UniProtKB - Q9NWZ5 (UCKL1_HUMAN)
Protein
Uridine-cytidine kinase-like 1
Gene
UCKL1
Organism
Homo sapiens (Human)
Status
Functioni
May contribute to UTP accumulation needed for blast transformation and proliferation.1 Publication
Catalytic activityi
: CTP biosynthesis via salvage pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes CTP from cytidine.Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- Uridine-cytidine kinase 2 (UCK2), Uridine-cytidine kinase (UCK1), Uridine-cytidine kinase, cDNA FLJ57922, highly similar to Uridine-cytidine kinase 2, Uridine-cytidine kinase 1 (UCK1), Uridine/cytidine kinase (UCK1), Uridine/cytidine kinase (UCK2), Uridine-cytidine kinase-like 1 (UCKL1), Uridine/cytidine kinase (UCK1), Uridine/cytidine kinase (UCK1)
- no protein annotated in this organism
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from cytidine, the pathway CTP biosynthesis via salvage pathway and in Pyrimidine metabolism.
Pathwayi: UMP biosynthesis via salvage pathway
This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.Proteins known to be involved in this subpathway in this organism are:
- Uridine-cytidine kinase 2 (UCK2), Uridine-cytidine kinase (UCK1), Uridine-cytidine kinase, Uridine-cytidine kinase 1 (UCK1), Uridine/cytidine kinase (UCK1), Uridine/cytidine kinase (UCK2), Uridine-cytidine kinase-like 1 (UCKL1), Uridine/cytidine kinase (UCK1), Uridine/cytidine kinase (UCK1)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 105 – 112 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- kinase activity Source: GO_Central
- uridine kinase activity Source: Reactome
GO - Biological processi
- CTP salvage Source: UniProtKB-UniPathway
- pyrimidine nucleoside salvage Source: Reactome
- UMP salvage Source: UniProtKB-UniPathway
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Host-virus interaction |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9NWZ5 |
Reactomei | R-HSA-73614, Pyrimidine salvage |
UniPathwayi | UPA00574;UER00637 UPA00579;UER00640 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:UCKL1 Synonyms:URKL1 ORF Names:F538 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15938, UCKL1 |
MIMi | 610866, gene |
neXtProti | NX_Q9NWZ5 |
VEuPathDBi | HostDB:ENSG00000198276.13 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 54963 |
OpenTargetsi | ENSG00000198276 |
PharmGKBi | PA38058 |
Miscellaneous databases
Pharosi | Q9NWZ5, Tdark |
Chemistry databases
DrugBanki | DB01632, 5-O-phosphono-alpha-D-ribofuranosyl diphosphate DB04137, Guanosine-5'-Triphosphate DB03419, Uracil DB03685, Uridine monophosphate |
Genetic variation databases
BioMutai | UCKL1 |
DMDMi | 84029407 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000164460 | 1 – 548 | Uridine-cytidine kinase-like 1Add BLAST | 548 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 16 | PhosphoserineCombined sources | 1 | |
Modified residuei | 56 | PhosphoserineCombined sources | 1 | |
Modified residuei | 63 | PhosphoserineBy similarity | 1 | |
Modified residuei | 539 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Ubiquitinated by RNF19B; which induces proteasomal degradation.1 Publication
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9NWZ5 |
jPOSTi | Q9NWZ5 |
MassIVEi | Q9NWZ5 |
MaxQBi | Q9NWZ5 |
PaxDbi | Q9NWZ5 |
PeptideAtlasi | Q9NWZ5 |
PRIDEi | Q9NWZ5 |
ProteomicsDBi | 83002 [Q9NWZ5-1] 83003 [Q9NWZ5-2] 83004 [Q9NWZ5-3] 83005 [Q9NWZ5-4] |
PTM databases
iPTMneti | Q9NWZ5 |
PhosphoSitePlusi | Q9NWZ5 |
Expressioni
Tissue specificityi
Ubiquitous.1 Publication
Gene expression databases
Bgeei | ENSG00000198276, Expressed in right hemisphere of cerebellum and 229 other tissues |
ExpressionAtlasi | Q9NWZ5, baseline and differential |
Genevisiblei | Q9NWZ5, HS |
Organism-specific databases
HPAi | ENSG00000198276, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RNF19B.
