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UniProtKB - Q9NX02 (NALP2_HUMAN)

Protein

NACHT, LRR and PYD domains-containing protein 2

Gene

NLRP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi213 – 220ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • Pyrin domain binding Source: HGNC
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Immunity, Inflammatory response, Innate immunity
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 2
Alternative name(s):
Nucleotide-binding site protein 1
PYRIN domain and NACHT domain-containing protein 1
PYRIN-containing APAF1-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NLRP2
Synonyms:NALP2, NBS1, PAN1, PYPAF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000022556.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:22948 NLRP2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609364 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NX02

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55655

Open Targets

More...OpenTargetsi		ENSG00000022556

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162397946

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NLRP2

Domain mapping of disease mutations (DMDM)

More...DMDMi		17380148

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000808881 – 1062NACHT, LRR and PYD domains-containing protein 2Add BLAST1062

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei671PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NX02

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NX02

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NX02

PeptideAtlas

More...PeptideAtlasi		Q9NX02

PRoteomics IDEntifications database

More...PRIDEi		Q9NX02

ProteomicsDB human proteome resource

More...ProteomicsDBi		83009
83010 [Q9NX02-2]
83011 [Q9NX02-3]
83012 [Q9NX02-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NX02

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NX02

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By interferons and bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000022556 Expressed in 147 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

More...CleanExi		HS_NLRP2

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NX02 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NX02 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA020765
HPA021183

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CHUK (PubMed:15456791). Interacts with IKBKB (PubMed:15456791). Interacts with IKBKG (PubMed:15456791). Interacts with MEFV (PubMed:17431422). Interacts with PYCARD (PubMed:15030775, PubMed:15456791). Interacts (via pyrin domain) with PYDC2 (PubMed:17178784). Interacts with CARD8 (PubMed:15030775).4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PYDC2Q56P426EBI-6374482,EBI-6374418

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		120787, 20 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9NX02

Database of interacting proteins

More...DIPi		DIP-42460N

Protein interaction database and analysis system

More...IntActi		Q9NX02, 10 interactors

Molecular INTeraction database

More...MINTi		Q9NX02

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000409370

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q9NX02

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 94PyrinPROSITE-ProRule annotationAdd BLAST94
Domaini207 – 526NACHTPROSITE-ProRule annotationAdd BLAST320
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati812 – 832LRR 1Add BLAST21
Repeati841 – 861LRR 2Add BLAST21
Repeati869 – 889LRR 3Add BLAST21
Repeati898 – 918LRR 4Add BLAST21
Repeati926 – 946LRR 5Add BLAST21
Repeati955 – 976LRR 6Add BLAST22
Repeati983 – 1003LRR 7Add BLAST21
Repeati1010 – 1033LRR 8Add BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi518 – 523Poly-Glu6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding.
The pyrin domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NLRP family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IM14 Eukaryota
ENOG410ZI5C LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161714

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG103856

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NX02

KEGG Orthology (KO)

