UniProtKB - Q9NX20 (RM16_HUMAN)
39S ribosomal protein L16, mitochondrial
MRPL16
Functioni
GO - Molecular functioni
- rRNA binding Source: GO_Central
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- mitochondrial translation Source: GO_Central
- mitochondrial translational elongation Source: Reactome
- mitochondrial translational termination Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | Q9NX20 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
Names & Taxonomyi
Protein namesi | Recommended name: 39S ribosomal protein L16, mitochondrialShort name: L16mt Short name: MRP-L16 Alternative name(s): Mitochondrial large ribosomal subunit protein uL16m1 Publication |
Gene namesi | Name:MRPL16 ORF Names:PNAS-111 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000166902.4 |
HGNCi | HGNC:14476, MRPL16 |
MIMi | 611829, gene |
neXtProti | NX_Q9NX20 |
Subcellular locationi
Mitochondrion
- Mitochondrion 3 Publications
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrial large ribosomal subunit Source: UniProtKB
- mitochondrion Source: UniProtKB
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 54948 |
OpenTargetsi | ENSG00000166902 |
PharmGKBi | PA30945 |
Miscellaneous databases
Pharosi | Q9NX20, Tdark |
Polymorphism and mutation databases
BioMutai | MRPL16 |
DMDMi | 74734684 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 29 | MitochondrionBy similarityAdd BLAST | 29 | |
ChainiPRO_0000239841 | 30 – 251 | 39S ribosomal protein L16, mitochondrialAdd BLAST | 222 |
Proteomic databases
EPDi | Q9NX20 |
jPOSTi | Q9NX20 |
MassIVEi | Q9NX20 |
MaxQBi | Q9NX20 |
PaxDbi | Q9NX20 |
PeptideAtlasi | Q9NX20 |
PRIDEi | Q9NX20 |
ProteomicsDBi | 83024 |
TopDownProteomicsi | Q9NX20 |
PTM databases
iPTMneti | Q9NX20 |
PhosphoSitePlusi | Q9NX20 |
SwissPalmi | Q9NX20 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166902, Expressed in quadriceps femoris and 228 other tissues |
ExpressionAtlasi | Q9NX20, baseline and differential |
Genevisiblei | Q9NX20, HS |
Organism-specific databases
HPAi | ENSG00000166902, Low tissue specificity |
Interactioni
Subunit structurei
Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
3 PublicationsProtein-protein interaction databases
BioGRIDi | 120287, 62 interactors |
ComplexPortali | CPX-5226, 39S mitochondrial large ribosomal subunit |
CORUMi | Q9NX20 |
IntActi | Q9NX20, 39 interactors |
MINTi | Q9NX20 |
STRINGi | 9606.ENSP00000300151 |
Miscellaneous databases
RNActi | Q9NX20, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9NX20 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG3422, Eukaryota |
GeneTreei | ENSGT00390000002038 |
HOGENOMi | CLU_096518_0_0_1 |
InParanoidi | Q9NX20 |
OMAi | VANQLPF |
OrthoDBi | 1420525at2759 |
PhylomeDBi | Q9NX20 |
TreeFami | TF312969 |
Family and domain databases
CDDi | cd01433, Ribosomal_L16_L10e, 1 hit |
Gene3Di | 3.90.1170.10, 1 hit |
InterProi | View protein in InterPro IPR016180, Ribosomal_L10e/L16 IPR036920, Ribosomal_L10e/L16_sf IPR000114, Ribosomal_L16 |
PANTHERi | PTHR12220, PTHR12220, 1 hit |
Pfami | View protein in Pfam PF00252, Ribosomal_L16, 1 hit |
PRINTSi | PR00060, RIBOSOMALL16 |
SUPFAMi | SSF54686, SSF54686, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MWRLLARASA PLLRVPLSDS WALLPASAGV KTLLPVPSFE DVSIPEKPKL
60 70 80 90 100
RFIERAPLVP KVRREPKNLS DIRGPSTEAT EFTEGNFAIL ALGGGYLHWG
110 120 130 140 150
HFEMMRLTIN RSMDPKNMFA IWRVPAPFKP ITRKSVGHRM GGGKGAIDHY
160 170 180 190 200
VTPVKAGRLV VEMGGRCEFE EVQGFLDQVA HKLPFAAKAV SRGTLEKMRK
210 220 230 240 250
DQEERERNNQ NPWTFERIAT ANMLGIRKVL SPYDLTHKGK YWGKFYMPKR
V
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PI14 | E9PI14_HUMAN | 39S ribosomal protein L16, mitochon... | MRPL16 | 86 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 15 | V → L in BAB40847 (PubMed:11279069).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052006 | 29 | G → S. Corresponds to variant dbSNP:rs7122468Ensembl. | 1 | |
Natural variantiVAR_052007 | 199 | R → Q. Corresponds to variant dbSNP:rs12787462Ensembl. | 1 | |
