UniProtKB - Q9NWU2 (GID8_HUMAN)
Glucose-induced degradation protein 8 homolog
GID8
Functioni
GO - Molecular functioni
- protein homodimerization activity Source: Ensembl
GO - Biological processi
- positive regulation of canonical Wnt signaling pathway Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9NWU2 |
Names & Taxonomyi
Protein namesi | Recommended name: Glucose-induced degradation protein 8 homologAlternative name(s): Two hybrid-associated protein 1 with RanBPM1 Publication Short name: Twa11 Publication |
Gene namesi | Name:GID8 Synonyms:C20orf11, TWA13 Publications |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15857, GID8 |
MIMi | 611625, gene |
neXtProti | NX_Q9NWU2 |
VEuPathDBi | HostDB:ENSG00000101193.7 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cell junction Source: HPA
- cytoplasm Source: UniProtKB
- ubiquitin ligase complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 54994 |
OpenTargetsi | ENSG00000101193 |
PharmGKBi | PA25649 |
Miscellaneous databases
Pharosi | Q9NWU2, Tbio |
Genetic variation databases
BioMutai | GID8 |
DMDMi | 28201788 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079411 | 1 – 228 | Glucose-induced degradation protein 8 homologAdd BLAST | 228 |
Post-translational modificationi
Keywords - PTMi
Ubl conjugationProteomic databases
EPDi | Q9NWU2 |
jPOSTi | Q9NWU2 |
MassIVEi | Q9NWU2 |
MaxQBi | Q9NWU2 |
PaxDbi | Q9NWU2 |
PeptideAtlasi | Q9NWU2 |
PRIDEi | Q9NWU2 |
ProteomicsDBi | 82982 |
PTM databases
iPTMneti | Q9NWU2 |
PhosphoSitePlusi | Q9NWU2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000101193, Expressed in vagina and 237 other tissues |
Genevisiblei | Q9NWU2, HS |
Organism-specific databases
HPAi | ENSG00000101193, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer; may also form higher oligomers (By similarity). Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5 (PubMed:17467196, PubMed:29911972). Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles (PubMed:29911972).
Interacts with RANBP9.
Part of a complex consisting of RANBP9, MKLN1 and GID8 (PubMed:12559565).
Interacts with CTNNB1, AXIN1 and GSK3B (PubMed:28829046).
By similarity4 PublicationsBinary interactionsi
Hide detailsQ9NWU2
With | #Exp. | IntAct |
---|---|---|
ARMC8 - isoform 6 [Q8IUR7-6] | 4 | EBI-1051077,EBI-11942961 |
RMND5A [Q9H871] | 8 | EBI-1051077,EBI-2797992 |
GO - Molecular functioni
- protein homodimerization activity Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 120327, 83 interactors |
CORUMi | Q9NWU2 |
IntActi | Q9NWU2, 49 interactors |
MINTi | Q9NWU2 |
STRINGi | 9606.ENSP00000266069 |
Miscellaneous databases
RNActi | Q9NWU2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 57 | LisHPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 63 – 120 | CTLHPROSITE-ProRule annotationAdd BLAST | 58 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 116 – 212 | Interaction with CTNNB11 PublicationAdd BLAST | 97 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2659, Eukaryota |
GeneTreei | ENSGT00390000015162 |
HOGENOMi | CLU_073203_1_0_1 |
InParanoidi | Q9NWU2 |
OMAi | QNGRIQE |
OrthoDBi | 1365635at2759 |
PhylomeDBi | Q9NWU2 |
TreeFami | TF300176 |
Family and domain databases
InterProi | View protein in InterPro IPR013144, CRA_dom IPR024964, CTLH/CRA IPR006595, CTLH_C IPR006594, LisH |
Pfami | View protein in Pfam PF10607, CLTH, 1 hit PF08513, LisH, 1 hit |
SMARTi | View protein in SMART SM00757, CRA, 1 hit SM00668, CTLH, 1 hit SM00667, LisH, 1 hit |
