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Protein

Constitutive coactivator of PPAR-gamma-like protein 2

Gene

FAM120C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Constitutive coactivator of PPAR-gamma-like protein 2
Alternative name(s):
Protein FAM120C
Tumor antigen BJ-HCC-21
Gene namesi
Name:FAM120C
Synonyms:CXorf17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000184083.11
HGNCiHGNC:16949 FAM120C
MIMi300741 gene
neXtProtiNX_Q9NX05

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi54954
PharmGKBiPA134932227

Polymorphism and mutation databases

BioMutaiFAM120C
DMDMi311033453

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002216281 – 1096Constitutive coactivator of PPAR-gamma-like protein 2Add BLAST1096

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58Omega-N-methylarginineBy similarity1
Modified residuei977Omega-N-methylarginineBy similarity1
Cross-linki1042Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

EPDiQ9NX05
MaxQBiQ9NX05
PaxDbiQ9NX05
PeptideAtlasiQ9NX05
PRIDEiQ9NX05
ProteomicsDBi83015
83016 [Q9NX05-2]

PTM databases

iPTMnetiQ9NX05
PhosphoSitePlusiQ9NX05

Expressioni

Tissue specificityi

Expressed at low levels in a number of tissues.1 Publication

Gene expression databases

BgeeiENSG00000184083
CleanExiHS_FAM120C
ExpressionAtlasiQ9NX05 baseline and differential
GenevisibleiQ9NX05 HS

Organism-specific databases

HPAiHPA047677

Interactioni

Protein-protein interaction databases

BioGridi120292, 9 interactors
IntActiQ9NX05, 6 interactors
MINTiQ9NX05
STRINGi9606.ENSP00000364324

Structurei

3D structure databases

ProteinModelPortaliQ9NX05
SMRiQ9NX05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IE6R Eukaryota
ENOG410XPY7 LUCA
HOGENOMiHOG000112430
HOVERGENiHBG050957
InParanoidiQ9NX05
OrthoDBiEOG091G030W
PhylomeDBiQ9NX05
TreeFamiTF328642

Family and domain databases

InterProiView protein in InterPro
IPR026784 Coact_PPARg
IPR026785 Coact_PPARg-like_2
IPR029060 PIN-like_dom_sf
PANTHERiPTHR15976 PTHR15976, 1 hit
PTHR15976:SF15 PTHR15976:SF15, 1 hit
SUPFAMiSSF88723 SSF88723, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NX05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVQGFQEFL EKRCPGAVVP VDLLKLARTV SRQQQQQHLH RQLPPTAALA
60 70 80 90 100
PGAPRAARGS VPLQPPLPPA ALGAYSGGAG PIRHHHPAHH FHHHGQAQPG
110 120 130 140 150
LHPPLPPPPP PQLPGARVLV DAGSALPRLY GGYQTDWVCG GQWNAMLGYL
160 170 180 190 200
SALCQACAYP GGDGLELVVM FPGGLGKDRL AEWGRRCQAE RQTAQLIVGH
210 220 230 240 250
VGNKGTPPPR AWFLPPACLS HCVRLALIRF RVKVFQSLED HHLEVVAFFR
260 270 280 290 300
ENGFHGLLAH DSEYALYNIP SYYSSHALKL SWNGKNLTTN QFLMQEVAKQ
310 320 330 340 350
LGLKRMNFPI FAALLGNHIL PDEDLAAFHW SLLGPEHPLA SLKVRAHQLV
360 370 380 390 400
LPPCDVVIKA VSEYVSSIKD PSNLDVVGKD VFKQSQSRTE DKIERFKKAV
410 420 430 440 450
EYYSVTTKLS SLPVGPSFLG FRNNRLGNPP LPRNQVGTIS AGKPMFSHQV
460 470 480 490 500
PQKVKYPPPF PVGPNSSLLF SSHALGESHA FSEDPMLQNS PFANWAVSYD
510 520 530 540 550
SSASQFPNYL PSKASPPLGP DSSHSSSSDG DEPNGASSDH ITEAFHHQPE
560 570 580 590 600
WGNPNRDRGS WAQPVDTGVS EASLGDGEPH IPSLLSMSTR NHMDITIPPL
610 620 630 640 650
PPVAPEVLRV AEHRHRRGLM YPYIYHVLTK GEIKIPVCIE DECNMELPPA
660 670 680 690 700
ALLFRSARQY VYGVLFSLAE TQRKMERLAM RRRLPVEVPS VILKEWSAYK
710 720 730 740 750
GKSPQTPELV SALTFREWTC PNLKKLWLGK AVEDKNRRMR AFLACMKSDT
760 770 780 790 800
PSMLNPANVP THLLLMCCVL RYMVQWPGGR ILHRHELDTF LAQAVSTQLY
810 820 830 840 850
EPDRLQELKI EKLDARGIQL AALFMSGVDT ALFANDACGQ PVPWEHCCPW
860 870 880 890 900
IYFDGKLFQS KLIKAGRERV SLVELCDGQA DLATKVEKMR QSILEGVNMN
910 920 930 940 950
HPPPSALLPS PTFVPPMVPS LYPVSLYSRA MGSMPLPPQG RSRGFAGLHP
960 970 980 990 1000
IPPQGGKLEI AGMVVGQWAG SRSSRGRGSF GMQVVSVGGP GKGHGKEQTG
1010 1020 1030 1040 1050
RGSKGHKKGN KQGSSDGVSK SLELHQGRSR SQVNGNSGAL IKEEKSDHRL
1060 1070 1080 1090
PAPSQCALSR DSNECNNGNR YLPMNNREKN HLQEQKLETV AQRKED
Length:1,096
Mass (Da):120,588
Last modified:November 2, 2010 - v3
Checksum:i0BF2647EF9BFE1F1
GO
Isoform 2 (identifier: Q9NX05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-238: VFQSL → QAAML
     239-1096: Missing.

Show »
Length:238
Mass (Da):25,477
Checksum:iB4BCB860C18784D9
GO

Sequence cautioni

The sequence AAM82751 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAA91219 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04753882I → T4 PublicationsCorresponds to variant dbSNP:rs2495783Ensembl.1
Natural variantiVAR_062001934M → I. Corresponds to variant dbSNP:rs41304786Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010519234 – 238VFQSL → QAAML in isoform 2. 3 Publications5
Alternative sequenceiVSP_010520239 – 1096Missing in isoform 2. 3 PublicationsAdd BLAST858

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150025 mRNA Translation: AAO24121.1
AY121803 mRNA Translation: AAM82751.1 Sequence problems.
AK000513 mRNA Translation: BAA91219.1 Sequence problems.
AL589872 Genomic DNA No translation available.
Z84469 Genomic DNA No translation available.
BC016138 mRNA Translation: AAH16138.2
BC136413 mRNA Translation: AAI36414.1
CCDSiCCDS14356.1 [Q9NX05-1]
CCDS55421.1 [Q9NX05-2]
RefSeqiNP_060318.4, NM_017848.5
NP_940858.2, NM_198456.2
UniGeneiHs.86045

Genome annotation databases

EnsembliENST00000375180; ENSP00000364324; ENSG00000184083
ENST00000477084; ENSP00000420718; ENSG00000184083
GeneIDi54954
KEGGihsa:54954
UCSCiuc004dsz.5 human [Q9NX05-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF120C_HUMAN
AccessioniPrimary (citable) accession number: Q9NX05
Secondary accession number(s): B2RMT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 2, 2010
Last modified: June 20, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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