More...KOi		K19409

Identification of Orthologs from Complete Genome Data

More...OMAi		NDQNDML

Database of Orthologous Groups

More...OrthoDBi		EOG091G01Q7

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NX02

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13516 LRR_6, 4 hits
PF05729 NACHT, 1 hit
PF02758 PYRIN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01289 PYRIN, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986 SSF47986, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50824 DAPIN, 1 hit
PS50837 NACHT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NX02-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEVDKA 
        60         70         80         90        100
DGKQLVEILT THCDSYWVEM ASLQVFEKMH RMDLSERAKD EVREAALKSF 
       110        120        130        140        150
NKRKPLSLGI TRKERPPLDV DEMLERFKTE AQAFTETKGN VICLGKEVFK 
       160        170        180        190        200
GKKPDKDNRC RYILKTKFRE MWKSWPGDSK EVQVMAERYK MLIPFSNPRV 
       210        220        230        240        250
LPGPFSYTVV LYGPAGLGKT TLAQKLMLDW AEDNLIHKFK YAFYLSCREL 
       260        270        280        290        300
SRLGPCSFAE LVFRDWPELQ DDIPHILAQA RKILFVIDGF DELGAAPGAL 
       310        320        330        340        350
IEDICGDWEK KKPVPVLLGS LLNRVMLPKA ALLVTTRPRA LRDLRILAEE 
       360        370        380        390        400
PIYIRVEGFL EEDRRAYFLR HFGDEDQAMR AFELMRSNAA LFQLGSAPAV 
       410        420        430        440        450
CWIVCTTLKL QMEKGEDPVP TCLTRTGLFL RFLCSRFPQG AQLRGALRTL 
       460        470        480        490        500
SLLAAQGLWA QTSVLHREDL ERLGVQESDL RLFLDGDILR QDRVSKGCYS 
       510        520        530        540        550
FIHLSFQQFL TALFYTLEKE EEEDRDGHTW DIGDVQKLLS GVERLRNPDL 
       560        570        580        590        600
IQAGYYSFGL ANEKRAKELE ATFGCRMSPD IKQELLRCDI SCKGGHSTVT 
       610        620        630        640        650
DLQELLGCLY ESQEEELVKE VMAQFKEISL HLNAVDVVPS SFCVKHCRNL 
       660        670        680        690        700
QKMSLQVIKE NLPENVTASE SDAEVERSQD DQHMLPFWTD LCSIFGSNKD 
       710        720        730        740        750
LMGLAINDSF LSASLVRILC EQIASDTCHL QRVVFKNISP ADAHRNLCLA 
       760        770        780        790        800
LRGHKTVTYL TLQGNDQDDM FPALCEVLRH PECNLRYLGL VSCSATTQQW 
       810        820        830        840        850
ADLSLALEVN QSLTCVNLSD NELLDEGAKL LYTTLRHPKC FLQRLSLENC 
       860        870        880        890        900
HLTEANCKDL AAVLVVSREL THLCLAKNPI GNTGVKFLCE GLRYPECKLQ 
       910        920        930        940        950
TLVLWNCDIT SDGCCDLTKL LQEKSSLLCL DLGLNHIGVK GMKFLCEALR 
       960        970        980        990       1000
KPLCNLRCLW LWGCSIPPFS CEDLCSALSC NQSLVTLDLG QNPLGSSGVK 
      1010       1020       1030       1040       1050
MLFETLTCSS GTLRTLRLKI DDFNDELNKL LEEIEEKNPQ LIIDTEKHHP 
      1060 
WAERPSSHDF MI
Length:1,062
Mass (Da):120,515
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DBB0F6E9C2BC8A7
GO
Isoform 2 (identifier: Q9NX02-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-154: Missing.

Show »
Length:1,040
Mass (Da):118,138
Checksum:i0FF49C18762CEDB4
GO
Isoform 3 (identifier: Q9NX02-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     847-1062: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:846
Mass (Da):96,383
Checksum:i22DD3265062DC0CB
GO
Isoform 4 (identifier: Q9NX02-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-132: Missing.

Note: No experimental confirmation available.
Show »
Length:1,038
Mass (Da):117,674
Checksum:iAA066954D53827F2
GO
Isoform 5 (identifier: Q9NX02-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-69: Missing.

Note: No experimental confirmation available.
Show »
Length:1,039
Mass (Da):117,883
Checksum:iB55EABADF1A74126
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KN39J3KN39_HUMAN
NACHT, LRR and PYD domains-containi...
NLRP2
1,059Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMK2K7EMK2_HUMAN
NACHT, LRR and PYD domains-containi...
NLRP2
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JMG8A0A0G2JMG8_HUMAN
NACHT, LRR and PYD domains-containi...
NLRP2
1,039Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPQ2A0A0G2JPQ2_HUMAN
NACHT, LRR and PYD domains-containi...
NLRP2
1,062Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLX3A0A0G2JLX3_HUMAN
NACHT, LRR and PYD domains-containi...
NLRP2
1,040Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLQ8A0A0G2JLQ8_HUMAN
NACHT, LRR and PYD domains-containi...
NLRP2
879Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNC8A0A0G2JNC8_HUMAN
NACHT, LRR and PYD domains-containi...
NLRP2
903Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JP37A0A0G2JP37_HUMAN
NACHT, LRR and PYD domains-containi...
NLRP2
881Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPB6A0A0G2JPB6_HUMAN
NACHT, LRR and PYD domains-containi...
NLRP2
846Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H5B1F5H5B1_HUMAN
NACHT, LRR and PYD domains-containi...
NLRP2
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG15253 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91377 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92537 differs from that shown. Erroneous prediction of the initiator methionine.Curated
The sequence BAD92537 differs from that shown. Reason: Frameshift at position 769.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1M → V in AAG15253 (PubMed:11270363).Curated1
Sequence conflicti35L → P in AAG15253 (PubMed:11270363).Curated1
Sequence conflicti46E → G in BAG64129 (PubMed:14702039).Curated1
Sequence conflicti58I → V in AAH39269 (PubMed:15489334).Curated1
Sequence conflicti175W → C in BAD96973 (Ref. 5) Curated1
Sequence conflicti175W → C in BAD96989 (Ref. 5) Curated1
Sequence conflicti216G → S in BAG64129 (PubMed:14702039).Curated1
Sequence conflicti304I → S in BAB15293 (PubMed:14702039).Curated1
Sequence conflicti980Missing in AAG15253 (PubMed:11270363).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053616221T → M. Corresponds to variant dbSNP:rs17699678Ensembl.1
Natural variantiVAR_053617302E → Q. Corresponds to variant dbSNP:rs3745904Ensembl.1
Natural variantiVAR_025011364R → K1 PublicationCorresponds to variant dbSNP:rs4306647Ensembl.1
Natural variantiVAR_068977516T → A1 PublicationCorresponds to variant dbSNP:rs61735082Ensembl.1
Natural variantiVAR_068978522E → G1 PublicationCorresponds to variant dbSNP:rs61735083Ensembl.1
Natural variantiVAR_068979529T → A2 PublicationsCorresponds to variant dbSNP:rs34804158Ensembl.1
Natural variantiVAR_062140884G → R. Corresponds to variant dbSNP:rs59779270Ensembl.1
Natural variantiVAR_0200061052A → E1 PublicationCorresponds to variant dbSNP:rs1043673Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04489847 – 69Missing in isoform 5. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_017085109 – 132Missing in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_005522133 – 154Missing in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_017086847 – 1062Missing in isoform 3. 1 PublicationAdd BLAST216

