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Protein

Uncharacterized protein C1orf109

Gene

C1orf109

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May promote cancer cell proliferation by controlling the G1 to S phase transition.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf109Curated
Gene namesi
Name:C1orf109Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116922.14
HGNCiHGNC:26039 C1orf109
MIMi614799 gene
neXtProtiNX_Q9NX04

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi104S → A: Abolishes phosphorylation by CK2 kinase; when associated with A-134 and A-182. 1 Publication1
Mutagenesisi134S → A: Abolishes phosphorylation by CK2 kinase; when associated with A-104 and A-182. 1 Publication1
Mutagenesisi182S → A: Abolishes phosphorylation by CK2 kinase; when associated with A-104 and A-134. 1 Publication1

Organism-specific databases

DisGeNETi54955
OpenTargetsiENSG00000116922
PharmGKBiPA142672493

Polymorphism and mutation databases

BioMutaiC1orf109
DMDMi74761780

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743821 – 203Uncharacterized protein C1orf109Add BLAST203

Post-translational modificationi

Phosphorylated on serines by CK2 kinase.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NX04
MaxQBiQ9NX04
PaxDbiQ9NX04
PeptideAtlasiQ9NX04
PRIDEiQ9NX04
ProteomicsDBi83013
83014 [Q9NX04-2]

PTM databases

iPTMnetiQ9NX04
PhosphoSitePlusiQ9NX04

Expressioni

Gene expression databases

BgeeiENSG00000116922 Expressed in 205 organ(s), highest expression level in urinary bladder
CleanExiHS_C1orf109
ExpressionAtlasiQ9NX04 baseline and differential
GenevisibleiQ9NX04 HS

Organism-specific databases

HPAiHPA027110
HPA027127

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi120293, 51 interactors
IntActiQ9NX04, 139 interactors
MINTiQ9NX04

Structurei

3D structure databases

ProteinModelPortaliQ9NX04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IGVE Eukaryota
ENOG41127GW LUCA
GeneTreeiENSGT00390000008551
HOVERGENiHBG080964
InParanoidiQ9NX04
OMAiRHYRNSY
OrthoDBiEOG091G0KY0
PhylomeDBiQ9NX04
TreeFamiTF332524

Family and domain databases

InterProiView protein in InterPro
IPR029159 CK2S
PfamiView protein in Pfam
PF15011 CK2S, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NX04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTQDRPLLAV QEALKKCFPV VEEQQGLWQS ALRDCQPLLS SLSNLAEQLQ
60 70 80 90 100
AAQNLRFEDV PALRAFPDLK ERLRRKQLVA GDIVLDKLGE RLAILLKVRD
110 120 130 140 150
MVSSHVERVF QIYEQHADTV GIDAVLQPSA VSPSVADMLE WLQDIERHYR
160 170 180 190 200
KSYLKRKYLL SSIQWGDLAN IQALPKAWDR ISKDEHQDLV QDILLNVSFF

LEE
Length:203
Mass (Da):23,373
Last modified:October 1, 2000 - v1
Checksum:iCBD3883CB1A2C281
GO
Isoform 2 (identifier: Q9NX04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-113: RKQLVAGDIV...SHVERVFQIY → QPSSSRCETW...ALMLSCSLQQ
     114-203: Missing.

Show »
Length:113
Mass (Da):12,861
Checksum:iC243446688C8499F
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYQ8V9GYQ8_HUMAN
Uncharacterized protein C1orf109
C1orf109
191Annotation score:
V9GYI2V9GYI2_HUMAN
Uncharacterized protein C1orf109
C1orf109
113Annotation score:
V9GY35V9GY35_HUMAN
Uncharacterized protein C1orf109
C1orf109
142Annotation score:
V9GYN4V9GYN4_HUMAN
Uncharacterized protein C1orf109
C1orf109
151Annotation score:
V9GYT8V9GYT8_HUMAN
Uncharacterized protein C1orf109
C1orf109
91Annotation score:
A0A087WUX7A0A087WUX7_HUMAN
Uncharacterized protein C1orf109
C1orf109
37Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02273375 – 113RKQLV…VFQIY → QPSSSRCETWSAAMWSECFR SMSNTQTQLALMLSCSLQQ in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_022734114 – 203Missing in isoform 2. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000515 mRNA Translation: BAA91221.1
CH471059 Genomic DNA Translation: EAX07327.1
CH471059 Genomic DNA Translation: EAX07329.1
CH471059 Genomic DNA Translation: EAX07330.1
BC018109 mRNA Translation: AAH18109.1
BC063843 mRNA Translation: AAH63843.1
CCDSiCCDS423.1 [Q9NX04-1]
RefSeqiNP_001289959.1, NM_001303030.1
NP_001289960.1, NM_001303031.1
NP_060320.1, NM_017850.2 [Q9NX04-1]
XP_016857035.1, XM_017001546.1
XP_016857036.1, XM_017001547.1
XP_016857040.1, XM_017001551.1
XP_016857041.1, XM_017001552.1
XP_016857042.1, XM_017001553.1
XP_016857043.1, XM_017001554.1
XP_016857044.1, XM_017001555.1
XP_016857045.1, XM_017001556.1 [Q9NX04-1]
UniGeneiHs.272673
Hs.733219

