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Protein

Ankyrin repeat and SOCS box protein 6

Gene

ASB6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 6
Short name:
ASB-6
Gene namesi
Name:ASB6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148331.11
HGNCiHGNC:17181 ASB6
MIMi615051 gene
neXtProtiNX_Q9NWX5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148331
PharmGKBiPA25034

Polymorphism and mutation databases

BioMutaiASB6
DMDMi41688801

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669331 – 421Ankyrin repeat and SOCS box protein 6Add BLAST421

Proteomic databases

EPDiQ9NWX5
MaxQBiQ9NWX5
PaxDbiQ9NWX5
PeptideAtlasiQ9NWX5
PRIDEiQ9NWX5
ProteomicsDBi82996
82997 [Q9NWX5-2]

PTM databases

iPTMnetiQ9NWX5
PhosphoSitePlusiQ9NWX5

Expressioni

Gene expression databases

BgeeiENSG00000148331 Expressed in 197 organ(s), highest expression level in esophagus
CleanExiHS_ASB6
ExpressionAtlasiQ9NWX5 baseline and differential
GenevisibleiQ9NWX5 HS

Organism-specific databases

HPAiHPA004341

Interactioni

Subunit structurei

Binds APS. Identified in a complex with ELOB and ELOC (By similarity). Interacts with CUL5 and RNF7.By similarity1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi126612, 51 interactors
CORUMiQ9NWX5
IntActiQ9NWX5, 19 interactors
MINTiQ9NWX5
STRINGi9606.ENSP00000277458

Structurei

3D structure databases

ProteinModelPortaliQ9NWX5
SMRiQ9NWX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati67 – 97ANK 1Add BLAST31
Repeati102 – 131ANK 2Add BLAST30
Repeati136 – 166ANK 3Add BLAST31
Repeati170 – 205ANK 4Add BLAST36
Repeati226 – 255ANK 5Add BLAST30
Repeati260 – 289ANK 6Add BLAST30
Domaini360 – 415SOCS boxPROSITE-ProRule annotationAdd BLAST56

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000006784
HOGENOMiHOG000231756
HOVERGENiHBG037329
InParanoidiQ9NWX5
KOiK10328
OMAiFCFQVTQ
OrthoDBiEOG091G07QG
PhylomeDBiQ9NWX5
TreeFamiTF330837

Family and domain databases

CDDicd00204 ANK, 2 hits
cd03725 SOCS_ASB6, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037327 ASB6_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50225 SOCS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NWX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPFLHGFRRI IFEYQPLVDA ILGSLGIQDP ERQESLDRPS YVASEESRIL
60 70 80 90 100
VLTELLERKA HSPFYQEGVS NALLKMAELG LTRAADVLLR HGANLNFEDP
110 120 130 140 150
VTYYTALHIA VLRNQPDMVE LLVHHGADVN RRDRIHESSP LDLASEEPER
160 170 180 190 200
LPCLQRLLDL GADVNAADKH GKTALLHALA SSDGVQIHNT ENIRLLLEGG
210 220 230 240 250
ADVKATTKDG DTVFTCIIFL LGETVGGDKE EAQMINRFCF QVTRLLLAHG
260 270 280 290 300
ADPSECPAHE SLTHICLKSF KLHFPLLRFL LESGAAYNCS LHGASCWSGF
310 320 330 340 350
HIIFERLCSH PGCTEDESHA DLLRKAETVL DLMVTNSQKL QLPENFDIHP
360 370 380 390 400
VGSLAEKIQA LHFSLRQLES YPPPLKHLCR VAIRLYLQPW PVDVKVKALP
410 420
LPDRLKWYLL SEHSGSVEDD I
Length:421
Mass (Da):47,136
Last modified:October 1, 2000 - v1
Checksum:i2DBAF086B54FF1CB
GO
Isoform 2 (identifier: Q9NWX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-421: IHESSPLDLA...EHSGSVEDDI → EKLLCSMLWP...PWEGTKRRPR

