UniProtKB - Q9NX02 (NALP2_HUMAN)
NACHT, LRR and PYD domains-containing protein 2
NLRP2
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 213 – 220 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- Pyrin domain binding Source: HGNC-UCL
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: HGNC-UCL
- positive regulation of interleukin-1 beta production Source: HGNC-UCL
Keywordsi
Biological process | Apoptosis, Immunity, Inflammatory response, Innate immunity |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9NX02 |
Names & Taxonomyi
Protein namesi | Recommended name: NACHT, LRR and PYD domains-containing protein 2Alternative name(s): Nucleotide-binding site protein 1 PYRIN domain and NACHT domain-containing protein 1 PYRIN-containing APAF1-like protein 2 |
Gene namesi | Name:NLRP2 Synonyms:NALP2, NBS1, PAN1, PYPAF2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000022556.15 |
HGNCi | HGNC:22948, NLRP2 |
MIMi | 609364, gene |
neXtProti | NX_Q9NX02 |
Subcellular locationi
Other locations
- Cytoplasm 2 Publications
Cytosol
- cytosol Source: HPA
Golgi apparatus
- Golgi apparatus Source: HPA
Other locations
- cytoplasm Source: HGNC-UCL
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 55655 |
OpenTargetsi | ENSG00000022556 |
PharmGKBi | PA162397946 |
Miscellaneous databases
Pharosi | Q9NX02, Tbio |
Polymorphism and mutation databases
BioMutai | NLRP2 |
DMDMi | 17380148 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080888 | 1 – 1062 | NACHT, LRR and PYD domains-containing protein 2Add BLAST | 1062 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 671 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NX02 |
jPOSTi | Q9NX02 |
MassIVEi | Q9NX02 |
MaxQBi | Q9NX02 |
PaxDbi | Q9NX02 |
PeptideAtlasi | Q9NX02 |
PRIDEi | Q9NX02 |
ProteomicsDBi | 46351 83009 [Q9NX02-1] 83010 [Q9NX02-2] 83011 [Q9NX02-3] 83012 [Q9NX02-4] |
PTM databases
iPTMneti | Q9NX02 |
PhosphoSitePlusi | Q9NX02 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000022556, Expressed in secondary oocyte and 167 other tissues |
ExpressionAtlasi | Q9NX02, baseline and differential |
Genevisiblei | Q9NX02, HS |
Organism-specific databases
HPAi | ENSG00000022556, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Interacts with CHUK (PubMed:15456791).
Interacts with IKBKB (PubMed:15456791).
Interacts with IKBKG (PubMed:15456791).
Interacts with MEFV (PubMed:17431422).
Interacts with PYCARD (PubMed:15030775, PubMed:15456791).
Interacts (via pyrin domain) with PYDC2 (PubMed:17178784).
Interacts with CARD8 (PubMed:15030775).
4 PublicationsBinary interactionsi
Q9NX02
With | #Exp. | IntAct |
---|---|---|
PYDC2 [Q56P42] | 6 | EBI-6374482,EBI-6374418 |
GO - Molecular functioni
- Pyrin domain binding Source: HGNC-UCL
Protein-protein interaction databases
BioGRIDi | 120787, 22 interactors |
CORUMi | Q9NX02 |
DIPi | DIP-42460N |
IntActi | Q9NX02, 10 interactors |
MINTi | Q9NX02 |
STRINGi | 9606.ENSP00000445135 |
Miscellaneous databases
RNActi | Q9NX02, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 94 | PyrinPROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 207 – 526 | NACHTPROSITE-ProRule annotationAdd BLAST | 320 | |
Repeati | 812 – 832 | LRR 1Add BLAST | 21 | |
Repeati | 841 – 861 | LRR 2Add BLAST | 21 | |
