NACHT, LRR and PYD domains-containing protein 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• Pyrin domain binding Source: HGNC <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 15030775

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• apoptotic process Source: UniProtKB-KW
• inflammatory response Source: UniProtKB-KW
• innate immune response Source: UniProtKB-KW
• negative regulation of NF-kappaB transcription factor activity Source: UniProtKB <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 15817483
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: HGNC <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 15030775
• positive regulation of interleukin-1 beta secretion Source: HGNC <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 15030775

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• Pyrin domain binding Source: HGNC <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 15030775

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEVDKA 
        60         70         80         90        100
DGKQLVEILT THCDSYWVEM ASLQVFEKMH RMDLSERAKD EVREAALKSF 
       110        120        130        140        150
NKRKPLSLGI TRKERPPLDV DEMLERFKTE AQAFTETKGN VICLGKEVFK 
       160        170        180        190        200
GKKPDKDNRC RYILKTKFRE MWKSWPGDSK EVQVMAERYK MLIPFSNPRV 
       210        220        230        240        250
LPGPFSYTVV LYGPAGLGKT TLAQKLMLDW AEDNLIHKFK YAFYLSCREL 
       260        270        280        290        300
SRLGPCSFAE LVFRDWPELQ DDIPHILAQA RKILFVIDGF DELGAAPGAL 
       310        320        330        340        350
IEDICGDWEK KKPVPVLLGS LLNRVMLPKA ALLVTTRPRA LRDLRILAEE 
       360        370        380        390        400
PIYIRVEGFL EEDRRAYFLR HFGDEDQAMR AFELMRSNAA LFQLGSAPAV 
       410        420        430        440        450
CWIVCTTLKL QMEKGEDPVP TCLTRTGLFL RFLCSRFPQG AQLRGALRTL 
       460        470        480        490        500
SLLAAQGLWA QTSVLHREDL ERLGVQESDL RLFLDGDILR QDRVSKGCYS 
       510        520        530        540        550
FIHLSFQQFL TALFYTLEKE EEEDRDGHTW DIGDVQKLLS GVERLRNPDL 
       560        570        580        590        600
IQAGYYSFGL ANEKRAKELE ATFGCRMSPD IKQELLRCDI SCKGGHSTVT 
       610        620        630        640        650
DLQELLGCLY ESQEEELVKE VMAQFKEISL HLNAVDVVPS SFCVKHCRNL 
       660        670        680        690        700
QKMSLQVIKE NLPENVTASE SDAEVERSQD DQHMLPFWTD LCSIFGSNKD 
       710        720        730        740        750
LMGLAINDSF LSASLVRILC EQIASDTCHL QRVVFKNISP ADAHRNLCLA 
       760        770        780        790        800
LRGHKTVTYL TLQGNDQDDM FPALCEVLRH PECNLRYLGL VSCSATTQQW 
       810        820        830        840        850
ADLSLALEVN QSLTCVNLSD NELLDEGAKL LYTTLRHPKC FLQRLSLENC 
       860        870        880        890        900
HLTEANCKDL AAVLVVSREL THLCLAKNPI GNTGVKFLCE GLRYPECKLQ 
       910        920        930        940        950
TLVLWNCDIT SDGCCDLTKL LQEKSSLLCL DLGLNHIGVK GMKFLCEALR 
       960        970        980        990       1000
KPLCNLRCLW LWGCSIPPFS CEDLCSALSC NQSLVTLDLG QNPLGSSGVK 
      1010       1020       1030       1040       1050
MLFETLTCSS GTLRTLRLKI DDFNDELNKL LEEIEEKNPQ LIIDTEKHHP 
      1060 
WAERPSSHDF MI                                          