PROSITEi | View protein in PROSITE PS50897, CTLH, 1 hit PS50896, LISH, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSYAEKPDEI TKDEWMEKLN NLHVQRADMN RLIMNYLVTE GFKEAAEKFR
60 70 80 90 100
MESGIEPSVD LETLDERIKI REMILKGQIQ EAIALINSLH PELLDTNRYL
110 120 130 140 150
YFHLQQQHLI ELIRQRETEA ALEFAQTQLA EQGEESRECL TEMERTLALL
160 170 180 190 200
AFDSPEESPF GDLLHTMQRQ KVWSEVNQAV LDYENRESTP KLAKLLKLLL
210 220
WAQNELDQKK VKYPKMTDLS KGVIEEPK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 59 | V → L in AAH32120 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000609 mRNA Translation: BAA91285.1 AL121673 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75318.1 CH471077 Genomic DNA Translation: EAW75319.1 BC032120 mRNA Translation: AAH32120.1 |
CCDSi | CCDS13510.1 |
RefSeqi | NP_060366.1, NM_017896.2 |
Genome annotation databases
Ensembli | ENST00000266069; ENSP00000266069; ENSG00000101193 |
GeneIDi | 54994 |
KEGGi | hsa:54994 |
UCSCi | uc002ydy.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000609 mRNA Translation: BAA91285.1 AL121673 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75318.1 CH471077 Genomic DNA Translation: EAW75319.1 BC032120 mRNA Translation: AAH32120.1 |
CCDSi | CCDS13510.1 |
RefSeqi | NP_060366.1, NM_017896.2 |
3D structure databases
SMRi | Q9NWU2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120327, 83 interactors |
CORUMi | Q9NWU2 |
IntActi | Q9NWU2, 49 interactors |
MINTi | Q9NWU2 |
STRINGi | 9606.ENSP00000266069 |
PTM databases
iPTMneti | Q9NWU2 |
PhosphoSitePlusi | Q9NWU2 |
Genetic variation databases
BioMutai | GID8 |
DMDMi | 28201788 |
Proteomic databases
EPDi | Q9NWU2 |
jPOSTi | Q9NWU2 |
MassIVEi | Q9NWU2 |
MaxQBi | Q9NWU2 |
PaxDbi | Q9NWU2 |
PeptideAtlasi | Q9NWU2 |
PRIDEi | Q9NWU2 |
ProteomicsDBi | 82982 |
Protocols and materials databases
Antibodypediai | 29626, 149 antibodies |
DNASUi | 54994 |
Genome annotation databases
Ensembli | ENST00000266069; ENSP00000266069; ENSG00000101193 |
GeneIDi | 54994 |
KEGGi | hsa:54994 |
UCSCi | uc002ydy.4, human |
Organism-specific databases
CTDi | 54994 |
DisGeNETi | 54994 |
GeneCardsi | GID8 |
HGNCi | HGNC:15857, GID8 |
HPAi | ENSG00000101193, Low tissue specificity |
MIMi | 611625, gene |
neXtProti | NX_Q9NWU2 |
OpenTargetsi | ENSG00000101193 |
PharmGKBi | PA25649 |
VEuPathDBi | HostDB:ENSG00000101193.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2659, Eukaryota |
GeneTreei | ENSGT00390000015162 |
HOGENOMi | CLU_073203_1_0_1 |
InParanoidi | Q9NWU2 |
OMAi | QNGRIQE |
OrthoDBi | 1365635at2759 |
PhylomeDBi | Q9NWU2 |
TreeFami | TF300176 |
Enzyme and pathway databases
PathwayCommonsi | Q9NWU2 |
Miscellaneous databases
BioGRID-ORCSi | 54994, 47 hits in 1004 CRISPR screens |
ChiTaRSi | GID8, human |
GenomeRNAii | 54994 |
Pharosi | Q9NWU2, Tbio |
PROi | PR:Q9NWU2 |
RNActi | Q9NWU2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101193, Expressed in vagina and 237 other tissues |
Genevisiblei | Q9NWU2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013144, CRA_dom IPR024964, CTLH/CRA IPR006595, CTLH_C IPR006594, LisH |
Pfami | View protein in Pfam PF10607, CLTH, 1 hit PF08513, LisH, 1 hit |
SMARTi | View protein in SMART SM00757, CRA, 1 hit SM00668, CTLH, 1 hit SM00667, LisH, 1 hit |
PROSITEi | View protein in PROSITE PS50897, CTLH, 1 hit PS50896, LISH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GID8_HUMAN | |
Accessioni | Q9NWU2Primary (citable) accession number: Q9NWU2 Secondary accession number(s): E1P5I3, Q8N5M5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2003 |
Last sequence update: | October 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families