Repeati | 869 – 889 | LRR 3Add BLAST | 21 | |
Repeati | 898 – 918 | LRR 4Add BLAST | 21 | |
Repeati | 926 – 946 | LRR 5Add BLAST | 21 | |
Repeati | 955 – 976 | LRR 6Add BLAST | 22 | |
Repeati | 983 – 1003 | LRR 7Add BLAST | 21 | |
Repeati | 1010 – 1033 | LRR 8Add BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 518 – 523 | Poly-Glu | 6 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | ENOG502S92U, Eukaryota |
GeneTreei | ENSGT00940000161714 |
HOGENOMi | CLU_002274_2_1_1 |
InParanoidi | Q9NX02 |
OMAi | AFYISCR |
OrthoDBi | 155336at2759 |
PhylomeDBi | Q9NX02 |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR007111, NACHT_NTPase IPR041267, NLRP_HD2 IPR041075, NOD2_WH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13516, LRR_6, 4 hits PF05729, NACHT, 1 hit PF17776, NLRC4_HD2, 1 hit PF17779, NOD2_WH, 1 hit PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50824, DAPIN, 1 hit PS50837, NACHT, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEVDKA
60 70 80 90 100
DGKQLVEILT THCDSYWVEM ASLQVFEKMH RMDLSERAKD EVREAALKSF
110 120 130 140 150
NKRKPLSLGI TRKERPPLDV DEMLERFKTE AQAFTETKGN VICLGKEVFK
160 170 180 190 200
GKKPDKDNRC RYILKTKFRE MWKSWPGDSK EVQVMAERYK MLIPFSNPRV
210 220 230 240 250
LPGPFSYTVV LYGPAGLGKT TLAQKLMLDW AEDNLIHKFK YAFYLSCREL
260 270 280 290 300
SRLGPCSFAE LVFRDWPELQ DDIPHILAQA RKILFVIDGF DELGAAPGAL
310 320 330 340 350
IEDICGDWEK KKPVPVLLGS LLNRVMLPKA ALLVTTRPRA LRDLRILAEE
360 370 380 390 400
PIYIRVEGFL EEDRRAYFLR HFGDEDQAMR AFELMRSNAA LFQLGSAPAV
410 420 430 440 450
CWIVCTTLKL QMEKGEDPVP TCLTRTGLFL RFLCSRFPQG AQLRGALRTL
460 470 480 490 500
SLLAAQGLWA QTSVLHREDL ERLGVQESDL RLFLDGDILR QDRVSKGCYS
510 520 530 540 550
FIHLSFQQFL TALFYTLEKE EEEDRDGHTW DIGDVQKLLS GVERLRNPDL
560 570 580 590 600
IQAGYYSFGL ANEKRAKELE ATFGCRMSPD IKQELLRCDI SCKGGHSTVT
610 620 630 640 650
DLQELLGCLY ESQEEELVKE VMAQFKEISL HLNAVDVVPS SFCVKHCRNL
660 670 680 690 700
QKMSLQVIKE NLPENVTASE SDAEVERSQD DQHMLPFWTD LCSIFGSNKD
710 720 730 740 750
LMGLAINDSF LSASLVRILC EQIASDTCHL QRVVFKNISP ADAHRNLCLA
760 770 780 790 800
LRGHKTVTYL TLQGNDQDDM FPALCEVLRH PECNLRYLGL VSCSATTQQW
810 820 830 840 850
ADLSLALEVN QSLTCVNLSD NELLDEGAKL LYTTLRHPKC FLQRLSLENC
860 870 880 890 900
HLTEANCKDL AAVLVVSREL THLCLAKNPI GNTGVKFLCE GLRYPECKLQ
910 920 930 940 950
TLVLWNCDIT SDGCCDLTKL LQEKSSLLCL DLGLNHIGVK GMKFLCEALR
960 970 980 990 1000
KPLCNLRCLW LWGCSIPPFS CEDLCSALSC NQSLVTLDLG QNPLGSSGVK
1010 1020 1030 1040 1050
MLFETLTCSS GTLRTLRLKI DDFNDELNKL LEEIEEKNPQ LIIDTEKHHP
1060
WAERPSSHDF MI
Computationally mapped potential isoform sequencesi
There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KN39 | J3KN39_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 1,059 | Annotation score: | ||
K7EMK2 | K7EMK2_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 197 | Annotation score: | ||
A0A0G2JLX3 | A0A0G2JLX3_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 1,040 | Annotation score: | ||
A0A0G2JMG8 | A0A0G2JMG8_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 1,039 | Annotation score: | ||
A0A0G2JPQ2 | A0A0G2JPQ2_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 1,062 | Annotation score: | ||
F5H5B1 | F5H5B1_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 154 | Annotation score: | ||
