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Entry version 123 (22 Apr 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Uncharacterized protein C1orf109

Gene

C1orf109

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May promote cancer cell proliferation by controlling the G1 to S phase transition.1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C1orf109Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C1orf109Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:26039 C1orf109

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614799 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NX04

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi104S → A: Abolishes phosphorylation by CK2 kinase; when associated with A-134 and A-182. 1 Publication1
Mutagenesisi134S → A: Abolishes phosphorylation by CK2 kinase; when associated with A-104 and A-182. 1 Publication1
Mutagenesisi182S → A: Abolishes phosphorylation by CK2 kinase; when associated with A-104 and A-134. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
54955

Open Targets

More...
OpenTargetsi
ENSG00000116922

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA142672493

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9NX04 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C1orf109

Domain mapping of disease mutations (DMDM)

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DMDMi
74761780

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002743821 – 203Uncharacterized protein C1orf109Add BLAST203

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serines by CK2 kinase.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NX04

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NX04

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NX04

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NX04

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NX04

PeptideAtlas

More...
PeptideAtlasi
Q9NX04

PRoteomics IDEntifications database

More...
PRIDEi
Q9NX04

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
83013 [Q9NX04-1]
83014 [Q9NX04-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NX04

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NX04

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116922 Expressed in urinary bladder and 204 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NX04 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NX04 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000116922 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9NX04
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-8643161,EBI-11096309
ADD1 [Q96D30]5EBI-8643161,EBI-9089447
ANTKMT [Q9BQD7]3EBI-8643161,EBI-713602
ATP23 [Q9Y6H3]3EBI-8643161,EBI-12811889
AVPI1 [Q5T686]3EBI-8643161,EBI-8640233
BORCS6 [Q96GS4]3EBI-8643161,EBI-10193358
C1orf94 [Q6P1W5]3EBI-8643161,EBI-946029