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF298547 mRNA Translation: AAG15253.1 Different initiation.
AF310106 mRNA Translation: AAG30289.1
AF464764 mRNA Translation: AAL69962.1
AK000517 mRNA Translation: BAA91223.1
AK000784 mRNA Translation: BAA91377.1 Different initiation.
AK025952 mRNA Translation: BAB15293.1
AK302989 mRNA Translation: BAG64129.1
AB209300 mRNA Translation: BAD92537.1 Sequence problems.
AK223253 mRNA Translation: BAD96973.1
AK223269 mRNA Translation: BAD96989.1
AC011476 Genomic DNA No translation available.
BC001039 mRNA Translation: AAH01039.1
BC003592 mRNA Translation: AAH03592.1
BC039269 mRNA Translation: AAH39269.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12913.1 [Q9NX02-1]
CCDS54318.1 [Q9NX02-5]
CCDS54319.1 [Q9NX02-2]

NCBI Reference Sequences

More...RefSeqi		NP_001167552.1, NM_001174081.2 [Q9NX02-1]
NP_001167553.1, NM_001174082.2 [Q9NX02-2]
NP_001167554.1, NM_001174083.1 [Q9NX02-5]
NP_001334932.1, NM_001348003.1
NP_060322.1, NM_017852.4 [Q9NX02-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.369279