        10         20         30         40         50
MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEVDKA 
        60         70         80         90        100
DGKQLVEILT THCDSYWVEM ASLQVFEKMH RMDLSERAKD EVREAALKSF 
       110        120        130        140        150
NKRKPLSLGI TRKERPPLDV DEMLERFKTE AQDKDNRCRY ILKTKFREMW 
       160        170        180        190        200
KSWPGDSKEV QVMAERYKML IPFSNPRVLP GPFSYTVVLY GPAGLGKTTL 
       210        220        230        240        250
AQKLMLDWAE DNLIHKFKYA FYLSCRELSR LGPCSFAELV FRDWPELQDD 
       260        270        280        290        300
IPHILAQARK ILFVIDGFDE LGAAPGALIE DICGDWEKKK PVPVLLGSLL 
       310        320        330        340        350
NRVMLPKAAL LVTTRPRALR DLRILAEEPI YIRVEGFLEE DRRAYFLRHF 
       360        370        380        390        400
GDEDQAMRAF ELMRSNAALF QLGSAPAVCW IVCTTLKLQM EKGEDPVPTC 
       410        420        430        440        450
LTRTGLFLRF LCSRFPQGAQ LRGALRTLSL LAAQGLWAQT SVLHREDLER 
       460        470        480        490        500
LGVQESDLRL FLDGDILRQD RVSKGCYSFI HLSFQQFLTA LFYTLEKEEE 
       510        520        530        540        550
EDRDGHTWDI GDVQKLLSGV ERLRNPDLIQ AGYYSFGLAN EKRAKELEAT 
       560        570        580        590        600
FGCRMSPDIK QELLRCDISC KGGHSTVTDL QELLGCLYES QEEELVKEVM 
       610        620        630        640        650
AQFKEISLHL NAVDVVPSSF CVKHCRNLQK MSLQVIKENL PENVTASESD 
       660        670        680        690        700
AEVERSQDDQ HMLPFWTDLC SIFGSNKDLM GLAINDSFLS ASLVRILCEQ 
       710        720        730        740        750
IASDTCHLQR VVFKNISPAD AHRNLCLALR GHKTVTYLTL QGNDQDDMFP 
       760        770        780        790        800
ALCEVLRHPE CNLRYLGLVS CSATTQQWAD LSLALEVNQS LTCVNLSDNE 
       810        820        830        840        850
LLDEGAKLLY TTLRHPKCFL QRLSLENCHL TEANCKDLAA VLVVSRELTH 
       860        870        880        890        900
LCLAKNPIGN TGVKFLCEGL RYPECKLQTL VLWNCDITSD GCCDLTKLLQ 
       910        920        930        940        950
EKSSLLCLDL GLNHIGVKGM KFLCEALRKP LCNLRCLWLW GCSIPPFSCE 
       960        970        980        990       1000
DLCSALSCNQ SLVTLDLGQN PLGSSGVKML FETLTCSSGT LRTLRLKIDD 
      1010       1020       1030       1040
FNDELNKLLE EIEEKNPQLI IDTEKHHPWA ERPSSHDFMI            

        10         20         30         40         50
MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEVDKA 
        60         70         80         90        100
DGKQLVEILT THCDSYWVEM ASLQVFEKMH RMDLSERAKD EVREAALKSF 
       110        120        130        140        150
NKRKPLSLGI TRKERPPLDV DEMLERFKTE AQAFTETKGN VICLGKEVFK 
       160        170        180        190        200
GKKPDKDNRC RYILKTKFRE MWKSWPGDSK EVQVMAERYK MLIPFSNPRV 
       210        220        230        240        250
LPGPFSYTVV LYGPAGLGKT TLAQKLMLDW AEDNLIHKFK YAFYLSCREL 
       260        270        280        290        300
SRLGPCSFAE LVFRDWPELQ DDIPHILAQA RKILFVIDGF DELGAAPGAL 
       310        320        330        340        350
IEDICGDWEK KKPVPVLLGS LLNRVMLPKA ALLVTTRPRA LRDLRILAEE 
       360        370        380        390        400
PIYIRVEGFL EEDRRAYFLR HFGDEDQAMR AFELMRSNAA LFQLGSAPAV 
       410        420        430        440        450
CWIVCTTLKL QMEKGEDPVP TCLTRTGLFL RFLCSRFPQG AQLRGALRTL 
       460        470        480        490        500
SLLAAQGLWA QTSVLHREDL ERLGVQESDL RLFLDGDILR QDRVSKGCYS 
       510        520        530        540        550
FIHLSFQQFL TALFYTLEKE EEEDRDGHTW DIGDVQKLLS GVERLRNPDL 
       560        570        580        590        600
IQAGYYSFGL ANEKRAKELE ATFGCRMSPD IKQELLRCDI SCKGGHSTVT 
       610        620        630        640        650
DLQELLGCLY ESQEEELVKE VMAQFKEISL HLNAVDVVPS SFCVKHCRNL 
       660        670        680        690        700
QKMSLQVIKE NLPENVTASE SDAEVERSQD DQHMLPFWTD LCSIFGSNKD 
       710        720        730        740        750
LMGLAINDSF LSASLVRILC EQIASDTCHL QRVVFKNISP ADAHRNLCLA 
       760        770        780        790        800
LRGHKTVTYL TLQGNDQDDM FPALCEVLRH PECNLRYLGL VSCSATTQQW 
       810        820        830        840 
ADLSLALEVN QSLTCVNLSD NELLDEGAKL LYTTLRHPKC FLQRLS     