C1QTNF2 [Q9BXJ5]3EBI-8643161,EBI-2817707
CCDC120 [Q96HB5]3EBI-8643161,EBI-744556
CCDC125 [Q86Z20]3EBI-8643161,EBI-11977221
CCDC36 [Q8IYA8]6EBI-8643161,EBI-8638439
CCDC88B [A6NC98]3EBI-8643161,EBI-347573
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-8643161,EBI-10175300
CDCA4 [Q9BXL8]3EBI-8643161,EBI-1773949
CEP55 [Q53EZ4]6EBI-8643161,EBI-747776
CINP [Q9BW66]9EBI-8643161,EBI-739784
CRX [O43186]3EBI-8643161,EBI-748171
CT55 [Q8WUE5]3EBI-8643161,EBI-6873363
CTAG1B [P78358]3EBI-8643161,EBI-1188472
DISC1 - isoform 2 [Q9NRI5-2]3EBI-8643161,EBI-11988027
ECM1 [Q16610]3EBI-8643161,EBI-947964
ECSIT [Q9BQ95]3EBI-8643161,EBI-712452
FAM217B [Q9NTX9]3EBI-8643161,EBI-19153639
FAM22F [B7ZLH0]3EBI-8643161,EBI-10220102
FAM86C1 - isoform 2 [Q9NVL1-2]3EBI-8643161,EBI-12845222
FTO - isoform 2 [Q9C0B1-2]3EBI-8643161,EBI-18138793
GET4 [Q7L5D6]3EBI-8643161,EBI-711823
GIGYF1 [O75420]3EBI-8643161,EBI-947774
GOLGA2 [Q08379]3EBI-8643161,EBI-618309
GOLGA6A [Q9NYA3]3EBI-8643161,EBI-11163335
GOLGA6L9 [A6NEM1]3EBI-8643161,EBI-5916454
HESX1 [Q9UBX0]3EBI-8643161,EBI-8470369
HOOK2 - isoform 2 [Q96ED9-2]3EBI-8643161,EBI-10961706
HOXC8 [P31273]3EBI-8643161,EBI-1752118
IKZF1 [Q13422]3EBI-8643161,EBI-745305
IKZF1 - isoform Ik7 [Q13422-7]3EBI-8643161,EBI-11522367
IKZF3 [Q9UKT9]6EBI-8643161,EBI-747204
INKA1 [Q96EL1]3EBI-8643161,EBI-10285157
KATNAL1 [Q9BW62]6EBI-8643161,EBI-743591
KIAA0753 [Q2KHM9]3EBI-8643161,EBI-2805604
KIFC3 [Q9BVG8]4EBI-8643161,EBI-2125614
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-8643161,EBI-14069005
KLF15 [Q9UIH9]3EBI-8643161,EBI-2796400
KRT13 [A1A4E9]3EBI-8643161,EBI-10171552
KRT16 [P08779]3EBI-8643161,EBI-356410
KRT18 [P05783]3EBI-8643161,EBI-297888
KRT19 [P08727]6EBI-8643161,EBI-742756
KRT24 [Q2M2I5]3EBI-8643161,EBI-2952736
KRT31 [Q15323]6EBI-8643161,EBI-948001
KRT35 [Q92764]3EBI-8643161,EBI-1058674
KRT40 [Q6A162]3EBI-8643161,EBI-10171697
KRT75 [O95678]3EBI-8643161,EBI-2949715
KRT76 [Q01546]3EBI-8643161,EBI-2952745
KRT80 - isoform 2 [Q6KB66-2]3EBI-8643161,EBI-11999246
KRTAP13-3 [Q3SY46]3EBI-8643161,EBI-10241252
LDOC1 [O95751]3EBI-8643161,EBI-740738
LMO2 - isoform 3 [P25791-3]5EBI-8643161,EBI-11959475
LZTS2 [Q9BRK4]6EBI-8643161,EBI-741037
MBD3L1 [Q8WWY6]3EBI-8643161,EBI-12516603
MDM4 [O15151]3EBI-8643161,EBI-398437
MEI4 [A8MW99]3EBI-8643161,EBI-19944212
MEOX1 [P50221]3EBI-8643161,EBI-2864512
MEOX2 [P50222]3EBI-8643161,EBI-748397
MEOX2 [Q6FHY5]3EBI-8643161,EBI-16439278
MIPOL1 [Q8TD10]3EBI-8643161,EBI-2548751
MKRN2 [Q9H000]3EBI-8643161,EBI-2341005
MTFR1L [Q9H019]3EBI-8643161,EBI-2824497
MTUS2 [Q5JR59]3EBI-8643161,EBI-742948
NDUFB7 [P17568]3EBI-8643161,EBI-1246238
NECAB2 - isoform 2 [Q7Z6G3-2]6EBI-8643161,EBI-10172876
NFKBID [Q8NI38]3EBI-8643161,EBI-10271199
NME4 [O00746]3EBI-8643161,EBI-744871
NUP54 [Q7Z3B4]5EBI-8643161,EBI-741048
OOEP [A6NGQ2]3EBI-8643161,EBI-18583589
PAX5 [Q02548]3EBI-8643161,EBI-296331
PAX6 [P26367]3EBI-8643161,EBI-747278
