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UniProtKB - Q9NWS9 (ZN446_HUMAN)

Entry version 166 (07 Apr 2021)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
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Protein

Zinc finger protein 446

Gene

ZNF446

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri332 – 359C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri395 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri423 – 450C2H2-type 3PROSITE-ProRule annotationAdd BLAST28

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NWS9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 446
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 20
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF446
Synonyms:ZKSCAN20
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21036, ZNF446

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NWS9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000083838.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55663

Open Targets

More...OpenTargetsi		ENSG00000083838

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134863395

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NWS9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF446

Domain mapping of disease mutations (DMDM)

More...DMDMi		55976772

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475961 – 450Zinc finger protein 446Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei137PhosphoserineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei308PhosphothreonineCombined sources1
Cross-linki330Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NWS9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NWS9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NWS9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NWS9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NWS9

PeptideAtlas

More...PeptideAtlasi		Q9NWS9

PRoteomics IDEntifications database

More...PRIDEi		Q9NWS9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82976

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NWS9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NWS9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000083838, Expressed in adenohypophysis and 158 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NWS9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NWS9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000083838, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9NWS9
With#Exp.IntAct
PGBD1 [Q96JS3]5EBI-3925851,EBI-10290053
ZNF446 - isoform 2 [Q9NWS9-2]
With#Exp.IntAct
ANKRD1 [Q15327]6EBI-740232,EBI-5653378
CCNK - isoform 2 [O75909-2]3EBI-740232,EBI-12010594
COPS2 [P61201]3EBI-740232,EBI-1050386
CYSRT1 [A8MQ03]3EBI-740232,EBI-3867333
EHMT2 [Q96KQ7]3EBI-740232,EBI-744366
EVI5 [O60447]3EBI-740232,EBI-852291
FRMD8 [Q9BZ67]3EBI-740232,EBI-5773072
FRS3 [O43559]3EBI-740232,EBI-725515
GOLGA6L9 [A6NEM1]3EBI-740232,EBI-5916454
INCA1 [Q0VD86]3EBI-740232,EBI-6509505
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-740232,EBI-14069005
KRT31 [Q15323]3EBI-740232,EBI-948001
KRT34 [O76011]3EBI-740232,EBI-1047093
KRT35 [Q92764]3EBI-740232,EBI-1058674
KRT40 [Q6A162]6EBI-740232,EBI-10171697
KRTAP1-1 [Q07627]3EBI-740232,EBI-11959885
KRTAP3-1 [Q9BYR8]3EBI-740232,EBI-9996449
LNX1 [Q8TBB1]3EBI-740232,EBI-739832
LZTS2 [Q9BRK4]3EBI-740232,EBI-741037
MAGOHB [Q96A72]3EBI-740232,EBI-746778
MDFI [Q99750]3EBI-740232,EBI-724076
NOTCH2NLA [Q7Z3S9]3EBI-740232,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-740232,EBI-22310682
OPTN [Q96CV9]3EBI-740232,EBI-748974
PGBD1 [Q96JS3]6EBI-740232,EBI-10290053
PIN1 [Q13526]6EBI-740232,EBI-714158
REL - isoform 2 [Q04864-2]3EBI-740232,EBI-10829018
SCAND1 [P57086]5EBI-740232,EBI-745846
SIVA1 - isoform 2 [O15304-2]3EBI-740232,EBI-12372219
SUFU [Q9UMX1]4EBI-740232,EBI-740595
TAX1BP1 [Q86VP1]3EBI-740232,EBI-529518
TRIM27 [P14373]3EBI-740232,EBI-719493
UBE2I [Q7KZS0]3EBI-740232,EBI-10180829
ZKSCAN4 [Q969J2]9EBI-740232,EBI-2818641
ZKSCAN7 [Q9P0L1]3EBI-740232,EBI-743851
ZNF165 [P49910]9EBI-740232,EBI-741694
ZNF165 [Q53Z40]3EBI-740232,EBI-10186058
ZNF18 [P17022]3EBI-740232,EBI-8648067
ZNF232 [Q9UNY5]7EBI-740232,EBI-749023
ZNF24 [P17028]13EBI-740232,EBI-707773
ZNF396 - isoform 3 [Q96N95-3]3EBI-740232,EBI-12328453
ZNF397 [Q8NF99]5EBI-740232,EBI-10213894
ZNF397 - isoform 2 [Q8NF99-2]5EBI-740232,EBI-11524467
itself4EBI-740232,EBI-740232
ZNF483 [Q6P088]4EBI-740232,EBI-10196963
ZNF496 [Q96IT1]7EBI-740232,EBI-743906
ZSCAN12 [O43309]7EBI-740232,EBI-1210440
ZSCAN16 [Q9H4T2]10EBI-740232,EBI-723596
ZSCAN18 [Q8TBC5]3EBI-740232,EBI-3919096
ZSCAN21 [Q9Y5A6]8EBI-740232,EBI-10281938
ZSCAN22 [P10073]8EBI-740232,EBI-10178224
ZSCAN23 [Q3MJ62]5EBI-740232,EBI-5667532
ZSCAN29 - isoform 3 [Q8IWY8-3]3EBI-740232,EBI-14188237
ZSCAN30 [Q86W11]3EBI-740232,EBI-11793064
ZSCAN32 [Q9NX65]4EBI-740232,EBI-739949
ZSCAN9 [O15535]9EBI-740232,EBI-751531

