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Entry version 199 (29 Sep 2021)
Sequence version 1 (01 Oct 2000)
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Protein

Interleukin-1 receptor-associated kinase 4

Gene

IRAK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374).

Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.

9 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=650 µM for ATP (at pH 7.5)1 Publication
  2. KM=1100 µM for substrate (at pH 7.5)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei213ATP1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei311Proton acceptorPROSITE-ProRule annotation1
Binding sitei329ATP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi192 – 200ATPPROSITE-ProRule annotation9
Nucleotide bindingi313 – 316ATP4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processImmunity, Innate immunity
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NWZ3

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-5603037, IRAK4 deficiency (TLR5)
R-HSA-5603041, IRAK4 deficiency (TLR2/4)
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9020702, Interleukin-1 signaling
R-HSA-975110, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-HSA-975138, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155, MyD88 dependent cascade initiated on endosome
R-HSA-975871, MyD88 cascade initiated on plasma membrane

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9NWZ3

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q9NWZ3

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NWZ3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-1 receptor-associated kinase 4 (EC:2.7.11.1)
Short name:
IRAK-4
Alternative name(s):
Renal carcinoma antigen NY-REN-64
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IRAK4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:17967, IRAK4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606883, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NWZ3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000198001

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency 67 (IMD67)7 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive primary immunodeficiency characterized by recurrent, life-threatening systemic and invasive bacterial infections beginning in infancy or early childhood.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07288812R → C in IMD67; no effect on inhibition of NF-kappa-B complex activation; loss of interaction with MYD88; decreases protein stability. 2 PublicationsCorresponds to variant dbSNP:rs377584435EnsemblClinVar.1
Natural variantiVAR_072892298G → D in IMD67; decreases inhibition of NF-kappa-B complex activation; impairs neutrophil migration and phagocytosis. 3 PublicationsCorresponds to variant dbSNP:rs568782766Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi213K → A: Loss of kinase activity. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...
DisGeNETi
51135

MalaCards human disease database

More...
MalaCardsi
IRAK4
MIMi607676, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000198001

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
70592, Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134914577

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9NWZ3, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3778

Drug and drug target database

More...
DrugBanki
DB08590, 1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE
DB12010, Fostamatinib

DrugCentral

More...
DrugCentrali
Q9NWZ3

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2045

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
IRAK4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50401181

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000860351 – 460Interleukin-1 receptor-associated kinase 4Add BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei34N6-acetyllysineCombined sources1
Modified residuei342Phosphothreonine2 Publications1
Modified residuei345Phosphothreonine3 Publications1
Modified residuei346Phosphoserine2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NWZ3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NWZ3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NWZ3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NWZ3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NWZ3

PeptideAtlas

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PeptideAtlasi
Q9NWZ3

PRoteomics IDEntifications database

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PRIDEi
Q9NWZ3

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
83000 [Q9NWZ3-1]
83001 [Q9NWZ3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NWZ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NWZ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198001, Expressed in monocyte and 196 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NWZ3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NWZ3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000198001, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome (PubMed:16951688, PubMed:24316379). Once phosphorylated, IRAK4 dissociates from the receptor complex and then associates with the TNF receptor-associated factor 6 (TRAF6), IRAK1, and PELI1; this intermediate complex is required for subsequent NF-kappa-B activation (PubMed:11960013, PubMed:12496252, PubMed:16951688). Direct binding of SMAD6 to PELI1 prevents complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression (PubMed:16951688).

Interacts with IL1RL1 (PubMed:16286016).

Interacts (when phosphorylated) with IRAK1 (PubMed:33238146). May interact (when phosphorylated) with IRAK3 (PubMed:33238146).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
119322, 30 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9NWZ3

Database of interacting proteins

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DIPi
DIP-31351N

Protein interaction database and analysis system

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IntActi
Q9NWZ3, 18 interactors

Molecular INTeraction database

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MINTi
Q9NWZ3

STRING: functional protein association networks

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STRINGi
9606.ENSP00000390651

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9NWZ3

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q9NWZ3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1460
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NWZ3

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NWZ3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 104DeathAdd BLAST85
Domaini186 – 454Protein kinasePROSITE-ProRule annotationAdd BLAST269

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1187, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000158792

