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UniProtKB - Q9NWZ5 (UCKL1_HUMAN)

Protein

Uridine-cytidine kinase-like 1

Gene

UCKL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May contribute to UTP accumulation needed for blast transformation and proliferation.1 Publication

Catalytic activityi

ATP + uridine = ADP + UMP.
ATP + cytidine = ADP + CMP.

Pathwayi: CTP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes CTP from cytidine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uridine-cytidine kinase-like 1 (UCKL1), Uridine-cytidine kinase 2 (UCK2), Uridine-cytidine kinase 1 (UCK1), Uridine-cytidine kinase, Uridine-cytidine kinase (UCK2), Uridine-cytidine kinase (UCK1)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CTP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from cytidine, the pathway CTP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine-cytidine kinase-like 1 (UCKL1), Uridine-cytidine kinase 2 (UCK2), Uridine-cytidine kinase 1 (UCK1), Uridine-cytidine kinase, Uridine-cytidine kinase (UCK2), Uridine-cytidine kinase (UCK1)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi105 – 112ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • uridine kinase activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionKinase, Transferase
Biological processHost-virus interaction
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-73614 Pyrimidine salvage
UniPathwayi
UPA00574;UER00637

UPA00579;UER00640

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine-cytidine kinase-like 1 (EC:2.7.1.48)
Gene namesi
Name:UCKL1
Synonyms:URKL1
ORF Names:F538
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000198276.13
HGNCiHGNC:15938 UCKL1
MIMi610866 gene
neXtProtiNX_Q9NWZ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54963
OpenTargetsiENSG00000198276
PharmGKBiPA38058

Chemistry databases

DrugBankiDB01632 Alpha-Phosphoribosylpyrophosphoric Acid
DB04137 Guanosine-5'-Triphosphate
DB03419 Uracil
DB03685 Uridine-5'-Monophosphate

Polymorphism and mutation databases

BioMutaiUCKL1
DMDMi84029407

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001644601 – 548Uridine-cytidine kinase-like 1Add BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei63PhosphoserineBy similarity1
Modified residuei539PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated by RNF19B; which induces proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NWZ5
MaxQBiQ9NWZ5
PaxDbiQ9NWZ5
PeptideAtlasiQ9NWZ5
PRIDEiQ9NWZ5
ProteomicsDBi83002
83003 [Q9NWZ5-2]
83004 [Q9NWZ5-3]
83005 [Q9NWZ5-4]

PTM databases

iPTMnetiQ9NWZ5
PhosphoSitePlusiQ9NWZ5

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000198276 Expressed in 217 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_UCKL1
ExpressionAtlasiQ9NWZ5 baseline and differential
GenevisibleiQ9NWZ5 HS

Organism-specific databases

HPAiHPA004722
HPA004769

Interactioni

Subunit structurei

Interacts with RNF19B.1 Publication
(Microbial infection) Interacts with Epstein-Barr virus/EBV EBNA3.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi120301, 19 interactors
IntActiQ9NWZ5, 5 interactors
STRINGi9606.ENSP00000346155

Structurei

3D structure databases

ProteinModelPortaliQ9NWZ5
SMRiQ9NWZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uridine kinase family.Curated

Phylogenomic databases

eggNOGiKOG4203 Eukaryota
COG0035 LUCA
COG0572 LUCA
GeneTreeiENSGT00390000015696
HOGENOMiHOG000262757
HOVERGENiHBG055146
InParanoidiQ9NWZ5
KOiK00876
OMAiQCDSDLM
OrthoDBiEOG091G04SI
PhylomeDBiQ9NWZ5
TreeFamiTF105902

