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UniProtKB - Q9NWZ5 (UCKL1_HUMAN)

Entry version 164 (10 Feb 2021)
Sequence version 2 (13 Sep 2005)
Previous versions | rss
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Protein

Uridine-cytidine kinase-like 1

Gene

UCKL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May contribute to UTP accumulation needed for blast transformation and proliferation.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: CTP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes CTP from cytidine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uridine-cytidine kinase 2 (UCK2), Uridine-cytidine kinase (UCK1), Uridine-cytidine kinase, cDNA FLJ57922, highly similar to Uridine-cytidine kinase 2, Uridine-cytidine kinase 1 (UCK1), Uridine/cytidine kinase (UCK1), Uridine/cytidine kinase (UCK2), Uridine-cytidine kinase-like 1 (UCKL1), Uridine/cytidine kinase (UCK1), Uridine/cytidine kinase (UCK1)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CTP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from cytidine, the pathway CTP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine-cytidine kinase 2 (UCK2), Uridine-cytidine kinase (UCK1), Uridine-cytidine kinase, Uridine-cytidine kinase 1 (UCK1), Uridine/cytidine kinase (UCK1), Uridine/cytidine kinase (UCK2), Uridine-cytidine kinase-like 1 (UCKL1), Uridine/cytidine kinase (UCK1), Uridine/cytidine kinase (UCK1)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi105 – 112ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processHost-virus interaction
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NWZ5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-73614, Pyrimidine salvage

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00574;UER00637
UPA00579;UER00640

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uridine-cytidine kinase-like 1 (EC:2.7.1.48)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UCKL1
Synonyms:URKL1
ORF Names:F538
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15938, UCKL1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610866, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NWZ5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198276.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		54963

Open Targets

More...OpenTargetsi		ENSG00000198276

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38058

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NWZ5, Tdark

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01632, 5-O-phosphono-alpha-D-ribofuranosyl diphosphate
DB04137, Guanosine-5'-Triphosphate
DB03419, Uracil
DB03685, Uridine monophosphate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UCKL1

Domain mapping of disease mutations (DMDM)

More...DMDMi		84029407

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001644601 – 548Uridine-cytidine kinase-like 1Add BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei16PhosphoserineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei63PhosphoserineBy similarity1
Modified residuei539PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by RNF19B; which induces proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NWZ5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NWZ5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NWZ5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NWZ5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NWZ5

PeptideAtlas

More...PeptideAtlasi		Q9NWZ5

PRoteomics IDEntifications database

More...PRIDEi		Q9NWZ5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83002 [Q9NWZ5-1]
83003 [Q9NWZ5-2]
83004 [Q9NWZ5-3]
83005 [Q9NWZ5-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NWZ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NWZ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198276, Expressed in right hemisphere of cerebellum and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NWZ5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NWZ5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198276, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RNF19B.

1 Publication

(Microbial infection) Interacts with Epstein-Barr virus/EBV EBNA3.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120301, 21 interactors

Protein interaction database and analysis system

More...IntActi		Q9NWZ5, 16 interactors

Molecular INTeraction database

More...MINTi		Q9NWZ5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000346155

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NWZ5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NWZ5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the uridine kinase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4203, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01010000222379

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021278_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NWZ5

Identification of Orthologs from Complete Genome Data

More...OMAi		QCDSDLM

Database of Orthologous Groups

More...OrthoDBi		929897at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NWZ5

TreeFam database of animal gene trees

More...TreeFami		TF105902

Family and domain databases

Conserved Domains Database

More...CDDi		cd06223, PRTases_typeI, 1 hit
cd02023, UMPK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.2020, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027417, P-loop_NTPase
IPR000836, PRibTrfase_dom
IPR006083, PRK/URK
IPR029057, PRTase-like
IPR029933, UCKL1
IPR000764, Uridine_kinase-like