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_000288_21_4_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NWZ3

Identification of Orthologs from Complete Genome Data

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OMAi
GYVNNRT

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NWZ3

TreeFam database of animal gene trees

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TreeFami
TF351380

Family and domain databases

Conserved Domains Database

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CDDi
cd08793, Death_IRAK4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.533.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR017428, IRAK4
IPR037970, IRAK4_Death
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR001245, Ser-Thr/Tyr_kinase_cat_dom

Pfam protein domain database

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Pfami
View protein in Pfam
PF07714, PK_Tyr_Ser-Thr, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF038189, IRAK4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47986, SSF47986, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NWZ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNKPITPSTY VRCLNVGLIR KLSDFIDPQE GWKKLAVAIK KPSGDDRYNQ
60 70 80 90 100
FHIRRFEALL QTGKSPTSEL LFDWGTTNCT VGDLVDLLIQ NEFFAPASLL
110 120 130 140 150
LPDAVPKTAN TLPSKEAITV QQKQMPFCDK DRTLMTPVQN LEQSYMPPDS
160 170 180 190 200
SSPENKSLEV SDTRFHSFSF YELKNVTNNF DERPISVGGN KMGEGGFGVV
210 220 230 240 250
YKGYVNNTTV AVKKLAAMVD ITTEELKQQF DQEIKVMAKC QHENLVELLG
260 270 280 290 300
FSSDGDDLCL VYVYMPNGSL LDRLSCLDGT PPLSWHMRCK IAQGAANGIN
310 320 330 340 350
FLHENHHIHR DIKSANILLD EAFTAKISDF GLARASEKFA QTVMTSRIVG
360 370 380 390 400
TTAYMAPEAL RGEITPKSDI YSFGVVLLEI ITGLPAVDEH REPQLLLDIK
410 420 430 440 450
EEIEDEEKTI EDYIDKKMND ADSTSVEAMY SVASQCLHEK KNKRPDIKKV
460
QQLLQEMTAS
Length:460
Mass (Da):51,530
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C8156ADF25FF81E
GO
Isoform 2 (identifier: Q9NWZ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: Missing.

Show »
Length:336
Mass (Da):37,674
Checksum:i6608D68A2EE4138C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VVZ1F8VVZ1_HUMAN
Interleukin-1 receptor-associated k...
IRAK4
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VR40F8VR40_HUMAN
Interleukin-1 receptor-associated k...
IRAK4
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VW24F8VW24_HUMAN
Interleukin-1 receptor-associated k...
IRAK4
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J2F4A0A0R4J2F4_HUMAN
Interleukin-1 receptor-associated k...
IRAK4
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81V → A in AAM15772 (PubMed:11960013).Curated1
Sequence conflicti432V → G in AAD42884 (PubMed:10508479).Curated1
Sequence conflicti437L → R in AAD42884 (PubMed:10508479).Curated1
Sequence conflicti444R → S in AAD42884 (PubMed:10508479).Curated1
Sequence conflicti451Q → H in AAD42884 (PubMed:10508479).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0405885I → V No effect on inhibition of NF-kappa-B activation; no effect on interaction with MYD88. 2 PublicationsCorresponds to variant dbSNP:rs56312115EnsemblClinVar.1
Natural variantiVAR_07288812R → C in IMD67; no effect on inhibition of NF-kappa-B complex activation; loss of interaction with MYD88; decreases protein stability. 2 PublicationsCorresponds to variant dbSNP:rs377584435EnsemblClinVar.1
Natural variantiVAR_07288920R → W Increases inhibition of NF-kappa-B complex activation; decreases interaction with MYD88; decreases protein stability. 1 PublicationCorresponds to variant dbSNP:rs143625818Ensembl.1
Natural variantiVAR_07289026I → T No effect on inhibition of NF-kappa-B activation; no effect on interaction with MYD88. 1 PublicationCorresponds to variant dbSNP:rs138116867Ensembl.1
Natural variantiVAR_07289139I → V No effect on inhibition of NF-kappa-B activation; no effect on interaction with MYD88. 1 PublicationCorresponds to variant dbSNP:rs113588409Ensembl.1
Natural variantiVAR_01935498S → R No effect on inhibition of NF-kappa-B activation; no effect on interaction with MYD88. 2 PublicationsCorresponds to variant dbSNP:rs4251469Ensembl.1
Natural variantiVAR_072892298G → D in IMD67; decreases inhibition of NF-kappa-B complex activation; impairs neutrophil migration and phagocytosis. 3 PublicationsCorresponds to variant dbSNP:rs568782766Ensembl.1
Natural variantiVAR_040589355M → V1 PublicationCorresponds to variant dbSNP:rs142376871Ensembl.1
Natural variantiVAR_019355390H → R1 PublicationCorresponds to variant dbSNP:rs4251583EnsemblClinVar.1
Natural variantiVAR_040590391R → H2 PublicationsCorresponds to variant dbSNP:rs55944915EnsemblClinVar.1
Natural variantiVAR_019356428A → T2 PublicationsCorresponds to variant dbSNP:rs4251545EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0415561 – 124Missing in isoform 2. 2 PublicationsAdd BLAST124