1 Publication(Microbial infection) Interacts with Epstein-Barr virus/EBV EBNA3.
1 PublicationBinary interactionsi
Hide detailsQ9NWZ5
With | #Exp. | IntAct |
---|---|---|
RNF19B [Q6ZMZ0] | 4 | EBI-2466660,EBI-2466594 |
EBNA3 [P12977] from Epstein-Barr virus (strain B95-8). | 4 | EBI-2466660,EBI-993115 |
Protein-protein interaction databases
BioGRIDi | 120301, 21 interactors |
IntActi | Q9NWZ5, 16 interactors |
MINTi | Q9NWZ5 |
STRINGi | 9606.ENSP00000346155 |
Miscellaneous databases
RNActi | Q9NWZ5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the uridine kinase family.Curated
Phylogenomic databases
eggNOGi | KOG4203, Eukaryota |
GeneTreei | ENSGT01010000222379 |
HOGENOMi | CLU_021278_0_1_1 |
InParanoidi | Q9NWZ5 |
OMAi | QCDSDLM |
OrthoDBi | 929897at2759 |
PhylomeDBi | Q9NWZ5 |
TreeFami | TF105902 |
Family and domain databases
CDDi | cd06223, PRTases_typeI, 1 hit cd02023, UMPK, 1 hit |
Gene3Di | 3.40.50.2020, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR000836, PRibTrfase_dom IPR006083, PRK/URK IPR029057, PRTase-like IPR029933, UCKL1 IPR000764, Uridine_kinase-like |
PANTHERi | PTHR10285:SF68, PTHR10285:SF68, 1 hit |
Pfami | View protein in Pfam PF00485, PRK, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF53271, SSF53271, 1 hit |
TIGRFAMsi | TIGR00235, udk, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NWZ5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAPPARADA DPSPTSPPTA RDTPGRQAEK SETACEDRSN AESLDRLLPP
60 70 80 90 100
VGTGRSPRKR TTSQCKSEPP LLRTSKRTIY TAGRPPWYNE HGTQSKEAFA
110 120 130 140 150
IGLGGGSASG KTTVARMIIE ALDVPWVVLL SMDSFYKVLT EQQQEQAAHN
160 170 180 190 200
NFNFDHPDAF DFDLIISTLK KLKQGKSVKV PIYDFTTHSR KKDWKTLYGA
210 220 230 240 250
NVIIFEGIMA FADKTLLELL DMKIFVDTDS DIRLVRRLRR DISERGRDIE
260 270 280 290 300
GVIKQYNKFV KPSFDQYIQP TMRLADIVVP RGSGNTVAID LIVQHVHSQL
310 320 330 340 350
EERELSVRAA LASAHQCHPL PRTLSVLKST PQVRGMHTII RDKETSRDEF
360 370 380 390 400
IFYSKRLMRL LIEHALSFLP FQDCVVQTPQ GQDYAGKCYA GKQITGVSIL
410 420 430 440 450
RAGETMEPAL RAVCKDVRIG TILIQTNQLT GEPELHYLRL PKDISDDHVI
460 470 480 490 500
LMDCTVSTGA AAMMAVRVLL DHDVPEDKIF LLSLLMAEMG VHSVAYAFPR
510 520 530 540
VRIITTAVDK RVNDLFRIIP GIGNFGDRYF GTDAVPDGSD EEEVAYTG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5JWV1 | Q5JWV1_HUMAN | Uridine-cytidine kinase-like 1 | UCKL1 | 135 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 290 | D → N in CAE54074 (PubMed:12199906).Curated | 1 | |
Sequence conflicti | 290 | D → N in BAA91230 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043171 | 1 – 38 | MAAPP…ACEDR → MSSPPAYPGIRISGCRALGA EGS in isoform 4. 1 PublicationAdd BLAST | 38 | |
Alternative sequenceiVSP_021802 | 303 – 548 | RELSV…VAYTG → GCAGLGTPVPPAAPDAERPE EHAAGTGHAHHHQVRAHLGT GRPRARAPAQLLAPQGQGDQ SRRVHLLLQETDAAAHRARA LLPALSGLRRTDPAGAGLCG QVLCGEADHRCVHSARR in isoform 2. 1 PublicationAdd BLAST | 246 | |
Alternative sequenceiVSP_025641 | 386 – 395 | GKCYAGKQIT → DHRCVHSARR in isoform 3. 1 Publication | 10 | |
Alternative sequenceiVSP_025642 | 396 – 548 | Missing in isoform 3. 1 PublicationAdd BLAST | 153 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ605558 mRNA Translation: CAE54074.1 AK000524 mRNA Translation: BAA91230.1 AK303688 mRNA Translation: BAH14018.1 AK223220 mRNA Translation: BAD96940.1 AL118506 Genomic DNA No translation available. BC033078 mRNA Translation: AAH33078.1 |
CCDSi | CCDS13547.1 [Q9NWZ5-1] CCDS54479.1 [Q9NWZ5-4] |
RefSeqi | NP_001180308.1, NM_001193379.1 [Q9NWZ5-4] NP_060329.2, NM_017859.3 [Q9NWZ5-1] |
Genome annotation databases
Ensembli | ENST00000354216; ENSP00000346155; ENSG00000198276 [Q9NWZ5-1] ENST00000358711; ENSP00000351546; ENSG00000198276 [Q9NWZ5-2] ENST00000369908; ENSP00000358924; ENSG00000198276 [Q9NWZ5-4] |
