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Entry version 174 (08 May 2019)
Sequence version 2 (16 Jun 2003)
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Protein

Hypoxia-inducible factor 1-alpha inhibitor

Gene

HIF1AN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+8 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

The kinetic constants are determined for the recombinant FLAG-His-tagged protein.
  1. KM=100 µM for HIF1A (788-822) peptide1 Publication
  2. KM=160 µM for HIF2A (832-866) peptide1 Publication
  3. KM=0.5 µM for Fe2+1 Publication
  4. KM=25 µM for 2-oxoglutarate1 Publication
  5. KM=260 µM for ascorbate1 Publication
  6. KM=90 µM for O21 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1452-oxoglutarate3 Publications1
    Binding sitei152Substrate1 Publication1
    Binding sitei1962-oxoglutarate3 Publications1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi199Iron; via tele nitrogen; catalytic8 Publications1
    Metal bindingi201Iron; catalytic8 Publications1
    Binding sitei2052-oxoglutarate3 Publications1
    Binding sitei2142-oxoglutarate3 Publications1
    Metal bindingi279Iron; via tele nitrogen; catalytic8 Publications1
    Binding sitei2942-oxoglutarate3 Publications1
    Binding sitei300Substrate; via amide nitrogen1 Publication1
    Binding sitei321Substrate1 Publication1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei340Important for dimer formation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionDioxygenase, Oxidoreductase
    Biological processTranscription, Transcription regulation
    LigandIron, Metal-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS15407-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.14.11.16 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1234174 Cellular response to hypoxia

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q9NWT6

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Hypoxia-inducible factor 1-alpha inhibitor (EC:1.14.11.30, EC:1.14.11.n4)
    Alternative name(s):
    Factor inhibiting HIF-1
    Short name:
    FIH-1
    Hypoxia-inducible factor asparagine hydroxylase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:HIF1AN
    Synonyms:FIH1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:17113 HIF1AN

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    606615 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9NWT6

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi199H → A: Prevents suppression of HIF CAD activity. Strongly stimulates 2-oxoglutarate turnover. No stimulation of 2-oxoglutarate turnover; when associated with R-340. 1 Publication1
    Mutagenesisi201D → A: Prevents suppression of HIF CAD activity. 3 Publications1
    Mutagenesisi201D → E: Loss of HIF1A Asn hydroxylation activity. Slightly stimulates 2-oxoglutarate turnover. 3 Publications1
    Mutagenesisi201D → G: No impact on HIF1A Asn hydroxylation activity. Loss of Asp hydroxylation ability. Strongly stimulates 2-oxoglutarate turnover. Loss of HIF1A Asn hydroxylation activity and slight stimulation of 2-oxoglutarate turnover; when associated with R-296. 3 Publications1
    Mutagenesisi239Q → H: No effect on Asp hydroxylation ability. 1 Publication1
    Mutagenesisi296W → R: Loss of HIF1A Asn hydroxylation activity and slight stimulation of 2-oxoglutarate turnover; when associated with G-201. 1 Publication1
    Mutagenesisi340L → R: Impairs dimer formation, leading to loss of HIF1A Asn hydroxylation activity. No stimulation of 2-oxoglutarate turnover; when associated with A-201. 2 Publications1
    Mutagenesisi344I → R: No effect on dimer formation and HIF1A Asn hydroxylation activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    55662

    Open Targets

    More...
    OpenTargetsi
    ENSG00000166135

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA29284

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL5909

    Drug and drug target database

    More...
    DrugBanki
    DB01694 D-tartaric acid
    DB08263 N-(carboxycarbonyl)-D-phenylalanine
    DB09459 Tartaric acid

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    HIF1AN

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    32129605

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000839742 – 349Hypoxia-inducible factor 1-alpha inhibitorAdd BLAST348

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9NWT6

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9NWT6

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9NWT6

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9NWT6

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9NWT6

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9NWT6

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    82978

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9NWT6

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9NWT6

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000166135 Expressed in 219 organ(s), highest expression level in muscle of leg

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9NWT6 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9NWT6 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB069903
    HPA048742
    HPA065302

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer; homodimerization is essential for catalytic activity.

    Interacts with VHL and HIF1A.

    Part of a complex with VHL, HIF1A and HDAC1 or HDAC2 or HDAC3.

    Interacts with NFKB1 and NFKBIA.

    Interacts with NOTCH1, NOTCH2 and NOTCH3 but not with NOTCH4.

    Interacts with APBA3; binding inhibits HIF1AN binding to HIF1A.

    Interacts with TNKS2.

    Interacts with PPP1R12A.

    Interacts with ASB4 (By similarity).

    Interacts with UBE3A.

    Interacts with ANKS3 (By similarity).

