UniProtKB - Q9NWS9 (ZN446_HUMAN)

BLAST

>sp|Q9NWS9|ZN446_HUMAN Zinc finger protein 446 OS=Homo sapiens OX=9606 GN=ZNF446 PE=1 SV=1
MPSPLGPPCLPVMDPETTLEEPETARLRFRGFCYQEVAGPREALARLRELCCQWLQPEAH
SKEQMLEMLVLEQFLGTLPPEIQAWVRGQRPGSPEEAAALVEGLQHDPGQLLGWITAHVL
KQEVLPAAQKTEEPLGSPHPSGTVESPGEGPQDTRIEGSVQLSCSVKEEPNVDGQEVAPS
SPPLAAQSPEGNHGHQEPASTSFHPPRIQEEWGLLDRSQKELYWDAMLEKYGTVVSLGLP
PHQPEAQAQSELGMLLTGTGVCRSLRSGNESEGPPGCPEAQPPQGPGPAAWEGLSGAATP
APTVRPGTPPVPTQPTPAETRLEPAATPRKPYTCEQCGRGFDWKSVFVIHHRTHTSGPGV
QSPGLATGESTEKPPQGEVAFPHHPRRSLTGPRSYPCEECGCSFSWKSQLVIHRKSHTGQ
RRHFCSDCGRAFDWKSQLVIHRKGHRPEVP

Align

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History
Entry version 149 (07 Nov 2018)
Sequence version 1 (01 Oct 2000)
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Protein

Zinc finger protein 446

Gene

ZNF446

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	332 – 359	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	28
Zinc fingerⁱ	395 – 422	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	28
Zinc fingerⁱ	423 – 450	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	28

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25416956
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 446 Alternative name(s): Zinc finger protein with KRAB and SCAN domains 20
Gene namesⁱ	Name:ZNF446 Synonyms:ZKSCAN20
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000083838.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21036 ZNF446
neXtProtⁱ	NX_Q9NWS9

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000083838
PharmGKBⁱ	PA134863395

Polymorphism and mutation databases

BioMutaⁱ	ZNF446
DMDMⁱ	55976772

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047596	1 – 450	Zinc finger protein 446Add BLAST		450

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	130	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	137	PhosphoserineCombined sources	1
Modified residueⁱ	218	PhosphoserineCombined sources	1
Modified residueⁱ	308	PhosphothreonineCombined sources	1
Cross-linkⁱ	330	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9NWS9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NWS9
PaxDbⁱ	Q9NWS9
PeptideAtlas More...PeptideAtlasⁱ	Q9NWS9
PRIDEⁱ	Q9NWS9
ProteomicsDBⁱ	82976

PTM databases

iPTMnetⁱ	Q9NWS9
PhosphoSitePlusⁱ	Q9NWS9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000083838 Expressed in 142 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_ZNF446
ExpressionAtlasⁱ	Q9NWS9 baseline and differential
Genevisibleⁱ	Q9NWS9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA052786

HPAⁱ

HPA052786

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ANKRD1	Q15327	4	EBI-740232,EBI-5653378
KRT40	Q6A162	5	EBI-740232,EBI-10171697
LZTS2	Q9BRK4	3	EBI-740232,EBI-741037
NOTCH2NL	Q7Z3S9	5	EBI-740232,EBI-945833
PGBD1	Q96JS3	7	EBI-740232,EBI-10290053
PIN1	Q13526	5	EBI-740232,EBI-714158
SUFU	Q9UMX1	3	EBI-740232,EBI-740595
TRIM27	P14373	3	EBI-740232,EBI-719493
ZKSCAN4	Q969J2	7	EBI-740232,EBI-2818641
ZKSCAN7	Q9P0L1	3	EBI-740232,EBI-743851
ZNF165	P49910	5	EBI-740232,EBI-741694
ZNF165	Q53Z40	3	EBI-740232,EBI-10186058
ZNF232	Q9UNY5	8	EBI-740232,EBI-749023
ZNF24	P17028	10	EBI-740232,EBI-707773
ZNF397	Q8NF99	5	EBI-740232,EBI-10213894
ZNF397	Q8NF99-2	4	EBI-740232,EBI-11524467
ZNF496	Q96IT1	6	EBI-740232,EBI-743906
ZSCAN12	O43309	4	EBI-740232,EBI-1210440
ZSCAN16	Q9H4T2	8	EBI-740232,EBI-723596
ZSCAN21	Q9Y5A6	7	EBI-740232,EBI-10281938
ZSCAN22	P10073	5	EBI-740232,EBI-10178224
ZSCAN23	Q3MJ62	4	EBI-740232,EBI-5667532
ZSCAN32	I3L3J2	3	EBI-740232,EBI-10178206
ZSCAN9	O15535	6	EBI-740232,EBI-751531

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25416956

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	120795, 39 interactors
IntActⁱ	Q9NWS9, 57 interactors
STRINGⁱ	9606.ENSP00000472802

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NWS9
SMRⁱ	Q9NWS9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	26 – 108	SCAN boxPROSITE-ProRule annotationAdd BLAST		83
Domainⁱ	208 – 254	KRABAdd BLAST		47

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	274 – 331	Pro-richAdd BLAST		58

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	332 – 359	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	28
Zinc fingerⁱ	395 – 422	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	28
Zinc fingerⁱ	423 – 450	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	28

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144000
HOGENOMⁱ	HOG000234619
HOVERGENⁱ	HBG098310
InParanoidⁱ	Q9NWS9
KEGG Orthology (KO) More...KOⁱ	K09229
OMAⁱ	GQEMAPS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08W1
PhylomeDBⁱ	Q9NWS9
TreeFamⁱ	TF337489

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR003309 SCAN_dom IPR038269 SCAN_sf IPR027764 Zfp18/Zfp446 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR45403 PTHR45403, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF02023 SCAN, 1 hit PF00096 zf-C2H2, 1 hit
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NWS9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSPLGPPCL PVMDPETTLE EPETARLRFR GFCYQEVAGP REALARLREL 
        60         70         80         90        100
CCQWLQPEAH SKEQMLEMLV LEQFLGTLPP EIQAWVRGQR PGSPEEAAAL 
       110        120        130        140        150
VEGLQHDPGQ LLGWITAHVL KQEVLPAAQK TEEPLGSPHP SGTVESPGEG 
       160        170        180        190        200
PQDTRIEGSV QLSCSVKEEP NVDGQEVAPS SPPLAAQSPE GNHGHQEPAS 
       210        220        230        240        250
TSFHPPRIQE EWGLLDRSQK ELYWDAMLEK YGTVVSLGLP PHQPEAQAQS 
       260        270        280        290        300
ELGMLLTGTG VCRSLRSGNE SEGPPGCPEA QPPQGPGPAA WEGLSGAATP 
       310        320        330        340        350
APTVRPGTPP VPTQPTPAET RLEPAATPRK PYTCEQCGRG FDWKSVFVIH 
       360        370        380        390        400
HRTHTSGPGV QSPGLATGES TEKPPQGEVA FPHHPRRSLT GPRSYPCEEC 
       410        420        430        440        450
GCSFSWKSQL VIHRKSHTGQ RRHFCSDCGR AFDWKSQLVI HRKGHRPEVP

Length:450

Mass (Da):48,957

Last modified:October 1, 2000 - v1

Checksum:ⁱ8D8B65137855E91E

Isoform 2 (identifier: Q9NWS9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
417-444: Missing.

« Hide

        10         20         30         40         50
MPSPLGPPCL PVMDPETTLE EPETARLRFR GFCYQEVAGP REALARLREL 
        60         70         80         90        100
CCQWLQPEAH SKEQMLEMLV LEQFLGTLPP EIQAWVRGQR PGSPEEAAAL 
       110        120        130        140        150
VEGLQHDPGQ LLGWITAHVL KQEVLPAAQK TEEPLGSPHP SGTVESPGEG 
       160        170        180        190        200
PQDTRIEGSV QLSCSVKEEP NVDGQEVAPS SPPLAAQSPE GNHGHQEPAS 
       210        220        230        240        250
TSFHPPRIQE EWGLLDRSQK ELYWDAMLEK YGTVVSLGLP PHQPEAQAQS 
       260        270        280        290        300
ELGMLLTGTG VCRSLRSGNE SEGPPGCPEA QPPQGPGPAA WEGLSGAATP 
       310        320        330        340        350
APTVRPGTPP VPTQPTPAET RLEPAATPRK PYTCEQCGRG FDWKSVFVIH 
       360        370        380        390        400
HRTHTSGPGV QSPGLATGES TEKPPQGEVA FPHHPRRSLT GPRSYPCEEC 
       410        420 
GCSFSWKSQL VIHRKSHRPE VP

Show »

Length:422

Mass (Da):45,648

Checksum:ⁱD1878D81688F415E

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087WUM8	A0A087WUM8_HUMAN	Zinc finger protein 446 Zinc finger protein 446	ZNF446	422	Annotation score:
M0R202	M0R202_HUMAN	Zinc finger protein 446 Zinc finger protein 446	ZNF446	399	Annotation score:
A0A0B4J2G2	A0A0B4J2G2_HUMAN	Zinc finger protein 446 Zinc finger protein 446	ZNF446	422	Annotation score:
M0R034	M0R034_HUMAN	Zinc finger protein 446 Zinc finger protein 446	ZNF446	141	Annotation score:
A0A0A0MR84	A0A0A0MR84_HUMAN	Zinc finger protein 446 Zinc finger protein 446	ZNF446	336	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_033566	192	N → H1 PublicationCorresponds to variant dbSNP:rs893185Ensembl.	1
Natural variantⁱVAR_033567	300	P → S. Corresponds to variant dbSNP:rs36095067Ensembl.	1
Natural variantⁱVAR_052833	387	R → H1 PublicationCorresponds to variant dbSNP:rs882610Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_058945	417 – 444	Missing in isoform 2. Add BLAST		28