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
cd02023 UMPK, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000836 PRibTrfase_dom
IPR006083 PRK/URK
IPR029057 PRTase-like
IPR029933 UCKL1
IPR000764 Uridine_kinase-like
PANTHERiPTHR10285:SF68 PTHR10285:SF68, 1 hit
PfamiView protein in Pfam
PF00485 PRK, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR00235 udk, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NWZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPPARADA DPSPTSPPTA RDTPGRQAEK SETACEDRSN AESLDRLLPP 
        60         70         80         90        100
VGTGRSPRKR TTSQCKSEPP LLRTSKRTIY TAGRPPWYNE HGTQSKEAFA 
       110        120        130        140        150
IGLGGGSASG KTTVARMIIE ALDVPWVVLL SMDSFYKVLT EQQQEQAAHN 
       160        170        180        190        200
NFNFDHPDAF DFDLIISTLK KLKQGKSVKV PIYDFTTHSR KKDWKTLYGA 
       210        220        230        240        250
NVIIFEGIMA FADKTLLELL DMKIFVDTDS DIRLVRRLRR DISERGRDIE 
       260        270        280        290        300
GVIKQYNKFV KPSFDQYIQP TMRLADIVVP RGSGNTVAID LIVQHVHSQL 
       310        320        330        340        350
EERELSVRAA LASAHQCHPL PRTLSVLKST PQVRGMHTII RDKETSRDEF 
       360        370        380        390        400
IFYSKRLMRL LIEHALSFLP FQDCVVQTPQ GQDYAGKCYA GKQITGVSIL 
       410        420        430        440        450
RAGETMEPAL RAVCKDVRIG TILIQTNQLT GEPELHYLRL PKDISDDHVI 
       460        470        480        490        500
LMDCTVSTGA AAMMAVRVLL DHDVPEDKIF LLSLLMAEMG VHSVAYAFPR 
       510        520        530        540 
VRIITTAVDK RVNDLFRIIP GIGNFGDRYF GTDAVPDGSD EEEVAYTG
Length:548
Mass (Da):61,141
Last modified:September 13, 2005 - v2
Checksum:i0CD0351A802FE199
GO
Isoform 2 (identifier: Q9NWZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     303-548: RELSVRAALA...SDEEEVAYTG → GCAGLGTPVP...DHRCVHSARR

Note: No experimental confirmation available.
Show »
Length:419
Mass (Da):45,972
Checksum:i1D1F11E75305AD25
GO
Isoform 3 (identifier: Q9NWZ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-395: GKCYAGKQIT → DHRCVHSARR
     396-548: Missing.

Show »
Length:395
Mass (Da):44,568
Checksum:i437D0B1A665CCE30
GO
Isoform 4 (identifier: Q9NWZ5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MAAPPARADADPSPTSPPTARDTPGRQAEKSETACEDR → MSSPPAYPGIRISGCRALGAEGS

Show »
Length:533
Mass (Da):59,466
Checksum:iE578C67A1AB86E15
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JWV1Q5JWV1_HUMAN
Uridine-cytidine kinase-like 1
UCKL1
135Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti290D → N in CAE54074 (PubMed:12199906).Curated1
Sequence conflicti290D → N in BAA91230 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0431711 – 38MAAPP…ACEDR → MSSPPAYPGIRISGCRALGA EGS in isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_021802303 – 548RELSV…VAYTG → GCAGLGTPVPPAAPDAERPE EHAAGTGHAHHHQVRAHLGT GRPRARAPAQLLAPQGQGDQ SRRVHLLLQETDAAAHRARA LLPALSGLRRTDPAGAGLCG QVLCGEADHRCVHSARR in isoform 2. 1 PublicationAdd BLAST246
Alternative sequenceiVSP_025641386 – 395GKCYAGKQIT → DHRCVHSARR in isoform 3. 1 Publication10
Alternative sequenceiVSP_025642396 – 548Missing in isoform 3. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ605558 mRNA Translation: CAE54074.1
AK000524 mRNA Translation: BAA91230.1
AK303688 mRNA Translation: BAH14018.1
AK223220 mRNA Translation: BAD96940.1
AL118506 Genomic DNA No translation available.
BC033078 mRNA Translation: AAH33078.1
CCDSiCCDS13547.1 [Q9NWZ5-1]
CCDS54479.1 [Q9NWZ5-4]
RefSeqiNP_001180308.1, NM_001193379.1 [Q9NWZ5-4]
NP_060329.2, NM_017859.3 [Q9NWZ5-1]
UniGeneiHs.504998
Hs.695829