Natural variantiVAR_052008 | 207 | R → C. Corresponds to variant dbSNP:rs491671EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB049642 mRNA Translation: BAB40847.1 AF183428 mRNA Translation: AAG09697.1 AK000491 mRNA Translation: BAA91202.1 CR457117 mRNA Translation: CAG33398.1 BC001040 mRNA Translation: AAH01040.1 BC019269 mRNA Translation: AAH19269.1 AF275806 mRNA Translation: AAG23818.1 Different initiation. |
CCDSi | CCDS7976.1 |
RefSeqi | NP_060310.1, NM_017840.3 |
Genome annotation databases
Ensembli | ENST00000300151; ENSP00000300151; ENSG00000166902 |
GeneIDi | 54948 |
KEGGi | hsa:54948 |
UCSCi | uc001noh.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB049642 mRNA Translation: BAB40847.1 AF183428 mRNA Translation: AAG09697.1 AK000491 mRNA Translation: BAA91202.1 CR457117 mRNA Translation: CAG33398.1 BC001040 mRNA Translation: AAH01040.1 BC019269 mRNA Translation: AAH19269.1 AF275806 mRNA Translation: AAG23818.1 Different initiation. |
CCDSi | CCDS7976.1 |
RefSeqi | NP_060310.1, NM_017840.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J7Y | electron microscopy | 3.40 | N | 1-251 | [»] | |
3J9M | electron microscopy | 3.50 | N | 1-251 | [»] | |
5OOL | electron microscopy | 3.06 | N | 1-251 | [»] | |
5OOM | electron microscopy | 3.03 | N | 1-251 | [»] | |
6I9R | electron microscopy | 3.90 | N | 1-251 | [»] | |
6NU2 | electron microscopy | 3.90 | N | 47-251 | [»] | |
6NU3 | electron microscopy | 4.40 | N | 1-251 | [»] | |
6VLZ | electron microscopy | 2.97 | N | 1-251 | [»] | |
6VMI | electron microscopy | 2.96 | N | 1-251 | [»] | |
SMRi | Q9NX20 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120287, 62 interactors |
ComplexPortali | CPX-5226, 39S mitochondrial large ribosomal subunit |
CORUMi | Q9NX20 |
IntActi | Q9NX20, 39 interactors |
MINTi | Q9NX20 |
STRINGi | 9606.ENSP00000300151 |
PTM databases
iPTMneti | Q9NX20 |
PhosphoSitePlusi | Q9NX20 |
SwissPalmi | Q9NX20 |
Polymorphism and mutation databases
BioMutai | MRPL16 |
DMDMi | 74734684 |
Proteomic databases
EPDi | Q9NX20 |
jPOSTi | Q9NX20 |
MassIVEi | Q9NX20 |
MaxQBi | Q9NX20 |
PaxDbi | Q9NX20 |
PeptideAtlasi | Q9NX20 |
PRIDEi | Q9NX20 |
ProteomicsDBi | 83024 |
TopDownProteomicsi | Q9NX20 |
Protocols and materials databases
Antibodypediai | 52764, 103 antibodies |
DNASUi | 54948 |
Genome annotation databases
Ensembli | ENST00000300151; ENSP00000300151; ENSG00000166902 |
GeneIDi | 54948 |
KEGGi | hsa:54948 |
UCSCi | uc001noh.2, human |
Organism-specific databases
CTDi | 54948 |
DisGeNETi | 54948 |
EuPathDBi | HostDB:ENSG00000166902.4 |
GeneCardsi | MRPL16 |
HGNCi | HGNC:14476, MRPL16 |
HPAi | ENSG00000166902, Low tissue specificity |
MIMi | 611829, gene |
neXtProti | NX_Q9NX20 |
OpenTargetsi | ENSG00000166902 |
PharmGKBi | PA30945 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3422, Eukaryota |
GeneTreei | ENSGT00390000002038 |
HOGENOMi | CLU_096518_0_0_1 |
InParanoidi | Q9NX20 |
OMAi | VANQLPF |
OrthoDBi | 1420525at2759 |
PhylomeDBi | Q9NX20 |
TreeFami | TF312969 |
Enzyme and pathway databases
PathwayCommonsi | Q9NX20 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
Miscellaneous databases
BioGRID-ORCSi | 54948, 401 hits in 849 CRISPR screens |
ChiTaRSi | MRPL16, human |
GenomeRNAii | 54948 |
Pharosi | Q9NX20, Tdark |
PROi | PR:Q9NX20 |
RNActi | Q9NX20, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166902, Expressed in quadriceps femoris and 228 other tissues |
ExpressionAtlasi | Q9NX20, baseline and differential |
Genevisiblei | Q9NX20, HS |
Family and domain databases
CDDi | cd01433, Ribosomal_L16_L10e, 1 hit |
Gene3Di | 3.90.1170.10, 1 hit |
InterProi | View protein in InterPro IPR016180, Ribosomal_L10e/L16 IPR036920, Ribosomal_L10e/L16_sf IPR000114, Ribosomal_L16 |
PANTHERi | PTHR12220, PTHR12220, 1 hit |
Pfami | View protein in Pfam PF00252, Ribosomal_L16, 1 hit |
PRINTSi | PR00060, RIBOSOMALL16 |
SUPFAMi | SSF54686, SSF54686, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RM16_HUMAN | |
Accessioni | Q9NX20Primary (citable) accession number: Q9NX20 Secondary accession number(s): Q9BYD0, Q9HB70 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 13, 2006 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Ribosomal proteins
Ribosomal proteins families and list of entries