Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 117 (18 Sep 2019)
Sequence version 3 (05 Oct 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

PCNA-interacting partner

Gene

PARPBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PCNA-interacting partner
Short name:
PARI
Alternative name(s):
PARP-1 binding protein
PARP1-binding protein
Short name:
PARPBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PARPBP
Synonyms:C12orf48, PARI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26074 PARPBP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613687 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NWS1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55010

Open Targets

More...
OpenTargetsi
ENSG00000185480

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485378

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PARPBP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153618

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002802691 – 579PCNA-interacting partnerAdd BLAST579

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NWS1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NWS1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NWS1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NWS1

PeptideAtlas

More...
PeptideAtlasi
Q9NWS1

PRoteomics IDEntifications database

More...
PRIDEi
Q9NWS1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82965 [Q9NWS1-1]
82966 [Q9NWS1-2]
82967 [Q9NWS1-3]
82968 [Q9NWS1-4]
82969 [Q9NWS1-5]
82970 [Q9NWS1-6]
82971 [Q9NWS1-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NWS1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NWS1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to testis. Overexpressed in multiple cancer cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185480 Expressed in 147 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NWS1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NWS1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039677

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAD51 and PCNA.

Interacts with PARP1.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120342, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NWS1, 3 interactors

Molecular INTeraction database

More...
MINTi
Q9NWS1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000332915

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Although it shares some sequence similarity with SRS2 yeast helicase, does not contain a functional ATPase domain suggesting it has no helicase activity.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PARI family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEAT Eukaryota
ENOG4111W85 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006088

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NWS1

Database of Orthologous Groups

More...
OrthoDBi
355941at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NWS1

TreeFam database of animal gene trees

More...
TreeFami
TF332230

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR038932 PARPBP

The PANTHER Classification System

More...
PANTHERi
PTHR32121 PTHR32121, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NWS1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVFNQKSVS DMIKEFRKNW RALCNSERTT LCGADSMLLA LQLSMAENNK
60 70 80 90 100
QHSGEFTVSL SDVLLTWKYL LHEKLNLPVE NMDVTDHYED VRKIYDDFLK
110 120 130 140 150
NSNMLDLIDV YQKCRALTSN CENYNTVSPS QLLDFLSGKQ YAVGDETDLS
160 170 180 190 200
IPTSPTSKYN RDNEKVQLLA RKIIFSYLNL LVNSKNDLAV AYILNIPDRG
210 220 230 240 250
LGREAFTDLK HAAREKQMSI FLVATSFIRT IELGGKGYAP PPSDPLRTHV
260 270 280 290 300
KGLSNFINFI DKLDEILGEI PNPSIAGGQI LSVIKMQLIK GQNSRDPFCK
310 320 330 340 350
AIEEVAQDLD LRIKNIINSQ EGVVALSTTD ISPARPKSHA INHGTAYCGR
360 370 380 390 400
DTVKALLVLL DEEAANAPTK NKAELLYDEE NTIHHHGTSI LTLFRSPTQV
410 420 430 440 450
NNSIKPLRER ICVSMQEKKI KMKQTLIRSQ FACTYKDDYM ISKDNWNNVN
460 470 480 490 500
LASKPLCVLY MENDLSEGVN PSVGRSTIGT SFGNVHLDRS KNEKVSRKST
510 520 530 540 550
SQTGNKSSKR KQVDLDGENI LCDNRNEPPQ HKNAKIPKKS NDSQNRLYGK
560 570
LAKVAKSNKC TAKDKLISGQ AKLTQFFRL
Length:579
Mass (Da):65,054
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC576A868DD1F331
GO
Isoform 2 (identifier: Q9NWS1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Show »
Length:498
Mass (Da):55,784
Checksum:iD053D73B3B67AE7F
GO
Isoform 3 (identifier: Q9NWS1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-172: VQLLARK → ALPVLKR
     173-579: Missing.

Note: No experimental confirmation available.
Show »
Length:172
Mass (Da):19,740
Checksum:iA4DF4E7C66A5B910
GO
Isoform 4 (identifier: Q9NWS1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-133: SQLL → VSIF
     134-579: Missing.

Note: No experimental confirmation available.
Show »
Length:133
Mass (Da):15,409
Checksum:iED1F2E72A6A18ACE
GO
Isoform 5 (identifier: Q9NWS1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-285: Missing.