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120795, 71 interactors

Protein interaction database and analysis system

More...IntActi		Q9NWS9, 69 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000472802

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NWS9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NWS9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 108SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini208 – 254KRABAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi274 – 331Pro-richAdd BLAST58

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri332 – 359C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri395 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri423 – 450C2H2-type 3PROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162092

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NWS9

Identification of Orthologs from Complete Genome Data

More...OMAi		RRKPYTC

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NWS9

TreeFam database of animal gene trees

More...TreeFami		TF337489

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit
cd07936, SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR027768, Zfp446
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...PANTHERi		PTHR23226:SF210, PTHR23226:SF210, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NWS9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSPLGPPCL PVMDPETTLE EPETARLRFR GFCYQEVAGP REALARLREL 
        60         70         80         90        100
CCQWLQPEAH SKEQMLEMLV LEQFLGTLPP EIQAWVRGQR PGSPEEAAAL 
       110        120        130        140        150
VEGLQHDPGQ LLGWITAHVL KQEVLPAAQK TEEPLGSPHP SGTVESPGEG 
       160        170        180        190        200
PQDTRIEGSV QLSCSVKEEP NVDGQEVAPS SPPLAAQSPE GNHGHQEPAS 
       210        220        230        240        250
TSFHPPRIQE EWGLLDRSQK ELYWDAMLEK YGTVVSLGLP PHQPEAQAQS 
       260        270        280        290        300
ELGMLLTGTG VCRSLRSGNE SEGPPGCPEA QPPQGPGPAA WEGLSGAATP 
       310        320        330        340        350
APTVRPGTPP VPTQPTPAET RLEPAATPRK PYTCEQCGRG FDWKSVFVIH 
       360        370        380        390        400
HRTHTSGPGV QSPGLATGES TEKPPQGEVA FPHHPRRSLT GPRSYPCEEC 
       410        420        430        440        450
GCSFSWKSQL VIHRKSHTGQ RRHFCSDCGR AFDWKSQLVI HRKGHRPEVP
Length:450
Mass (Da):48,957
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D8B65137855E91E
GO
Isoform 2 (identifier: Q9NWS9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     417-444: Missing.

