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Entry version 131 (26 Feb 2020)
Sequence version 2 (18 May 2010)
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Protein

Histone PARylation factor 1

Gene

HPF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid specificity toward serine (PubMed:28190768, PubMed:29480802). Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability (PubMed:27067600, PubMed:28190768). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:29480802). HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1 (PubMed:30257210).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone PARylation factor 11 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HPF11 PublicationImported
Synonyms:C4orf27
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26051 HPF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616614 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NWY4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi238 – 239YR → AA: Loss of ability to bind PARP1 and histones. Abolishes PARP1 ability to mediate ADP-ribosylation. 2 Publications2
Mutagenesisi239R → A: Decreases PARP1 ability to mediate tyrosine ADP-ribosylation. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000056050

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145149735

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NWY4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HPF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434433

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002944461 – 346Histone PARylation factor 1Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei19N6-acetyllysineBy similarity1
Modified residuei97ADP-ribosylserine1 Publication1
Modified residuei186N6-acetyllysineCombined sources1
Modified residuei233N6-acetyllysineCombined sources1
Modified residuei238ADP-ribosyltyrosine1 Publication1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, ADP-ribosylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NWY4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NWY4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NWY4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NWY4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NWY4

PeptideAtlas

More...
PeptideAtlasi
Q9NWY4

PRoteomics IDEntifications database

More...
PRIDEi
Q9NWY4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82999

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NWY4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NWY4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000056050 Expressed in oocyte and 225 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NWY4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043467

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PARP1 (via the PARP catalytic domain) (PubMed:27067600).

Interacts with histone H2A and histone H3 in a PARP1-dependent manner (PubMed:27067600). Weakly interacts with PARP2 (via the PARP catalytic domain) (PubMed:27067600).

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120306, 30 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NWY4, 5 interactors

Molecular INTeraction database

More...
MINTi
Q9NWY4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000406598

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NWY4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni242 – 346Interaction with PARP11 PublicationAdd BLAST105

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HPF1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3952 Eukaryota
ENOG410XQRN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014876

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_053037_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NWY4

Identification of Orthologs from Complete Genome Data

More...
OMAi
RPQFIAI

Database of Orthologous Groups

More...
OrthoDBi
1077112at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NWY4

TreeFam database of animal gene trees

More...
TreeFami
TF317026

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019361 HPF1

The PANTHER Classification System

More...
PANTHERi
PTHR13386 PTHR13386, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10228 DUF2228, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NWY4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGGGGKRRP GGEGPQCEKT TDVKKSKFCE ADVSSDLRKE VENHYKLSLP
60 70 80 90 100
EDFYHFWKFC EELDPEKPSD SLSASLGLQL VGPYDILAGK HKTKKKSTGL
110 120 130 140 150
NFNLHWRFYY DPPEFQTIII GDNKTQYHMG YFRDSPDEFP VYVGINEAKK
160 170 180 190 200
NCIIVPNGDN VFAAVKLFLT KKLREITDKK KINLLKNIDE KLTEAARELG
210 220 230 240 250
YSLEQRTVKM KQRDKKVVTK TFHGAGLVVP VDKNDVGYRE LPETDADLKR
260 270 280 290 300
ICKTIVEAAS DEERLKAFAP IQEMMTFVQF ANDECDYGMG LELGMDLFCY
310 320 330 340
GSHYFHKVAG QLLPLAYNLL KRNLFAEIIE EHLANRSQEN IDQLAA
Length:346
Mass (Da):39,436
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF411C9AE254E1E1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033183174R → K3 PublicationsCorresponds to variant dbSNP:rs1047642Ensembl.1
Natural variantiVAR_033184331E → D. Corresponds to variant dbSNP:rs1047706Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136673 mRNA Translation: CAB66608.1
AK000541 mRNA Translation: BAA91241.1
AC106878 Genomic DNA No translation available.
BC010367 mRNA Translation: AAH10367.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3813.1

NCBI Reference Sequences

More...
RefSeqi
NP_060337.2, NM_017867.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000393381; ENSP00000406598; ENSG00000056050

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54969

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54969

UCSC genome browser

More...
UCSCi
uc003isl.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136673 mRNA Translation: CAB66608.1
AK000541 mRNA Translation: BAA91241.1
AC106878 Genomic DNA No translation available.
BC010367 mRNA Translation: AAH10367.1
CCDSiCCDS3813.1
RefSeqiNP_060337.2, NM_017867.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120306, 30 interactors
IntActiQ9NWY4, 5 interactors
MINTiQ9NWY4
STRINGi9606.ENSP00000406598

PTM databases

iPTMnetiQ9NWY4
PhosphoSitePlusiQ9NWY4

Polymorphism and mutation databases

BioMutaiHPF1
DMDMi296434433

Proteomic databases

EPDiQ9NWY4
jPOSTiQ9NWY4
MassIVEiQ9NWY4
MaxQBiQ9NWY4
PaxDbiQ9NWY4
PeptideAtlasiQ9NWY4
PRIDEiQ9NWY4
ProteomicsDBi82999

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54969

Genome annotation databases

EnsembliENST00000393381; ENSP00000406598; ENSG00000056050
GeneIDi54969
KEGGihsa:54969
UCSCiuc003isl.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54969

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HPF1
HGNCiHGNC:26051 HPF1
HPAiHPA043467
MIMi616614 gene
neXtProtiNX_Q9NWY4
OpenTargetsiENSG00000056050
PharmGKBiPA145149735

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3952 Eukaryota
ENOG410XQRN LUCA
GeneTreeiENSGT00390000014876
HOGENOMiCLU_053037_0_0_1
InParanoidiQ9NWY4
OMAiRPQFIAI
OrthoDBi1077112at2759
PhylomeDBiQ9NWY4
TreeFamiTF317026

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HPF1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54969
PharosiQ9NWY4 Tbio

Protein Ontology

More...
PROi
PR:Q9NWY4
RNActiQ9NWY4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000056050 Expressed in oocyte and 225 other tissues
GenevisibleiQ9NWY4 HS

Family and domain databases

InterProiView protein in InterPro
IPR019361 HPF1
PANTHERiPTHR13386 PTHR13386, 1 hit
PfamiView protein in Pfam
PF10228 DUF2228, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHPF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NWY4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 18, 2010
Last modified: February 26, 2020
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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