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF445802 mRNA Translation: AAM15772.1
AF155118 mRNA Translation: AAD42884.1
AY340964 mRNA Translation: AAR02360.1
AY340965 mRNA Translation: AAR02361.1
AY340966 mRNA Translation: AAR02362.1
AY340967 mRNA Translation: AAR02363.1
AK000528 mRNA Translation: BAA91232.1
AK299944 mRNA Translation: BAG61774.1
AY186092 Genomic DNA Translation: AAN75440.1
AC093012 Genomic DNA No translation available.
BC013316 mRNA Translation: AAH13316.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44862.1 [Q9NWZ3-2]
CCDS8744.1 [Q9NWZ3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001107654.1, NM_001114182.2 [Q9NWZ3-1]
NP_001138728.1, NM_001145256.1 [Q9NWZ3-2]
NP_001138729.1, NM_001145257.1 [Q9NWZ3-2]
NP_001138730.1, NM_001145258.1 [Q9NWZ3-2]
NP_057207.2, NM_016123.3 [Q9NWZ3-1]
XP_005269000.1, XM_005268943.3 [Q9NWZ3-1]
XP_005269001.1, XM_005268944.4 [Q9NWZ3-1]
XP_005269002.1, XM_005268945.4 [Q9NWZ3-1]
XP_005269004.1, XM_005268947.4
XP_005269005.1, XM_005268948.2
XP_005269006.1, XM_005268949.2 [Q9NWZ3-2]
XP_006719501.1, XM_006719438.3 [Q9NWZ3-1]
XP_006719502.1, XM_006719439.2
XP_011536733.1, XM_011538431.2 [Q9NWZ3-1]
XP_011536734.1, XM_011538432.1
XP_011536735.1, XM_011538433.2 [Q9NWZ3-1]
XP_016874879.1, XM_017019390.1 [Q9NWZ3-1]
XP_016874880.1, XM_017019391.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000431837; ENSP00000390327; ENSG00000198001 [Q9NWZ3-2]
ENST00000440781; ENSP00000408734; ENSG00000198001 [Q9NWZ3-2]
ENST00000551736; ENSP00000446490; ENSG00000198001 [Q9NWZ3-1]
ENST00000613694; ENSP00000479889; ENSG00000198001 [Q9NWZ3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51135

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51135

UCSC genome browser

More...
UCSCi
uc001rnt.4, human [Q9NWZ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