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000339757; ENSP00000344074; ENSG00000022556 [Q9NX02-2]
ENST00000391721; ENSP00000375601; ENSG00000022556 [Q9NX02-4]
ENST00000427260; ENSP00000402474; ENSG00000022556 [Q9NX02-5]
ENST00000448584; ENSP00000409370; ENSG00000022556 [Q9NX02-1]
ENST00000537859; ENSP00000440601; ENSG00000022556 [Q9NX02-2]
ENST00000543010; ENSP00000445135; ENSG00000022556 [Q9NX02-1]
ENST00000611410; ENSP00000479220; ENSG00000275843 [Q9NX02-1]
ENST00000611642; ENSP00000484150; ENSG00000275082 [Q9NX02-5]
ENST00000611676; ENSP00000481999; ENSG00000275399 [Q9NX02-2]
ENST00000611679; ENSP00000484354; ENSG00000278682 [Q9NX02-1]
ENST00000611772; ENSP00000479109; ENSG00000278682 [Q9NX02-1]
ENST00000613062; ENSP00000483281; ENSG00000273992 [Q9NX02-1]
ENST00000613485; ENSP00000484351; ENSG00000273992 [Q9NX02-2]
ENST00000613825; ENSP00000483963; ENSG00000274638 [Q9NX02-1]
ENST00000613851; ENSP00000482628; ENSG00000278789 [Q9NX02-5]
ENST00000615173; ENSP00000482889; ENSG00000273992 [Q9NX02-1]
ENST00000615391; ENSP00000481851; ENSG00000275399 [Q9NX02-1]
ENST00000615521; ENSP00000479352; ENSG00000275399 [Q9NX02-1]
ENST00000616040; ENSP00000478876; ENSG00000278789 [Q9NX02-1]
ENST00000616903; ENSP00000482355; ENSG00000275399 [Q9NX02-5]
ENST00000616919; ENSP00000481564; ENSG00000278789 [Q9NX02-2]
ENST00000618018; ENSP00000483886; ENSG00000275843 [Q9NX02-2]
ENST00000618694; ENSP00000482465; ENSG00000275843 [Q9NX02-5]
ENST00000618731; ENSP00000478787; ENSG00000273992 [Q9NX02-2]
ENST00000618789; ENSP00000478318; ENSG00000275796 [Q9NX02-5]
ENST00000618943; ENSP00000482309; ENSG00000274638 [Q9NX02-5]
ENST00000619281; ENSP00000478265; ENSG00000278789 [Q9NX02-1]
ENST00000619454; ENSP00000483528; ENSG00000274638 [Q9NX02-1]
ENST00000619664; ENSP00000478774; ENSG00000275796 [Q9NX02-1]
ENST00000619885; ENSP00000483389; ENSG00000278682 [Q9NX02-2]
ENST00000621057; ENSP00000484382; ENSG00000273992 [Q9NX02-4]
ENST00000621200; ENSP00000479783; ENSG00000275082 [Q9NX02-1]
ENST00000621239; ENSP00000479713; ENSG00000275082 [Q9NX02-1]
ENST00000621594; ENSP00000478450; ENSG00000275843 [Q9NX02-1]
ENST00000622042; ENSP00000482253; ENSG00000275796 [Q9NX02-1]
ENST00000622216; ENSP00000482044; ENSG00000275082 [Q9NX02-2]
ENST00000622444; ENSP00000482065; ENSG00000278682 [Q9NX02-5]
ENST00000622600; ENSP00000482727; ENSG00000274638 [Q9NX02-2]
ENST00000622773; ENSP00000484759; ENSG00000273992 [Q9NX02-5]
ENST00000622864; ENSP00000477726; ENSG00000275796 [Q9NX02-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55655

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55655

UCSC genome browser

More...UCSCi		uc002qij.4 human [Q9NX02-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298547 mRNA Translation: AAG15253.1 Different initiation.
AF310106 mRNA Translation: AAG30289.1
AF464764 mRNA Translation: AAL69962.1
AK000517 mRNA Translation: BAA91223.1
AK000784 mRNA Translation: BAA91377.1 Different initiation.
AK025952 mRNA Translation: BAB15293.1
AK302989 mRNA Translation: BAG64129.1
AB209300 mRNA Translation: BAD92537.1 Sequence problems.
AK223253 mRNA Translation: BAD96973.1
AK223269 mRNA Translation: BAD96989.1
AC011476 Genomic DNA No translation available.
BC001039 mRNA Translation: AAH01039.1
BC003592 mRNA Translation: AAH03592.1
BC039269 mRNA Translation: AAH39269.1
CCDSiCCDS12913.1 [Q9NX02-1]
CCDS54318.1 [Q9NX02-5]
CCDS54319.1 [Q9NX02-2]
RefSeqiNP_001167552.1, NM_001174081.2 [Q9NX02-1]
NP_001167553.1, NM_001174082.2 [Q9NX02-2]
NP_001167554.1, NM_001174083.1 [Q9NX02-5]
NP_001334932.1, NM_001348003.1
NP_060322.1, NM_017852.4 [Q9NX02-1]
UniGeneiHs.369279

3D structure databases

ProteinModelPortaliQ9NX02
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120787, 20 interactors
CORUMiQ9NX02
DIPiDIP-42460N
IntActiQ9NX02, 10 interactors
MINTiQ9NX02
STRINGi9606.ENSP00000409370

