UniProtKB - Q9NX20 (RM16_HUMAN)

BLAST

>sp|Q9NX20|RM16_HUMAN 39S ribosomal protein L16, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL16 PE=1 SV=1
MWRLLARASAPLLRVPLSDSWALLPASAGVKTLLPVPSFEDVSIPEKPKLRFIERAPLVP
KVRREPKNLSDIRGPSTEATEFTEGNFAILALGGGYLHWGHFEMMRLTINRSMDPKNMFA
IWRVPAPFKPITRKSVGHRMGGGKGAIDHYVTPVKAGRLVVEMGGRCEFEEVQGFLDQVA
HKLPFAAKAVSRGTLEKMRKDQEERERNNQNPWTFERIATANMLGIRKVLSPYDLTHKGK
YWGKFYMPKRV

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History
Entry version 135 (10 Oct 2018)
Sequence version 1 (01 Oct 2000)
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Protein

39S ribosomal protein L16, mitochondrial

Gene

MRPL16

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

rRNA binding Source: GO_Central
structural constituent of ribosome Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mitochondrial translation Source: GO_Central
mitochondrial translational elongation Source: Reactome
mitochondrial translational termination Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein

Molecular function

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5368286 Mitochondrial translation initiation R-HSA-5389840 Mitochondrial translation elongation R-HSA-5419276 Mitochondrial translation termination

Reactomeⁱ

R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 39S ribosomal protein L16, mitochondrial Short name: L16mt Short name: MRP-L16 Alternative name(s): Mitochondrial large ribosomal subunit protein uL16m1 Publication
Gene namesⁱ	Name:MRPL16 ORF Names:PNAS-111
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000166902.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14476 MRPL16
MIMⁱ	611829 gene
neXtProtⁱ	NX_Q9NX20

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000166902
PharmGKBⁱ	PA30945

Polymorphism and mutation databases

BioMutaⁱ	MRPL16
DMDMⁱ	74734684

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 29	MitochondrionBy similarityAdd BLAST		29
ChainⁱPRO_0000239841	30 – 251	39S ribosomal protein L16, mitochondrialAdd BLAST		222

Proteomic databases

EPDⁱ	Q9NX20
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NX20
PaxDbⁱ	Q9NX20
PeptideAtlas More...PeptideAtlasⁱ	Q9NX20
PRIDEⁱ	Q9NX20
ProteomicsDBⁱ	83024
TopDownProteomicsⁱ	Q9NX20

PTM databases

iPTMnetⁱ	Q9NX20
PhosphoSitePlusⁱ	Q9NX20
SwissPalmⁱ	Q9NX20

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000166902 Expressed in 217 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_MRPL16
ExpressionAtlasⁱ	Q9NX20 baseline and differential
Genevisibleⁱ	Q9NX20 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA054133

HPAⁱ

HPA054133

Interactionⁱ

Subunit structureⁱ

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.3 Publications

Protein-protein interaction databases

BioGridⁱ	120287, 52 interactors
CORUMⁱ	Q9NX20
IntActⁱ	Q9NX20, 14 interactors
Molecular INTeraction database More...MINTⁱ	Q9NX20
STRINGⁱ	9606.ENSP00000300151

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	69 – 71	Combined sources	3
Beta strandⁱ	73 – 75	Combined sources	3
Beta strandⁱ	77 – 79	Combined sources	3
Beta strandⁱ	86 – 93	Combined sources	8
Beta strandⁱ	95 – 97	Combined sources	3
Helixⁱ	99 – 111	Combined sources	13
Turnⁱ	115 – 117	Combined sources	3
Beta strandⁱ	118 – 122	Combined sources	5
Beta strandⁱ	129 – 132	Combined sources	4
Beta strandⁱ	142 – 144	Combined sources	3
Beta strandⁱ	147 – 154	Combined sources	8
Beta strandⁱ	161 – 166	Combined sources	6
Helixⁱ	169 – 182	Combined sources	14
Beta strandⁱ	183 – 185	Combined sources	3
Beta strandⁱ	187 – 192	Combined sources	6
Helixⁱ	193 – 208	Combined sources	16
Helixⁱ	215 – 221	Combined sources	7
Turnⁱ	222 – 224	Combined sources	3
Helixⁱ	226 – 228	Combined sources	3
Helixⁱ	233 – 235	Combined sources	3
Beta strandⁱ	240 – 242	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9NX20
SMRⁱ	Q9NX20
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the universal ribosomal protein uL16 family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG3422 Eukaryota COG0197 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002038
HOGENOMⁱ	HOG000021349
HOVERGENⁱ	HBG056553
InParanoidⁱ	Q9NX20
KEGG Orthology (KO) More...KOⁱ	K02878
OMAⁱ	MFAIWRV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KF0
PhylomeDBⁱ	Q9NX20
TreeFamⁱ	TF312969

