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Protein

Zinc finger protein 446

Gene

ZNF446

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri332 – 359C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri395 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri423 – 450C2H2-type 3PROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 446
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 20
Gene namesi
Name:ZNF446
Synonyms:ZKSCAN20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000083838.15
HGNCiHGNC:21036 ZNF446
neXtProtiNX_Q9NWS9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000083838
PharmGKBiPA134863395

Polymorphism and mutation databases

BioMutaiZNF446
DMDMi55976772

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475961 – 450Zinc finger protein 446Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei137PhosphoserineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei308PhosphothreonineCombined sources1
Cross-linki330Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NWS9
MaxQBiQ9NWS9
PaxDbiQ9NWS9
PeptideAtlasiQ9NWS9
PRIDEiQ9NWS9
ProteomicsDBi82976

PTM databases

iPTMnetiQ9NWS9
PhosphoSitePlusiQ9NWS9

Expressioni

Gene expression databases

BgeeiENSG00000083838 Expressed in 142 organ(s), highest expression level in adenohypophysis
CleanExiHS_ZNF446
ExpressionAtlasiQ9NWS9 baseline and differential
GenevisibleiQ9NWS9 HS

Organism-specific databases

HPAiHPA052786

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120795, 39 interactors
IntActiQ9NWS9, 57 interactors
STRINGi9606.ENSP00000472802

Structurei

3D structure databases

ProteinModelPortaliQ9NWS9
SMRiQ9NWS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 108SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini208 – 254KRABAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi274 – 331Pro-richAdd BLAST58

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri332 – 359C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri395 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri423 – 450C2H2-type 3PROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOGENOMiHOG000234619
HOVERGENiHBG098310
InParanoidiQ9NWS9
KOiK09229
OMAiGQEMAPS
OrthoDBiEOG091G08W1
PhylomeDBiQ9NWS9
TreeFamiTF337489

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR027764 Zfp18/Zfp446
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR45403 PTHR45403, 2 hits
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NWS9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSPLGPPCL PVMDPETTLE EPETARLRFR GFCYQEVAGP REALARLREL
60 70 80 90 100
CCQWLQPEAH SKEQMLEMLV LEQFLGTLPP EIQAWVRGQR PGSPEEAAAL
110 120 130 140 150
VEGLQHDPGQ LLGWITAHVL KQEVLPAAQK TEEPLGSPHP SGTVESPGEG
160 170 180 190 200
PQDTRIEGSV QLSCSVKEEP NVDGQEVAPS SPPLAAQSPE GNHGHQEPAS
210 220 230 240 250
TSFHPPRIQE EWGLLDRSQK ELYWDAMLEK YGTVVSLGLP PHQPEAQAQS
260 270 280 290 300
ELGMLLTGTG VCRSLRSGNE SEGPPGCPEA QPPQGPGPAA WEGLSGAATP
310 320 330 340 350
APTVRPGTPP VPTQPTPAET RLEPAATPRK PYTCEQCGRG FDWKSVFVIH
360 370 380 390 400
HRTHTSGPGV QSPGLATGES TEKPPQGEVA FPHHPRRSLT GPRSYPCEEC
410 420 430 440 450
GCSFSWKSQL VIHRKSHTGQ RRHFCSDCGR AFDWKSQLVI HRKGHRPEVP
Length:450
Mass (Da):48,957
Last modified:October 1, 2000 - v1
Checksum:i8D8B65137855E91E
GO
Isoform 2 (identifier: Q9NWS9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     417-444: Missing.

Show »
Length:422
Mass (Da):45,648
Checksum:iD1878D81688F415E
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUM8A0A087WUM8_HUMAN
Zinc finger protein 446
ZNF446
422Annotation score:
M0R202M0R202_HUMAN
Zinc finger protein 446
ZNF446
399Annotation score:
A0A0B4J2G2A0A0B4J2G2_HUMAN
Zinc finger protein 446
ZNF446
422Annotation score:
M0R034M0R034_HUMAN
Zinc finger protein 446
ZNF446
141Annotation score:
A0A0A0MR84A0A0A0MR84_HUMAN
Zinc finger protein 446
ZNF446
336Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033566192N → H1 PublicationCorresponds to variant dbSNP:rs893185Ensembl.1
Natural variantiVAR_033567300P → S. Corresponds to variant dbSNP:rs36095067Ensembl.1
Natural variantiVAR_052833387R → H1 PublicationCorresponds to variant dbSNP:rs882610Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_058945417 – 444Missing in isoform 2. Add BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000633 mRNA Translation: BAA91298.1
AY280800 mRNA Translation: AAQ16304.1
BC017206 mRNA Translation: AAH17206.1
CCDSiCCDS12982.1 [Q9NWS9-1]
RefSeqiNP_060378.1, NM_017908.3 [Q9NWS9-1]
XP_005259109.1, XM_005259052.4 [Q9NWS9-1]
UniGeneiHs.710284

Genome annotation databases

EnsembliENST00000594369; ENSP00000472802; ENSG00000083838 [Q9NWS9-1]
ENST00000610298; ENSP00000478778; ENSG00000083838 [Q9NWS9-2]
GeneIDi55663
KEGGihsa:55663
UCSCiuc002qsz.4 human [Q9NWS9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000633 mRNA Translation: BAA91298.1
AY280800 mRNA Translation: AAQ16304.1
BC017206 mRNA Translation: AAH17206.1
CCDSiCCDS12982.1 [Q9NWS9-1]
RefSeqiNP_060378.1, NM_017908.3 [Q9NWS9-1]
XP_005259109.1, XM_005259052.4 [Q9NWS9-1]
UniGeneiHs.710284

3D structure databases

ProteinModelPortaliQ9NWS9
SMRiQ9NWS9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120795, 39 interactors
IntActiQ9NWS9, 57 interactors
STRINGi9606.ENSP00000472802

PTM databases

iPTMnetiQ9NWS9
PhosphoSitePlusiQ9NWS9

Polymorphism and mutation databases

BioMutaiZNF446
DMDMi55976772

Proteomic databases

EPDiQ9NWS9
MaxQBiQ9NWS9
PaxDbiQ9NWS9
PeptideAtlasiQ9NWS9
PRIDEiQ9NWS9
ProteomicsDBi82976

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000594369; ENSP00000472802; ENSG00000083838 [Q9NWS9-1]
ENST00000610298; ENSP00000478778; ENSG00000083838 [Q9NWS9-2]
GeneIDi55663
KEGGihsa:55663
UCSCiuc002qsz.4 human [Q9NWS9-1]

Organism-specific databases

CTDi55663
EuPathDBiHostDB:ENSG00000083838.15
GeneCardsiZNF446
HGNCiHGNC:21036 ZNF446
HPAiHPA052786
neXtProtiNX_Q9NWS9
OpenTargetsiENSG00000083838
PharmGKBiPA134863395
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOGENOMiHOG000234619
HOVERGENiHBG098310
InParanoidiQ9NWS9
KOiK09229
OMAiGQEMAPS
OrthoDBiEOG091G08W1
PhylomeDBiQ9NWS9
TreeFamiTF337489

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF446 human
GenomeRNAii55663
PROiPR:Q9NWS9

Gene expression databases

BgeeiENSG00000083838 Expressed in 142 organ(s), highest expression level in adenohypophysis
CleanExiHS_ZNF446
ExpressionAtlasiQ9NWS9 baseline and differential
GenevisibleiQ9NWS9 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR027764 Zfp18/Zfp446
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR45403 PTHR45403, 2 hits
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN446_HUMAN
AccessioniPrimary (citable) accession number: Q9NWS9
Secondary accession number(s): Q96AF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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