PTM databases

iPTMnetiQ9NX02
PhosphoSitePlusiQ9NX02

Polymorphism and mutation databases

BioMutaiNLRP2
DMDMi17380148

Proteomic databases

EPDiQ9NX02
MaxQBiQ9NX02
PaxDbiQ9NX02
PeptideAtlasiQ9NX02
PRIDEiQ9NX02
ProteomicsDBi83009
83010 [Q9NX02-2]
83011 [Q9NX02-3]
83012 [Q9NX02-4]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		55655
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339757; ENSP00000344074; ENSG00000022556 [Q9NX02-2]
ENST00000391721; ENSP00000375601; ENSG00000022556 [Q9NX02-4]
ENST00000427260; ENSP00000402474; ENSG00000022556 [Q9NX02-5]
ENST00000448584; ENSP00000409370; ENSG00000022556 [Q9NX02-1]
ENST00000537859; ENSP00000440601; ENSG00000022556 [Q9NX02-2]
ENST00000543010; ENSP00000445135; ENSG00000022556 [Q9NX02-1]
ENST00000611410; ENSP00000479220; ENSG00000275843 [Q9NX02-1]
ENST00000611642; ENSP00000484150; ENSG00000275082 [Q9NX02-5]
ENST00000611676; ENSP00000481999; ENSG00000275399 [Q9NX02-2]
ENST00000611679; ENSP00000484354; ENSG00000278682 [Q9NX02-1]
ENST00000611772; ENSP00000479109; ENSG00000278682 [Q9NX02-1]
ENST00000613062; ENSP00000483281; ENSG00000273992 [Q9NX02-1]
ENST00000613485; ENSP00000484351; ENSG00000273992 [Q9NX02-2]
ENST00000613825; ENSP00000483963; ENSG00000274638 [Q9NX02-1]
ENST00000613851; ENSP00000482628; ENSG00000278789 [Q9NX02-5]
ENST00000615173; ENSP00000482889; ENSG00000273992 [Q9NX02-1]
ENST00000615391; ENSP00000481851; ENSG00000275399 [Q9NX02-1]
ENST00000615521; ENSP00000479352; ENSG00000275399 [Q9NX02-1]
ENST00000616040; ENSP00000478876; ENSG00000278789 [Q9NX02-1]
ENST00000616903; ENSP00000482355; ENSG00000275399 [Q9NX02-5]
ENST00000616919; ENSP00000481564; ENSG00000278789 [Q9NX02-2]
ENST00000618018; ENSP00000483886; ENSG00000275843 [Q9NX02-2]
ENST00000618694; ENSP00000482465; ENSG00000275843 [Q9NX02-5]
ENST00000618731; ENSP00000478787; ENSG00000273992 [Q9NX02-2]
ENST00000618789; ENSP00000478318; ENSG00000275796 [Q9NX02-5]
ENST00000618943; ENSP00000482309; ENSG00000274638 [Q9NX02-5]
ENST00000619281; ENSP00000478265; ENSG00000278789 [Q9NX02-1]
ENST00000619454; ENSP00000483528; ENSG00000274638 [Q9NX02-1]
ENST00000619664; ENSP00000478774; ENSG00000275796 [Q9NX02-1]
ENST00000619885; ENSP00000483389; ENSG00000278682 [Q9NX02-2]
ENST00000621057; ENSP00000484382; ENSG00000273992 [Q9NX02-4]
ENST00000621200; ENSP00000479783; ENSG00000275082 [Q9NX02-1]
ENST00000621239; ENSP00000479713; ENSG00000275082 [Q9NX02-1]
ENST00000621594; ENSP00000478450; ENSG00000275843 [Q9NX02-1]
ENST00000622042; ENSP00000482253; ENSG00000275796 [Q9NX02-1]
ENST00000622216; ENSP00000482044; ENSG00000275082 [Q9NX02-2]
ENST00000622444; ENSP00000482065; ENSG00000278682 [Q9NX02-5]
ENST00000622600; ENSP00000482727; ENSG00000274638 [Q9NX02-2]
ENST00000622773; ENSP00000484759; ENSG00000273992 [Q9NX02-5]
ENST00000622864; ENSP00000477726; ENSG00000275796 [Q9NX02-2]
GeneIDi55655
KEGGihsa:55655
UCSCiuc002qij.4 human [Q9NX02-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55655
DisGeNETi55655
EuPathDBiHostDB:ENSG00000022556.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		NLRP2
HGNCiHGNC:22948 NLRP2
HPAiHPA020765
HPA021183
MIMi609364 gene
neXtProtiNX_Q9NX02
OpenTargetsiENSG00000022556
PharmGKBiPA162397946

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IM14 Eukaryota
ENOG410ZI5C LUCA
GeneTreeiENSGT00940000161714
HOVERGENiHBG103856
InParanoidiQ9NX02
KOiK19409
OMAiNDQNDML
OrthoDBiEOG091G01Q7
PhylomeDBiQ9NX02

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NLRP2 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NLRP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55655

Protein Ontology

More...PROi		PR:Q9NX02

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000022556 Expressed in 147 organ(s), highest expression level in secondary oocyte
CleanExiHS_NLRP2
ExpressionAtlasiQ9NX02 baseline and differential
GenevisibleiQ9NX02 HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF13516 LRR_6, 4 hits
PF05729 NACHT, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS50837 NACHT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNALP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NX02
Secondary accession number(s): B4DZL7
, I3L0G4, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 1, 2000
Last modified: December 5, 2018
This is version 183 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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