The PANTHER Classification System

More...PANTHERi		PTHR10285:SF68, PTHR10285:SF68, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00485, PRK, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit
SSF53271, SSF53271, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00235, udk, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NWZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPPARADA DPSPTSPPTA RDTPGRQAEK SETACEDRSN AESLDRLLPP 
        60         70         80         90        100
VGTGRSPRKR TTSQCKSEPP LLRTSKRTIY TAGRPPWYNE HGTQSKEAFA 
       110        120        130        140        150
IGLGGGSASG KTTVARMIIE ALDVPWVVLL SMDSFYKVLT EQQQEQAAHN 
       160        170        180        190        200
NFNFDHPDAF DFDLIISTLK KLKQGKSVKV PIYDFTTHSR KKDWKTLYGA 
       210        220        230        240        250
NVIIFEGIMA FADKTLLELL DMKIFVDTDS DIRLVRRLRR DISERGRDIE 
       260        270        280        290        300
GVIKQYNKFV KPSFDQYIQP TMRLADIVVP RGSGNTVAID LIVQHVHSQL 
       310        320        330        340        350
EERELSVRAA LASAHQCHPL PRTLSVLKST PQVRGMHTII RDKETSRDEF 
       360        370        380        390        400
IFYSKRLMRL LIEHALSFLP FQDCVVQTPQ GQDYAGKCYA GKQITGVSIL 
       410        420        430        440        450
RAGETMEPAL RAVCKDVRIG TILIQTNQLT GEPELHYLRL PKDISDDHVI 
       460        470        480        490        500
LMDCTVSTGA AAMMAVRVLL DHDVPEDKIF LLSLLMAEMG VHSVAYAFPR 
       510        520        530        540 
VRIITTAVDK RVNDLFRIIP GIGNFGDRYF GTDAVPDGSD EEEVAYTG
Length:548
Mass (Da):61,141
Last modified:September 13, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0CD0351A802FE199
GO
Isoform 2 (identifier: Q9NWZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     303-548: RELSVRAALA...SDEEEVAYTG → GCAGLGTPVP...DHRCVHSARR

Show »
Length:419
Mass (Da):45,972
Checksum:i1D1F11E75305AD25
GO
Isoform 3 (identifier: Q9NWZ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-395: GKCYAGKQIT → DHRCVHSARR
     396-548: Missing.

Show »
Length:395
Mass (Da):44,568
Checksum:i437D0B1A665CCE30
GO
Isoform 4 (identifier: Q9NWZ5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MAAPPARADADPSPTSPPTARDTPGRQAEKSETACEDR → MSSPPAYPGIRISGCRALGAEGS

Show »
Length:533
Mass (Da):59,466
Checksum:iE578C67A1AB86E15
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JWV1Q5JWV1_HUMAN
Uridine-cytidine kinase-like 1
UCKL1
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti290D → N in CAE54074 (PubMed:12199906).Curated1
Sequence conflicti290D → N in BAA91230 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0431711 – 38MAAPP…ACEDR → MSSPPAYPGIRISGCRALGA EGS in isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_021802303 – 548RELSV…VAYTG → GCAGLGTPVPPAAPDAERPE EHAAGTGHAHHHQVRAHLGT GRPRARAPAQLLAPQGQGDQ SRRVHLLLQETDAAAHRARA LLPALSGLRRTDPAGAGLCG QVLCGEADHRCVHSARR in isoform 2. 1 PublicationAdd BLAST246
Alternative sequenceiVSP_025641386 – 395GKCYAGKQIT → DHRCVHSARR in isoform 3. 1 Publication10
Alternative sequenceiVSP_025642396 – 548Missing in isoform 3. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ605558 mRNA Translation: CAE54074.1
AK000524 mRNA Translation: BAA91230.1
AK303688 mRNA Translation: BAH14018.1
AK223220 mRNA Translation: BAD96940.1
AL118506 Genomic DNA No translation available.
BC033078 mRNA Translation: AAH33078.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13547.1 [Q9NWZ5-1]
CCDS54479.1 [Q9NWZ5-4]

NCBI Reference Sequences

More...RefSeqi		NP_001180308.1, NM_001193379.1 [Q9NWZ5-4]
NP_060329.2, NM_017859.3 [Q9NWZ5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000354216; ENSP00000346155; ENSG00000198276 [Q9NWZ5-1]
ENST00000358711; ENSP00000351546; ENSG00000198276 [Q9NWZ5-2]
ENST00000369908; ENSP00000358924; ENSG00000198276 [Q9NWZ5-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54963

