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Protein

39S ribosomal protein L22, mitochondrial

Gene

MRPL22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L22, mitochondrial
Short name:
L22mt
Short name:
MRP-L22
Alternative name(s):
39S ribosomal protein L25, mitochondrial
Short name:
L25mt
Short name:
MRP-L25
Mitochondrial large ribosomal subunit protein uL22m1 Publication
Gene namesi
Name:MRPL22
Synonyms:MRPL25, RPML25
ORF Names:HSPC158
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000082515.16
HGNCiHGNC:14480 MRPL22
MIMi611835 gene
neXtProtiNX_Q9NWU5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi29093
OpenTargetsiENSG00000082515
PharmGKBiPA30952

Polymorphism and mutation databases

BioMutaiMRPL22
DMDMi74753031

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 40MitochondrionBy similarityAdd BLAST40
ChainiPRO_000026164441 – 20639S ribosomal protein L22, mitochondrialAdd BLAST166

Proteomic databases

EPDiQ9NWU5
MaxQBiQ9NWU5
PaxDbiQ9NWU5
PeptideAtlasiQ9NWU5
PRIDEiQ9NWU5
ProteomicsDBi82983
82984 [Q9NWU5-2]
TopDownProteomicsiQ9NWU5-1 [Q9NWU5-1]

PTM databases

iPTMnetiQ9NWU5
PhosphoSitePlusiQ9NWU5

Expressioni

Gene expression databases

BgeeiENSG00000082515 Expressed in 226 organ(s), highest expression level in adrenal gland
CleanExiHS_MRPL22
ExpressionAtlasiQ9NWU5 baseline and differential
GenevisibleiQ9NWU5 HS

Organism-specific databases

HPAiHPA047063

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Protein-protein interaction databases

BioGridi118862, 97 interactors
CORUMiQ9NWU5
IntActiQ9NWU5, 17 interactors
MINTiQ9NWU5
STRINGi9606.ENSP00000431040

Structurei

Secondary structure

1206
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NWU5
SMRiQ9NWU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi176 – 183Poly-Pro8

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1711 Eukaryota
COG0091 LUCA
GeneTreeiENSGT00390000002110
HOGENOMiHOG000048027
HOVERGENiHBG093486
InParanoidiQ9NWU5
KOiK02890
PhylomeDBiQ9NWU5
TreeFamiTF315111

Family and domain databases

CDDicd00336 Ribosomal_L22, 1 hit
Gene3Di3.90.470.10, 1 hit
InterProiView protein in InterPro
IPR001063 Ribosomal_L22
IPR036394 Ribosomal_L22/L17_sf
IPR005727 Ribosomal_L22_bac/chlpt-type
PANTHERiPTHR13501 PTHR13501, 1 hit
PfamiView protein in Pfam
PF00237 Ribosomal_L22, 1 hit
SUPFAMiSSF54843 SSF54843, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NWU5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAVLGQLG ALWIHNLRSR GKLALGVLPQ SYIHTSASLD ISRKWEKKNK
60 70 80 90 100
IVYPPQLPGE PRRPAEIYHC RRQIKYSKDK MWYLAKLIRG MSIDQALAQL
110 120 130 140 150
EFNDKKGAKI IKEVLLEAQD MAVRDHNVEF RSNLYIAEST SGRGQCLKRI
160 170 180 190 200
RYHGRGRFGI MEKVYCHYFV KLVEGPPPPP EPPKTAVAHA KEYIQQLRSR

TIVHTL
Length:206
Mass (Da):23,641
Last modified:October 1, 2000 - v1
Checksum:iEDF999932609F05D
GO
Isoform 2 (identifier: Q9NWU5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-87: Missing.

Show »
Length:120
Mass (Da):13,734
Checksum:i6CED8B2464B72378
GO
Isoform 3 (identifier: Q9NWU5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Show »
Length:126
Mass (Da):14,509
Checksum:i93AB1871CCD4CF74
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ESL0E7ESL0_HUMAN
39S ribosomal protein L22, mitochon...
MRPL22
212Annotation score:
J3KQY1J3KQY1_HUMAN
39S ribosomal protein L22, mitochon...
MRPL22
232Annotation score:
H0YBZ7H0YBZ7_HUMAN
39S ribosomal protein L22, mitochon...
MRPL22
38Annotation score:

Sequence cautioni

The sequence AAF29122 differs from that shown. Reason: Frameshift at position 197.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029471154G → S. Corresponds to variant dbSNP:rs3749671Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0445011 – 80Missing in isoform 3. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_0217452 – 87Missing in isoform 2. 1 PublicationAdd BLAST86

