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Protein

Host cell factor C1 regulator 1

Gene

HCFC1R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Host cell factor C1 regulator 1
Alternative name(s):
HCF-1 beta-propeller-interacting protein
Gene namesi
Name:HCFC1R1
Synonyms:HPIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103145.10
HGNCiHGNC:21198 HCFC1R1
neXtProtiNX_Q9NWW0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi76 – 79DHPY → AAPA: Loss of interaction with HCFC1. 1 Publication4
Mutagenesisi117 – 119LRL → ARA: Reduces nuclear export. 1 Publication3

Organism-specific databases

OpenTargetsiENSG00000103145
PharmGKBiPA134951485

Polymorphism and mutation databases

BioMutaiHCFC1R1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003389781 – 138Host cell factor C1 regulator 1Add BLAST138

Proteomic databases

PaxDbiQ9NWW0
PeptideAtlasiQ9NWW0
PRIDEiQ9NWW0
ProteomicsDBi82989
82990 [Q9NWW0-2]

PTM databases

iPTMnetiQ9NWW0
PhosphoSitePlusiQ9NWW0

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000103145 Expressed in 227 organ(s), highest expression level in muscle of leg
CleanExiHS_HCFC1R1
ExpressionAtlasiQ9NWW0 baseline and differential
GenevisibleiQ9NWW0 HS

Organism-specific databases

HPAiHPA059647

Interactioni

Subunit structurei

Interacts with HCFC1.1 Publication

Protein-protein interaction databases

BioGridi120320, 3 interactors
ELMiQ9NWW0
IntActiQ9NWW0, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ9NWW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni76 – 79Interaction with HCFC11 Publication4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi110 – 119Nuclear export signal10

Phylogenomic databases

eggNOGiENOG410IZTH Eukaryota
ENOG4111EF3 LUCA
GeneTreeiENSGT00390000015785
HOGENOMiHOG000112942
HOVERGENiHBG107981
InParanoidiQ9NWW0
OrthoDBiEOG091G0VZ8
PhylomeDBiQ9NWW0
TreeFamiTF338381

Family and domain databases

InterProiView protein in InterPro
IPR029195 HCFC1R1
PfamiView protein in Pfam
PF15226 HPIP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NWW0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MILQQPLQRG PQGGAQRLPR AALGVTWGLD ASSPLRGAVP MSTKRRLEEE
60 70 80 90 100
QEPLRKQFLS EENMATHFSQ LSLHNDHPYC SPPMTFSPAL PPLRSPCSEL
110 120 130
LLWRYPGSLI PEALRLLRLG DTPSPPYPAT PAGDIMEL
Length:138
Mass (Da):15,291
Last modified:October 1, 2000 - v1
Checksum:i34A9A04735276A16
GO
Isoform 2 (identifier: Q9NWW0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-51: SSPLRGAVPMSTKRRLEEEQ → R

Show »
Length:119
Mass (Da):13,193
Checksum:i827839C0CE4B2FAF
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L174I3L174_HUMAN
Host cell factor C1 regulator 1
HCFC1R1
120Annotation score:
J3KNY1J3KNY1_HUMAN
Host cell factor C1 regulator 1
HCFC1R1
136Annotation score:
I3L1N5I3L1N5_HUMAN
Host cell factor C1 regulator 1
HCFC1R1
98Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04384992P → Q1 PublicationCorresponds to variant dbSNP:rs10508Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03408232 – 51SSPLR…LEEEQ → R in isoform 2. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY116892 mRNA Translation: AAM49798.1
AK000575 mRNA Translation: BAA91265.1
CR457245 mRNA Translation: CAG33526.1
CH471112 Genomic DNA Translation: EAW85425.1
CH471112 Genomic DNA Translation: EAW85426.1
BC064026 mRNA Translation: AAH64026.1
BC080178 mRNA Translation: AAH80178.1
CCDSiCCDS10490.1 [Q9NWW0-1]
CCDS32375.1 [Q9NWW0-2]
RefSeqiNP_001002017.1, NM_001002017.2 [Q9NWW0-2]
NP_001002018.1, NM_001002018.2 [Q9NWW0-1]
NP_001275594.1, NM_001288665.1 [Q9NWW0-1]
NP_001275595.1, NM_001288666.1 [Q9NWW0-2]
NP_001275596.1, NM_001288667.1
NP_001275597.1, NM_001288668.1
NP_060355.1, NM_017885.3 [Q9NWW0-1]
UniGeneiHs.423103

Genome annotation databases

EnsembliENST00000248089; ENSP00000248089; ENSG00000103145 [Q9NWW0-1]
ENST00000574151; ENSP00000459178; ENSG00000103145 [Q9NWW0-2]
ENST00000574980; ENSP00000460639; ENSG00000103145 [Q9NWW0-1]
GeneIDi54985
KEGGihsa:54985
UCSCiuc002csy.3 human [Q9NWW0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY116892 mRNA Translation: AAM49798.1
AK000575 mRNA Translation: BAA91265.1
CR457245 mRNA Translation: CAG33526.1
CH471112 Genomic DNA Translation: EAW85425.1
CH471112 Genomic DNA Translation: EAW85426.1
BC064026 mRNA Translation: AAH64026.1
BC080178 mRNA Translation: AAH80178.1
CCDSiCCDS10490.1 [Q9NWW0-1]
CCDS32375.1 [Q9NWW0-2]
RefSeqiNP_001002017.1, NM_001002017.2 [Q9NWW0-2]
NP_001002018.1, NM_001002018.2 [Q9NWW0-1]
NP_001275594.1, NM_001288665.1 [Q9NWW0-1]
NP_001275595.1, NM_001288666.1 [Q9NWW0-2]
NP_001275596.1, NM_001288667.1
NP_001275597.1, NM_001288668.1
NP_060355.1, NM_017885.3 [Q9NWW0-1]
UniGeneiHs.423103

3D structure databases

ProteinModelPortaliQ9NWW0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120320, 3 interactors
ELMiQ9NWW0
IntActiQ9NWW0, 1 interactor

PTM databases

iPTMnetiQ9NWW0
PhosphoSitePlusiQ9NWW0

Polymorphism and mutation databases

BioMutaiHCFC1R1

Proteomic databases

PaxDbiQ9NWW0
PeptideAtlasiQ9NWW0
PRIDEiQ9NWW0
ProteomicsDBi82989
82990 [Q9NWW0-2]

Protocols and materials databases

DNASUi54985
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248089; ENSP00000248089; ENSG00000103145 [Q9NWW0-1]
ENST00000574151; ENSP00000459178; ENSG00000103145 [Q9NWW0-2]
ENST00000574980; ENSP00000460639; ENSG00000103145 [Q9NWW0-1]
GeneIDi54985
KEGGihsa:54985
UCSCiuc002csy.3 human [Q9NWW0-1]

Organism-specific databases

CTDi54985
EuPathDBiHostDB:ENSG00000103145.10
GeneCardsiHCFC1R1
HGNCiHGNC:21198 HCFC1R1
HPAiHPA059647
neXtProtiNX_Q9NWW0
OpenTargetsiENSG00000103145
PharmGKBiPA134951485
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZTH Eukaryota
ENOG4111EF3 LUCA
GeneTreeiENSGT00390000015785
HOGENOMiHOG000112942
HOVERGENiHBG107981
InParanoidiQ9NWW0
OrthoDBiEOG091G0VZ8
PhylomeDBiQ9NWW0
TreeFamiTF338381

Miscellaneous databases

ChiTaRSiHCFC1R1 human
GenomeRNAii54985
PROiPR:Q9NWW0

Gene expression databases

BgeeiENSG00000103145 Expressed in 227 organ(s), highest expression level in muscle of leg
CleanExiHS_HCFC1R1
ExpressionAtlasiQ9NWW0 baseline and differential
GenevisibleiQ9NWW0 HS

Family and domain databases

InterProiView protein in InterPro
IPR029195 HCFC1R1
PfamiView protein in Pfam
PF15226 HPIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHPIP_HUMAN
AccessioniPrimary (citable) accession number: Q9NWW0
Secondary accession number(s): D3DUA7, Q68EN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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