the fetal and adult brain, testis, uterus, spleen and liver.
Developmental stagei
Not expressed in 8 and 10 weeks old fetuses.
Gene expression databases
Bgeei | ENSG00000177692, Expressed in testis and 153 other tissues |
Genevisiblei | Q9NX36, HS |
Organism-specific databases
HPAi | ENSG00000177692, Tissue enhanced (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120283, 95 interactors |
IntActi | Q9NX36, 6 interactors |
MINTi | Q9NX36 |
STRINGi | 9606.ENSP00000479716 |
Miscellaneous databases
RNActi | Q9NX36, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 115 | JPROSITE-ProRule annotationAdd BLAST | 65 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 261 – 349 | Sequence analysisAdd BLAST | 89 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0568, Eukaryota |
GeneTreei | ENSGT00940000154065 |
HOGENOMi | CLU_040968_1_0_1 |
InParanoidi | Q9NX36 |
OMAi | EWISLGK |
OrthoDBi | 1394654at2759 |
PhylomeDBi | Q9NX36 |
TreeFami | TF323730 |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit |
Gene3Di | 1.10.287.110, 1 hit |
InterProi | View protein in InterPro IPR001623, DnaJ_domain IPR018961, DnaJ_homolog_subfam-C_membr-28 IPR036869, J_dom_sf |
Pfami | View protein in Pfam PF00226, DnaJ, 1 hit PF09350, DUF1992, 1 hit |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit |
SUPFAMi | SSF46565, SSF46565, 1 hit |
PROSITEi | View protein in PROSITE PS50076, DNAJ_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9NX36-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNTMYVMMAQ ILRSHLIKAT VIPNRVKMLP YFGIIRNRMM STHKSKKKIR
60 70 80 90 100
EYYRLLNVEE GCSADEVRES FHKLAKQYHP DSGSNTADSA TFIRIEKAYR
110 120 130 140 150
KVLSHVIEQT NASQSKGEEE EDVEKFKYKT PQHRHYLSFE GIGFGTPTQR
160 170 180 190 200
EKHYRQFRAD RAAEQVMEYQ KQKLQSQYFP DSVIVKNIRQ SKQQKITQAI
210 220 230 240 250
ERLVEDLIQE SMAKGDFDNL SGKGKPLKKF SDCSYIDPMT HNLNRILIDN
260 270 280 290 300
GYQPEWILKQ KEISDTIEQL REAILVSRKK LGNPMTPTEK KQWNHVCEQF
310 320 330 340 350
QENIRKLNKR INDFNLIVPI LTRQKVHFDA QKEIVRAQKI YETLIKTKEV
360 370 380
TDRNPNNLDQ GEGEKTPEIK KGFLNWMNLW KFIKIRSF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 316 – 388 | LIVPI…KIRSF → CSHPDQAKSPF in BAA91185 (PubMed:14702039).CuratedAdd BLAST | 73 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF462153 mRNA Translation: AAL59618.2 AK000468 mRNA Translation: BAA91185.1 CH471079 Genomic DNA Translation: EAX09830.1 CH471079 Genomic DNA Translation: EAX09831.1 |
CCDSi | CCDS13626.1 |
RefSeqi | NP_001035282.1, NM_001040192.2 NP_001307675.1, NM_001320746.2 NP_060303.2, NM_017833.4 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF462153 mRNA Translation: AAL59618.2 AK000468 mRNA Translation: BAA91185.1 CH471079 Genomic DNA Translation: EAX09830.1 CH471079 Genomic DNA Translation: EAX09831.1 |
CCDSi | CCDS13626.1 |
RefSeqi | NP_001035282.1, NM_001040192.2 NP_001307675.1, NM_001320746.2 NP_060303.2, NM_017833.4 |
3D structure databases
SMRi | Q9NX36 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120283, 95 interactors |
IntActi | Q9NX36, 6 interactors |
MINTi | Q9NX36 |
STRINGi | 9606.ENSP00000479716 |
PTM databases
iPTMneti | Q9NX36 |
PhosphoSitePlusi | Q9NX36 |
Genetic variation databases
BioMutai | DNAJC28 |
DMDMi | 23396536 |
Proteomic databases
EPDi | Q9NX36 |
MassIVEi | Q9NX36 |
MaxQBi | Q9NX36 |
PaxDbi | Q9NX36 |
PeptideAtlasi | Q9NX36 |
PRIDEi | Q9NX36 |
ProteomicsDBi | 83029 |
Protocols and materials databases
Antibodypediai | 7335, 111 antibodies from 16 providers |
DNASUi | 54943 |
Genome annotation databases
Organism-specific databases
CTDi | 54943 |
GeneCardsi | DNAJC28 |
HGNCi | HGNC:1297, DNAJC28 |
HPAi | ENSG00000177692, Tissue enhanced (testis) |
neXtProti | NX_Q9NX36 |
OpenTargetsi | ENSG00000177692 |
PharmGKBi | PA162383922 |
VEuPathDBi | HostDB:ENSG00000177692 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0568, Eukaryota |
GeneTreei | ENSGT00940000154065 |
HOGENOMi | CLU_040968_1_0_1 |
InParanoidi | Q9NX36 |
OMAi | EWISLGK |
OrthoDBi | 1394654at2759 |
PhylomeDBi | Q9NX36 |
TreeFami | TF323730 |
Enzyme and pathway databases
PathwayCommonsi | Q9NX36 |
SignaLinki | Q9NX36 |
Miscellaneous databases
BioGRID-ORCSi | 54943, 4 hits in 1033 CRISPR screens |
GeneWikii | C21orf55 |
GenomeRNAii | 54943 |
Pharosi | Q9NX36, Tbio |
PROi | PR:Q9NX36 |
RNActi | Q9NX36, protein |
Gene expression databases
Bgeei | ENSG00000177692, Expressed in testis and 153 other tissues |
Genevisiblei | Q9NX36, HS |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit |
Gene3Di | 1.10.287.110, 1 hit |
InterProi | View protein in InterPro IPR001623, DnaJ_domain IPR018961, DnaJ_homolog_subfam-C_membr-28 IPR036869, J_dom_sf |
Pfami | View protein in Pfam PF00226, DnaJ, 1 hit PF09350, DUF1992, 1 hit |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit |
SUPFAMi | SSF46565, SSF46565, 1 hit |
PROSITEi | View protein in PROSITE PS50076, DNAJ_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DJC28_HUMAN | |
Accessioni | Q9NX36Primary (citable) accession number: Q9NX36 Secondary accession number(s): D3DSF2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | September 19, 2002 | |
Last modified: | February 23, 2022 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM