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Protein

Interleukin-1 receptor-associated kinase 4

Gene

IRAK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.9 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=650 µM for ATP (at pH 7.5)1 Publication
  2. KM=1100 µM for substrate (at pH 7.5)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei213ATP1
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei311Proton acceptorPROSITE-ProRule annotation1
    Binding sitei329ATP1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi192 – 200ATPPROSITE-ProRule annotation9
    Nucleotide bindingi313 – 316ATP4

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Serine/threonine-protein kinase, Transferase
    Biological processImmunity, Innate immunity
    LigandATP-binding, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1257604 PIP3 activates AKT signaling
    R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
    R-HSA-5603037 IRAK4 deficiency (TLR5)
    R-HSA-5603041 IRAK4 deficiency (TLR2/4)
    R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
    R-HSA-9020702 Interleukin-1 signaling
    R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
    R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
    R-HSA-975155 MyD88 dependent cascade initiated on endosome
    R-HSA-975871 MyD88 cascade initiated on plasma membrane

    SignaLink: a signaling pathway resource with multi-layered regulatory networks

    More...
    SignaLinki
    Q9NWZ3

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q9NWZ3

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Interleukin-1 receptor-associated kinase 4 (EC:2.7.11.1)
    Short name:
    IRAK-4
    Alternative name(s):
    Renal carcinoma antigen NY-REN-64
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:IRAK4
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000198001.13

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:17967 IRAK4

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    606883 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9NWZ3

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Recurrent isolated invasive pneumococcal disease 1 (IPD1)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionRecurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD.
    See also OMIM:610799
    IRAK4 deficiency (IRAK4D)6 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionCauses extracellular pyogenic bacterial and fungal infections in otherwise healthy children.
    See also OMIM:607676
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07288812R → C in IRAK4D; no effect on inhibition of NF-kappa-B complex activation; loss of interaction with MYD88; decreases protein stability. 2 PublicationsCorresponds to variant dbSNP:rs377584435EnsemblClinVar.1
    Natural variantiVAR_072892298G → D in IRAK4D; decreases inhibition of NF-kappa-B complex activation; impairs neutrophil migration and phagocytosis. 3 PublicationsCorresponds to variant dbSNP:rs568782766Ensembl.1

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi213K → A: Loss of kinase activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    51135

    MalaCards human disease database

    More...
    MalaCardsi
    IRAK4
    MIMi607676 phenotype
    610799 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000198001

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    70592 Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134914577

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3778

    Drug and drug target database

    More...
    DrugBanki
    DB08590 1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    2045

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    IRAK4

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    50401181

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000860351 – 460Interleukin-1 receptor-associated kinase 4Add BLAST460

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
    Modified residuei34N6-acetyllysineCombined sources1
    Modified residuei342Phosphothreonine2 Publications1
    Modified residuei345Phosphothreonine3 Publications1
    Modified residuei346Phosphoserine2 Publications1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Phosphorylated.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9NWZ3

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9NWZ3

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9NWZ3

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9NWZ3

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9NWZ3

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    83000
    83001 [Q9NWZ3-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9NWZ3

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9NWZ3

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000198001 Expressed in 180 organ(s), highest expression level in body of pancreas

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_IRAK4

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9NWZ3 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9NWZ3 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB016685
    CAB022077

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome. Once phosphorylated, IRAK4 dissociates from the receptor complex and then associates with the TNF receptor-associated factor 6 (TRAF6), IRAK1, and PELI1; this intermediate complex is required for subsequent NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. Interacts with IL1RL1.7 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    119322, 26 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    Q9NWZ3

    Database of interacting proteins

    More...
    DIPi
    DIP-31351N

    Protein interaction database and analysis system

    More...
    IntActi
    Q9NWZ3, 17 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q9NWZ3

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000390651

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q9NWZ3

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1460
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q9NWZ3

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9NWZ3

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q9NWZ3

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 104DeathAdd BLAST85
    Domaini186 – 454Protein kinasePROSITE-ProRule annotationAdd BLAST269

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1187 Eukaryota
    COG0515 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000158792

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000116550

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG066836

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9NWZ3

    KEGG Orthology (KO)

    More...
    KOi
    K04733

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    TSVEAMY

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G0YKT

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9NWZ3

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF351380

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd08793 Death_IRAK4, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR011029 DEATH-like_dom_sf
    IPR017428 IRAK4
    IPR037970 IRAK4_Death
    IPR011009 Kinase-like_dom_sf
    IPR000719 Prot_kinase_dom
    IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF07714 Pkinase_Tyr, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF038189 IRAK4, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00220 S_TKc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF47986 SSF47986, 1 hit
    SSF56112 SSF56112, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50011 PROTEIN_KINASE_DOM, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9NWZ3-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MNKPITPSTY VRCLNVGLIR KLSDFIDPQE GWKKLAVAIK KPSGDDRYNQ
    60 70 80 90 100
    FHIRRFEALL QTGKSPTSEL LFDWGTTNCT VGDLVDLLIQ NEFFAPASLL
    110 120 130 140 150
    LPDAVPKTAN TLPSKEAITV QQKQMPFCDK DRTLMTPVQN LEQSYMPPDS
    160 170 180 190 200
    SSPENKSLEV SDTRFHSFSF YELKNVTNNF DERPISVGGN KMGEGGFGVV
    210 220 230 240 250
    YKGYVNNTTV AVKKLAAMVD ITTEELKQQF DQEIKVMAKC QHENLVELLG
    260 270 280 290 300
    FSSDGDDLCL VYVYMPNGSL LDRLSCLDGT PPLSWHMRCK IAQGAANGIN
    310 320 330 340 350
    FLHENHHIHR DIKSANILLD EAFTAKISDF GLARASEKFA QTVMTSRIVG
    360 370 380 390 400
    TTAYMAPEAL RGEITPKSDI YSFGVVLLEI ITGLPAVDEH REPQLLLDIK
    410 420 430 440 450
    EEIEDEEKTI EDYIDKKMND ADSTSVEAMY SVASQCLHEK KNKRPDIKKV
    460
    QQLLQEMTAS
    Length:460
    Mass (Da):51,530
    Last modified:October 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C8156ADF25FF81E
    GO
    Isoform 2 (identifier: Q9NWZ3-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-124: Missing.

    Show »
    Length:336
    Mass (Da):37,674
    Checksum:i6608D68A2EE4138C
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    F8VVZ1F8VVZ1_HUMAN
    Interleukin-1 receptor-associated k...
    IRAK4
    60Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8VR40F8VR40_HUMAN
    Interleukin-1 receptor-associated k...
    IRAK4
    89Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8VW24F8VW24_HUMAN
    Interleukin-1 receptor-associated k...
    IRAK4
    54Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0R4J2F4A0A0R4J2F4_HUMAN
    Interleukin-1 receptor-associated k...
    IRAK4
    218Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81V → A in AAM15772 (PubMed:11960013).Curated1
    Sequence conflicti432V → G in AAD42884 (PubMed:10508479).Curated1
    Sequence conflicti437L → R in AAD42884 (PubMed:10508479).Curated1
    Sequence conflicti444R → S in AAD42884 (PubMed:10508479).Curated1
    Sequence conflicti451Q → H in AAD42884 (PubMed:10508479).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_0405885I → V Polymorphism; no effect on inhibition of NF-kappa-B activation; no effect on interaction with MYD88. 2 PublicationsCorresponds to variant dbSNP:rs56312115Ensembl.1
    Natural variantiVAR_07288812R → C in IRAK4D; no effect on inhibition of NF-kappa-B complex activation; loss of interaction with MYD88; decreases protein stability. 2 PublicationsCorresponds to variant dbSNP:rs377584435EnsemblClinVar.1
    Natural variantiVAR_07288920R → W Polymorphism; increases inhibition of NF-kappa-B complex activation; decreases interaction with MYD88; decreases protein stability. 1 PublicationCorresponds to variant dbSNP:rs143625818Ensembl.1
    Natural variantiVAR_07289026I → T Polymorphism; no effect on inhibition of NF-kappa-B activation; no effect on interaction with MYD88. 1 PublicationCorresponds to variant dbSNP:rs138116867Ensembl.1
    Natural variantiVAR_07289139I → V Polymorphism; no effect on inhibition of NF-kappa-B activation; no effect on interaction with MYD88. 1 PublicationCorresponds to variant dbSNP:rs113588409Ensembl.1
    Natural variantiVAR_01935498S → R Polymorphism; no effect on inhibition of NF-kappa-B activation; no effect on interaction with MYD88. 2 PublicationsCorresponds to variant dbSNP:rs4251469Ensembl.1
    Natural variantiVAR_072892298G → D in IRAK4D; decreases inhibition of NF-kappa-B complex activation; impairs neutrophil migration and phagocytosis. 3 PublicationsCorresponds to variant dbSNP:rs568782766Ensembl.1
    Natural variantiVAR_040589355M → V1 PublicationCorresponds to variant dbSNP:rs142376871Ensembl.1
    Natural variantiVAR_019355390H → R1 PublicationCorresponds to variant dbSNP:rs4251583Ensembl.1
    Natural variantiVAR_040590391R → H Found in a patient with IRAK4D in association with C-12; probable neutral polymorphism. 2 PublicationsCorresponds to variant dbSNP:rs55944915EnsemblClinVar.1
    Natural variantiVAR_019356428A → T2 PublicationsCorresponds to variant dbSNP:rs4251545EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0415561 – 124Missing in isoform 2. 2 PublicationsAdd BLAST124

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF445802 mRNA Translation: AAM15772.1
    AF155118 mRNA Translation: AAD42884.1
    AY340964 mRNA Translation: AAR02360.1
    AY340965 mRNA Translation: AAR02361.1
    AY340966 mRNA Translation: AAR02362.1
    AY340967 mRNA Translation: AAR02363.1
    AK000528 mRNA Translation: BAA91232.1
    AK299944 mRNA Translation: BAG61774.1
    AY186092 Genomic DNA Translation: AAN75440.1
    AC093012 Genomic DNA No translation available.
    BC013316 mRNA Translation: AAH13316.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS44862.1 [Q9NWZ3-2]
    CCDS8744.1 [Q9NWZ3-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001107654.1, NM_001114182.2 [Q9NWZ3-1]
    NP_001138728.1, NM_001145256.1 [Q9NWZ3-2]
    NP_001138729.1, NM_001145257.1 [Q9NWZ3-2]
    NP_001138730.1, NM_001145258.1 [Q9NWZ3-2]
    NP_057207.2, NM_016123.3 [Q9NWZ3-1]
    XP_005269000.1, XM_005268943.3 [Q9NWZ3-1]
    XP_005269001.1, XM_005268944.4 [Q9NWZ3-1]
    XP_005269002.1, XM_005268945.4 [Q9NWZ3-1]
    XP_005269004.1, XM_005268947.4
    XP_005269005.1, XM_005268948.2
    XP_005269006.1, XM_005268949.2 [Q9NWZ3-2]
    XP_006719501.1, XM_006719438.3 [Q9NWZ3-1]
    XP_006719502.1, XM_006719439.2
    XP_011536733.1, XM_011538431.2 [Q9NWZ3-1]
    XP_011536734.1, XM_011538432.1
    XP_011536735.1, XM_011538433.2 [Q9NWZ3-1]
    XP_016874879.1, XM_017019390.1 [Q9NWZ3-1]
    XP_016874880.1, XM_017019391.1

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.138499

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000431837; ENSP00000390327; ENSG00000198001 [Q9NWZ3-2]
    ENST00000440781; ENSP00000408734; ENSG00000198001 [Q9NWZ3-2]
    ENST00000551736; ENSP00000446490; ENSG00000198001 [Q9NWZ3-1]
    ENST00000613694; ENSP00000479889; ENSG00000198001 [Q9NWZ3-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    51135

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:51135

    UCSC genome browser

    More...
    UCSCi
    uc001rnt.4 human [Q9NWZ3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    IRAK4base

    IRAK4 mutation db

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF445802 mRNA Translation: AAM15772.1
    AF155118 mRNA Translation: AAD42884.1
    AY340964 mRNA Translation: AAR02360.1
    AY340965 mRNA Translation: AAR02361.1
    AY340966 mRNA Translation: AAR02362.1
    AY340967 mRNA Translation: AAR02363.1
    AK000528 mRNA Translation: BAA91232.1
    AK299944 mRNA Translation: BAG61774.1
    AY186092 Genomic DNA Translation: AAN75440.1
    AC093012 Genomic DNA No translation available.
    BC013316 mRNA Translation: AAH13316.1
    CCDSiCCDS44862.1 [Q9NWZ3-2]
    CCDS8744.1 [Q9NWZ3-1]
    RefSeqiNP_001107654.1, NM_001114182.2 [Q9NWZ3-1]
    NP_001138728.1, NM_001145256.1 [Q9NWZ3-2]
    NP_001138729.1, NM_001145257.1 [Q9NWZ3-2]
    NP_001138730.1, NM_001145258.1 [Q9NWZ3-2]
    NP_057207.2, NM_016123.3 [Q9NWZ3-1]
    XP_005269000.1, XM_005268943.3 [Q9NWZ3-1]
    XP_005269001.1, XM_005268944.4 [Q9NWZ3-1]
    XP_005269002.1, XM_005268945.4 [Q9NWZ3-1]
    XP_005269004.1, XM_005268947.4
    XP_005269005.1, XM_005268948.2
    XP_005269006.1, XM_005268949.2 [Q9NWZ3-2]
    XP_006719501.1, XM_006719438.3 [Q9NWZ3-1]
    XP_006719502.1, XM_006719439.2
    XP_011536733.1, XM_011538431.2 [Q9NWZ3-1]
    XP_011536734.1, XM_011538432.1
    XP_011536735.1, XM_011538433.2 [Q9NWZ3-1]
    XP_016874879.1, XM_017019390.1 [Q9NWZ3-1]
    XP_016874880.1, XM_017019391.1
    UniGeneiHs.138499

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2NRUX-ray2.00A/B/C/D154-460[»]
    2NRYX-ray2.15A/B/C/D154-460[»]
    2O8YX-ray2.40A/B163-460[»]
    2OIBX-ray2.00A/B/C/D160-460[»]
    2OICX-ray2.40A/B/C/D160-460[»]
    2OIDX-ray2.30A/B/C/D160-460[»]
    3MOPX-ray3.40G/H/I/J4-106[»]
    4RMZX-ray2.20A/B154-460[»]
    4U97X-ray2.65A/B154-460[»]
    4U9AX-ray2.80A/B154-460[»]
    4XS2X-ray2.73A/B/C/D160-460[»]
    4Y73X-ray2.14A/B/C/D160-460[»]
    4YO6X-ray2.32A/B/C/D160-460[»]
    4YP8X-ray2.64A/B/C/D160-460[»]
    4ZTLX-ray2.39A/B/C/D160-460[»]
    4ZTMX-ray2.66A/B/C/D160-460[»]
    4ZTNX-ray2.23A/B/C/D160-460[»]
    5K72X-ray2.22A/B/C/D160-460[»]
    5K75X-ray2.03A/B/C/D160-460[»]
    5K76X-ray2.74A/B160-460[»]
    5K7GX-ray2.23A/B/C/D160-460[»]
    5K7IX-ray2.31A/B160-460[»]
    5KX7X-ray2.80A/B160-460[»]
    5KX8X-ray2.67A/B/C/D160-460[»]
    5T1SX-ray2.30A/B/C/D160-460[»]
    5T1TX-ray2.34A/B/C/D160-460[»]
    5UIQX-ray2.64A/B/C/D154-460[»]
    5UIRX-ray2.64A/B154-460[»]
    5UISX-ray2.50A/B/C/D154-460[»]
    5UITX-ray1.84A/B154-460[»]
    5UIUX-ray2.02A/B154-460[»]
    5W84X-ray2.90A/B160-460[»]
    5W85X-ray2.25A/B160-460[»]
    6F3DX-ray2.38A/B164-458[»]
    6F3EX-ray2.67A/B164-458[»]
    6F3GX-ray2.37A/B164-458[»]
    6F3IX-ray2.14A/B154-460[»]
    ProteinModelPortaliQ9NWZ3
    SMRiQ9NWZ3
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi119322, 26 interactors
    CORUMiQ9NWZ3
    DIPiDIP-31351N
    IntActiQ9NWZ3, 17 interactors
    MINTiQ9NWZ3
    STRINGi9606.ENSP00000390651

    Chemistry databases

    BindingDBiQ9NWZ3
    ChEMBLiCHEMBL3778
    DrugBankiDB08590 1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE
    GuidetoPHARMACOLOGYi2045

    PTM databases

    iPTMnetiQ9NWZ3
    PhosphoSitePlusiQ9NWZ3

    Polymorphism and mutation databases

    BioMutaiIRAK4
    DMDMi50401181

    Proteomic databases

    EPDiQ9NWZ3
    MaxQBiQ9NWZ3
    PaxDbiQ9NWZ3
    PeptideAtlasiQ9NWZ3
    PRIDEiQ9NWZ3
    ProteomicsDBi83000
    83001 [Q9NWZ3-2]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    51135
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000431837; ENSP00000390327; ENSG00000198001 [Q9NWZ3-2]
    ENST00000440781; ENSP00000408734; ENSG00000198001 [Q9NWZ3-2]
    ENST00000551736; ENSP00000446490; ENSG00000198001 [Q9NWZ3-1]
    ENST00000613694; ENSP00000479889; ENSG00000198001 [Q9NWZ3-1]
    GeneIDi51135
    KEGGihsa:51135
    UCSCiuc001rnt.4 human [Q9NWZ3-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    51135
    DisGeNETi51135
    EuPathDBiHostDB:ENSG00000198001.13

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    IRAK4
    HGNCiHGNC:17967 IRAK4
    HPAiCAB016685
    CAB022077
    MalaCardsiIRAK4
    MIMi606883 gene
    607676 phenotype
    610799 phenotype
    neXtProtiNX_Q9NWZ3
    OpenTargetsiENSG00000198001
    Orphaneti70592 Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency
    PharmGKBiPA134914577

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1187 Eukaryota
    COG0515 LUCA
    GeneTreeiENSGT00940000158792
    HOGENOMiHOG000116550
    HOVERGENiHBG066836
    InParanoidiQ9NWZ3
    KOiK04733
    OMAiTSVEAMY
    OrthoDBiEOG091G0YKT
    PhylomeDBiQ9NWZ3
    TreeFamiTF351380

    Enzyme and pathway databases

    ReactomeiR-HSA-1257604 PIP3 activates AKT signaling
    R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
    R-HSA-5603037 IRAK4 deficiency (TLR5)
    R-HSA-5603041 IRAK4 deficiency (TLR2/4)
    R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
    R-HSA-9020702 Interleukin-1 signaling
    R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
    R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
    R-HSA-975155 MyD88 dependent cascade initiated on endosome
    R-HSA-975871 MyD88 cascade initiated on plasma membrane
    SignaLinkiQ9NWZ3
    SIGNORiQ9NWZ3

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    IRAK4 human
    EvolutionaryTraceiQ9NWZ3

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    51135

    Protein Ontology

    More...
    PROi
    PR:Q9NWZ3

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000198001 Expressed in 180 organ(s), highest expression level in body of pancreas
    CleanExiHS_IRAK4
    ExpressionAtlasiQ9NWZ3 baseline and differential
    GenevisibleiQ9NWZ3 HS

    Family and domain databases

    CDDicd08793 Death_IRAK4, 1 hit
    InterProiView protein in InterPro
    IPR011029 DEATH-like_dom_sf
    IPR017428 IRAK4
    IPR037970 IRAK4_Death
    IPR011009 Kinase-like_dom_sf
    IPR000719 Prot_kinase_dom
    IPR001245 Ser-Thr/Tyr_kinase_cat_dom
    PfamiView protein in Pfam
    PF07714 Pkinase_Tyr, 1 hit
    PIRSFiPIRSF038189 IRAK4, 1 hit
    SMARTiView protein in SMART
    SM00220 S_TKc, 1 hit
    SUPFAMiSSF47986 SSF47986, 1 hit
    SSF56112 SSF56112, 1 hit
    PROSITEiView protein in PROSITE
    PS50011 PROTEIN_KINASE_DOM, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIRAK4_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NWZ3
    Secondary accession number(s): Q69FE1, Q8TDF7, Q9Y589
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: October 1, 2000
    Last modified: December 5, 2018
    This is version 179 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    4. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    7. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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