IRAK4base

IRAK4 mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF445802 mRNA Translation: AAM15772.1
AF155118 mRNA Translation: AAD42884.1
AY340964 mRNA Translation: AAR02360.1
AY340965 mRNA Translation: AAR02361.1
AY340966 mRNA Translation: AAR02362.1
AY340967 mRNA Translation: AAR02363.1
AK000528 mRNA Translation: BAA91232.1
AK299944 mRNA Translation: BAG61774.1
AY186092 Genomic DNA Translation: AAN75440.1
AC093012 Genomic DNA No translation available.
BC013316 mRNA Translation: AAH13316.1
CCDSiCCDS44862.1 [Q9NWZ3-2]
CCDS8744.1 [Q9NWZ3-1]
RefSeqiNP_001107654.1, NM_001114182.2 [Q9NWZ3-1]
NP_001138728.1, NM_001145256.1 [Q9NWZ3-2]
NP_001138729.1, NM_001145257.1 [Q9NWZ3-2]
NP_001138730.1, NM_001145258.1 [Q9NWZ3-2]
NP_057207.2, NM_016123.3 [Q9NWZ3-1]
XP_005269000.1, XM_005268943.3 [Q9NWZ3-1]
XP_005269001.1, XM_005268944.4 [Q9NWZ3-1]
XP_005269002.1, XM_005268945.4 [Q9NWZ3-1]
XP_005269004.1, XM_005268947.4
XP_005269005.1, XM_005268948.2
XP_005269006.1, XM_005268949.2 [Q9NWZ3-2]
XP_006719501.1, XM_006719438.3 [Q9NWZ3-1]
XP_006719502.1, XM_006719439.2
XP_011536733.1, XM_011538431.2 [Q9NWZ3-1]
XP_011536734.1, XM_011538432.1
XP_011536735.1, XM_011538433.2 [Q9NWZ3-1]
XP_016874879.1, XM_017019390.1 [Q9NWZ3-1]
XP_016874880.1, XM_017019391.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NRUX-ray2.00A/B/C/D154-460[»]
2NRYX-ray2.15A/B/C/D154-460[»]
2O8YX-ray2.40A/B163-460[»]
2OIBX-ray2.00A/B/C/D160-460[»]
2OICX-ray2.40A/B/C/D160-460[»]
2OIDX-ray2.30A/B/C/D160-460[»]
3MOPX-ray3.40G/H/I/J4-106[»]
4RMZX-ray2.20A/B154-460[»]
4U97X-ray2.65A/B154-460[»]
4U9AX-ray2.80A/B154-460[»]
4XS2X-ray2.73A/B/C/D160-460[»]
4Y73X-ray2.14A/B/C/D160-460[»]
4YO6X-ray2.32A/B/C/D160-460[»]
4YP8X-ray2.64A/B/C/D160-460[»]
4ZTLX-ray2.39A/B/C/D160-460[»]
4ZTMX-ray2.66A/B/C/D160-460[»]
4ZTNX-ray2.23A/B/C/D160-460[»]
5K72X-ray2.22A/B/C/D160-460[»]
5K75X-ray2.03A/B/C/D160-460[»]
5K76X-ray2.74A/B160-460[»]
5K7GX-ray2.23A/B/C/D160-460[»]
5K7IX-ray2.31A/B160-460[»]
5KX7X-ray2.80A/B160-460[»]
5KX8X-ray2.67A/B/C/D160-460[»]
5T1SX-ray2.30A/B/C/D160-460[»]
5T1TX-ray2.34A/B/C/D160-460[»]
5UIQX-ray2.64A/B/C/D154-460[»]
5UIRX-ray2.64A/B154-460[»]
5UISX-ray2.50A/B/C/D154-460[»]
5UITX-ray1.84A/B154-460[»]
5UIUX-ray2.02A/B154-460[»]
5W84X-ray2.90A/B160-460[»]
5W85X-ray2.25A/B160-460[»]
6EG9X-ray2.41A/B154-460[»]
6EGAX-ray2.51A/B154-460[»]
6EGDX-ray2.10A/D164-460[»]
6EGEX-ray1.40A/D164-460[»]
6EGFX-ray2.61B164-460[»]
6F3DX-ray2.38A/B164-458[»]
6F3EX-ray2.67A/B164-458[»]
6F3GX-ray2.37A/B164-458[»]
6F3IX-ray2.14A/B154-460[»]
6LXYX-ray2.19A/B/D/E160-460[»]
6MOMX-ray2.10A/B/C/D160-460[»]
6N8GX-ray2.00A/B/C/D164-460[»]
6O8UX-ray1.80A/B/C/D160-460[»]
6O94X-ray1.98A/B/C/D160-460[»]
6O95X-ray1.77A/B/C/D160-460[»]
6O9DX-ray2.51A/B/C/D160-460[»]
6RFIX-ray2.31A/B154-460[»]
6RFJX-ray2.61A/B154-460[»]
6THWX-ray2.44A/B154-460[»]
6THXX-ray1.99A/B154-460[»]
6THZX-ray2.38A/B154-460[»]
6TI8X-ray2.32A/B/C/D154-460[»]
6TIAX-ray2.52A/B154-460[»]
6UYAX-ray1.74A/B/C/D160-460[»]
6VQLX-ray2.07A/B/C/D160-460[»]
7C2VX-ray2.44A/B/C/D162-460[»]
7C2WX-ray3.20A/B/C/D163-458[»]
SMRiQ9NWZ3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119322, 30 interactors
CORUMiQ9NWZ3
DIPiDIP-31351N
IntActiQ9NWZ3, 18 interactors
MINTiQ9NWZ3
STRINGi9606.ENSP00000390651

Chemistry databases

BindingDBiQ9NWZ3
ChEMBLiCHEMBL3778
DrugBankiDB08590, 1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE
DB12010, Fostamatinib
DrugCentraliQ9NWZ3
GuidetoPHARMACOLOGYi2045

PTM databases

iPTMnetiQ9NWZ3
PhosphoSitePlusiQ9NWZ3

Genetic variation databases

BioMutaiIRAK4
DMDMi50401181

Proteomic databases

EPDiQ9NWZ3
jPOSTiQ9NWZ3
MassIVEiQ9NWZ3
MaxQBiQ9NWZ3
PaxDbiQ9NWZ3
PeptideAtlasiQ9NWZ3
PRIDEiQ9NWZ3
ProteomicsDBi83000 [Q9NWZ3-1]
83001 [Q9NWZ3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
696, 771 antibodies

The DNASU plasmid repository

More...
DNASUi
51135

Genome annotation databases

EnsembliENST00000431837; ENSP00000390327; ENSG00000198001 [Q9NWZ3-2]
ENST00000440781; ENSP00000408734; ENSG00000198001 [Q9NWZ3-2]
ENST00000551736; ENSP00000446490; ENSG00000198001 [Q9NWZ3-1]
ENST00000613694; ENSP00000479889; ENSG00000198001 [Q9NWZ3-1]
GeneIDi51135
KEGGihsa:51135
UCSCiuc001rnt.4, human [Q9NWZ3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51135
DisGeNETi51135

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IRAK4
HGNCiHGNC:17967, IRAK4
HPAiENSG00000198001, Low tissue specificity
MalaCardsiIRAK4
MIMi606883, gene
607676, phenotype
neXtProtiNX_Q9NWZ3
OpenTargetsiENSG00000198001
Orphaneti70592, Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency
PharmGKBiPA134914577
VEuPathDBiHostDB:ENSG00000198001

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1187, Eukaryota
GeneTreeiENSGT00940000158792
HOGENOMiCLU_000288_21_4_1
InParanoidiQ9NWZ3
OMAiGYVNNRT
PhylomeDBiQ9NWZ3
TreeFamiTF351380

Enzyme and pathway databases

PathwayCommonsiQ9NWZ3
ReactomeiR-HSA-1257604, PIP3 activates AKT signaling
R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-5603037, IRAK4 deficiency (TLR5)
R-HSA-5603041, IRAK4 deficiency (TLR2/4)
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9020702, Interleukin-1 signaling
R-HSA-975110, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-HSA-975138, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155, MyD88 dependent cascade initiated on endosome
R-HSA-975871, MyD88 cascade initiated on plasma membrane
SABIO-RKiQ9NWZ3
SignaLinkiQ9NWZ3
SIGNORiQ9NWZ3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
51135, 14 hits in 1016 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IRAK4, human
EvolutionaryTraceiQ9NWZ3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51135
PharosiQ9NWZ3, Tchem

Protein Ontology

More...
PROi
PR:Q9NWZ3
RNActiQ9NWZ3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198001, Expressed in monocyte and 196 other tissues
ExpressionAtlasiQ9NWZ3, baseline and differential
GenevisibleiQ9NWZ3, HS

Family and domain databases

CDDicd08793, Death_IRAK4, 1 hit
Gene3Di1.10.533.10, 1 hit
InterProiView protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR017428, IRAK4
IPR037970, IRAK4_Death
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714, PK_Tyr_Ser-Thr, 1 hit
PIRSFiPIRSF038189, IRAK4, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIRAK4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NWZ3
Secondary accession number(s): Q69FE1, Q8TDF7, Q9Y589
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2000
Last modified: September 29, 2021
This is version 199 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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