    Interacts with NECAB3; the interaction is indirect and seems to be mediated by APBA3.

    By similarity18 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    120794, 288 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-35527N

    Protein interaction database and analysis system

    More...
    IntActi
    Q9NWT6, 187 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q9NWT6

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000299163

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q9NWT6

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1349
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9NWT6

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q9NWT6

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini142 – 312JmjCPROSITE-ProRule annotationAdd BLAST171

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 125Interaction with VHL1 PublicationAdd BLAST124
    Regioni181 – 183Substrate binding1 Publication3
    Regioni201 – 203Substrate binding1 Publication3
    Regioni238 – 239Substrate binding1 Publication2

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2132 Eukaryota
    ENOG410XQDR LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157409

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000008146

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9NWT6

    KEGG Orthology (KO)

    More...
    KOi
    K18055

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    MMIKGRY

    Database of Orthologous Groups

    More...
    OrthoDBi
    1385616at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9NWT6

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF329609

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.287.1010, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR041667 Cupin_8
    IPR027445 FIH-1
    IPR027452 FIH-1_dom_II
    IPR003347 JmjC_dom

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR12461:SF51 PTHR12461:SF51, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF13621 Cupin_8, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00558 JmjC, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51184 JMJC, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    Q9NWT6-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAATAAEAVA SGSGEPREEA GALGPAWDES QLRSYSFPTR PIPRLSQSDP
    60 70 80 90 100
    RAEELIENEE PVVLTDTNLV YPALKWDLEY LQENIGNGDF SVYSASTHKF
    110 120 130 140 150
    LYYDEKKMAN FQNFKPRSNR EEMKFHEFVE KLQDIQQRGG EERLYLQQTL
    160 170 180 190 200
    NDTVGRKIVM DFLGFNWNWI NKQQGKRGWG QLTSNLLLIG MEGNVTPAHY
    210 220 230 240 250
    DEQQNFFAQI KGYKRCILFP PDQFECLYPY PVHHPCDRQS QVDFDNPDYE
    260 270 280 290 300
    RFPNFQNVVG YETVVGPGDV LYIPMYWWHH IESLLNGGIT ITVNFWYKGA
    310 320 330 340
    PTPKRIEYPL KAHQKVAIMR NIEKMLGEAL GNPQEVGPLL NTMIKGRYN
    Length:349
    Mass (Da):40,285
    Last modified:June 16, 2003 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i96A033BA7B3BD8C7
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E9PNR8E9PNR8_HUMAN
    Hypoxia-inducible factor 1-alpha in...
    HIF1AN
    35Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PL41E9PL41_HUMAN
    Hypoxia-inducible factor 1-alpha in...
    HIF1AN
    191Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10A → T in BAA91291 (PubMed:14702039).Curated1
    Sequence conflicti28D → H in BAA91291 (PubMed:14702039).Curated1
    Sequence conflicti156R → G in BAA91291 (PubMed:14702039).Curated1

    <p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

    Molecular mass is 40566 Da from positions 1 - 349. Determined by ESI. 1 Publication

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05102841P → A1 PublicationCorresponds to variant dbSNP:rs2295778Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF395830 mRNA Translation: AAL27308.1
    AK000622 mRNA Translation: BAA91291.1
    AL133352 Genomic DNA No translation available.
    CH471066 Genomic DNA Translation: EAW49817.1
    CH471066 Genomic DNA Translation: EAW49818.1
    BC007719 mRNA Translation: AAH07719.1
    AL359615 mRNA Translation: CAB94885.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS7498.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T50633

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_060372.2, NM_017902.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000299163; ENSP00000299163; ENSG00000166135

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    55662

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:55662

    UCSC genome browser

    More...
    UCSCi
    uc001krj.5 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF395830 mRNA Translation: AAL27308.1
    AK000622 mRNA Translation: BAA91291.1
    AL133352 Genomic DNA No translation available.
    CH471066 Genomic DNA Translation: EAW49817.1
    CH471066 Genomic DNA Translation: EAW49818.1
    BC007719 mRNA Translation: AAH07719.1
    AL359615 mRNA Translation: CAB94885.1
    CCDSiCCDS7498.1
    PIRiT50633
    RefSeqiNP_060372.2, NM_017902.2