F5GYZ4 | F5GYZ4_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 165 | Annotation score: | ||
F5H7Q5 | F5H7Q5_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 109 | Annotation score: | ||
K7EJ90 | K7EJ90_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 124 | Annotation score: | ||
K7ELX1 | K7ELX1_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 140 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1 | M → V in AAG15253 (PubMed:11270363).Curated | 1 | |
Sequence conflicti | 35 | L → P in AAG15253 (PubMed:11270363).Curated | 1 | |
Sequence conflicti | 46 | E → G in BAG64129 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 58 | I → V in AAH39269 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 175 | W → C in BAD96973 (Ref. 5) Curated | 1 | |
Sequence conflicti | 175 | W → C in BAD96989 (Ref. 5) Curated | 1 | |
Sequence conflicti | 216 | G → S in BAG64129 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 304 | I → S in BAB15293 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 980 | Missing in AAG15253 (PubMed:11270363).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053616 | 221 | T → M. Corresponds to variant dbSNP:rs17699678Ensembl. | 1 | |
Natural variantiVAR_053617 | 302 | E → Q. Corresponds to variant dbSNP:rs3745904Ensembl. | 1 | |
Natural variantiVAR_025011 | 364 | R → K1 PublicationCorresponds to variant dbSNP:rs4306647Ensembl. | 1 | |
Natural variantiVAR_068977 | 516 | T → A1 PublicationCorresponds to variant dbSNP:rs61735082EnsemblClinVar. | 1 | |
Natural variantiVAR_068978 | 522 | E → G1 PublicationCorresponds to variant dbSNP:rs61735083EnsemblClinVar. | 1 | |
Natural variantiVAR_068979 | 529 | T → A2 PublicationsCorresponds to variant dbSNP:rs34804158Ensembl. | 1 | |
Natural variantiVAR_062140 | 884 | G → R. Corresponds to variant dbSNP:rs59779270Ensembl. | 1 | |
Natural variantiVAR_020006 | 1052 | A → E1 PublicationCorresponds to variant dbSNP:rs1043673Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044898 | 47 – 69 | Missing in isoform 5. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_017085 | 109 – 132 | Missing in isoform 4. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_005522 | 133 – 154 | Missing in isoform 2. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_017086 | 847 – 1062 | Missing in isoform 3. 1 PublicationAdd BLAST | 216 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF298547 mRNA Translation: AAG15253.1 Different initiation. AF310106 mRNA Translation: AAG30289.1 AF464764 mRNA Translation: AAL69962.1 AK000517 mRNA Translation: BAA91223.1 AK000784 mRNA Translation: BAA91377.1 Different initiation. AK025952 mRNA Translation: BAB15293.1 AK302989 mRNA Translation: BAG64129.1 AB209300 mRNA Translation: BAD92537.1 Sequence problems. AK223253 mRNA Translation: BAD96973.1 AK223269 mRNA Translation: BAD96989.1 AC011476 Genomic DNA No translation available. BC001039 mRNA Translation: AAH01039.1 BC003592 mRNA Translation: AAH03592.1 BC039269 mRNA Translation: AAH39269.1 |
CCDSi | CCDS12913.1 [Q9NX02-1] CCDS54318.1 [Q9NX02-5] CCDS54319.1 [Q9NX02-2] |
