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Protein

COMM domain-containing protein 8

Gene

COMMD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).1 Publication1 Publication

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 8
Gene namesi
Name:COMMD8
ORF Names:MDS022
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000169019.10
HGNCiHGNC:26036 COMMD8
MIMi616656 gene
neXtProtiNX_Q9NX08

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54951
OpenTargetsiENSG00000169019
PharmGKBiPA134876825

Polymorphism and mutation databases

BioMutaiCOMMD8
DMDMi51316105

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000774011 – 183COMM domain-containing protein 8Add BLAST183

Proteomic databases

EPDiQ9NX08
MaxQBiQ9NX08
PaxDbiQ9NX08
PeptideAtlasiQ9NX08
PRIDEiQ9NX08
ProteomicsDBi83019
TopDownProteomicsiQ9NX08

PTM databases

iPTMnetiQ9NX08
PhosphoSitePlusiQ9NX08

Expressioni

Tissue specificityi

Widely expressed with highest expression in thyroid.1 Publication

Gene expression databases

BgeeiENSG00000169019 Expressed in 220 organ(s), highest expression level in renal glomerulus
CleanExiHS_COMMD8
GenevisibleiQ9NX08 HS

Organism-specific databases

HPAiHPA035887

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5.5 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi120289, 49 interactors
CORUMiQ9NX08
IntActiQ9NX08, 18 interactors
MINTiQ9NX08
STRINGi9606.ENSP00000370984

Structurei

3D structure databases

ProteinModelPortaliQ9NX08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 183COMMPROSITE-ProRule annotationAdd BLAST68

Phylogenomic databases

eggNOGiENOG410IHDB Eukaryota
ENOG4111JYC LUCA
GeneTreeiENSGT00390000018121
HOGENOMiHOG000007080
HOVERGENiHBG051073
InParanoidiQ9NX08
KOiK22564
OMAiVWDSTEW
OrthoDBiEOG091G18T9
PhylomeDBiQ9NX08
TreeFamiTF328403

Family and domain databases

InterProiView protein in InterPro
IPR017920 COMM
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NX08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPEEGTPLW RLQKLPAELG PQLLHKIIDG ICGRAYPVYQ DYHTVWESEE
60 70 80 90 100
WMHVLEDIAK FFKAIVGKNL PDEEIFQQLN QLNSLHQETI MKCVKSRKDE
110 120 130 140 150
IKQALSREIV AISSAQLQDF DWQVKLALSS DKIAALRMPL LSLHLDVKEN
160 170 180
GEVKPYSIEM SREELQNLIQ SLEAANKVVL QLK
Length:183
Mass (Da):21,090
Last modified:October 1, 2000 - v1
Checksum:i59B48D6D7CECCCC7
GO

Sequence cautioni

The sequence AAG14957 differs from that shown. Reason: Frameshift at position 11.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127A → L in AAH19826 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04881417A → P. Corresponds to variant dbSNP:rs35444219Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542163 mRNA Translation: AAS22245.1
AF182421 mRNA Translation: AAG14957.1 Frameshift.
AK000509 mRNA Translation: BAA91216.1
BC015145 mRNA Translation: AAH15145.1
BC008371 mRNA Translation: AAH08371.1
BC019826 mRNA Translation: AAH19826.1
CCDSiCCDS3475.1
RefSeqiNP_001316597.1, NM_001329668.1
NP_060315.1, NM_017845.4
UniGeneiHs.23956

Genome annotation databases

EnsembliENST00000381571; ENSP00000370984; ENSG00000169019
GeneIDi54951
KEGGihsa:54951
UCSCiuc003gxi.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542163 mRNA Translation: AAS22245.1
AF182421 mRNA Translation: AAG14957.1 Frameshift.
AK000509 mRNA Translation: BAA91216.1
BC015145 mRNA Translation: AAH15145.1
BC008371 mRNA Translation: AAH08371.1
BC019826 mRNA Translation: AAH19826.1
CCDSiCCDS3475.1
RefSeqiNP_001316597.1, NM_001329668.1
NP_060315.1, NM_017845.4
UniGeneiHs.23956

3D structure databases

ProteinModelPortaliQ9NX08
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120289, 49 interactors
CORUMiQ9NX08
IntActiQ9NX08, 18 interactors
MINTiQ9NX08
STRINGi9606.ENSP00000370984

PTM databases

iPTMnetiQ9NX08
PhosphoSitePlusiQ9NX08

Polymorphism and mutation databases

BioMutaiCOMMD8
DMDMi51316105

Proteomic databases

EPDiQ9NX08
MaxQBiQ9NX08
PaxDbiQ9NX08
PeptideAtlasiQ9NX08
PRIDEiQ9NX08
ProteomicsDBi83019
TopDownProteomicsiQ9NX08

Protocols and materials databases

DNASUi54951
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381571; ENSP00000370984; ENSG00000169019
GeneIDi54951
KEGGihsa:54951
UCSCiuc003gxi.4 human

Organism-specific databases

CTDi54951
DisGeNETi54951
EuPathDBiHostDB:ENSG00000169019.10
GeneCardsiCOMMD8
HGNCiHGNC:26036 COMMD8
HPAiHPA035887
MIMi616656 gene
neXtProtiNX_Q9NX08
OpenTargetsiENSG00000169019
PharmGKBiPA134876825
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHDB Eukaryota
ENOG4111JYC LUCA
GeneTreeiENSGT00390000018121
HOGENOMiHOG000007080
HOVERGENiHBG051073
InParanoidiQ9NX08
KOiK22564
OMAiVWDSTEW
OrthoDBiEOG091G18T9
PhylomeDBiQ9NX08
TreeFamiTF328403

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation

Miscellaneous databases

GenomeRNAii54951
PROiPR:Q9NX08
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169019 Expressed in 220 organ(s), highest expression level in renal glomerulus
CleanExiHS_COMMD8
GenevisibleiQ9NX08 HS

Family and domain databases

InterProiView protein in InterPro
IPR017920 COMM
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOMD8_HUMAN
AccessioniPrimary (citable) accession number: Q9NX08
Secondary accession number(s): Q8WUR4, Q9HC15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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