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01433 Ribosomal_L16_L10e, 1 hit
Gene3Dⁱ	3.90.1170.10, 1 hit
InterProⁱ	View protein in InterPro IPR016180 Ribosomal_L10e/L16 IPR036920 Ribosomal_L10e/L16_sf IPR000114 Ribosomal_L16
PANTHERⁱ	PTHR12220 PTHR12220, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00252 Ribosomal_L16, 1 hit
PRINTSⁱ	PR00060 RIBOSOMALL16
SUPFAMⁱ	SSF54686 SSF54686, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9NX20-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MWRLLARASA PLLRVPLSDS WALLPASAGV KTLLPVPSFE DVSIPEKPKL 
        60         70         80         90        100
RFIERAPLVP KVRREPKNLS DIRGPSTEAT EFTEGNFAIL ALGGGYLHWG 
       110        120        130        140        150
HFEMMRLTIN RSMDPKNMFA IWRVPAPFKP ITRKSVGHRM GGGKGAIDHY 
       160        170        180        190        200
VTPVKAGRLV VEMGGRCEFE EVQGFLDQVA HKLPFAAKAV SRGTLEKMRK 
       210        220        230        240        250
DQEERERNNQ NPWTFERIAT ANMLGIRKVL SPYDLTHKGK YWGKFYMPKR 

V

Length:251

Mass (Da):28,449

Last modified:October 1, 2000 - v1

Checksum:ⁱ8A42A67DA80A6FEF

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E9PI14	E9PI14_HUMAN		39S ribosomal protein L16, mitochon... 39S ribosomal protein L16, mitochondrial	MRPL16	86	Annotation score:

Sequence cautionⁱ

The sequence AAG23818 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	15	V → L in BAB40847 (PubMed:11279069).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_052006	29	G → S. Corresponds to variant dbSNP:rs7122468Ensembl.	1
Natural variantⁱVAR_052007	199	R → Q. Corresponds to variant dbSNP:rs12787462Ensembl.	1
Natural variantⁱVAR_052008	207	R → C. Corresponds to variant dbSNP:rs491671EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB049642 mRNA Translation: BAB40847.1 AF183428 mRNA Translation: AAG09697.1 AK000491 mRNA Translation: BAA91202.1 CR457117 mRNA Translation: CAG33398.1 BC001040 mRNA Translation: AAH01040.1 BC019269 mRNA Translation: AAH19269.1 AF275806 mRNA Translation: AAG23818.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7976.1
NCBI Reference Sequences More...RefSeqⁱ	NP_060310.1, NM_017840.3
UniGeneⁱ	Hs.530734

Genome annotation databases

Ensemblⁱ	ENST00000300151; ENSP00000300151; ENSG00000166902
GeneIDⁱ	54948
KEGGⁱ	hsa:54948
UCSC genome browser More...UCSCⁱ	uc001noh.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NX20	39S ribosomal protein L16, mitochondrial		PONAB		251	UniRef100_Q9NX20
39S ribosomal protein L16, mitochondrial (Fragment)		HUMAN		86
MRPL16 isoform 2 (Fragment)		PANTR		86
UPI0000D579D9		HUMAN		118

Protein	Similar proteins		Species	Score	Length	Source
Q9NX20	39S ribosomal protein L16, mitochondrial		PONAB		251	UniRef90_Q9NX20
39S ribosomal protein L16, mitochondrial (Fragment)		HUMAN		86
MRPL16 isoform 2 (Fragment)		PANTR		86
39S ribosomal protein L16, mitochondrial		MACMU		251
Uncharacterized protein		MACFA		251
+23

Protein	Similar proteins		Species	Score	Length	Source
Q9NX20	39S ribosomal protein L16, mitochondrial		PONAB		251	UniRef50_Q9NX20
39S ribosomal protein L16, mitochondrial	)	BOVIN		251
39S ribosomal protein L16, mitochondrial		MOUSE		251
39S ribosomal protein L16, mitochondrial		RAT		251
39S ribosomal protein L16, mitochondrial (Fragment)		HUMAN		86
+266