PAX7 - isoform 2 [P23759-2]3EBI-8643161,EBI-12859446
PBX4 [Q9BYU1]5EBI-8643161,EBI-10302990
PDE4DIP [Q5VU43]3EBI-8643161,EBI-1105124
PDE4DIP - isoform 2 [Q5VU43-2]3EBI-8643161,EBI-9640281
PHC2 [Q8IXK0]3EBI-8643161,EBI-713786
PLK4 [O00444]3EBI-8643161,EBI-746202
PNMA1 [Q8ND90]3EBI-8643161,EBI-302345
POMC [P01189]3EBI-8643161,EBI-12219503
POU6F2 [P78424]3EBI-8643161,EBI-12029004
PPP1R12C [Q9BZL4]3EBI-8643161,EBI-721802
PPP1R12C - isoform 5 [Q9BZL4-5]3EBI-8643161,EBI-10289057
PRDM6 [Q9NQX0]3EBI-8643161,EBI-11320284
PRMT5 [O14744]3EBI-8643161,EBI-351098
PSMB4 [P28070]3EBI-8643161,EBI-603350
PUDP [Q08623]3EBI-8643161,EBI-12807240
REL [Q04864]3EBI-8643161,EBI-307352
REL - isoform 2 [Q04864-2]3EBI-8643161,EBI-10829018
RINT1 [Q6NUQ1]6EBI-8643161,EBI-726876
RNF20 [Q5VTR2]3EBI-8643161,EBI-2372238
RNF41 [Q9H4P4]6EBI-8643161,EBI-2130266
RPH3AL [Q9UNE2]3EBI-8643161,EBI-2855824
RUSC1 [Q9BVN2]5EBI-8643161,EBI-6257312
SAPCD2 [Q86UD0]5EBI-8643161,EBI-2561646
SDCBP [O00560]3EBI-8643161,EBI-727004
SERTAD1 [Q9UHV2]3EBI-8643161,EBI-748601
SERTAD2 [Q14140]3EBI-8643161,EBI-2822051
SLAIN1 [Q8ND83]3EBI-8643161,EBI-10269374
SMARCD1 [Q96GM5]3EBI-8643161,EBI-358489
SMRP1 [Q8NCR6]3EBI-8643161,EBI-10269322
SOCS6 [O14544]3EBI-8643161,EBI-3929549
SORBS3 [O60504]3EBI-8643161,EBI-741237
SPAG5 [Q96R06]3EBI-8643161,EBI-413317
SPERT [Q8NA61]3EBI-8643161,EBI-741724
SPERT - isoform 2 [Q8NA61-2]3EBI-8643161,EBI-11524851
STMN3 [Q9NZ72]3EBI-8643161,EBI-725557
STN1 [Q9H668]5EBI-8643161,EBI-746930
STX11 [O75558]6EBI-8643161,EBI-714135
TADA2A [O75478]6EBI-8643161,EBI-742268
TASOR2 [Q5VWN6]3EBI-8643161,EBI-745958
TCF12 [Q99081]3EBI-8643161,EBI-722877
TCF4 [P15884]3EBI-8643161,EBI-533224
TEKT4 [Q8WW24]3EBI-8643161,EBI-750487
TEPSIN [Q96N21]3EBI-8643161,EBI-11139477
TFIP11 [Q9UBB9]6EBI-8643161,EBI-1105213
TLE5 [Q08117]3EBI-8643161,EBI-717810
TLE5 - isoform 2 [Q08117-2]3EBI-8643161,EBI-11741437
TNNI2 [P48788]3EBI-8643161,EBI-7746394
TRAF1 [Q13077]6EBI-8643161,EBI-359224
TRIM42 [Q8IWZ5]3EBI-8643161,EBI-5235829
TRIM54 [Q9BYV2]6EBI-8643161,EBI-2130429
TSGA10IP [Q3SY00]3EBI-8643161,EBI-10241197
TTC12 - isoform 2 [Q9H892-2]3EBI-8643161,EBI-10274410
TTC23 - isoform 3 [Q5W5X9-3]3EBI-8643161,EBI-9090990
TTC23L [Q6PF05]3EBI-8643161,EBI-8656864
UHMK1 - isoform 2 [Q8TAS1-2]3EBI-8643161,EBI-12157345
USH1G [Q495M9]3EBI-8643161,EBI-8601749
USHBP1 [Q8N6Y0]3EBI-8643161,EBI-739895
VBP1 [P61758]3EBI-8643161,EBI-357430
VGLL1 [Q99990]3EBI-8643161,EBI-11983165
VPS52 [Q8N1B4]6EBI-8643161,EBI-2799833
ZBED1 [O96006]7EBI-8643161,EBI-740037
ZBTB42 [B2RXF5]3EBI-8643161,EBI-12287587
ZMAT5 [Q9UDW3]3EBI-8643161,EBI-7850213
ZMYND12 [Q9H0C1]3EBI-8643161,EBI-12030590
ZNF17 [P17021]3EBI-8643161,EBI-1105334
ZNF20 [P17024]3EBI-8643161,EBI-717634
ZNF398 [Q8TD17]4EBI-8643161,EBI-8643207
ZNF420 [Q8TAQ5]3EBI-8643161,EBI-3923307
ZNF688 [P0C7X2]3EBI-8643161,EBI-4395732
ZSCAN9 [O15535]3EBI-8643161,EBI-751531