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54963

UCSC genome browser

More...UCSCi		uc010gkn.4, human [Q9NWZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ605558 mRNA Translation: CAE54074.1
AK000524 mRNA Translation: BAA91230.1
AK303688 mRNA Translation: BAH14018.1
AK223220 mRNA Translation: BAD96940.1
AL118506 Genomic DNA No translation available.
BC033078 mRNA Translation: AAH33078.1
CCDSiCCDS13547.1 [Q9NWZ5-1]
CCDS54479.1 [Q9NWZ5-4]
RefSeqiNP_001180308.1, NM_001193379.1 [Q9NWZ5-4]
NP_060329.2, NM_017859.3 [Q9NWZ5-1]

3D structure databases

SMRiQ9NWZ5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120301, 21 interactors
IntActiQ9NWZ5, 16 interactors
MINTiQ9NWZ5
STRINGi9606.ENSP00000346155

Chemistry databases

DrugBankiDB01632, 5-O-phosphono-alpha-D-ribofuranosyl diphosphate
DB04137, Guanosine-5'-Triphosphate
DB03419, Uracil
DB03685, Uridine monophosphate

PTM databases

iPTMnetiQ9NWZ5
PhosphoSitePlusiQ9NWZ5

Genetic variation databases

BioMutaiUCKL1
DMDMi84029407

Proteomic databases

EPDiQ9NWZ5
jPOSTiQ9NWZ5
MassIVEiQ9NWZ5
MaxQBiQ9NWZ5
PaxDbiQ9NWZ5
PeptideAtlasiQ9NWZ5
PRIDEiQ9NWZ5
ProteomicsDBi83002 [Q9NWZ5-1]
83003 [Q9NWZ5-2]
83004 [Q9NWZ5-3]
83005 [Q9NWZ5-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1482, 130 antibodies

The DNASU plasmid repository

More...DNASUi		54963

Genome annotation databases

EnsembliENST00000354216; ENSP00000346155; ENSG00000198276 [Q9NWZ5-1]
ENST00000358711; ENSP00000351546; ENSG00000198276 [Q9NWZ5-2]
ENST00000369908; ENSP00000358924; ENSG00000198276 [Q9NWZ5-4]
GeneIDi54963
KEGGihsa:54963
UCSCiuc010gkn.4, human [Q9NWZ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54963
DisGeNETi54963

GeneCards: human genes, protein and diseases

More...GeneCardsi		UCKL1
HGNCiHGNC:15938, UCKL1
HPAiENSG00000198276, Low tissue specificity
MIMi610866, gene
neXtProtiNX_Q9NWZ5
OpenTargetsiENSG00000198276
PharmGKBiPA38058
VEuPathDBiHostDB:ENSG00000198276.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4203, Eukaryota
GeneTreeiENSGT01010000222379
HOGENOMiCLU_021278_0_1_1
InParanoidiQ9NWZ5
OMAiQCDSDLM
OrthoDBi929897at2759
PhylomeDBiQ9NWZ5
TreeFamiTF105902

Enzyme and pathway databases

UniPathwayiUPA00574;UER00637
UPA00579;UER00640
PathwayCommonsiQ9NWZ5
ReactomeiR-HSA-73614, Pyrimidine salvage

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54963, 4 hits in 879 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		UCKL1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		UCKL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54963
PharosiQ9NWZ5, Tdark

Protein Ontology

More...PROi		PR:Q9NWZ5
RNActiQ9NWZ5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198276, Expressed in right hemisphere of cerebellum and 229 other tissues
ExpressionAtlasiQ9NWZ5, baseline and differential
GenevisibleiQ9NWZ5, HS

Family and domain databases

CDDicd06223, PRTases_typeI, 1 hit
cd02023, UMPK, 1 hit
Gene3Di3.40.50.2020, 1 hit
InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR000836, PRibTrfase_dom
IPR006083, PRK/URK
IPR029057, PRTase-like
IPR029933, UCKL1
IPR000764, Uridine_kinase-like
PANTHERiPTHR10285:SF68, PTHR10285:SF68, 1 hit
PfamiView protein in Pfam
PF00485, PRK, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF53271, SSF53271, 1 hit
TIGRFAMsiTIGR00235, udk, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUCKL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NWZ5
Secondary accession number(s): B7Z8N2
, Q5JWV0, Q70AQ5, Q8N524, Q9H3Z2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: September 13, 2005
Last modified: February 10, 2021
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families
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