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1H2KX-ray2.15A1-349[»]
    1H2LX-ray2.25A1-349[»]
    1H2MX-ray2.50A1-349[»]
    1H2NX-ray2.84A1-349[»]
    1IZ3X-ray2.80A1-349[»]
    1MZEX-ray2.20A1-349[»]
    1MZFX-ray2.40A1-349[»]
    1YCIX-ray2.70A1-349[»]
    2CGNX-ray2.40A1-349[»]
    2CGOX-ray2.30A1-349[»]
    2ILMX-ray2.30A1-349[»]
    2W0XX-ray2.12A1-349[»]
    2WA3X-ray2.50A1-349[»]
    2WA4X-ray2.50A1-349[»]
    2XUMX-ray2.20A1-349[»]
    2Y0IX-ray2.28A1-349[»]
    2YC0X-ray2.15A1-349[»]
    2YDEX-ray2.28A1-349[»]
    3D8CX-ray2.10A11-349[»]
    3KCXX-ray2.60A15-349[»]
    3KCYX-ray2.59A15-349[»]
    3OD4X-ray2.20A1-349[»]
    3P3NX-ray2.40A1-349[»]
    3P3PX-ray2.60A1-349[»]
    4AI8X-ray2.40A1-349[»]
    4B7EX-ray2.50A1-349[»]
    4B7KX-ray2.39A1-349[»]
    4BIOX-ray2.45A1-349[»]
    4JAAX-ray2.39A1-349[»]
    4NR1X-ray2.68A1-349[»]
    4Z1VX-ray2.10A1-349[»]
    4Z2WX-ray2.50A1-349[»]
    5JWKX-ray2.30A1-349[»]
    5JWLX-ray2.40A1-349[»]
    5JWPX-ray2.10A1-349[»]
    5OP6X-ray2.45A1-349[»]
    5OP8X-ray2.30A1-349[»]
    5OPCX-ray2.30A1-349[»]
    SMRiQ9NWT6
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi120794, 288 interactors
    DIPiDIP-35527N
    IntActiQ9NWT6, 187 interactors
    MINTiQ9NWT6
    STRINGi9606.ENSP00000299163

    Chemistry databases

    BindingDBiQ9NWT6
    ChEMBLiCHEMBL5909
    DrugBankiDB01694 D-tartaric acid
    DB08263 N-(carboxycarbonyl)-D-phenylalanine
    DB09459 Tartaric acid

    PTM databases

    iPTMnetiQ9NWT6
    PhosphoSitePlusiQ9NWT6

    Polymorphism and mutation databases

    BioMutaiHIF1AN
    DMDMi32129605

    Proteomic databases

    EPDiQ9NWT6
    jPOSTiQ9NWT6
    MaxQBiQ9NWT6
    PaxDbiQ9NWT6
    PeptideAtlasiQ9NWT6
    PRIDEiQ9NWT6
    ProteomicsDBi82978

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    55662
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000299163; ENSP00000299163; ENSG00000166135
    GeneIDi55662
    KEGGihsa:55662
    UCSCiuc001krj.5 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    55662
    DisGeNETi55662

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    HIF1AN
    HGNCiHGNC:17113 HIF1AN
    HPAiCAB069903
    HPA048742
    HPA065302
    MIMi606615 gene
    neXtProtiNX_Q9NWT6
    OpenTargetsiENSG00000166135
    PharmGKBiPA29284

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2132 Eukaryota
    ENOG410XQDR LUCA
    GeneTreeiENSGT00940000157409
    HOGENOMiHOG000008146
    InParanoidiQ9NWT6
    KOiK18055
    OMAiMMIKGRY
    OrthoDBi1385616at2759
    PhylomeDBiQ9NWT6
    TreeFamiTF329609

    Enzyme and pathway databases

    BioCyciMetaCyc:HS15407-MONOMER
    BRENDAi1.14.11.16 2681
    ReactomeiR-HSA-1234174 Cellular response to hypoxia
    SIGNORiQ9NWT6

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    HIF1AN human
    EvolutionaryTraceiQ9NWT6

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    HIF1AN

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    55662

    Protein Ontology

    More...
    PROi
    PR:Q9NWT6

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000166135 Expressed in 219 organ(s), highest expression level in muscle of leg
    ExpressionAtlasiQ9NWT6 baseline and differential
    GenevisibleiQ9NWT6 HS

    Family and domain databases

    Gene3Di1.10.287.1010, 1 hit
    InterProiView protein in InterPro
    IPR041667 Cupin_8
    IPR027445 FIH-1
    IPR027452 FIH-1_dom_II
    IPR003347 JmjC_dom
    PANTHERiPTHR12461:SF51 PTHR12461:SF51, 1 hit
    PfamiView protein in Pfam
    PF13621 Cupin_8, 1 hit
    SMARTiView protein in SMART
    SM00558 JmjC, 1 hit
    PROSITEiView protein in PROSITE
    PS51184 JMJC, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHIF1N_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NWT6
    Secondary accession number(s): D3DR69
    , Q5W147, Q969Q7, Q9NPV5
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: June 16, 2003
    Last modified: May 8, 2019
    This is version 174 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
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