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000633 mRNA Translation: BAA91298.1 AY280800 mRNA Translation: AAQ16304.1 BC017206 mRNA Translation: AAH17206.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12982.1 [Q9NWS9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_060378.1, NM_017908.3 [Q9NWS9-1] XP_005259109.1, XM_005259052.4 [Q9NWS9-1]
UniGeneⁱ	Hs.710284

Genome annotation databases

Ensemblⁱ	ENST00000594369; ENSP00000472802; ENSG00000083838 [Q9NWS9-1] ENST00000610298; ENSP00000478778; ENSG00000083838 [Q9NWS9-2]
GeneIDⁱ	55663
KEGGⁱ	hsa:55663
UCSC genome browser More...UCSCⁱ	uc002qsz.4 human [Q9NWS9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NWS9	Uncharacterized protein DKFZp434L2027 (Fragment)		HUMAN		237	UniRef100_Q9NWS9
Zinc finger protein 446 (Fragment)		HUMAN		141
Q9NWS9-2	Zinc finger protein 446		HUMAN		422	UniRef100_A0A087WUM8

Protein	Similar proteins		Species	Score	Length	Source
Q9NWS9	Uncharacterized protein DKFZp434L2027 (Fragment)		HUMAN		237	UniRef90_Q9NWS9
Zinc finger protein 446		RHIBE		450
ZNF446 isoform 4		PONAB		450
Zinc finger protein 446		SAIBB		450
Uncharacterized protein		MACMU		450
+32

Protein	Similar proteins		Species	Score	Length	Source
Q9NWS9	Uncharacterized protein DKFZp434L2027 (Fragment)		HUMAN		237	UniRef50_Q9NWS9
Zinc finger protein 446		RHIBE		450
Zinc finger protein 446		MACMU		450
Uncharacterized protein		Cebus capucinus imitator		450
Uncharacterized protein		CALJA		450
+81

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000633 mRNA Translation: BAA91298.1 AY280800 mRNA Translation: AAQ16304.1 BC017206 mRNA Translation: AAH17206.1
CCDSⁱ	CCDS12982.1 [Q9NWS9-1]
RefSeqⁱ	NP_060378.1, NM_017908.3 [Q9NWS9-1] XP_005259109.1, XM_005259052.4 [Q9NWS9-1]
UniGeneⁱ	Hs.710284

3D structure databases

ProteinModelPortalⁱ	Q9NWS9
SMRⁱ	Q9NWS9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120795, 39 interactors
IntActⁱ	Q9NWS9, 57 interactors
STRINGⁱ	9606.ENSP00000472802

PTM databases

iPTMnetⁱ	Q9NWS9
PhosphoSitePlusⁱ	Q9NWS9

Polymorphism and mutation databases

BioMutaⁱ	ZNF446
DMDMⁱ	55976772

Proteomic databases

EPDⁱ	Q9NWS9
MaxQBⁱ	Q9NWS9
PaxDbⁱ	Q9NWS9
PeptideAtlasⁱ	Q9NWS9
PRIDEⁱ	Q9NWS9
ProteomicsDBⁱ	82976

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000594369; ENSP00000472802; ENSG00000083838 [Q9NWS9-1] ENST00000610298; ENSP00000478778; ENSG00000083838 [Q9NWS9-2]
GeneIDⁱ	55663
KEGGⁱ	hsa:55663
UCSCⁱ	uc002qsz.4 human [Q9NWS9-1]

Organism-specific databases

CTDⁱ	55663
EuPathDBⁱ	HostDB:ENSG00000083838.15
GeneCardsⁱ	ZNF446
HGNCⁱ	HGNC:21036 ZNF446
HPAⁱ	HPA052786
neXtProtⁱ	NX_Q9NWS9
OpenTargetsⁱ	ENSG00000083838
PharmGKBⁱ	PA134863395
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00910000144000
HOGENOMⁱ	HOG000234619
HOVERGENⁱ	HBG098310
InParanoidⁱ	Q9NWS9
KOⁱ	K09229
OMAⁱ	GQEMAPS
OrthoDBⁱ	EOG091G08W1
PhylomeDBⁱ	Q9NWS9
TreeFamⁱ	TF337489

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSⁱ	ZNF446 human
GenomeRNAiⁱ	55663
Protein Ontology More...PROⁱ	PR:Q9NWS9

Gene expression databases

Bgeeⁱ	ENSG00000083838 Expressed in 142 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_ZNF446
ExpressionAtlasⁱ	Q9NWS9 baseline and differential
Genevisibleⁱ	Q9NWS9 HS

Family and domain databases

CDDⁱ	cd07765 KRAB_A-box, 1 hit cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR003309 SCAN_dom IPR038269 SCAN_sf IPR027764 Zfp18/Zfp446 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR45403 PTHR45403, 2 hits
Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF02023 SCAN, 1 hit PF00096 zf-C2H2, 1 hit
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN446_HUMAN
Accessionⁱ	Q9NWS9Primary (citable) accession number: Q9NWS9 Secondary accession number(s): Q96AF5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NWS9 (ZN446_HUMAN)

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Zinc finger protein 446

ZNF446

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Extracellular region or secreted

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