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120293, 53 interactors

Protein interaction database and analysis system

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IntActi
Q9NX04, 144 interactors

Molecular INTeraction database

More...
MINTi
Q9NX04

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000350704

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NX04 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGVE Eukaryota
ENOG41127GW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008551

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_111850_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NX04

Identification of Orthologs from Complete Genome Data

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OMAi
SHVEQVF

Database of Orthologous Groups

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OrthoDBi
1504674at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NX04

TreeFam database of animal gene trees

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TreeFami
TF332524

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029159 CK2S

The PANTHER Classification System

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PANTHERi
PTHR16234 PTHR16234, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15011 CK2S, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NX04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTQDRPLLAV QEALKKCFPV VEEQQGLWQS ALRDCQPLLS SLSNLAEQLQ
60 70 80 90 100
AAQNLRFEDV PALRAFPDLK ERLRRKQLVA GDIVLDKLGE RLAILLKVRD
110 120 130 140 150
MVSSHVERVF QIYEQHADTV GIDAVLQPSA VSPSVADMLE WLQDIERHYR
160 170 180 190 200
KSYLKRKYLL SSIQWGDLAN IQALPKAWDR ISKDEHQDLV QDILLNVSFF

LEE
Length:203
Mass (Da):23,373
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCBD3883CB1A2C281
GO
Isoform 2 (identifier: Q9NX04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-113: RKQLVAGDIV...SHVERVFQIY → QPSSSRCETW...ALMLSCSLQQ
     114-203: Missing.

Show »
Length:113
Mass (Da):12,861
Checksum:iC243446688C8499F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYQ8V9GYQ8_HUMAN
Uncharacterized protein C1orf109
C1orf109
191Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GY35V9GY35_HUMAN
Uncharacterized protein C1orf109
C1orf109
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYI2V9GYI2_HUMAN
Uncharacterized protein C1orf109
C1orf109
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYT8V9GYT8_HUMAN
Uncharacterized protein C1orf109
C1orf109
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYN4V9GYN4_HUMAN
Uncharacterized protein C1orf109
C1orf109
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUX7A0A087WUX7_HUMAN
Uncharacterized protein C1orf109
C1orf109
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02273375 – 113RKQLV…VFQIY → QPSSSRCETWSAAMWSECFR SMSNTQTQLALMLSCSLQQ in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_022734114 – 203Missing in isoform 2. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000515 mRNA Translation: BAA91221.1
CH471059 Genomic DNA Translation: EAX07327.1
CH471059 Genomic DNA Translation: EAX07329.1
CH471059 Genomic DNA Translation: EAX07330.1
BC018109 mRNA Translation: AAH18109.1
BC063843 mRNA Translation: AAH63843.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS423.1 [Q9NX04-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001289959.1, NM_001303030.1
NP_001289960.1, NM_001303031.1
NP_060320.1, NM_017850.2 [Q9NX04-1]
XP_016857035.1, XM_017001546.1
XP_016857036.1, XM_017001547.1
XP_016857040.1, XM_017001551.1
XP_016857041.1, XM_017001552.1
XP_016857042.1, XM_017001553.1
XP_016857043.1, XM_017001554.1
XP_016857044.1, XM_017001555.1
XP_016857045.1, XM_017001556.1 [Q9NX04-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358011; ENSP00000350704; ENSG00000116922 [Q9NX04-1]
ENST00000464085; ENSP00000477159; ENSG00000116922 [Q9NX04-1]
ENST00000494120; ENSP00000477273; ENSG00000116922 [Q9NX04-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54955