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB049642 mRNA Translation: BAB40847.1 AF183428 mRNA Translation: AAG09697.1 AK000491 mRNA Translation: BAA91202.1 CR457117 mRNA Translation: CAG33398.1 BC001040 mRNA Translation: AAH01040.1 BC019269 mRNA Translation: AAH19269.1 AF275806 mRNA Translation: AAG23818.1 Different initiation.
CCDSⁱ	CCDS7976.1
RefSeqⁱ	NP_060310.1, NM_017840.3
UniGeneⁱ	Hs.530734

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3J7Y	electron microscopy	3.40	N	1-251	[»]
	3J9M	electron microscopy	3.50	N	1-251	[»]
	5OOL	electron microscopy	3.06	N	1-251	[»]
	5OOM	electron microscopy	3.03	N	1-251	[»]
ProteinModelPortalⁱ	Q9NX20
SMRⁱ	Q9NX20
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120287, 52 interactors
CORUMⁱ	Q9NX20
IntActⁱ	Q9NX20, 14 interactors
MINTⁱ	Q9NX20
STRINGⁱ	9606.ENSP00000300151

PTM databases

iPTMnetⁱ	Q9NX20
PhosphoSitePlusⁱ	Q9NX20
SwissPalmⁱ	Q9NX20

Polymorphism and mutation databases

BioMutaⁱ	MRPL16
DMDMⁱ	74734684

Proteomic databases

EPDⁱ	Q9NX20
MaxQBⁱ	Q9NX20
PaxDbⁱ	Q9NX20
PeptideAtlasⁱ	Q9NX20
PRIDEⁱ	Q9NX20
ProteomicsDBⁱ	83024
TopDownProteomicsⁱ	Q9NX20

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	54948
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000300151; ENSP00000300151; ENSG00000166902
GeneIDⁱ	54948
KEGGⁱ	hsa:54948
UCSCⁱ	uc001noh.2 human

Organism-specific databases

CTDⁱ	54948
EuPathDBⁱ	HostDB:ENSG00000166902.4
GeneCardsⁱ	MRPL16
HGNCⁱ	HGNC:14476 MRPL16
HPAⁱ	HPA054133
MIMⁱ	611829 gene
neXtProtⁱ	NX_Q9NX20
OpenTargetsⁱ	ENSG00000166902
PharmGKBⁱ	PA30945
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3422 Eukaryota COG0197 LUCA
GeneTreeⁱ	ENSGT00390000002038
HOGENOMⁱ	HOG000021349
HOVERGENⁱ	HBG056553
InParanoidⁱ	Q9NX20
KOⁱ	K02878
OMAⁱ	MFAIWRV
OrthoDBⁱ	EOG091G0KF0
PhylomeDBⁱ	Q9NX20
TreeFamⁱ	TF312969

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5368286 Mitochondrial translation initiation R-HSA-5389840 Mitochondrial translation elongation R-HSA-5419276 Mitochondrial translation termination

Reactomeⁱ

R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSⁱ	MRPL16 human
GenomeRNAiⁱ	54948
Protein Ontology More...PROⁱ	PR:Q9NX20
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000166902 Expressed in 217 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_MRPL16
ExpressionAtlasⁱ	Q9NX20 baseline and differential
Genevisibleⁱ	Q9NX20 HS

Family and domain databases

CDDⁱ	cd01433 Ribosomal_L16_L10e, 1 hit
Gene3Dⁱ	3.90.1170.10, 1 hit
InterProⁱ	View protein in InterPro IPR016180 Ribosomal_L10e/L16 IPR036920 Ribosomal_L10e/L16_sf IPR000114 Ribosomal_L16
PANTHERⁱ	PTHR12220 PTHR12220, 1 hit
Pfamⁱ	View protein in Pfam PF00252 Ribosomal_L16, 1 hit
PRINTSⁱ	PR00060 RIBOSOMALL16
SUPFAMⁱ	SSF54686 SSF54686, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RM16_HUMAN
Accessionⁱ	Q9NX20Primary (citable) accession number: Q9NX20 Secondary accession number(s): Q9BYD0, Q9HB70
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
	Last sequence update:	October 1, 2000
	Last modified:	October 10, 2018
	This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Ribosomal proteins
Ribosomal proteins families and list of entries
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NX20 (RM16_HUMAN)

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39S ribosomal protein L16, mitochondrial

MRPL16

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