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Protein

Thioredoxin-like protein 4B

Gene

TXNL4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G2 transition.1 Publication

GO - Biological processi

Keywordsi

Biological processCell cycle, mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein 4B
Alternative name(s):
Dim1-like protein
Gene namesi
Name:TXNL4B
Synonyms:DIM2, DLP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000140830.8
HGNCiHGNC:26041 TXNL4B
MIMi617722 gene
neXtProtiNX_Q9NX01

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54957
OpenTargetsiENSG00000140830
PharmGKBiPA134944912

Polymorphism and mutation databases

BioMutaiTXNL4B
DMDMi51702156

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002182891 – 149Thioredoxin-like protein 4BAdd BLAST149

Proteomic databases

EPDiQ9NX01
MaxQBiQ9NX01
PaxDbiQ9NX01
PeptideAtlasiQ9NX01
PRIDEiQ9NX01
ProteomicsDBi83008

PTM databases

iPTMnetiQ9NX01
PhosphoSitePlusiQ9NX01

Expressioni

Gene expression databases

BgeeiENSG00000140830 Expressed in 209 organ(s), highest expression level in medial globus pallidus
CleanExiHS_TXNL4B
ExpressionAtlasiQ9NX01 baseline and differential
GenevisibleiQ9NX01 HS

Organism-specific databases

HPAiHPA065865

Interactioni

Subunit structurei

Homodimer. Interacts with the U5-102 kDa protein subunit of the spliceosome.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi120295, 19 interactors
IntActiQ9NX01, 12 interactors
STRINGi9606.ENSP00000268483

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NX01
SMRiQ9NX01
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NX01

Family & Domainsi

Sequence similaritiesi

Belongs to the DIM1 family.Curated

Phylogenomic databases

eggNOGiKOG3414 Eukaryota
ENOG4111FE6 LUCA
GeneTreeiENSGT00390000010779
HOGENOMiHOG000198385
HOVERGENiHBG053996
InParanoidiQ9NX01
OMAiAMKGKMI
OrthoDBiEOG091G0QHA
PhylomeDBiQ9NX01
TreeFamiTF332397

Family and domain databases

InterProiView protein in InterPro
IPR004123 Dim1
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR12052 PTHR12052, 1 hit
PfamiView protein in Pfam
PF02966 DIM1, 1 hit
PIRSFiPIRSF017199 mRNA_splic_U5, 1 hit
SMARTiView protein in SMART
SM01410 DIM1, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9NX01-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFLLPKLTS KKEVDQAIKS TAEKVLVLRF GRDEDPVCLQ LDDILSKTSS
60 70 80 90 100
DLSKMAAIYL VDVDQTAVYT QYFDISYIPS TVFFFNGQHM KVDYGSPDHT
110 120 130 140
KFVGSFKTKQ DFIDLIEVIY RGAMRGKLIV QSPIDPKNIP KYDLLYQDI
Length:149
Mass (Da):17,015
Last modified:October 1, 2000 - v1
Checksum:i4C63CF5C05425738
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BN11H3BN11_HUMAN
Thioredoxin-like protein 4B
TXNL4B
117Annotation score:
H3BUL8H3BUL8_HUMAN
Thioredoxin-like protein 4B
TXNL4B
94Annotation score:
H3BQ09H3BQ09_HUMAN
Thioredoxin-like protein 4B
TXNL4B
57Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY566808 mRNA Translation: AAS68520.1
AK000518 mRNA Translation: BAA91224.1
CR457240 mRNA Translation: CAG33521.1
CH471166 Genomic DNA Translation: EAW59191.1
CH471166 Genomic DNA Translation: EAW59192.1
BC009646 mRNA Translation: AAH09646.1
CCDSiCCDS10906.1
RefSeqiNP_001135789.1, NM_001142317.1
NP_001135790.1, NM_001142318.1
NP_060323.1, NM_017853.2
UniGeneiHs.134406

Genome annotation databases

EnsembliENST00000268483; ENSP00000268483; ENSG00000140830
ENST00000423037; ENSP00000408130; ENSG00000140830
ENST00000426362; ENSP00000392310; ENSG00000140830
GeneIDi54957
KEGGihsa:54957
UCSCiuc002fca.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY566808 mRNA Translation: AAS68520.1
AK000518 mRNA Translation: BAA91224.1
CR457240 mRNA Translation: CAG33521.1
CH471166 Genomic DNA Translation: EAW59191.1
CH471166 Genomic DNA Translation: EAW59192.1
BC009646 mRNA Translation: AAH09646.1
CCDSiCCDS10906.1
RefSeqiNP_001135789.1, NM_001142317.1
NP_001135790.1, NM_001142318.1
NP_060323.1, NM_017853.2
UniGeneiHs.134406

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XBSX-ray2.50A1-149[»]
3GIXX-ray1.33A/B2-149[»]
4IN0X-ray1.33A/B2-149[»]
ProteinModelPortaliQ9NX01
SMRiQ9NX01
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120295, 19 interactors
IntActiQ9NX01, 12 interactors
STRINGi9606.ENSP00000268483

PTM databases

iPTMnetiQ9NX01
PhosphoSitePlusiQ9NX01

Polymorphism and mutation databases

BioMutaiTXNL4B
DMDMi51702156

Proteomic databases

EPDiQ9NX01
MaxQBiQ9NX01
PaxDbiQ9NX01
PeptideAtlasiQ9NX01
PRIDEiQ9NX01
ProteomicsDBi83008

Protocols and materials databases

DNASUi54957
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268483; ENSP00000268483; ENSG00000140830
ENST00000423037; ENSP00000408130; ENSG00000140830
ENST00000426362; ENSP00000392310; ENSG00000140830
GeneIDi54957
KEGGihsa:54957
UCSCiuc002fca.4 human

Organism-specific databases

CTDi54957
DisGeNETi54957
EuPathDBiHostDB:ENSG00000140830.8
GeneCardsiTXNL4B
HGNCiHGNC:26041 TXNL4B
HPAiHPA065865
MIMi617722 gene
neXtProtiNX_Q9NX01
OpenTargetsiENSG00000140830
PharmGKBiPA134944912
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3414 Eukaryota
ENOG4111FE6 LUCA
GeneTreeiENSGT00390000010779
HOGENOMiHOG000198385
HOVERGENiHBG053996
InParanoidiQ9NX01
OMAiAMKGKMI
OrthoDBiEOG091G0QHA
PhylomeDBiQ9NX01
TreeFamiTF332397

Miscellaneous databases

ChiTaRSiTXNL4B human
EvolutionaryTraceiQ9NX01
GeneWikiiTXNL4B
GenomeRNAii54957
PROiPR:Q9NX01
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140830 Expressed in 209 organ(s), highest expression level in medial globus pallidus
CleanExiHS_TXNL4B
ExpressionAtlasiQ9NX01 baseline and differential
GenevisibleiQ9NX01 HS

Family and domain databases

InterProiView protein in InterPro
IPR004123 Dim1
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR12052 PTHR12052, 1 hit
PfamiView protein in Pfam
PF02966 DIM1, 1 hit
PIRSFiPIRSF017199 mRNA_splic_U5, 1 hit
SMARTiView protein in SMART
SM01410 DIM1, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTXN4B_HUMAN
AccessioniPrimary (citable) accession number: Q9NX01
Secondary accession number(s): D3DWS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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