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54955

UCSC genome browser

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UCSCi
uc001cbn.4 human [Q9NX04-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000515 mRNA Translation: BAA91221.1
CH471059 Genomic DNA Translation: EAX07327.1
CH471059 Genomic DNA Translation: EAX07329.1
CH471059 Genomic DNA Translation: EAX07330.1
BC018109 mRNA Translation: AAH18109.1
BC063843 mRNA Translation: AAH63843.1
CCDSiCCDS423.1 [Q9NX04-1]
RefSeqiNP_001289959.1, NM_001303030.1
NP_001289960.1, NM_001303031.1
NP_060320.1, NM_017850.2 [Q9NX04-1]
XP_016857035.1, XM_017001546.1
XP_016857036.1, XM_017001547.1
XP_016857040.1, XM_017001551.1
XP_016857041.1, XM_017001552.1
XP_016857042.1, XM_017001553.1
XP_016857043.1, XM_017001554.1
XP_016857044.1, XM_017001555.1
XP_016857045.1, XM_017001556.1 [Q9NX04-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120293, 53 interactors
IntActiQ9NX04, 144 interactors
MINTiQ9NX04
STRINGi9606.ENSP00000350704

PTM databases

iPTMnetiQ9NX04
PhosphoSitePlusiQ9NX04

Polymorphism and mutation databases

BioMutaiC1orf109
DMDMi74761780

Proteomic databases

EPDiQ9NX04
jPOSTiQ9NX04
MassIVEiQ9NX04
MaxQBiQ9NX04
PaxDbiQ9NX04
PeptideAtlasiQ9NX04
PRIDEiQ9NX04
ProteomicsDBi83013 [Q9NX04-1]
83014 [Q9NX04-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
17567 48 antibodies

The DNASU plasmid repository

More...
DNASUi
54955

Genome annotation databases

EnsembliENST00000358011; ENSP00000350704; ENSG00000116922 [Q9NX04-1]
ENST00000464085; ENSP00000477159; ENSG00000116922 [Q9NX04-1]
ENST00000494120; ENSP00000477273; ENSG00000116922 [Q9NX04-2]
GeneIDi54955
KEGGihsa:54955
UCSCiuc001cbn.4 human [Q9NX04-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54955
DisGeNETi54955

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C1orf109
HGNCiHGNC:26039 C1orf109
HPAiENSG00000116922 Low tissue specificity
MIMi614799 gene
neXtProtiNX_Q9NX04
OpenTargetsiENSG00000116922
PharmGKBiPA142672493

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGVE Eukaryota
ENOG41127GW LUCA
GeneTreeiENSGT00390000008551
HOGENOMiCLU_111850_0_0_1
InParanoidiQ9NX04
OMAiSHVEQVF
OrthoDBi1504674at2759
PhylomeDBiQ9NX04
TreeFamiTF332524

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C1orf109 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
C1orf109_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54955
PharosiQ9NX04 Tdark

Protein Ontology

More...
PROi
PR:Q9NX04
RNActiQ9NX04 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116922 Expressed in urinary bladder and 204 other tissues
ExpressionAtlasiQ9NX04 baseline and differential
GenevisibleiQ9NX04 HS

Family and domain databases

InterProiView protein in InterPro
IPR029159 CK2S
PANTHERiPTHR16234 PTHR16234, 1 hit
PfamiView protein in Pfam
PF15011 CK2S, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCA109_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NX04
Secondary accession number(s): D3DPT1, Q8WVD1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2000
Last modified: April 22, 2020
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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