Genome annotation databases

EnsembliENST00000358011; ENSP00000350704; ENSG00000116922 [Q9NX04-1]
ENST00000464085; ENSP00000477159; ENSG00000116922 [Q9NX04-1]
ENST00000494120; ENSP00000477273; ENSG00000116922 [Q9NX04-2]
GeneIDi54955
KEGGihsa:54955
UCSCiuc001cbn.4 human [Q9NX04-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000515 mRNA Translation: BAA91221.1
CH471059 Genomic DNA Translation: EAX07327.1
CH471059 Genomic DNA Translation: EAX07329.1
CH471059 Genomic DNA Translation: EAX07330.1
BC018109 mRNA Translation: AAH18109.1
BC063843 mRNA Translation: AAH63843.1
CCDSiCCDS423.1 [Q9NX04-1]
RefSeqiNP_001289959.1, NM_001303030.1
NP_001289960.1, NM_001303031.1
NP_060320.1, NM_017850.2 [Q9NX04-1]
XP_016857035.1, XM_017001546.1
XP_016857036.1, XM_017001547.1
XP_016857040.1, XM_017001551.1
XP_016857041.1, XM_017001552.1
XP_016857042.1, XM_017001553.1
XP_016857043.1, XM_017001554.1
XP_016857044.1, XM_017001555.1
XP_016857045.1, XM_017001556.1 [Q9NX04-1]
UniGeneiHs.272673
Hs.733219

3D structure databases

ProteinModelPortaliQ9NX04
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120293, 51 interactors
IntActiQ9NX04, 139 interactors
MINTiQ9NX04

PTM databases

iPTMnetiQ9NX04
PhosphoSitePlusiQ9NX04

Polymorphism and mutation databases

BioMutaiC1orf109
DMDMi74761780

Proteomic databases

EPDiQ9NX04
MaxQBiQ9NX04
PaxDbiQ9NX04
PeptideAtlasiQ9NX04
PRIDEiQ9NX04
ProteomicsDBi83013
83014 [Q9NX04-2]

Protocols and materials databases

DNASUi54955
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358011; ENSP00000350704; ENSG00000116922 [Q9NX04-1]
ENST00000464085; ENSP00000477159; ENSG00000116922 [Q9NX04-1]
ENST00000494120; ENSP00000477273; ENSG00000116922 [Q9NX04-2]
GeneIDi54955
KEGGihsa:54955
UCSCiuc001cbn.4 human [Q9NX04-1]

Organism-specific databases

CTDi54955
DisGeNETi54955
EuPathDBiHostDB:ENSG00000116922.14
GeneCardsiC1orf109
HGNCiHGNC:26039 C1orf109
HPAiHPA027110
HPA027127
MIMi614799 gene
neXtProtiNX_Q9NX04
OpenTargetsiENSG00000116922
PharmGKBiPA142672493
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGVE Eukaryota
ENOG41127GW LUCA
GeneTreeiENSGT00390000008551
HOVERGENiHBG080964
InParanoidiQ9NX04
OMAiRHYRNSY
OrthoDBiEOG091G0KY0
PhylomeDBiQ9NX04
TreeFamiTF332524

Miscellaneous databases

ChiTaRSiC1orf109 human
GeneWikiiC1orf109_(gene)
GenomeRNAii54955
PROiPR:Q9NX04
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116922 Expressed in 205 organ(s), highest expression level in urinary bladder
CleanExiHS_C1orf109
ExpressionAtlasiQ9NX04 baseline and differential
GenevisibleiQ9NX04 HS

Family and domain databases

InterProiView protein in InterPro
IPR029159 CK2S
PfamiView protein in Pfam
PF15011 CK2S, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCA109_HUMAN
AccessioniPrimary (citable) accession number: Q9NX04
Secondary accession number(s): D3DPT1, Q8WVD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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