Genome annotation databases

EnsembliENST00000354216; ENSP00000346155; ENSG00000198276 [Q9NWZ5-1]
ENST00000358711; ENSP00000351546; ENSG00000198276 [Q9NWZ5-2]
ENST00000369908; ENSP00000358924; ENSG00000198276 [Q9NWZ5-4]
GeneIDi54963
KEGGihsa:54963
UCSCiuc010gkn.4 human [Q9NWZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ605558 mRNA Translation: CAE54074.1
AK000524 mRNA Translation: BAA91230.1
AK303688 mRNA Translation: BAH14018.1
AK223220 mRNA Translation: BAD96940.1
AL118506 Genomic DNA No translation available.
BC033078 mRNA Translation: AAH33078.1
CCDSiCCDS13547.1 [Q9NWZ5-1]
CCDS54479.1 [Q9NWZ5-4]
RefSeqiNP_001180308.1, NM_001193379.1 [Q9NWZ5-4]
NP_060329.2, NM_017859.3 [Q9NWZ5-1]
UniGeneiHs.504998
Hs.695829

3D structure databases

ProteinModelPortaliQ9NWZ5
SMRiQ9NWZ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120301, 19 interactors
IntActiQ9NWZ5, 5 interactors
STRINGi9606.ENSP00000346155

Chemistry databases

DrugBankiDB01632 Alpha-Phosphoribosylpyrophosphoric Acid
DB04137 Guanosine-5'-Triphosphate
DB03419 Uracil
DB03685 Uridine-5'-Monophosphate

PTM databases

iPTMnetiQ9NWZ5
PhosphoSitePlusiQ9NWZ5

Polymorphism and mutation databases

BioMutaiUCKL1
DMDMi84029407

Proteomic databases

EPDiQ9NWZ5
MaxQBiQ9NWZ5
PaxDbiQ9NWZ5
PeptideAtlasiQ9NWZ5
PRIDEiQ9NWZ5
ProteomicsDBi83002
83003 [Q9NWZ5-2]
83004 [Q9NWZ5-3]
83005 [Q9NWZ5-4]

Protocols and materials databases

DNASUi54963
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354216; ENSP00000346155; ENSG00000198276 [Q9NWZ5-1]
ENST00000358711; ENSP00000351546; ENSG00000198276 [Q9NWZ5-2]
ENST00000369908; ENSP00000358924; ENSG00000198276 [Q9NWZ5-4]
GeneIDi54963
KEGGihsa:54963
UCSCiuc010gkn.4 human [Q9NWZ5-1]

Organism-specific databases

CTDi54963
DisGeNETi54963
EuPathDBiHostDB:ENSG00000198276.13
GeneCardsiUCKL1
H-InvDBiHIX0027741
HGNCiHGNC:15938 UCKL1
HPAiHPA004722
HPA004769
MIMi610866 gene
neXtProtiNX_Q9NWZ5
OpenTargetsiENSG00000198276
PharmGKBiPA38058
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4203 Eukaryota
COG0035 LUCA
COG0572 LUCA
GeneTreeiENSGT00390000015696
HOGENOMiHOG000262757
HOVERGENiHBG055146
InParanoidiQ9NWZ5
KOiK00876
OMAiQCDSDLM
OrthoDBiEOG091G04SI
PhylomeDBiQ9NWZ5
TreeFamiTF105902

Enzyme and pathway databases

UniPathwayi
UPA00574;UER00637

UPA00579;UER00640

ReactomeiR-HSA-73614 Pyrimidine salvage

Miscellaneous databases

GeneWikiiUCKL1
GenomeRNAii54963
PROiPR:Q9NWZ5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198276 Expressed in 217 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_UCKL1
ExpressionAtlasiQ9NWZ5 baseline and differential
GenevisibleiQ9NWZ5 HS

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
cd02023 UMPK, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000836 PRibTrfase_dom
IPR006083 PRK/URK
IPR029057 PRTase-like
IPR029933 UCKL1
IPR000764 Uridine_kinase-like
PANTHERiPTHR10285:SF68 PTHR10285:SF68, 1 hit
PfamiView protein in Pfam
PF00485 PRK, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR00235 udk, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUCKL1_HUMAN
AccessioniPrimary (citable) accession number: Q9NWZ5
Secondary accession number(s): B7Z8N2
, Q5JWV0, Q70AQ5, Q8N524, Q9H3Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: September 13, 2005
Last modified: November 7, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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