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161507 mRNA Translation: AAF29122.1 Frameshift.
AK000601 mRNA Translation: BAA91282.1
AK302784 mRNA Translation: BAG63988.1
CR933679 mRNA Translation: CAI45973.1
AC008410 Genomic DNA No translation available.
AC008421 Genomic DNA No translation available.
BC012565 mRNA Translation: AAH12565.1
AB051622 Genomic DNA Translation: BAB54950.1
CCDSiCCDS4331.1 [Q9NWU5-1]
CCDS43391.1 [Q9NWU5-3]
RefSeqiNP_001014990.1, NM_001014990.2 [Q9NWU5-3]
NP_054899.2, NM_014180.3 [Q9NWU5-1]
UniGeneiHs.483924

Genome annotation databases

EnsembliENST00000265229; ENSP00000265229; ENSG00000082515 [Q9NWU5-3]
ENST00000523037; ENSP00000431040; ENSG00000082515 [Q9NWU5-1]
GeneIDi29093
KEGGihsa:29093
UCSCiuc003lvy.5 human [Q9NWU5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161507 mRNA Translation: AAF29122.1 Frameshift.
AK000601 mRNA Translation: BAA91282.1
AK302784 mRNA Translation: BAG63988.1
CR933679 mRNA Translation: CAI45973.1
AC008410 Genomic DNA No translation available.
AC008421 Genomic DNA No translation available.
BC012565 mRNA Translation: AAH12565.1
AB051622 Genomic DNA Translation: BAB54950.1
CCDSiCCDS4331.1 [Q9NWU5-1]
CCDS43391.1 [Q9NWU5-3]
RefSeqiNP_001014990.1, NM_001014990.2 [Q9NWU5-3]
NP_054899.2, NM_014180.3 [Q9NWU5-1]
UniGeneiHs.483924

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40T1-206[»]
5OOLelectron microscopy3.06T1-206[»]
5OOMelectron microscopy3.03T1-206[»]
ProteinModelPortaliQ9NWU5
SMRiQ9NWU5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118862, 97 interactors
CORUMiQ9NWU5
IntActiQ9NWU5, 17 interactors
MINTiQ9NWU5
STRINGi9606.ENSP00000431040

PTM databases

iPTMnetiQ9NWU5
PhosphoSitePlusiQ9NWU5

Polymorphism and mutation databases

BioMutaiMRPL22
DMDMi74753031

Proteomic databases

EPDiQ9NWU5
MaxQBiQ9NWU5
PaxDbiQ9NWU5
PeptideAtlasiQ9NWU5
PRIDEiQ9NWU5
ProteomicsDBi82983
82984 [Q9NWU5-2]
TopDownProteomicsiQ9NWU5-1 [Q9NWU5-1]

Protocols and materials databases

DNASUi29093
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265229; ENSP00000265229; ENSG00000082515 [Q9NWU5-3]
ENST00000523037; ENSP00000431040; ENSG00000082515 [Q9NWU5-1]
GeneIDi29093
KEGGihsa:29093
UCSCiuc003lvy.5 human [Q9NWU5-1]

Organism-specific databases

CTDi29093
DisGeNETi29093
EuPathDBiHostDB:ENSG00000082515.16
GeneCardsiMRPL22
HGNCiHGNC:14480 MRPL22
HPAiHPA047063
MIMi611835 gene
neXtProtiNX_Q9NWU5
OpenTargetsiENSG00000082515
PharmGKBiPA30952
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1711 Eukaryota
COG0091 LUCA
GeneTreeiENSGT00390000002110
HOGENOMiHOG000048027
HOVERGENiHBG093486
InParanoidiQ9NWU5
KOiK02890
PhylomeDBiQ9NWU5
TreeFamiTF315111

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL22 human
GeneWikiiMRPL22
GenomeRNAii29093
PROiPR:Q9NWU5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000082515 Expressed in 226 organ(s), highest expression level in adrenal gland
CleanExiHS_MRPL22
ExpressionAtlasiQ9NWU5 baseline and differential
GenevisibleiQ9NWU5 HS

Family and domain databases

CDDicd00336 Ribosomal_L22, 1 hit
Gene3Di3.90.470.10, 1 hit
InterProiView protein in InterPro
IPR001063 Ribosomal_L22
IPR036394 Ribosomal_L22/L17_sf
IPR005727 Ribosomal_L22_bac/chlpt-type
PANTHERiPTHR13501 PTHR13501, 1 hit
PfamiView protein in Pfam
PF00237 Ribosomal_L22, 1 hit
SUPFAMiSSF54843 SSF54843, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM22_HUMAN
AccessioniPrimary (citable) accession number: Q9NWU5
Secondary accession number(s): A6NGJ8
, Q5H9Q1, Q96Q51, Q9P006
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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