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Protein

39S ribosomal protein L16, mitochondrial

Gene

MRPL16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L16, mitochondrial
Short name:
L16mt
Short name:
MRP-L16
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL16m1 Publication
Gene namesi
Name:MRPL16
ORF Names:PNAS-111
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166902.4
HGNCiHGNC:14476 MRPL16
MIMi611829 gene
neXtProtiNX_Q9NX20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166902
PharmGKBiPA30945

Polymorphism and mutation databases

BioMutaiMRPL16
DMDMi74734684

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionBy similarityAdd BLAST29
ChainiPRO_000023984130 – 25139S ribosomal protein L16, mitochondrialAdd BLAST222

Proteomic databases

EPDiQ9NX20
MaxQBiQ9NX20
PaxDbiQ9NX20
PeptideAtlasiQ9NX20
PRIDEiQ9NX20
ProteomicsDBi83024
TopDownProteomicsiQ9NX20

PTM databases

iPTMnetiQ9NX20
PhosphoSitePlusiQ9NX20
SwissPalmiQ9NX20

Expressioni

Gene expression databases

BgeeiENSG00000166902 Expressed in 217 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MRPL16
ExpressionAtlasiQ9NX20 baseline and differential
GenevisibleiQ9NX20 HS

Organism-specific databases

HPAiHPA054133

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.3 Publications

Protein-protein interaction databases

BioGridi120287, 52 interactors
CORUMiQ9NX20
IntActiQ9NX20, 14 interactors
MINTiQ9NX20
STRINGi9606.ENSP00000300151

Structurei

Secondary structure

1251
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NX20
SMRiQ9NX20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3422 Eukaryota
COG0197 LUCA
GeneTreeiENSGT00390000002038
HOGENOMiHOG000021349
HOVERGENiHBG056553
InParanoidiQ9NX20
KOiK02878
OMAiMFAIWRV
OrthoDBiEOG091G0KF0
PhylomeDBiQ9NX20
TreeFamiTF312969

Family and domain databases

CDDicd01433 Ribosomal_L16_L10e, 1 hit
Gene3Di3.90.1170.10, 1 hit
InterProiView protein in InterPro
IPR016180 Ribosomal_L10e/L16
IPR036920 Ribosomal_L10e/L16_sf
IPR000114 Ribosomal_L16
PANTHERiPTHR12220 PTHR12220, 1 hit
PfamiView protein in Pfam
PF00252 Ribosomal_L16, 1 hit
PRINTSiPR00060 RIBOSOMALL16
SUPFAMiSSF54686 SSF54686, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NX20-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWRLLARASA PLLRVPLSDS WALLPASAGV KTLLPVPSFE DVSIPEKPKL
60 70 80 90 100
RFIERAPLVP KVRREPKNLS DIRGPSTEAT EFTEGNFAIL ALGGGYLHWG
110 120 130 140 150
HFEMMRLTIN RSMDPKNMFA IWRVPAPFKP ITRKSVGHRM GGGKGAIDHY
160 170 180 190 200
VTPVKAGRLV VEMGGRCEFE EVQGFLDQVA HKLPFAAKAV SRGTLEKMRK
210 220 230 240 250
DQEERERNNQ NPWTFERIAT ANMLGIRKVL SPYDLTHKGK YWGKFYMPKR

V
Length:251
Mass (Da):28,449
Last modified:October 1, 2000 - v1
Checksum:i8A42A67DA80A6FEF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PI14E9PI14_HUMAN
39S ribosomal protein L16, mitochon...
MRPL16
86Annotation score:

Sequence cautioni

The sequence AAG23818 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15V → L in BAB40847 (PubMed:11279069).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05200629G → S. Corresponds to variant dbSNP:rs7122468Ensembl.1
Natural variantiVAR_052007199R → Q. Corresponds to variant dbSNP:rs12787462Ensembl.1
Natural variantiVAR_052008207R → C. Corresponds to variant dbSNP:rs491671EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049642 mRNA Translation: BAB40847.1
AF183428 mRNA Translation: AAG09697.1
AK000491 mRNA Translation: BAA91202.1
CR457117 mRNA Translation: CAG33398.1
BC001040 mRNA Translation: AAH01040.1
BC019269 mRNA Translation: AAH19269.1
AF275806 mRNA Translation: AAG23818.1 Different initiation.
CCDSiCCDS7976.1
RefSeqiNP_060310.1, NM_017840.3
UniGeneiHs.530734

Genome annotation databases

EnsembliENST00000300151; ENSP00000300151; ENSG00000166902
GeneIDi54948
KEGGihsa:54948
UCSCiuc001noh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049642 mRNA Translation: BAB40847.1
AF183428 mRNA Translation: AAG09697.1
AK000491 mRNA Translation: BAA91202.1
CR457117 mRNA Translation: CAG33398.1
BC001040 mRNA Translation: AAH01040.1
BC019269 mRNA Translation: AAH19269.1
AF275806 mRNA Translation: AAG23818.1 Different initiation.
CCDSiCCDS7976.1
RefSeqiNP_060310.1, NM_017840.3
UniGeneiHs.530734

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40N1-251[»]
3J9Melectron microscopy3.50N1-251[»]
5OOLelectron microscopy3.06N1-251[»]
5OOMelectron microscopy3.03N1-251[»]
ProteinModelPortaliQ9NX20
SMRiQ9NX20
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120287, 52 interactors
CORUMiQ9NX20
IntActiQ9NX20, 14 interactors
MINTiQ9NX20
STRINGi9606.ENSP00000300151

PTM databases

iPTMnetiQ9NX20
PhosphoSitePlusiQ9NX20
SwissPalmiQ9NX20

Polymorphism and mutation databases

BioMutaiMRPL16
DMDMi74734684

Proteomic databases

EPDiQ9NX20
MaxQBiQ9NX20
PaxDbiQ9NX20
PeptideAtlasiQ9NX20
PRIDEiQ9NX20
ProteomicsDBi83024
TopDownProteomicsiQ9NX20

Protocols and materials databases

DNASUi54948
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300151; ENSP00000300151; ENSG00000166902
GeneIDi54948
KEGGihsa:54948
UCSCiuc001noh.2 human

Organism-specific databases

CTDi54948
EuPathDBiHostDB:ENSG00000166902.4
GeneCardsiMRPL16
HGNCiHGNC:14476 MRPL16
HPAiHPA054133
MIMi611829 gene
neXtProtiNX_Q9NX20
OpenTargetsiENSG00000166902
PharmGKBiPA30945
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3422 Eukaryota
COG0197 LUCA
GeneTreeiENSGT00390000002038
HOGENOMiHOG000021349
HOVERGENiHBG056553
InParanoidiQ9NX20
KOiK02878
OMAiMFAIWRV
OrthoDBiEOG091G0KF0
PhylomeDBiQ9NX20
TreeFamiTF312969

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL16 human
GenomeRNAii54948
PROiPR:Q9NX20
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166902 Expressed in 217 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MRPL16
ExpressionAtlasiQ9NX20 baseline and differential
GenevisibleiQ9NX20 HS

Family and domain databases

CDDicd01433 Ribosomal_L16_L10e, 1 hit
Gene3Di3.90.1170.10, 1 hit
InterProiView protein in InterPro
IPR016180 Ribosomal_L10e/L16
IPR036920 Ribosomal_L10e/L16_sf
IPR000114 Ribosomal_L16
PANTHERiPTHR12220 PTHR12220, 1 hit
PfamiView protein in Pfam
PF00252 Ribosomal_L16, 1 hit
PRINTSiPR00060 RIBOSOMALL16
SUPFAMiSSF54686 SSF54686, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM16_HUMAN
AccessioniPrimary (citable) accession number: Q9NX20
Secondary accession number(s): Q9BYD0, Q9HB70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2000
Last modified: October 10, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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