        10         20         30         40         50
MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEVDKA 
        60         70         80         90        100
DGKQLVEILT THCDSYWVEM ASLQVFEKMH RMDLSERAKD EVREAALKSF 
       110        120        130        140        150
NKRKPLSLAF TETKGNVICL GKEVFKGKKP DKDNRCRYIL KTKFREMWKS 
       160        170        180        190        200
WPGDSKEVQV MAERYKMLIP FSNPRVLPGP FSYTVVLYGP AGLGKTTLAQ 
       210        220        230        240        250
KLMLDWAEDN LIHKFKYAFY LSCRELSRLG PCSFAELVFR DWPELQDDIP 
       260        270        280        290        300
HILAQARKIL FVIDGFDELG AAPGALIEDI CGDWEKKKPV PVLLGSLLNR 
       310        320        330        340        350
VMLPKAALLV TTRPRALRDL RILAEEPIYI RVEGFLEEDR RAYFLRHFGD 
       360        370        380        390        400
EDQAMRAFEL MRSNAALFQL GSAPAVCWIV CTTLKLQMEK GEDPVPTCLT 
       410        420        430        440        450
RTGLFLRFLC SRFPQGAQLR GALRTLSLLA AQGLWAQTSV LHREDLERLG 
       460        470        480        490        500
VQESDLRLFL DGDILRQDRV SKGCYSFIHL SFQQFLTALF YTLEKEEEED 
       510        520        530        540        550
RDGHTWDIGD VQKLLSGVER LRNPDLIQAG YYSFGLANEK RAKELEATFG 
       560        570        580        590        600
CRMSPDIKQE LLRCDISCKG GHSTVTDLQE LLGCLYESQE EELVKEVMAQ 
       610        620        630        640        650
FKEISLHLNA VDVVPSSFCV KHCRNLQKMS LQVIKENLPE NVTASESDAE 
       660        670        680        690        700
VERSQDDQHM LPFWTDLCSI FGSNKDLMGL AINDSFLSAS LVRILCEQIA 
       710        720        730        740        750
SDTCHLQRVV FKNISPADAH RNLCLALRGH KTVTYLTLQG NDQDDMFPAL 
       760        770        780        790        800
CEVLRHPECN LRYLGLVSCS ATTQQWADLS LALEVNQSLT CVNLSDNELL 
       810        820        830        840        850
DEGAKLLYTT LRHPKCFLQR LSLENCHLTE ANCKDLAAVL VVSRELTHLC 
       860        870        880        890        900
LAKNPIGNTG VKFLCEGLRY PECKLQTLVL WNCDITSDGC CDLTKLLQEK 
       910        920        930        940        950
SSLLCLDLGL NHIGVKGMKF LCEALRKPLC NLRCLWLWGC SIPPFSCEDL 
       960        970        980        990       1000
CSALSCNQSL VTLDLGQNPL GSSGVKMLFE TLTCSSGTLR TLRLKIDDFN 
      1010       1020       1030 
DELNKLLEEI EEKNPQLIID TEKHHPWAER PSSHDFMI              

        10         20         30         40         50
MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEMASL 
        60         70         80         90        100
QVFEKMHRMD LSERAKDEVR EAALKSFNKR KPLSLGITRK ERPPLDVDEM 
       110        120        130        140        150
LERFKTEAQA FTETKGNVIC LGKEVFKGKK PDKDNRCRYI LKTKFREMWK 
       160        170        180        190        200
SWPGDSKEVQ VMAERYKMLI PFSNPRVLPG PFSYTVVLYG PAGLGKTTLA 
       210        220        230        240        250
QKLMLDWAED NLIHKFKYAF YLSCRELSRL GPCSFAELVF RDWPELQDDI 
       260        270        280        290        300
PHILAQARKI LFVIDGFDEL GAAPGALIED ICGDWEKKKP VPVLLGSLLN 
       310        320        330        340        350
RVMLPKAALL VTTRPRALRD LRILAEEPIY IRVEGFLEED RRAYFLRHFG 
       360        370        380        390        400
DEDQAMRAFE LMRSNAALFQ LGSAPAVCWI VCTTLKLQME KGEDPVPTCL 
       410        420        430        440        450
TRTGLFLRFL CSRFPQGAQL RGALRTLSLL AAQGLWAQTS VLHREDLERL 
       460        470        480        490        500
GVQESDLRLF LDGDILRQDR VSKGCYSFIH LSFQQFLTAL FYTLEKEEEE 
       510        520        530        540        550
DRDGHTWDIG DVQKLLSGVE RLRNPDLIQA GYYSFGLANE KRAKELEATF 
       560        570        580        590        600
GCRMSPDIKQ ELLRCDISCK GGHSTVTDLQ ELLGCLYESQ EEELVKEVMA 
       610        620        630        640        650
QFKEISLHLN AVDVVPSSFC VKHCRNLQKM SLQVIKENLP ENVTASESDA 
       660        670        680        690        700
EVERSQDDQH MLPFWTDLCS IFGSNKDLMG LAINDSFLSA SLVRILCEQI 
       710        720        730        740        750
ASDTCHLQRV VFKNISPADA HRNLCLALRG HKTVTYLTLQ GNDQDDMFPA 
       760        770        780        790        800
LCEVLRHPEC NLRYLGLVSC SATTQQWADL SLALEVNQSL TCVNLSDNEL 
       810        820        830        840        850
LDEGAKLLYT TLRHPKCFLQ RLSLENCHLT EANCKDLAAV LVVSRELTHL 
       860        870        880        890        900
CLAKNPIGNT GVKFLCEGLR YPECKLQTLV LWNCDITSDG CCDLTKLLQE 
       910        920        930        940        950
KSSLLCLDLG LNHIGVKGMK FLCEALRKPL CNLRCLWLWG CSIPPFSCED 
       960        970        980        990       1000
LCSALSCNQS LVTLDLGQNP LGSSGVKMLF ETLTCSSGTL RTLRLKIDDF 
      1010       1020       1030 
NDELNKLLEE IEEKNPQLII DTEKHHPWAE RPSSHDFMI             

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 19
   Human chromosome 19: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. SIMILARITY comments
   Index of protein domains and families