Show »
Length:422
Mass (Da):45,648
Checksum:iD1878D81688F415E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R202M0R202_HUMAN
Zinc finger protein 446
ZNF446
399Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MR84A0A0A0MR84_HUMAN
Zinc finger protein 446
ZNF446
336Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J2G2A0A0B4J2G2_HUMAN
Zinc finger protein 446
ZNF446
422Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R034M0R034_HUMAN
Zinc finger protein 446
ZNF446
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033566192N → H1 PublicationCorresponds to variant dbSNP:rs893185Ensembl.1
Natural variantiVAR_033567300P → S. Corresponds to variant dbSNP:rs36095067Ensembl.1
Natural variantiVAR_052833387R → H1 PublicationCorresponds to variant dbSNP:rs882610Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_058945417 – 444Missing in isoform 2. Add BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK000633 mRNA Translation: BAA91298.1
AY280800 mRNA Translation: AAQ16304.1
BC017206 mRNA Translation: AAH17206.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12982.1 [Q9NWS9-1]

NCBI Reference Sequences

More...RefSeqi		NP_060378.1, NM_017908.3 [Q9NWS9-1]
XP_005259109.1, XM_005259052.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000594369; ENSP00000472802; ENSG00000083838 [Q9NWS9-1]
ENST00000610298; ENSP00000478778; ENSG00000083838 [Q9NWS9-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55663

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55663

UCSC genome browser

More...UCSCi		uc002qsz.4, human [Q9NWS9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000633 mRNA Translation: BAA91298.1
AY280800 mRNA Translation: AAQ16304.1
BC017206 mRNA Translation: AAH17206.1
CCDSiCCDS12982.1 [Q9NWS9-1]
RefSeqiNP_060378.1, NM_017908.3 [Q9NWS9-1]
XP_005259109.1, XM_005259052.4

3D structure databases

SMRiQ9NWS9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120795, 71 interactors
IntActiQ9NWS9, 69 interactors
STRINGi9606.ENSP00000472802

PTM databases

iPTMnetiQ9NWS9
PhosphoSitePlusiQ9NWS9

Genetic variation databases

BioMutaiZNF446
DMDMi55976772

Proteomic databases

EPDiQ9NWS9
jPOSTiQ9NWS9
MassIVEiQ9NWS9
MaxQBiQ9NWS9
PaxDbiQ9NWS9
PeptideAtlasiQ9NWS9
PRIDEiQ9NWS9
ProteomicsDBi82976

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9NWS9, 6 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19695, 112 antibodies

Genome annotation databases

EnsembliENST00000594369; ENSP00000472802; ENSG00000083838 [Q9NWS9-1]
ENST00000610298; ENSP00000478778; ENSG00000083838 [Q9NWS9-2]
GeneIDi55663
KEGGihsa:55663
UCSCiuc002qsz.4, human [Q9NWS9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55663
DisGeNETi55663

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF446
HGNCiHGNC:21036, ZNF446
HPAiENSG00000083838, Low tissue specificity
neXtProtiNX_Q9NWS9
OpenTargetsiENSG00000083838
PharmGKBiPA134863395
VEuPathDBiHostDB:ENSG00000083838.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000162092
InParanoidiQ9NWS9
OMAiRRKPYTC
OrthoDBi1318335at2759
PhylomeDBiQ9NWS9
TreeFamiTF337489

Enzyme and pathway databases

PathwayCommonsiQ9NWS9
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55663, 10 hits in 1014 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF446, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55663
PharosiQ9NWS9, Tdark

Protein Ontology

More...PROi		PR:Q9NWS9
RNActiQ9NWS9, protein

Gene expression databases

BgeeiENSG00000083838, Expressed in adenohypophysis and 158 other tissues
ExpressionAtlasiQ9NWS9, baseline and differential
GenevisibleiQ9NWS9, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
cd07936, SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR027768, Zfp446
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PANTHERiPTHR23226:SF210, PTHR23226:SF210, 1 hit
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 3 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN446_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NWS9
Secondary accession number(s): Q96AF5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2000
Last modified: April 7, 2021
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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