Note: No experimental confirmation available.
Show »
Length:197
Mass (Da):22,373
Checksum:iDFF0F90AE956C069
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6TX30F6TX30_HUMAN
Ankyrin repeat and SOCS box protein...
ASB6
392Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042006135 – 421IHESS…VEDDI → EKLLCSMLWPAATGCRSTIL RTFVSYWKEGQTSRPPPKMG TQCSPASSSCLVRPWEGTKR RPR in isoform 2. 1 PublicationAdd BLAST287

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000555 mRNA Translation: BAA91250.1
AK023004 mRNA Translation: BAB14355.1
AL590369 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87899.1
CH471090 Genomic DNA Translation: EAW87900.1
BC001719 mRNA Translation: AAH01719.1
BC065913 mRNA Translation: AAH65913.1
CCDSiCCDS6924.1 [Q9NWX5-1]
CCDS6925.1 [Q9NWX5-2]
RefSeqiNP_001189332.1, NM_001202403.1
NP_060343.1, NM_017873.3 [Q9NWX5-1]
NP_821066.1, NM_177999.2 [Q9NWX5-2]
UniGeneiHs.125037

Genome annotation databases

EnsembliENST00000277458; ENSP00000277458; ENSG00000148331 [Q9NWX5-1]
ENST00000277459; ENSP00000277459; ENSG00000148331 [Q9NWX5-2]
GeneIDi140459
KEGGihsa:140459
UCSCiuc004byf.3 human [Q9NWX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000555 mRNA Translation: BAA91250.1
AK023004 mRNA Translation: BAB14355.1
AL590369 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87899.1
CH471090 Genomic DNA Translation: EAW87900.1
BC001719 mRNA Translation: AAH01719.1
BC065913 mRNA Translation: AAH65913.1
CCDSiCCDS6924.1 [Q9NWX5-1]
CCDS6925.1 [Q9NWX5-2]
RefSeqiNP_001189332.1, NM_001202403.1
NP_060343.1, NM_017873.3 [Q9NWX5-1]
NP_821066.1, NM_177999.2 [Q9NWX5-2]
UniGeneiHs.125037

3D structure databases

ProteinModelPortaliQ9NWX5
SMRiQ9NWX5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126612, 51 interactors
CORUMiQ9NWX5
IntActiQ9NWX5, 19 interactors
MINTiQ9NWX5
STRINGi9606.ENSP00000277458

PTM databases

iPTMnetiQ9NWX5
PhosphoSitePlusiQ9NWX5

Polymorphism and mutation databases

BioMutaiASB6
DMDMi41688801

Proteomic databases

EPDiQ9NWX5
MaxQBiQ9NWX5
PaxDbiQ9NWX5
PeptideAtlasiQ9NWX5
PRIDEiQ9NWX5
ProteomicsDBi82996
82997 [Q9NWX5-2]

Protocols and materials databases

DNASUi140459
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277458; ENSP00000277458; ENSG00000148331 [Q9NWX5-1]
ENST00000277459; ENSP00000277459; ENSG00000148331 [Q9NWX5-2]
GeneIDi140459
KEGGihsa:140459
UCSCiuc004byf.3 human [Q9NWX5-1]

Organism-specific databases

CTDi140459
EuPathDBiHostDB:ENSG00000148331.11
GeneCardsiASB6
HGNCiHGNC:17181 ASB6
HPAiHPA004341
MIMi615051 gene
neXtProtiNX_Q9NWX5
OpenTargetsiENSG00000148331
PharmGKBiPA25034
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000006784
HOGENOMiHOG000231756
HOVERGENiHBG037329
InParanoidiQ9NWX5
KOiK10328
OMAiFCFQVTQ
OrthoDBiEOG091G07QG
PhylomeDBiQ9NWX5
TreeFamiTF330837

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiASB6 human
GeneWikiiASB6
GenomeRNAii140459
PROiPR:Q9NWX5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148331 Expressed in 197 organ(s), highest expression level in esophagus
CleanExiHS_ASB6
ExpressionAtlasiQ9NWX5 baseline and differential
GenevisibleiQ9NWX5 HS

Family and domain databases

CDDicd00204 ANK, 2 hits
cd03725 SOCS_ASB6, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037327 ASB6_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASB6_HUMAN
AccessioniPrimary (citable) accession number: Q9NWX5
Secondary accession number(s): Q5SZB7, Q9BV15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: October 1, 2000
Last modified: October 10, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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