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Entry version 137 (12 Aug 2020)
Sequence version 2 (01 Feb 2003)
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Protein

Oxidative stress-responsive serine-rich protein 1

Gene

OSER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NX31

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oxidative stress-responsive serine-rich protein 1
Alternative name(s):
Oxidative stress-responsive protein 1
Peroxide-inducible transcript 1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OSER1
Synonyms:C20orf111
ORF Names:BM-038, HSPC168, HSPC207
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000132823.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16105, OSER1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NX31

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51526

Open Targets

More...
OpenTargetsi
ENSG00000132823

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25651

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NX31, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OSER1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
28212214

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000794531 – 292Oxidative stress-responsive serine-rich protein 1Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei143PhosphothreonineBy similarity1
Modified residuei233PhosphothreonineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NX31

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NX31

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NX31

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NX31

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NX31

PeptideAtlas

More...
PeptideAtlasi
Q9NX31

PRoteomics IDEntifications database

More...
PRIDEi
Q9NX31

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83026

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NX31

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NX31

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132823, Expressed in left testis and 240 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NX31, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000132823, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119588, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NX31, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362061

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NX31, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NX31

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi78 – 81Poly-Arg4
Compositional biasi100 – 104Poly-Ser5

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QUK0, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018547

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_050222_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NX31

Identification of Orthologs from Complete Genome Data

More...
OMAi
CSTKSHS

Database of Orthologous Groups

More...
OrthoDBi
1164781at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NX31

TreeFam database of animal gene trees

More...
TreeFami
TF331727

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008494, DUF776

The PANTHER Classification System

More...
PANTHERi
PTHR31383, PTHR31383, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05604, DUF776, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NX31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSEAKDGEE ESLQTAFKKL RVDASGSVAS LSVGEGTGVR APVRTATDDT
60 70 80 90 100
KPKTTCASKD SWHGSTRKSS RGAVRTQRRR RSKSPVLHPP KFIHCSTIAS
110 120 130 140 150
SSSSQLKHKS QTDSPDGSSG LGISSPKEFS AGESSTSLDA NHTGAVVEPL
160 170 180 190 200
RTSVPRLPSE SKKEDSSDAT QVPQASLKAS DLSDFQSVSK LNQGKPCTCI
210 220 230 240 250
GKECQCKRWH DMEVYSFSGL QSVPPLAPER RSTLEDYSQS LHARTLSGSP
260 270 280 290
RSCSEQARVF VDDVTIEDLS GYMEYYLYIP KKMSHMAEMM YT
Length:292
Mass (Da):31,779
Last modified:February 1, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DB0FFBA241FFEF4
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF36127 differs from that shown. Reason: Frameshift.Curated
The sequence AAF67625 differs from that shown. Reason: Frameshift.Curated
The sequence BAA91191 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02433374V → G. Corresponds to variant dbSNP:rs9346Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF161517 mRNA Translation: AAF29132.1
AF151041 mRNA Translation: AAF36127.1 Frameshift.
AF217514 mRNA Translation: AAF67625.1 Frameshift.
AL133000 mRNA Translation: CAB61348.1
AK000476 mRNA Translation: BAA91191.1 Frameshift.
AK315155 mRNA Translation: BAG37601.1
AL035447 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75938.1
BC064973 mRNA Translation: AAH64973.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13327.1

NCBI Reference Sequences

More...
RefSeqi
NP_057554.4, NM_016470.7
XP_011527153.1, XM_011528851.1
XP_011527155.1, XM_011528853.2
XP_016883362.1, XM_017027873.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000255174; ENSP00000255174; ENSG00000132823
ENST00000372970; ENSP00000362061; ENSG00000132823

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51526

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51526

UCSC genome browser

More...
UCSCi
uc002xlk.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161517 mRNA Translation: AAF29132.1
AF151041 mRNA Translation: AAF36127.1 Frameshift.
AF217514 mRNA Translation: AAF67625.1 Frameshift.
AL133000 mRNA Translation: CAB61348.1
AK000476 mRNA Translation: BAA91191.1 Frameshift.
AK315155 mRNA Translation: BAG37601.1
AL035447 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75938.1
BC064973 mRNA Translation: AAH64973.1
CCDSiCCDS13327.1
RefSeqiNP_057554.4, NM_016470.7
XP_011527153.1, XM_011528851.1
XP_011527155.1, XM_011528853.2
XP_016883362.1, XM_017027873.1

3D structure databases

SMRiQ9NX31
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119588, 7 interactors
IntActiQ9NX31, 9 interactors
STRINGi9606.ENSP00000362061

PTM databases

iPTMnetiQ9NX31
PhosphoSitePlusiQ9NX31

Polymorphism and mutation databases

BioMutaiOSER1
DMDMi28212214

Proteomic databases

EPDiQ9NX31
jPOSTiQ9NX31
MassIVEiQ9NX31
MaxQBiQ9NX31
PaxDbiQ9NX31
PeptideAtlasiQ9NX31
PRIDEiQ9NX31
ProteomicsDBi83026

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
43666, 70 antibodies

The DNASU plasmid repository

More...
DNASUi
51526

Genome annotation databases

EnsembliENST00000255174; ENSP00000255174; ENSG00000132823
ENST00000372970; ENSP00000362061; ENSG00000132823
GeneIDi51526
KEGGihsa:51526
UCSCiuc002xlk.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51526
DisGeNETi51526
EuPathDBiHostDB:ENSG00000132823.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
OSER1
HGNCiHGNC:16105, OSER1
HPAiENSG00000132823, Low tissue specificity
neXtProtiNX_Q9NX31
OpenTargetsiENSG00000132823
PharmGKBiPA25651

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QUK0, Eukaryota
GeneTreeiENSGT00390000018547
HOGENOMiCLU_050222_0_0_1
InParanoidiQ9NX31
OMAiCSTKSHS
OrthoDBi1164781at2759
PhylomeDBiQ9NX31
TreeFamiTF331727

Enzyme and pathway databases

PathwayCommonsiQ9NX31

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
51526, 5 hits in 854 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
OSER1, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
C20orf111

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51526
PharosiQ9NX31, Tdark

Protein Ontology

More...
PROi
PR:Q9NX31
RNActiQ9NX31, protein

Gene expression databases

BgeeiENSG00000132823, Expressed in left testis and 240 other tissues
GenevisibleiQ9NX31, HS

Family and domain databases

InterProiView protein in InterPro
IPR008494, DUF776
PANTHERiPTHR31383, PTHR31383, 1 hit
PfamiView protein in Pfam
PF05604, DUF776, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOSER1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NX31
Secondary accession number(s): B2RCK4
, O95912, Q9NZ84, Q9P0R8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: August 12, 2020
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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