Note: No experimental confirmation available.
Show »
Length:294
Mass (Da):32,927
Checksum:iE749A5C04223CFF9
GO
Isoform 6 (identifier: Q9NWS1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-297: SIAGGQILSVIKMQLIKGQNSRDP → RGCKSICWKINNWNEFWKCSSGQK
     298-579: Missing.

Note: No experimental confirmation available.
Show »
Length:297
Mass (Da):33,864
Checksum:i7DA47EE602E73B9F
GO
Isoform 7 (identifier: Q9NWS1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-394: Missing.
     422-423: MK → RV
     424-579: Missing.

Note: No experimental confirmation available.
Show »
Length:302
Mass (Da):34,399
Checksum:i3C1695D43960C230
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DZ31B4DZ31_HUMAN
PCNA-interacting partner
PARPBP
656Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KQY3J3KQY3_HUMAN
PCNA-interacting partner
PARPBP
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG30A0A0C4DG30_HUMAN
PCNA-interacting partner
PARPBP
264Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DT40B4DT40_HUMAN
PCNA-interacting partner
PARPBP
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G8JLI2G8JLI2_HUMAN
PCNA-interacting partner
PARPBP
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6B3H0Y6B3_HUMAN
PCNA-interacting partner
PARPBP
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH18903 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH30962 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH50696 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH70270 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH70270 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti76N → K in AAH99844 (PubMed:15489334).Curated1
Sequence conflicti155P → L in AAH30962 (PubMed:15489334).Curated1
Sequence conflicti322G → A in AAH98313 (PubMed:15489334).Curated1
Sequence conflicti343H → R in AAH70270 (PubMed:15489334).Curated1
Sequence conflicti381N → D in BAA91306 (PubMed:14702039).Curated1
Sequence conflicti403S → L in BAA91306 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031105400V → M. Corresponds to variant dbSNP:rs12227879Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0235871 – 285Missing in isoform 5. 1 PublicationAdd BLAST285
Alternative sequenceiVSP_0235881 – 81Missing in isoform 2. 2 PublicationsAdd BLAST81
Alternative sequenceiVSP_023589130 – 133SQLL → VSIF in isoform 4. 1 Publication4
Alternative sequenceiVSP_023590134 – 579Missing in isoform 4. 1 PublicationAdd BLAST446
Alternative sequenceiVSP_023591166 – 172VQLLARK → ALPVLKR in isoform 3. 1 Publication7
Alternative sequenceiVSP_023592173 – 579Missing in isoform 3. 1 PublicationAdd BLAST407
Alternative sequenceiVSP_023593274 – 394Missing in isoform 7. 1 PublicationAdd BLAST121
Alternative sequenceiVSP_023594274 – 297SIAGG…NSRDP → RGCKSICWKINNWNEFWKCS SGQK in isoform 6. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_023595298 – 579Missing in isoform 6. 1 PublicationAdd BLAST282
Alternative sequenceiVSP_023596422 – 423MK → RV in isoform 7. 1 Publication2
Alternative sequenceiVSP_023597424 – 579Missing in isoform 7. 1 PublicationAdd BLAST156

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000648 mRNA Translation: BAA91306.1
AK303571 mRNA Translation: BAG64592.1
AC087882 Genomic DNA No translation available.
BC018903 mRNA Translation: AAH18903.1 Different initiation.
BC030962 mRNA Translation: AAH30962.1 Sequence problems.
BC050696 mRNA Translation: AAH50696.1 Different initiation.
BC070270 mRNA Translation: AAH70270.1 Sequence problems.
BC098313 mRNA Translation: AAH98313.1
BC099734 mRNA Translation: AAH99734.2
BC099844 mRNA Translation: AAH99844.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS81729.1 [Q9NWS1-4]
CCDS81730.1 [Q9NWS1-2]
CCDS9090.2 [Q9NWS1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001306917.1, NM_001319988.1
NP_001306922.1, NM_001319993.1 [Q9NWS1-2]
NP_001306923.1, NM_001319994.1 [Q9NWS1-2]
NP_001306924.1, NM_001319995.1
NP_001306925.1, NM_001319996.1 [Q9NWS1-4]
NP_060385.3, NM_017915.4 [Q9NWS1-1]
XP_016875032.1, XM_017019543.1 [Q9NWS1-7]
XP_016875033.1, XM_017019544.1 [Q9NWS1-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000327680; ENSP00000332915; ENSG00000185480 [Q9NWS1-1]
ENST00000392911; ENSP00000376643; ENSG00000185480 [Q9NWS1-2]
ENST00000537257; ENSP00000442549; ENSG00000185480 [Q9NWS1-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55010

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55010

UCSC genome browser

More...
UCSCi
uc001tjd.4 human [Q9NWS1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000648 mRNA Translation: BAA91306.1
AK303571 mRNA Translation: BAG64592.1
AC087882 Genomic DNA No translation available.
BC018903 mRNA Translation: AAH18903.1 Different initiation.
BC030962 mRNA Translation: AAH30962.1 Sequence problems.
BC050696 mRNA Translation: AAH50696.1 Different initiation.
BC070270 mRNA Translation: AAH70270.1 Sequence problems.
BC098313 mRNA Translation: AAH98313.1
BC099734 mRNA Translation: AAH99734.2
BC099844 mRNA Translation: AAH99844.2
CCDSiCCDS81729.1 [Q9NWS1-4]
CCDS81730.1 [Q9NWS1-2]
CCDS9090.2 [Q9NWS1-1]
RefSeqiNP_001306917.1, NM_001319988.1
NP_001306922.1, NM_001319993.1 [Q9NWS1-2]
NP_001306923.1, NM_001319994.1 [Q9NWS1-2]
NP_001306924.1, NM_001319995.1
NP_001306925.1, NM_001319996.1 [Q9NWS1-4]
NP_060385.3, NM_017915.4 [Q9NWS1-1]
XP_016875032.1, XM_017019543.1 [Q9NWS1-7]
XP_016875033.1, XM_017019544.1 [Q9NWS1-6]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120342, 6 interactors
IntActiQ9NWS1, 3 interactors
MINTiQ9NWS1
STRINGi9606.ENSP00000332915

PTM databases

iPTMnetiQ9NWS1
PhosphoSitePlusiQ9NWS1

Polymorphism and mutation databases

BioMutaiPARPBP
DMDMi308153618

Proteomic databases

jPOSTiQ9NWS1
MassIVEiQ9NWS1
MaxQBiQ9NWS1
PaxDbiQ9NWS1
PeptideAtlasiQ9NWS1
PRIDEiQ9NWS1
ProteomicsDBi82965 [Q9NWS1-1]
82966 [Q9NWS1-2]
82967 [Q9NWS1-3]
82968 [Q9NWS1-4]
82969 [Q9NWS1-5]
82970 [Q9NWS1-6]
82971 [Q9NWS1-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327680; ENSP00000332915; ENSG00000185480 [Q9NWS1-1]
ENST00000392911; ENSP00000376643; ENSG00000185480 [Q9NWS1-2]
ENST00000537257; ENSP00000442549; ENSG00000185480 [Q9NWS1-4]
GeneIDi55010
KEGGihsa:55010
UCSCiuc001tjd.4 human [Q9NWS1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55010
DisGeNETi55010

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PARPBP
HGNCiHGNC:26074 PARPBP
HPAiHPA039677
MIMi613687 gene
neXtProtiNX_Q9NWS1
OpenTargetsiENSG00000185480
PharmGKBiPA143485378

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEAT Eukaryota
ENOG4111W85 LUCA
GeneTreeiENSGT00390000006088
InParanoidiQ9NWS1
OrthoDBi355941at2759
PhylomeDBiQ9NWS1
TreeFamiTF332230

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PARPBP human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55010

Pharos

More...
Pharosi
Q9NWS1

Protein Ontology

More...
PROi
PR:Q9NWS1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185480 Expressed in 147 organ(s), highest expression level in lung
ExpressionAtlasiQ9NWS1 baseline and differential
GenevisibleiQ9NWS1 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR038932 PARPBP
PANTHERiPTHR32121 PTHR32121, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPARI_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NWS1
Secondary accession number(s): B4E0Y0
, Q05C00, Q499L8, Q4FZA0, Q4KMW7, Q6NSC6, Q6PJA1, Q86W36
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 5, 2010
Last modified: September 18, 2019
This is version 117 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again