GeneIDi | 54963 |
KEGGi | hsa:54963 |
UCSCi | uc010gkn.4, human [Q9NWZ5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ605558 mRNA Translation: CAE54074.1 AK000524 mRNA Translation: BAA91230.1 AK303688 mRNA Translation: BAH14018.1 AK223220 mRNA Translation: BAD96940.1 AL118506 Genomic DNA No translation available. BC033078 mRNA Translation: AAH33078.1 |
CCDSi | CCDS13547.1 [Q9NWZ5-1] CCDS54479.1 [Q9NWZ5-4] |
RefSeqi | NP_001180308.1, NM_001193379.1 [Q9NWZ5-4] NP_060329.2, NM_017859.3 [Q9NWZ5-1] |
3D structure databases
SMRi | Q9NWZ5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120301, 21 interactors |
IntActi | Q9NWZ5, 16 interactors |
MINTi | Q9NWZ5 |
STRINGi | 9606.ENSP00000346155 |
Chemistry databases
DrugBanki | DB01632, 5-O-phosphono-alpha-D-ribofuranosyl diphosphate DB04137, Guanosine-5'-Triphosphate DB03419, Uracil DB03685, Uridine monophosphate |
PTM databases
iPTMneti | Q9NWZ5 |
PhosphoSitePlusi | Q9NWZ5 |
Genetic variation databases
BioMutai | UCKL1 |
DMDMi | 84029407 |
Proteomic databases
EPDi | Q9NWZ5 |
jPOSTi | Q9NWZ5 |
MassIVEi | Q9NWZ5 |
MaxQBi | Q9NWZ5 |
PaxDbi | Q9NWZ5 |
PeptideAtlasi | Q9NWZ5 |
PRIDEi | Q9NWZ5 |
ProteomicsDBi | 83002 [Q9NWZ5-1] 83003 [Q9NWZ5-2] 83004 [Q9NWZ5-3] 83005 [Q9NWZ5-4] |
Protocols and materials databases
Antibodypediai | 1482, 130 antibodies |
DNASUi | 54963 |
Genome annotation databases
Ensembli | ENST00000354216; ENSP00000346155; ENSG00000198276 [Q9NWZ5-1] ENST00000358711; ENSP00000351546; ENSG00000198276 [Q9NWZ5-2] ENST00000369908; ENSP00000358924; ENSG00000198276 [Q9NWZ5-4] |
GeneIDi | 54963 |
KEGGi | hsa:54963 |
UCSCi | uc010gkn.4, human [Q9NWZ5-1] |
Organism-specific databases
CTDi | 54963 |
DisGeNETi | 54963 |
GeneCardsi | UCKL1 |
HGNCi | HGNC:15938, UCKL1 |
HPAi | ENSG00000198276, Low tissue specificity |
MIMi | 610866, gene |
neXtProti | NX_Q9NWZ5 |
OpenTargetsi | ENSG00000198276 |
PharmGKBi | PA38058 |
VEuPathDBi | HostDB:ENSG00000198276.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4203, Eukaryota |
GeneTreei | ENSGT01010000222379 |
HOGENOMi | CLU_021278_0_1_1 |
InParanoidi | Q9NWZ5 |
OMAi | QCDSDLM |
OrthoDBi | 929897at2759 |
PhylomeDBi | Q9NWZ5 |
TreeFami | TF105902 |
Enzyme and pathway databases
UniPathwayi | UPA00574;UER00637 UPA00579;UER00640 |
PathwayCommonsi | Q9NWZ5 |
Reactomei | R-HSA-73614, Pyrimidine salvage |
Miscellaneous databases
BioGRID-ORCSi | 54963, 4 hits in 879 CRISPR screens |
ChiTaRSi | UCKL1, human |
GeneWikii | UCKL1 |
GenomeRNAii | 54963 |
Pharosi | Q9NWZ5, Tdark |
PROi | PR:Q9NWZ5 |
RNActi | Q9NWZ5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198276, Expressed in right hemisphere of cerebellum and 229 other tissues |
ExpressionAtlasi | Q9NWZ5, baseline and differential |
Genevisiblei | Q9NWZ5, HS |
Family and domain databases
CDDi | cd06223, PRTases_typeI, 1 hit cd02023, UMPK, 1 hit |
Gene3Di | 3.40.50.2020, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR000836, PRibTrfase_dom IPR006083, PRK/URK IPR029057, PRTase-like IPR029933, UCKL1 IPR000764, Uridine_kinase-like |
PANTHERi | PTHR10285:SF68, PTHR10285:SF68, 1 hit |
Pfami | View protein in Pfam PF00485, PRK, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF53271, SSF53271, 1 hit |
TIGRFAMsi | TIGR00235, udk, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UCKL1_HUMAN | |
Accessioni | Q9NWZ5Primary (citable) accession number: Q9NWZ5 Secondary accession number(s): B7Z8N2 Q9H3Z2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | September 13, 2005 | |
Last modified: | February 10, 2021 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families