RefSeqi | NP_001167552.1, NM_001174081.2 [Q9NX02-1] NP_001167553.1, NM_001174082.2 [Q9NX02-2] NP_001167554.1, NM_001174083.1 [Q9NX02-5] NP_001334932.1, NM_001348003.1 NP_060322.1, NM_017852.4 [Q9NX02-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF298547 mRNA Translation: AAG15253.1 Different initiation. AF310106 mRNA Translation: AAG30289.1 AF464764 mRNA Translation: AAL69962.1 AK000517 mRNA Translation: BAA91223.1 AK000784 mRNA Translation: BAA91377.1 Different initiation. AK025952 mRNA Translation: BAB15293.1 AK302989 mRNA Translation: BAG64129.1 AB209300 mRNA Translation: BAD92537.1 Sequence problems. AK223253 mRNA Translation: BAD96973.1 AK223269 mRNA Translation: BAD96989.1 AC011476 Genomic DNA No translation available. BC001039 mRNA Translation: AAH01039.1 BC003592 mRNA Translation: AAH03592.1 BC039269 mRNA Translation: AAH39269.1 |
CCDSi | CCDS12913.1 [Q9NX02-1] CCDS54318.1 [Q9NX02-5] CCDS54319.1 [Q9NX02-2] |
RefSeqi | NP_001167552.1, NM_001174081.2 [Q9NX02-1] NP_001167553.1, NM_001174082.2 [Q9NX02-2] NP_001167554.1, NM_001174083.1 [Q9NX02-5] NP_001334932.1, NM_001348003.1 NP_060322.1, NM_017852.4 [Q9NX02-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120787, 22 interactors |
CORUMi | Q9NX02 |
DIPi | DIP-42460N |
IntActi | Q9NX02, 10 interactors |
MINTi | Q9NX02 |
STRINGi | 9606.ENSP00000445135 |
PTM databases
iPTMneti | Q9NX02 |
PhosphoSitePlusi | Q9NX02 |
Polymorphism and mutation databases
BioMutai | NLRP2 |
DMDMi | 17380148 |
Proteomic databases
EPDi | Q9NX02 |
jPOSTi | Q9NX02 |
MassIVEi | Q9NX02 |
MaxQBi | Q9NX02 |
PaxDbi | Q9NX02 |
PeptideAtlasi | Q9NX02 |
PRIDEi | Q9NX02 |
ProteomicsDBi | 46351 83009 [Q9NX02-1] 83010 [Q9NX02-2] 83011 [Q9NX02-3] 83012 [Q9NX02-4] |
Protocols and materials databases
Antibodypediai | 19479, 301 antibodies |
DNASUi | 55655 |
Genome annotation databases
Organism-specific databases
CTDi | 55655 |
DisGeNETi | 55655 |
EuPathDBi | HostDB:ENSG00000022556.15 |
GeneCardsi | NLRP2 |
HGNCi | HGNC:22948, NLRP2 |
HPAi | ENSG00000022556, Tissue enhanced (testis) |
MIMi | 609364, gene |
neXtProti | NX_Q9NX02 |
OpenTargetsi | ENSG00000022556 |
PharmGKBi | PA162397946 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S92U, Eukaryota |
GeneTreei | ENSGT00940000161714 |
HOGENOMi | CLU_002274_2_1_1 |
InParanoidi | Q9NX02 |
OMAi | AFYISCR |
OrthoDBi | 155336at2759 |
PhylomeDBi | Q9NX02 |
Enzyme and pathway databases
PathwayCommonsi | Q9NX02 |
Miscellaneous databases
BioGRID-ORCSi | 55655, 7 hits in 840 CRISPR screens |
ChiTaRSi | NLRP2, human |
GeneWikii | NLRP2 |
GenomeRNAii | 55655 |
Pharosi | Q9NX02, Tbio |
PROi | PR:Q9NX02 |
RNActi | Q9NX02, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000022556, Expressed in secondary oocyte and 167 other tissues |
ExpressionAtlasi | Q9NX02, baseline and differential |
Genevisiblei | Q9NX02, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR007111, NACHT_NTPase IPR041267, NLRP_HD2 IPR041075, NOD2_WH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13516, LRR_6, 4 hits PF05729, NACHT, 1 hit PF17776, NLRC4_HD2, 1 hit PF17779, NOD2_WH, 1 hit PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50824, DAPIN, 1 hit PS50837, NACHT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NALP2_HUMAN | |
Accessioni | Q9NX02Primary (citable) accession number: Q9NX02 Secondary accession number(s): B4DZL7 Q9NWK3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 199 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations